CN101757311B

CN101757311B - Traditional Chinese medicine capsule for treating knee osteoarthritis

Info

Publication number: CN101757311B
Application number: CN2009102276034A
Authority: CN
Inventors: 葛孔顺
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-12-23
Filing date: 2009-12-23
Publication date: 2012-04-25
Anticipated expiration: 2029-12-23
Also published as: CN101757311A

Abstract

The invention relates to a traditional Chinese medicine capsule for treating knee osteoarthritis, which can effectively solve the problems of troublesome treatment of knee osteoarthritis, long period and poor curative effect. The technical scheme is that the traditional Chinese medicine capsule comprises the following components in parts by weight: 2-2.5 parts of cooked pseudo-ginseng, 2-2.5 parts of crude pseudo-ginseng, 1.5-2 parts of angelica sinensis, 0.5-1 part of pawpaw, 0.5-1 part of zaocys dhumnade, 0.5-1 part of eucommia ulmoides, 0.5-1 part of radix angelicae, 1-1.5 parts of cortex acanthopanacis, 1-1.5 parts of saffron and 0.5-1 part of liquorice. The traditional Chinese medicine capsule is prepared by cooking pseudo-ginseng at a constant temperature of 110 DEG C for one hour into cooked pseudo-ginseng and then drying, grinding into 120-meshe powder, purifying crude pseudo-ginseng, angelica sinensis, pawpaw, zaocys dhumnade, eucommia ulmoides, radix angelicae, cortex acanthopanacis, saffron and liquorice, air separating to remove dust, drying to prepare 120-mesh powder, evenly mixing the powder with the cooked pseudo-ginseng to prepare traditional Chinese medicine pellet, wherein ethocel or lac or sargassum packages enteric coating is packaged into the capsule. The invention has scientific and reasonable formulation, good treatment effect and no toxic side effect and is innovation in the traditional Chinese medicine.

Description

The Chinese medicinal capsule of treatment knee osteoarthritis

One, technical field

The present invention relates to medicine, particularly a kind of Chinese medicinal capsule (claiming golden bright promise enteric-coated pellet capsule again) of treating knee osteoarthritis.

Two, background technology

Knee osteoarthritis is clinical common osteoarthritis, good sending out in middle-aged and elderly people, and general chronic onset, outbreak increases the weight of gradually repeatedly.Chinese medicine is thought.Knee osteoarthritis belongs to " rheumatism involving the bone " category, asthenia how with age, and caused by liver and kidney deficiency, bone lose and nourish, disorder of QI and blood and causing.Wind-cold damp pathogen invasion and attack, external force impairment caused by overstrain can cause the resistance of meridians numbness and aggravate the pain, at present; The treatment knee osteoarthritis adopts oral drugs more, and double external application and massage treatment, the treatment trouble; Cycle is long, and the Chinese and western drugs of particularly treating usefulness at present is a lot, but for various reasons; The particularly pained difficult pharynx of Chinese medicine decoction is used loaded down with trivial detailsly, and part patient returns stomach, vomiting reaction.Though curative effect is remarkable, part patient is difficult for accepting, and in clinical use, doctor and patient usually sinks into the dilemma, has influenced use and therapeutic effect greatly, therefore, the innovation on its medicine and improve imperative.

