CN101766796A - Chinese medicine composite for treating dysmenorrhea and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicine composite for treating dysmenorrhea and preparation method thereof. The Chinese medicine composite comprises eleven active pharmaceutical ingredients of radix angelicae sinensis, white peony root, tuckahoe, rhizoma cyperi, fructus citri sarcodactylis, wild mint herb, radix bupleuri, radix glycyrrhizae, roasted ginger, Chinese cinnamon and fructus foeniculi. The Chinese medicine composite has the efficacy of soothing the liver and strengthening the spleen as well as harmonizing qi and blood, and can be used for treating premenstrual or menstrual pain and distension in lower abdomen, chest and hypochondrium, breast swollen or distension and pain, even unavailable touch due to pain, anxiety and irritability, different amount of menstrual blood, dark red or blood clot and the like.

Description

A kind of Chinese medicine composition for the treatment of dysmenorrhea and preparation method thereof

Technical field

The invention belongs to tcm field, be specifically related to a kind of Chinese medicine composition for the treatment of dysmenorrhea and preparation method thereof.

Background technology

What Chinese medicine was thought dysmenorrhea is because towards appointing QI-blood circulation not smooth, the circulation of uterus menses is obstructed, so that stagnation of QI and blood may bring about pain, or foster towards appointing uterus to lose in moistening, and Rong Ze bitterly.Western medicine thinks that dysmenorrhea is because the spastic contraction of uterine smooth muscle causes tissue ischemia to cause.

Preparation of the present invention is by the carefree Rhizoma Atractylodis Macrocephalae that leaves, and adds Rhizoma Cyperi, Fructus Citri Sarcodactylis, Cortex Cinnamomi, Fructus Foeniculi and forms.The hot dispersing the stagnated live-QI to relieve the stagnation of QI that looses of Radix Bupleuri in the XIAOYAO POWDER side; The Radix Paeoniae Alba, Chinese Angelica blood replonishing yin fluid astringing, the easing the affected liver emergency, with the medicine-feeding compatibility, make have in dredging gentle, have in loosing foster, soothing the liver easing the affected liver, body is cloudy with sun, QI and blood is in harmonious proportion; Poria, Radix Glycyrrhizae invigorating the spleen and benefiting QI are taken advantage of the forgetful in case liver of spleen soil; Herba Menthae, Roast Rhizoma Zingiberis Recens be hot loose reach strongly fragrant to help Radix Bupleuri catharsis bar to reach; Adding Rhizoma Cyperi, Fructus Citri Sarcodactylis, is the component that increases the weight of depressed liver-energy dispersing and QI regulating, the capable meaning of the residence capable then blood of gas; Cortex Cinnamomi, the soothing the liver circulation of qi promoting of Fructus Foeniculi, warming the meridian and promoting blood circulation.All medicines share, and irritability must be dredged, and insufficiency of the spleen must the benefit must be supported a little less than the blood, and the liver spleen is coordinated, and then all diseases of dysmenorrhea are from removing.

Summary of the invention

The invention provides a kind of Chinese medicine composition for the treatment of dysmenorrhea and preparation method thereof, purpose is to select for extensive patients provides new medication, makes things convenient for patient treatment.

The present invention is achieved by the following technical solutions:

A kind of Chinese medicine composition for the treatment of dysmenorrhea, it is that raw material is made by following parts by weight of Chinese traditional medicine material:

5～35 parts of 5～45 portions of Rhizoma Cyperis of 5～30 parts of Poria of 5～45 parts of Radix Paeoniae Alba of Radix Angelicae Sinensis

2～20 parts in 5～30 portions of Radix Glycyrrhizaes of 2～30 parts of Radix Bupleuri of 5～40 portions of Herba Menthaes of Fructus Citri Sarcodactylis

5～35 parts of 5～35 parts of Fructus Foeniculi of 2～15 portions of Cortex Cinnamomis of Roast Rhizoma Zingiberis Recens

And the weight portion proportioning of described each Chinese crude drug raw material is:

10 parts of 15 portions of Rhizoma Cyperis of 10 parts of Poria of 15 parts of Radix Paeoniae Alba of Radix Angelicae Sinensis

6 parts in 10 portions of Radix Glycyrrhizaes of 6 parts of Radix Bupleuri of 10 portions of Herba Menthaes of Fructus Citri Sarcodactylis

10 parts of 10 parts of Fructus Foeniculi of 5 portions of Cortex Cinnamomis of Roast Rhizoma Zingiberis Recens

Described preparation is a tablet.

