CN101757085A - Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof - Google Patents
Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof Download PDFInfo
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- CN101757085A CN101757085A CN200810153371A CN200810153371A CN101757085A CN 101757085 A CN101757085 A CN 101757085A CN 200810153371 A CN200810153371 A CN 200810153371A CN 200810153371 A CN200810153371 A CN 200810153371A CN 101757085 A CN101757085 A CN 101757085A
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Abstract
The present invention discloses a preparation method of Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases. The method comprises the following steps of: extracting and refining the ginkgo leaf and szechuan lovage rhizome to obtain the extract with higher content of active ingredient, adding the extract with pharmaceutic adjuvant with a ratio of 1 : 1 - 5 and 1 : 1 - 8, mixing uniformly, and preparing into soft capsule and pills respectively. The Chinese medicine preparation has significant effect on the treatment of ischemic cardiovascular and cerebrovascular diseases, coronary heart disease, angina pectoris, cerebral embolism, cerebral vasospasm and the like, no toxic and side-effect, the production technology is simple, and the quality control of product is convenient.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of Chinese medicine preparation that is used for the treatment of ischemic cardio cerebrovascular diseases, in particular, is a kind of preparation method that contains the soft capsule and the drop pill of Folium Ginkgo, Rhizoma Chuanxiong extract.
Background technology
Cardiovascular and cerebrovascular disease is the general designation of cardiovascular disease and cerebrovascular disease, and general reference is because the common name of ischemic or hemorrhage takes place in heart, brain and the body tissue that hyperlipemia, blood are sticky, atherosclerosis, hypertension etc. are caused.Occur in the disease meaning cardiovascular diseases of heart arter blood vessel, mainly contain: myocardial infarction, coronary heart disease, myocardial infarction etc.The pathological changes that occurs in cerebral artery vessel is called cerebrovascular, mainly contains cerebral hemorrhage, cerebral thrombosis, cerebral embolism etc.Cardiovascular and cerebrovascular disease is the high disease of a kind of disability rate.In case must go up this class disease, oneself be difficult to take care of oneself, cause very big financial burden and mental pressure to family.Usually because tied down the household, mood is not smooth, has influenced treatment of diseases on the contrary yet for patient oneself.For cardiovascular and cerebrovascular disease, no matter be from economic angle, family's angle, still from health perspectives, have prevention only and be only completely safe plan, brilliant act.Prevention in early one day is earlier felt at ease.
Yet along with economic development, growth in the living standard, the life style of Chinese population takes place and great variety has all taken place dietary structure, from five sixties serve as main three high dietetics that are transformed into higher fatty acid, high protein, high heat with grain and vegetable, adding gets on the car enters popularizing of family, TV and computer, hypokinesia, and national overweight crowd has reached 200,000,000, obese people reaches 60,000,000, and middle age and old people's prevalence are approaching, and differentials between town and country are little.These life style and risk factor will cause the cardiovascular disease incidence rate to increase rapidly, estimate that the probability that China's middle age in 2010 suffers from a heart complaint will maintain an equal level with the U.S., it is high to welcome apoplexy simultaneously, the tide of the myocardial infarction zooming second time of cardiovascular disease.This will cause white elephant, and the economic growth of influence.Therefore the exploitation of this project has bigger social benefit and economic benefit.
At present, be used for ischemic cardio cerebrovascular diseases, arteriosclerosis, cerebral thrombosis, cerebral ischemia, coronary heart disease, treatment of diseases such as angina pectoris.Folium Ginkgo is the conventional Chinese medicine of blood circulation promoting and blood stasis dispelling in the prescription, and Folium Ginkgo liposoluble ingredient wherein has antiplatelet aggregative activity, anti-thrombosis function, microcirculation improvement effect, anti-oxidative damage effect and multipath performance myocardium protecting action.
Rhizoma Chuanxiong in the prescription contains multiple compositions such as alkaloid, phenolic compound, lactone and neutral oils.Alkaloid main active ligustrazine very easily distils (22 ℃), and not soluble in water, is soluble in hot water, is dissolved in ethanol.The phenolic constituent master contains ferulic acid, and the ferulic acid water solublity is relatively poor, is dissolved in hot water, ethanol, and chemical stability is not high, and poor stability in aqueous solution sees that the light time decomposition is faster, and particularly high temperature sterilize is bigger to the destruction of ferulic acid.
