CN101757057A - Whiteflower leadword root chewable tablet - Google Patents
Whiteflower leadword root chewable tablet Download PDFInfo
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- CN101757057A CN101757057A CN200910230082A CN200910230082A CN101757057A CN 101757057 A CN101757057 A CN 101757057A CN 200910230082 A CN200910230082 A CN 200910230082A CN 200910230082 A CN200910230082 A CN 200910230082A CN 101757057 A CN101757057 A CN 101757057A
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- chewable tablet
- fructus
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- radix plumbaginis
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Abstract
The invention belongs to the technical field of medicine and discloses a chewable tablet which uses the whiteflower leadword root as the main raw materials. Various auxiliary materials and taste regulating agent are used secondarily, so the taste of medicine is improved while the pesticide effect is ensured. All the additives are edible and are in-noxious. By using a general processing technique, the combining cost is low, the yield is high, the reaction condition is mild and the chewable tablet can be applied in the technical field of medicine.
Description
Technical field:
The present invention relates to a kind of is the chewable tablet and preparation method thereof of primary raw material with the Radix Plumbaginis Zeylanicae, belongs to medical technical field.
Background technology:
Radix Plumbaginis Zeylanicae (Plum bago zeylanica L innl) is a Plumbaginaceae leadwort plant, and the beginning is stated from Tang Materia Medica, is herb and the root of Plumbaginaceae plant Radix Plumbaginis Zeylanicae.Originate in ground such as Taiwan, Fujian, Guangdong, Guangxi, South of Guizhou, Yunnan, Sichuan in China, be medicine commonly used among the people.This plant is arduous puckery, warm in nature, poisonous.Be used for the treatment of rheumatic arthralgia, blood stasis amenorrhea, traumatic injury, toxic swelling malignant boil, diseases such as scabies.Modern pharmacological research shows, the Radix Plumbaginis Zeylanicae extract has effects such as malaria protozoon, antibiotic, antiallergic, hyperglycemia disease and antitumor.Radix Plumbaginis Zeylanicae contains naphthoquinone, di-naphthoquinone, flavone compound etc., so far isolation identification tens chemical compounds, mostly be naphthoquinone compound.For further seeking its active component, develop plant resources better, the chemical constitution study of system has been carried out in this experiment to the aerial parts of Radix Plumbaginis Zeylanicae, therefrom separate obtaining 9 chemical compounds, be respectively plumbagin (I), isoshinanolone (II), plumbagic acid (III), β 2 sitosterol (IV), hydroxy benzaldehyde (V), trans isomer cinnamic acid (VI), chinese cymbidium acid (VII).
But existing Radix Plumbaginis Zeylanicae has all been adopted the form of direct administration, wherein the effective medicinal components utilization rate is low, can't reach the medicinal purpose of expection, and because the taste of medicine self, make user very inconvenient in use, also be not easy to swallowing of patient, in order to develop the medicine resource of Radix Plumbaginis Zeylanicae, be badly in need of a kind of can be with its mode of effectively utilizing.
Summary of the invention:
Go up the weak point that exists at existing Radix Plumbaginis Zeylanicae exploitation, the invention provides a kind of Radix Plumbaginis Zeylanicae chewable tablet and adopt conventional method to be prepared, mainly make chewable tablet with the raw material of Radix Plumbaginis Zeylanicae.Be aided with various adjuvants and correctives, when guaranteeing drug effect, improved taste of medicine, and various additive is edible, harmless.The conventional processing technique that adopts makes that synthetic cost is low, the productive rate height, and the reaction condition gentleness can be widely used in the field of medicaments.
Radix Plumbaginis Zeylanicae chewable tablet of the present invention is made up of Radix Plumbaginis Zeylanicae, and its raw material components is as follows, and each amounts of components is a weight portion:
5～20 parts of Radix Plumbaginis Zeylanicaes
30～80 parts of correctivess
5～15 parts of filleies
1～5 part of lubricant
0.05～3 part of binding agent
Wherein said Bai Huadan is that the herb of Radix Plumbaginis Zeylanicae and the mixture of root are pulverized the powder that 100 mesh sieves are crossed in the back;
The correctives that is adopted comprises one or more mixture in Fructus Musae, Fructus Fragariae Ananssae, Fructus Citri tangerinae, Fructus Vitis viniferae, Herba Menthae, Fructus Ananadis comosi, Fructus Musae, honey peach, essence, saccharin sodium, protein sugar, sucrose, the acesulfame potassium; The filler that is adopted comprises one or more mixture in starch, lactose, microcrystalline Cellulose, sorbitol, xylitol, calcium carbonate, sour hydrogen calcium, dextrin, the mannitol; The lubricant that is adopted comprises any one or a few mixture in magnesium stearate, micropowder silica gel, the Pulvis Talci; The binding agent that is adopted comprises water, one or more mixture in water and alkyd solution, starch slurry, methylcellulose, hydroxy methocel, Carboxymethyl cellulose sodium, the hydroxyethyl-cellulose.