Described adjuvant includes but not limited to one or more of starch, dextrin, lactose, microcrystalline Cellulose, soluble starch, carboxymethyl starch sodium, polyvidone apoplexy due to endogenous wind.

The preparation method of this drug regimen is:

(1) get Radix Angelicae Sinensis, Herba Menthae, Rhizoma Cyperi, Radix Bupleuri, Cortex Cinnamomi, Fructus Foeniculi and be ground into coarse powder, with 20～90% ethanol extractions 1～5 time, each 6～15 times of amounts 0.5～5 hour, filter, medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into the thick paste of relative density 1.05～1.35 (25～80 ℃).

(2) get that all the other ground spices such as Radix Paeoniae Alba are broken into coarse powder and above-mentioned medicinal residues merge, decoct with water 1～5 time, each 6～15 times of amounts 0.5～3 hour filter, and collecting decoction is concentrated into the thick paste of relative density 1.05～1.35 (25～85 ℃).

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds appropriate amount of auxiliary materials, sieves, and granulates, and makes tablet, promptly.

For beneficial effect of the present invention better is described, we have carried out following experimental study:

Adopt following principal agent for square substantially:

Radix Angelicae Sinensis 15g Radix Paeoniae Alba 10g Poria 15g Rhizoma Cyperi 10g

Fructus Citri Sarcodactylis 10g Herba Menthae 6g Radix Bupleuri 10g Radix Glycyrrhizae 6g

Roast Rhizoma Zingiberis Recens 5g Cortex Cinnamomi 10g Fructus Foeniculi 10g

Clinical research

1.1 laboratory animal KM kind female mice, body weight 20 ± 2 g, the quality certification number: moving word 14-006 number of doctor is provided by Jilin University medical college zoopery center.

1.2 reagent and medicine preparation of the present invention is developed voluntarily, preparation 1 (3 * 10 of the present invention ^-3G/mL), preparation 2 (1.5 * 10 of the present invention ^-3G/mL); The diethylstilbestrol sheet, the accurate H13020815 of traditional Chinese medicines, Shijiazhuang City China imperial Pharmaceutical limited company produces product batch number: 20040810; Oxytocin, the accurate word H34020474 of traditional Chinese medicines, Ma'an Mountain of Anhui BBCA Pharmaceuticals Co., Ltd. pharmaceutical factory produces, product batch number: 050522-1; Aspirin Enteric-coated Tablets, the accurate word H34021217 of traditional Chinese medicines, Hefei joins pharmaceutical Co. Ltd for a long time and produces product batch number: 20050702; Sodium chloride injection, the accurate word H51021157 of traditional Chinese medicines, Kelun Pharm Ind Co., Ltd., Sichuan produces, product batch number: 051106.

2 test methods

2.1 get 48 of mices, be divided into A (blank group), B (aspirin), C (1 group in preparation of the present invention), D (2 groups in preparation of the present invention, 4 groups) at random, 12 every group.Above-mentioned 4 groups of mice ig every day diethylstilbestrol 2mg/kg, successive administration 10d.Behind the last administration 1h, B organizes ig aspirin (0.06g/kg); C group ig preparation 1 of the present invention (0.06g/kg), D group ig preparation 2 of the present invention (0.03g/kg), A group ig equal-volume normal saline.Each organizes ip oxytocin 20/kg behind the mice administration 30min, and turning round of mice turned round the body number of times after the record injection oxytocin in body incubation period and the 30min.