But existing two kinds of dosage forms all exist in various degree shortcoming and deficiency, and for example, the electuary taking dose is big, takes inconvenience; Oral liquid is a liquid dosage form, and main effective ingredient salvianolic acid B is unstable in solution in the Folium Ginkgo, and long-term storage can affect the treatment.What is more important, above-mentioned two kinds of dosage forms all can not keep the oiliness composition in the Rhizoma Chuanxiong, and the effective ingredient in the Rhizoma Chuanxiong oil has heart tonifying, increases the effect of coronary flow.
Summary of the invention
The object of the present invention is to provide a kind of preparation method that is used for the treatment of the ischemic cardio cerebrovascular diseases Chinese medicine preparation.
The soft preparation technology of Chinese medicine preparation who is used for the treatment of ischemic cardio cerebrovascular diseases of the present invention comprises:
(1) Folium Ginkgo 1250g, Radix Puerariae 1250g are ground into coarse powder, add 2～10 times of 40～80% ethanol of medical material weight, and room temperature dipping 2～5 times each 12～48 hours, merges impregnation liquid;
(2) concentrating under reduced pressure filters, and filtrate is crossed macroporous adsorptive resins, for example macroporous adsorptive resins AB-8 or D101.With the aqueous hydrochloric acid solution washing resin bed of pH2～7 of 3～10 times of amounts of column volume, wash post after, with 30～90% ethanol elutions of 2～5 times of amounts of column volume, collect eluent, concentrating under reduced pressure, vacuum drying, dry extract 50～200g, pulverize standby;
(3) Rhizoma Chuanxiong power is broken into coarse powder, adds 2～10 times of amount 60～90% ethanol, room temperature dipping 2～5 times, each 12～48 hours, merge impregnation liquid, concentrating under reduced pressure, static layering, Rhizoma Chuanxiong extract 50～150g, standby;
(4) preparation of drop pill: according to the above ratio extract is mixed with the adjuvant Polyethylene Glycol, stirring makes whole dissolvings and mix homogeneously, keep under 60～90 ℃ of constant temperatures, splash in liquid paraffin or the methyl-silicone oil in 5～10 ℃, be condensed into drop pill, exhaust liquid paraffin or methyl-silicone oil, the choosing grain, 10000 drop pill, promptly.
The capsule that is used for the treatment of the ischemic cardio cerebrovascular diseases Chinese medicine preparation of the present invention has at utmost kept the active ingredient of three flavor medical materials, and taking convenience.Wherein, the adjuvant of soft capsule is an oil, adds gelatin-sealed, can be suspended in Rhizoma Chuanxiong oil, Folium Ginkgo and the Radix Puerariae extract processing technique by the capsule core material of soft capsule in the oil, can fully keep the medicine active ingredient like this.Because all medicines have increased the stability of sour B of red acid and Rhizoma Chuanxiong volatile ingredient by the sealing of gelatin flexible glue skin, and do not have drug flavor when taking, the patient is acceptant.
Pulse invigorating pill is a kind of herbal mixture dropping pill formulation that modern high technology is produced of using, and, is splashed in the condensed fluid that mixes and formation through the suitable drip of bore with after the substrate heating and melting becomes solution by medicine.It has the title of solid solution, and dissolution rate is fast, bioavailability is high, and consumption is little, and the effect of having immediate effect.The medicine stability height that adopts drops to make, not facile hydrolysis, be difficult for oxidation, owing under liquid state, operate, no dust pollution, not influenced by crystal formation, be easy to guarantee the quality of medicine, it is quality controllable, dosage form is advanced, quick-acting, efficient, no gastric irritation, dissolving is fast, taking dose is little, stability is high.It is a kind of advanced person's form of Chinese drug.The arteries and veins soft capsule has obvious anti-cardiac-cerebral ischemia effect and function of promoting blood circulation to disperse blood clots, and its action intensity and oral liquid are suitable.
The specific embodiment:
The following examples can help those skilled in the art more fully to understand the present invention, but do not limit the present invention in any way.
Embodiment 1
Preparation technology
Folium Ginkgo 1250g, Radix Puerariae 1250g are ground into coarse powder, add 10 times of amount 80% ethanol room temperatures dippings 5 times, each 48 hours, merge impregnation liquid.Decompression recycling ethanol also concentrates, and filters, and filtrate is crossed macroporous adsorbent resin AB-8 post, aqueous hydrochloric acid solution washing resin bed with the pH7 of 10 times of amounts of column volume, after washing post,, collect eluent with 90% ethanol elution of 5 times of amounts of column volume, decompression recycling ethanol, concentrate, vacuum drying gets dry extract, pulverize, standby.
Rhizoma Chuanxiong power 1250g is broken into coarse powder, adds 10 times of amount 90% ethanol room temperatures dippings 5 times, each 48 hours, merges impregnation liquid.Decompression recycling ethanol concentrates, and layering gets Rhizoma Chuanxiong extract, and is standby.