Three, summary of the invention

To above-mentioned situation, for overcoming the prior art defective, the present invention's purpose just provides a kind of Chinese medicinal capsule of treating knee osteoarthritis, can effectively solve the problem of knee osteoarthritis treatment trouble, cycle length, weak curative effect; The technical scheme of its solution is that according to the Chinese medicine and pharmacy principle, knee osteoarthritis is many because of weak, caused by liver and kidney deficiency; Bone lose to nourish, disorder of QI and blood and causing, and due to the wind-cold damp pathogen invasion and attack, its Therapeutic Principle is a strengthening the body resistance; Enrich blood and invigorate blood circulation, reducing swelling and alleviating pain, the removing dampness of dispeling the wind, channels sootheing and network vessel quickening, so Chinese medicinal capsule of the present invention adopts the parts by weight meter: 2～2.5 parts of cooked Radix Notoginseng, 2～2.5 parts of raw sangqi ginsengs, 1.5～2 parts of Radix Angelicae Sinensis, 0.5～1 part of Fructus Chaenomelis, 0.5～1 part of Zaocys, 0.5～1 part of the Cortex Eucommiae, 0.5～1 part of the Radix Angelicae Dahuricae, 1～1.5 part of Cortex Acanthopancis, 1～1.5 part of Stigma Croci, Radix Glycyrrhizae are processed for 0.5～1 part; Wherein, cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, heats to take out in 1 hour to dry and processes cooked Radix Notoginseng; Be ground into 120 order powder,, pick up clean impurity raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Selecting crude drugs with winnower is removed dust, and 120 order powder are processed in oven dry, process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously; In case of necessity, can add pharmaceutic adjuvant dextrin, starch, ethyl cellulose or Lac or alginate jelly are enteric coated; Incapsulate, promptly get, prescription science of the present invention, reasonable; Therapeutic effect is good, has no side effect, and not only can be effective to treat knee osteoarthritis; Also can be widely used in the arthralgia that wind and cold wet arthritis, myofascitis, scapulohumeral periarthritis, external humeral epicondylitis, tendinitis, pyriformis syndrome, peripheral neuritis, soft tissue injury, damage sequela, osteoarthritis and other rheumatism cause, joint stuffiness, muscles and bones acid is expanded profound uncomfortable; Sciatica, limbs contracture pain, tingle disease such as unable are the innovations on the Chinese medicine.

Four, the specific embodiment

Elaborate below in conjunction with the embodiment specific embodiments of the invention.

Embodiment 1

In practical implementation, Chinese medicinal capsule of the present invention can be implemented by following concrete mode, and promptly in parts by weight: 2 parts of cooked Radix Notoginseng, 2 parts of raw sangqi ginsengs, 1.5 parts of Radix Angelicae Sinensis, 0.5 part of Fructus Chaenomelis, 0.5 part of Zaocys, 0.5 part of the Cortex Eucommiae, 0.5 part of the Radix Angelicae Dahuricae, 1 part of Cortex Acanthopancis, 1 part of Stigma Croci, Radix Glycyrrhizae are processed for 0.5 part; Wherein, cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, and heating became cooked Radix Notoginseng in 1 hour; Take out oven dry and process 120 order powder,, pick up clean impurity raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Selecting crude drugs with winnower is removed dust; 120 order powder are processed in oven dry, process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously, and ethyl cellulose is enteric coated; The capsule of packing into No. 1, every capsules includes Chinese medicine 0.2g.

Embodiment 2

In practical implementation, what Chinese medicinal capsule of the present invention also can be by the parts by weight meter: 2.5 parts of cooked Radix Notoginseng, 2.5 parts of raw sangqi ginsengs, 2 parts of Radix Angelicae Sinensis, 1 part of Fructus Chaenomelis, 1 part of Zaocys, 1 part of the Cortex Eucommiae, 1 part of the Radix Angelicae Dahuricae, 1.5 parts of Cortex Acanthopanciss, 1.5 parts of Stigma Crocis, Radix Glycyrrhizae are processed for 1 part, wherein; Cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, heats to become cooked Radix Notoginseng in 1 hour, takes out oven dry and processes 120 order powder; With raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Pick up clean impurity, selecting crude drugs with winnower is removed dust, and 120 order powder are processed in oven dry; Process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously; Lac is enteric coated, the capsule of packing into No. 1, and every capsules includes Chinese medicine 0.2g.

Embodiment 3

In practical implementation, what Chinese medicinal capsule of the present invention also can be by the parts by weight meter: 2.25 parts of cooked Radix Notoginseng, 2.25 parts of raw sangqi ginsengs, 1.75 parts of Radix Angelicae Sinensis, 0.75 part of Fructus Chaenomelis, 0.75 part of Zaocys, 0.75 part of the Cortex Eucommiae, 0.75 part of the Radix Angelicae Dahuricae, 1.25 parts of Cortex Acanthopanciss, 1.25 parts of Stigma Crocis, Radix Glycyrrhizae are processed for 0.75 part, wherein; Cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, heats to become cooked Radix Notoginseng in 1 hour, takes out oven dry and processes 120 order powder; With raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Pick up clean impurity, selecting crude drugs with winnower is removed dust, and 120 order powder are processed in oven dry; Process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously; Alginate jelly is enteric coated, the capsule of packing into No. 1, and every capsules includes Chinese medicine 0.2g.