2.2 the statistical method experimental data adopts the SPSS11.0 statistical disposition, experimental result is so that (z ± SD) expression adopts the t check to compare.

3 results

Result of the test shows, 1 group in preparation of the present invention and aspirin group and the comparison of blank group can prolong turns round body incubation period, difference has statistical significance (P＜0.05), and 2 groups in preparation of the present invention and blank group relatively influence difference not statistically significant (P＞0.05) incubation period to turning round body.Aspirin, 1,2 groups in preparation of the present invention and the comparison of blank group can reduce turns round the body number of times, and difference has statistical significance.The results are shown in Table 1

Table 1 Radix Angelicae Sinensis oil is to the influence of oxytocin induced mice dysmenorrhea model (x ± SD)

* represents and blank relatively P＜0.01 of organizing that * represents to compare P＜0.01 with blank group

4 conclusions

This experiment is by tentatively inquiring into the analgesic activity of preparation of the present invention to dysmenorrhea model in mice in body research, this modular concept is that diethylstilbestrol increases the sensitivity to oxytocin, after mouse peritoneal injection oxytocin, cause that uterine smooth muscle shrinks strongly, cause pain, because its lax uterine smooth muscle effect is found in preparation isolated uterine experiment of the present invention, by after body experiment administration, find that it has analgesic activity to dysmenorrhea model, illustrate that preparation of the present invention is to there being the analgesic activities of lax spasm uterine smooth muscle in the body uterus, and preliminary dosage inquired into, mice 0.06g/kg, 0.03g/kg all belong to effective dose, preparation consumption 1.836g/kg of the present invention obeys Radix Angelicae Sinensis amount (0.2g/kg) with the people and calculates, and the dosage of mice is people's (165 times of the consumption of body weight=50kg) approximately, 82.5 doubly.This experimentation shows, this preparation is to having the analgesic activities of lax spasm uterine smooth muscle in the body uterus, and effect is better than matched group.

The specific embodiment

Embodiment 1: pharmaceutical composition tablet of the present invention

Radix Angelicae Sinensis 15g Radix Paeoniae Alba 10g Poria 15g Rhizoma Cyperi 10g

Fructus Citri Sarcodactylis 10g Herba Menthae 6g Radix Bupleuri 10g Radix Glycyrrhizae 6g

Roast Rhizoma Zingiberis Recens 5g Cortex Cinnamomi 10g Fructus Foeniculi 10g

(1) get Radix Angelicae Sinensis, Herba Menthae, Rhizoma Cyperi, Radix Bupleuri, Cortex Cinnamomi, Fructus Foeniculi and be ground into coarse powder, with 70% ethanol extraction 2 times, each 8 times of amounts 1.5 hours filter, and medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.20 (70 ℃).

(2) get that all the other ground spices such as Radix Paeoniae Alba are broken into coarse powder and above-mentioned medicinal residues merge, decoct with water 2 times, each 10 times of amounts 1.5 hours filter, and collecting decoction is concentrated into the thick paste of relative density 1.20 (60 ℃).

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds 8g starch, sieves, and granulates, and makes 48, promptly.

Embodiment 2: medicament composition granule agent of the present invention

Radix Angelicae Sinensis 40g Radix Paeoniae Alba 25g Poria 30g Rhizoma Cyperi 35g

Fructus Citri Sarcodactylis 40g Herba Menthae 20g Radix Bupleuri 25g Radix Glycyrrhizae 20g

Roast Rhizoma Zingiberis Recens 15g Cortex Cinnamomi 35g Fructus Foeniculi 30g

(1) get Radix Angelicae Sinensis, Herba Menthae, Rhizoma Cyperi, Radix Bupleuri, Cortex Cinnamomi, Fructus Foeniculi and be ground into coarse powder, with 65% ethanol extraction 2 times, each 10 times of amounts 2 hours filter, and medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.20 (70 ℃).