(1). qi-circulation promoting soft capsule
Above-mentioned dry extract and Rhizoma Chuanxiong extract are merged, add adjuvant Petiolus Trachycarpi oil 10%, Cera Flava 5%, supply final quantity, make suspension with soybean oil.Be pressed into 1000 of soft capsules on the mould machine rolling automatically.Through washing ball, drying, polishing, packing are promptly.
(2). pulse invigorating pill
Dry extract and Rhizoma Chuanxiong extract are merged, add Polyethylene Glycol-4000, stir and make whole dissolvings and mix homogeneously, keep splashing in the liquid paraffin (5～10 ℃) under 60～90 ℃ of constant temperatures, be condensed into drop pill, exhaust liquid paraffin, the choosing grain, promptly.
Embodiment 2
Preparation technology
Folium Ginkgo 1250g, Radix Puerariae 1250g are ground into coarse powder, add 2 times of amount 40% ethanol room temperatures dippings 2 times, each 12 hours, merge impregnation liquid.Decompression recycling ethanol also concentrates, and filters, and filtrate is crossed macroporous adsorbent resin D101 post, aqueous hydrochloric acid solution washing resin bed with the pH2 of 3 times of amounts of column volume, after washing post,, collect eluent with 30% ethanol elution of 2 times of amounts of column volume, decompression recycling ethanol, concentrate, vacuum drying gets dry extract, pulverize, standby.
Rhizoma Chuanxiong 1250g is ground into coarse powder, adds 2 times of amount 60% ethanol room temperatures dippings 2 times, each 12 hours, merges impregnation liquid.Decompression recycling ethanol concentrates, and layering gets Rhizoma Chuanxiong extract, and is standby.
(1). qi-circulation promoting soft capsule
Dry extract and Rhizoma Chuanxiong extract are merged, add Petiolus Trachycarpi oil 12%, Cera Flava 7%g, soybean oil is supplied final quantity, makes suspension.Be pressed into soft capsule rolling automatically on the mould machine.Through washing ball, drying, polishing, packing are promptly.
(2). pulse invigorating pill
Dry extract and Rhizoma Chuanxiong extract are merged, add 30% Polyethylene Glycol-4000,50%g Polyethylene Glycol-6000, stir and make whole dissolvings and mix homogeneously, keep splashing in the methyl-silicone oil (5～10 ℃) under 60 ℃ of constant temperatures, be condensed into drop pill.Blot methyl-silicone oil, the choosing grain, promptly.
Embodiment 3
Preparation technology
Folium Ginkgo 1250g, Radix Puerariae 1250g are ground into coarse powder, add 5 times of amount 60% ethanol room temperatures dippings 4 times, each 20 hours, merge impregnation liquid.Decompression recycling ethanol also concentrates, and filters, and filtrate is crossed macroporous adsorbent resin AB-8 post, aqueous hydrochloric acid solution washing resin bed with the pH3 of 5 times of amounts of column volume, after washing post,, collect eluent with 50% ethanol elution of 5 times of amounts of column volume, decompression recycling ethanol, concentrate, vacuum drying gets dry extract, pulverize, standby.
Rhizoma Chuanxiong 1250g is ground into coarse powder, adds 4 times of amount 70% ethanol room temperatures dippings 2 times, each 20 hours, merges impregnation liquid.Decompression recycling ethanol concentrates, and layering gets Rhizoma Chuanxiong extract, and is standby.
(1). qi-circulation promoting soft capsule
Dry extract and Rhizoma Chuanxiong extract are merged, add adjuvant Cera Flava 6%, Petiolus Trachycarpi oil 4%, soybean oil is supplied final quantity, makes suspension.Be pressed into soft capsule rolling automatically on the mould machine.Through washing ball, drying, polishing, packing are promptly.
(2). pulse invigorating pill
Just dry extract and Rhizoma Chuanxiong extract merge, and add 70% Polyethylene Glycol-6000, stir and make whole dissolvings and mix homogeneously, keep splashing in the methyl-silicone oil (5～10 ℃) under 60 ℃ of constant temperatures, are condensed into drop pill, exhaust methyl-silicone oil, the choosing grain, promptly.
Embodiment 4
Preparation technology
Folium Ginkgo 1250g, Radix Puerariae 1250g are ground into coarse powder, add 5 times of amount 60% ethanol room temperatures dippings 4 times, each 20 hours, merge impregnation liquid.Decompression recycling ethanol also concentrates, and filters, and filtrate is crossed macroporous adsorbent resin D101 post, aqueous hydrochloric acid solution washing resin bed with the pH2 of 3 times of amounts of column volume, after washing post,, collect eluent with 30 ethanol elutions of 2 times of amounts of column volume, decompression recycling ethanol, concentrate, vacuum drying gets dry extract, pulverize, standby.