In said medicine, wherein Radix Notoginseng (claiming Radix Notoginseng again) gives birth to the hemostasis of article function dissipating blood stasis, reducing swelling and alleviating pain; Ripe article function is enriched blood and is invigorated blood circulation, and the effect of strengthening by means of tonics is arranged; Radix Angelicae Sinensis can be enriched blood and invigorated blood circulation; Fructus Chaenomelis (claim not only Fructus Chaenomelis), Cortex Acanthopancis, the Cortex Eucommiae (claim not only Cortex Eucommiae), Zaocys, the Radix Angelicae Dahuricae (but also claiming angelica anomala) can expelling wind and removing dampness, relieving spasm to stop pain, nourishing the liver and kidney; Stigma Croci can be invigorated blood circulation, blood stasis dispelling, collateral dredging; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, cushion toxicity.

The organic assembling of said medicine supports to have strengthening the body resistance mutually, enriches blood and invigorates blood circulation; Reducing swelling and alleviating pain, the effect of the removing dampness of dispeling the wind, channels sootheing and network vessel quickening can make the blood vessels circulation, and mechanism of qi is unobstructed; Meridians are able to warm, and muscles and bones being able to moistened foster, and pain, all diseases of swelling can be eliminated thereupon; Reach the purpose of effective treatment knee osteoarthritis, and obtained fully proving through clinical data, relevant clinical data is following:

Knee osteoarthritis is the common disease of middle-aged and elderly people, and from year March in November, 2006 to 2008, treatment knee osteoarthritis 252 examples have obtained satisfactory effect, and concrete outcome is following:

Knee osteoarthritis patient 252 examples, male 100 examples, women 152 examples, 40～76 years old age, average 52 years old, two knee joints 68 examples of falling ill, single knee joint 184 examples of falling ill all have the gonalgia, limitation of activity, tired postemphasis alleviates after the rest.Talipes varus 22 examples in the knee joint have friction sound 80 examples, knee joint swelling, floating patella test positive person 26 examples, limited person's 188 examples of can normally squatting down of joint flexing when movable.Have a medical check-up tenderness is arranged around two Xiyans and the patella.X ray examination knee joint all has degeneration in various degree, narrow person's 62 examples in joint space wherein, and tibia spinous process of tibia 192 examples that come to a point, edge, joint hyperosteogeny forms 96 examples, lower edge hyperosteogeny person 124 examples on the patella, facies articularis patellae osteosclerosis person 60 examples.All meet the diagnosis of knee osteoarthritis.

Above-mentioned 252 routine patients are treated oral 1 time 4 (every intragranular contains Chinese medicine 0.2g), 3 times on the 1st with Chinese medicinal capsule of the present invention; Two weeks were 1 course of treatment, the shortest 1 course of treatment of treatment time, the longest 4 courses of treatment; Average 1.8 courses of treatment; By " disease of tcm diagnoses and treatment standard " evaluation, result's 152 examples of fully recovering account for 60.32%; Produce effects 76 examples account for 30.16%; 20 examples that take a turn for the better account for 7.94%; Invalid 4 examples account for 1.59%.Total effective rate 98.41%.

When above-mentioned knee osteoarthritis 252 routine patient treatments are observed, also bones and muscles pain, rheumatic Bi syndrome patient 158 examples are observed treatment with the present invention, every day, oral capsule of the present invention was 3 times; Each 4, every contains Chinese medicine 0.2g, and two weeks were a course of treatment; Add up after two courses of treatment, the result is:

Pain symptom complete obiteration, and operate as normal, studying and living work healing person 119 people, pain symptom has clear improvement or improver 37 people, invalid 2 people, total effective rate 98.7%.

Can find out by above-mentioned situation; The present invention is the active drug of chronic pain patients such as treatment bones and muscles pain, rheumatic Bi syndrome, osteoarthritis, and its curative effect has outstanding clinical meaning up to more than 98%; And in clinical trial, do not find to have any toxic and side effects and untoward reaction; Drug safety, stable curative effect is that one on the Chinese medicine is created greatly.