(2) get that all the other ground spices such as Radix Paeoniae Alba are broken into coarse powder and above-mentioned medicinal residues merge, decoct with water 2 times, each 10 times of amounts 1.5 hours filter, and collecting decoction is concentrated into the thick paste of relative density 1.25 (50 ℃).

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds the 25g dextrin, sieves, and granulates, and makes 150, promptly.

Embodiment 3: medicament composition capsule agent of the present invention

Radix Angelicae Sinensis 10g Radix Paeoniae Alba 10g Poria 8g Rhizoma Cyperi 7g

Fructus Citri Sarcodactylis 10g Herba Menthae 6g Radix Bupleuri 14g Radix Glycyrrhizae 5g

Roast Rhizoma Zingiberis Recens 5g Cortex Cinnamomi 10g Fructus Foeniculi 10g

(1) get Radix Angelicae Sinensis, Herba Menthae, Rhizoma Cyperi, Radix Bupleuri, Cortex Cinnamomi, Fructus Foeniculi and be ground into coarse powder, with 75% ethanol extraction 2 times, each 10 times of amounts 1.5 hours filter, and medicinal residues are standby, and merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.25 (50 ℃).

(2) get that all the other ground spices such as Radix Paeoniae Alba are broken into coarse powder and above-mentioned medicinal residues merge, decoct with water 2 times, each 8 times of amounts 2 hours filter, and collecting decoction is concentrated into the thick paste of relative density 1.20 (55 ℃).

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds 10g, sieves, and granulates, and makes 60, promptly.

Claims (3)

1. Chinese medicine composition for the treatment of dysmenorrhea is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:

5～35 parts of 5～45 portions of Rhizoma Cyperis of 5～30 parts of Poria of 5～45 parts of Radix Paeoniae Alba of Radix Angelicae Sinensis

2～20 parts in 5～30 portions of Radix Glycyrrhizaes of 2～30 parts of Radix Bupleuri of 5～40 portions of Herba Menthaes of Fructus Citri Sarcodactylis

5～35 parts of 5～35 parts of Fructus Foeniculi of 2～15 portions of Cortex Cinnamomis of Roast Rhizoma Zingiberis Recens.

2. a kind of Chinese medicine composition for the treatment of dysmenorrhea according to claim 1 is characterized in that it is made up of by the raw material of Chinese medicine of part following unit of weight:

10 parts of 15 portions of Rhizoma Cyperis of 10 parts of Poria of 15 parts of Radix Paeoniae Alba of Radix Angelicae Sinensis

6 parts in 10 portions of Radix Glycyrrhizaes of 6 parts of Radix Bupleuri of 10 portions of Herba Menthaes of Fructus Citri Sarcodactylis

10 parts of 10 parts of Fructus Foeniculi of 5 portions of Cortex Cinnamomis of Roast Rhizoma Zingiberis Recens.

3. according to each described a kind of Chinese medicine composition for the treatment of dysmenorrhea of claim 1-2, its preparation method is:

(1) get Radix Angelicae Sinensis, Herba Menthae, Rhizoma Cyperi, Radix Bupleuri, Cortex Cinnamomi, Fructus Foeniculi and be ground into coarse powder, with 20～90% ethanol extractions 1～5 time, each 6～15 times of amounts 0.5～5 hour, filter, medicinal residues are standby, merging filtrate, reclaim ethanol, be concentrated into the thick paste of relative density 1.05～1.35 (25～80 ℃).

(2) get that all the other ground spices such as Radix Paeoniae Alba are broken into coarse powder and above-mentioned medicinal residues merge, decoct with water 1～5 time, each 6～15 times of amounts 0.5～3 hour filter, and collecting decoction is concentrated into the thick paste of relative density 1.05～1.35 (25～85 ℃).

(3) above-mentioned steps (1) (2) gained thick paste is mixed, drying is pulverized, and adds appropriate amount of auxiliary materials, sieves, and granulates, and makes tablet, promptly.