Rhizoma Chuanxiong 1250g is ground into coarse powder, adds 4 times of amount 75% ethanol room temperatures dippings 2 times, each 18 hours, merges impregnation liquid.Decompression recycling ethanol concentrates, and layering gets Rhizoma Chuanxiong extract, and is standby.
(1). qi-circulation promoting soft capsule
Above-mentioned two kinds of extracts merge, and add adjuvant Petiolus Trachycarpi oil 8%, Cera Flava 3%, and soybean oil is supplied final quantity, makes suspension.Be pressed into soft capsule rolling automatically on the mould machine.Through washing ball, drying, polishing, packing are promptly.
(2). pulse invigorating pill
Dry extract and Rhizoma Chuanxiong extract are merged, add 20%g Macrogol 4000,50% polyethylene glycol 6000, stir and make whole dissolvings and mix homogeneously, keep splashing in the white oil (5～10 ℃) under 60 ℃ of constant temperatures, be condensed into drop pill, exhaust white oil, the choosing grain, promptly.
Claims (2)
1. preparation method that is used for the treatment of the ischemic cardio cerebrovascular diseases Chinese medicine preparation is characterized in that:
(1) Folium Ginkgo, powder of Radix Puerariae are broken into coarse powder, add 2～10 times of 40～80% ethanol of medical material weight, room temperature dipping 2～5 times each 12～48 hours, merges impregnation liquid;
(2) concentrating under reduced pressure filters, and filtrate is crossed macroporous adsorptive resins, with the aqueous hydrochloric acid solution washing resin bed of pH2～7 of 3～10 times of amounts of column volume, after washing post,, collect eluent, concentrating under reduced pressure with 30～90% ethanol elutions of 2～5 times of amounts of column volume, vacuum drying gets dry extract, pulverizes standby;
(3) Rhizoma Chuanxiong power is broken into coarse powder, adds 2～10 times of amount 60～90% ethanol, room temperature dipping 2～5 times, each 12～48 hours, merge impregnation liquid, concentrating under reduced pressure, static layering, Rhizoma Chuanxiong extract, standby;
(4) in proportion above-mentioned 2,3 extracts are merged, add Polyethylene Glycol, stir and make whole dissolvings and mix homogeneously, keep under 60～90 ℃ of constant temperatures, splash in liquid paraffin or the methyl-silicone oil in 5～10 ℃, be condensed into drop pill, exhaust liquid paraffin or methyl-silicone oil, coating, the choosing grain, promptly.
2. Chinese medicine preparation as claimed in claim 1, wherein, the weight ratio of described Macrogol 4000 and polyethylene glycol 6000 is 1: 1～4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN200810153371A CN101757085A (en) | 2008-11-25 | 2008-11-25 | Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof |
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| CN200810153371A CN101757085A (en) | 2008-11-25 | 2008-11-25 | Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626160A (en) * | 2012-04-23 | 2012-08-08 | 北京绿源求证科技发展有限责任公司 | Brain-nourishing nutritional food, brain-nourishing tea granules |
| CN104435213A (en) * | 2014-11-13 | 2015-03-25 | 成都医路康医学技术服务有限公司 | Persimmon-leaf-containing traditional Chinese medicine composition for treating cardia-cerebrovascular disease |
| CN106563077A (en) * | 2016-08-22 | 2017-04-19 | 王林玉 | Traditional Chinese medicinal composition for treating ischemic cardiovascular disease |
-
2008
- 2008-11-25 CN CN200810153371A patent/CN101757085A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102626160A (en) * | 2012-04-23 | 2012-08-08 | 北京绿源求证科技发展有限责任公司 | Brain-nourishing nutritional food, brain-nourishing tea granules |
| CN102626160B (en) * | 2012-04-23 | 2013-07-17 | 北京绿源求证科技发展有限责任公司 | Brain-nourishing nutritional food, brain-nourishing tea granules |
| CN104435213A (en) * | 2014-11-13 | 2015-03-25 | 成都医路康医学技术服务有限公司 | Persimmon-leaf-containing traditional Chinese medicine composition for treating cardia-cerebrovascular disease |
| CN106563077A (en) * | 2016-08-22 | 2017-04-19 | 王林玉 | Traditional Chinese medicinal composition for treating ischemic cardiovascular disease |
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Open date: 20100630 |