Claims

1. a Chinese medicinal capsule of treating knee osteoarthritis is characterized in that, by the parts by weight meter: 2～2.5 parts of cooked Radix Notoginseng, 2～2.5 parts of raw sangqi ginsengs, 1.5～2 parts of Radix Angelicae Sinensis, 0.5～1 part of Fructus Chaenomelis, 0.5～1 part of Zaocys, 0.5～1 part of the Cortex Eucommiae, 0.5～1 part of the Radix Angelicae Dahuricae, 1～1.5 part of Cortex Acanthopancis, 1～1.5 part of Stigma Croci, Radix Glycyrrhizae are processed for 0.5～1 part; Wherein, cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, heats to take out in 1 hour to dry and processes cooked Radix Notoginseng; Be ground into 120 order powder; With raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae, pick up clean impurity, selecting crude drugs with winnower is removed dust; 120 order powder are processed in oven dry; Process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously, ethyl cellulose or Lac or alginate jelly are enteric coated, incapsulate.

2. the Chinese medicinal capsule of treatment knee osteoarthritis according to claim 1 is characterized in that, in parts by weight: 2 parts of cooked Radix Notoginseng, 2 parts of raw sangqi ginsengs, 1.5 parts of Radix Angelicae Sinensis, 0.5 part of Fructus Chaenomelis, 0.5 part of Zaocys, 0.5 part of the Cortex Eucommiae, 0.5 part of the Radix Angelicae Dahuricae, 1 part of Cortex Acanthopancis, 1 part of Stigma Croci, Radix Glycyrrhizae are processed for 0.5 part; Wherein, cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, and heating became cooked Radix Notoginseng in 1 hour; Take out oven dry and process 120 order powder,, pick up clean impurity raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Selecting crude drugs with winnower is removed dust; 120 order powder are processed in oven dry, process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously, and ethyl cellulose is enteric coated; The capsule of packing into No. 1, every capsules includes Chinese medicine 0.2g.

3. the Chinese medicinal capsule of treatment knee osteoarthritis according to claim 1 is characterized in that, by the parts by weight meter: 2.5 parts of cooked Radix Notoginseng, 2.5 parts of raw sangqi ginsengs, 2 parts of Radix Angelicae Sinensis, 1 part of Fructus Chaenomelis, 1 part of Zaocys, 1 part of the Cortex Eucommiae, 1 part of the Radix Angelicae Dahuricae, 1.5 parts of Cortex Acanthopanciss, 1.5 parts of Stigma Crocis, Radix Glycyrrhizae are processed for 1 part; Wherein, cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, and heating became cooked Radix Notoginseng in 1 hour; Take out oven dry and process 120 order powder,, pick up clean impurity raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Selecting crude drugs with winnower is removed dust; 120 order powder are processed in oven dry, process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously, and Lac is enteric coated; The capsule of packing into No. 1, every capsules includes Chinese medicine 0.2g.

4. the Chinese medicinal capsule of treatment knee osteoarthritis according to claim 1 is characterized in that, by the parts by weight meter: 2.25 parts of cooked Radix Notoginseng, 2.25 parts of raw sangqi ginsengs, 1.75 parts of Radix Angelicae Sinensis, 0.75 part of Fructus Chaenomelis, 0.75 part of Zaocys, 0.75 part of the Cortex Eucommiae, 0.75 part of the Radix Angelicae Dahuricae, 1.25 parts of Cortex Acanthopanciss, 1.25 parts of Stigma Crocis, Radix Glycyrrhizae are processed for 0.75 part; Wherein, cooked Radix Notoginseng is with 110 degrees centigrade of Radix Notoginseng constant temperature, and heating became cooked Radix Notoginseng in 1 hour; Take out oven dry and process 120 order powder,, pick up clean impurity raw sangqi ginseng, Radix Angelicae Sinensis, Fructus Chaenomelis, Zaocys, the Cortex Eucommiae, the Radix Angelicae Dahuricae, Cortex Acanthopancis, Stigma Croci and Radix Glycyrrhizae; Selecting crude drugs with winnower is removed dust; 120 order powder are processed in oven dry, process Chinese medicine pellet with cooked Radix Notoginseng powder mix homogeneously, and alginate jelly is enteric coated; The capsule of packing into No. 1, every capsules includes Chinese medicine 0.2g.