Select above-mentioned various adjuvants, can effectively improve the mouthfeel of gained chewable tablet, prevent owing to Bai Huadan self taste cause the patient be difficult to take, various adjuvants uses with simultaneously, better preparation can be provided for follow-up manufacturing procedure, make the chewable tablet of final gained on being shaped, better basis be arranged.
The method for preparing this chewable tablet adopts tabletting behind direct powder compression or the wet granulation, but when adopting direct powder compression to be, must be in advance with raw material drying, and prevent that raw material is moist and cause adhesion and cause producing and can't carry out smoothly.
Adopt these two kinds of preparation technologies all can make chewable tablet, and because employing is conventional preparation method, can adopt existing equipment directly to produce, saved production cost, convenient simultaneously large-area promotion and application, thereby drive the deep processing of Bai Huadan, guaranteed its application pharmaceutically simultaneously.
The present invention makes full use of the Bai Huadan kind of China and plants advantage, develop easy to carry, be absorbed by the body by oral mucosa and digestive system, Bai Huadan chewable tablet with remarkable therapeutical effect, described production technology is simple, has guaranteed Bai Huadan chewable tablet content of effective in the proportioning, makes it have mouthfeel preferably again simultaneously, make things convenient for patient's use, can large tracts of land promote the use of.
The specific embodiment:
Understand technical scheme of the present invention for better, below describe in further detail by specific embodiment.
Embodiment 1:
A kind of Radix Plumbaginis Zeylanicae chewable tablet is made up of Radix Plumbaginis Zeylanicae, and its raw material components is as follows:
Radix Plumbaginis Zeylanicae 12g
Correctives 78g
Filler 6g
Lubricant 2.5g
Binding agent 1.5g
Raw material is carried out dry in advance, adopt powder method directly to carry out tabletting then, correctives is honey peach, each 39g of essence, filler is xylitol, each 3g of calcium carbonate, lubricant is micropowder silica gel 1.5g, Pulvis Talci 1g, binding agent is a Carboxymethyl cellulose sodium, by the requirement of check character composite medicine, and good mouthfeel.
Embodiment 2:
A kind of Radix Plumbaginis Zeylanicae chewable tablet is made up of Radix Plumbaginis Zeylanicae, and its raw material components is as follows:
Radix Plumbaginis Zeylanicae 15g
Correctives 74g
Filler 8g
Lubricant 2g
Binding agent 1g
Raw material is not carried out pelletize under the state of drying, correctives is protein sugar 40g, sucrose 34g, filler is starch 6g, lactose 2g, lubricant is magnesium stearate, each 1g of Pulvis Talci, binding agent is a hydroxyethyl-cellulose, galenic pharmacy carries out tabletting and tests its performance routinely then, by the requirement of check character composite medicine, and good mouthfeel.
Its result shows: be chewable tablet of primary raw material and preparation method thereof with Bai Huadan, this tablet has good drug effect and good mouthfeel, and harmless.
Claims (6)
1. Radix Plumbaginis Zeylanicae chewable tablet, it is characterized in that: its raw material components is as follows, and each amounts of components is a weight portion:
5～20 parts of Radix Plumbaginis Zeylanicaes
30～80 parts of correctivess
5～15 parts of filleies
1～5 part of lubricant
0.05～3 part of binding agent
2. chewable tablet as claimed in claim 1 is characterized in that: correctives comprises one or more mixture in Fructus Musae, Fructus Fragariae Ananssae, Fructus Citri tangerinae, Fructus Vitis viniferae, Herba Menthae, Fructus Ananadis comosi, Fructus Musae, honey peach, essence, saccharin sodium, protein sugar, sucrose, the acesulfame potassium.
3. chewable tablet as claimed in claim 1 is characterized in that: filler comprises one or more mixture in starch, lactose, microcrystalline Cellulose, sorbitol, xylitol, calcium carbonate, sour hydrogen calcium, dextrin, the mannitol.
4. chewable tablet as claimed in claim 1 is characterized in that: lubricant comprises any one or a few mixture in magnesium stearate, micropowder silica gel, the Pulvis Talci.
5. chewable tablet as claimed in claim 1 is characterized in that: binding agent comprises water, one or more mixture in water and alkyd solution, starch slurry, methylcellulose, hydroxy methocel, Carboxymethyl cellulose sodium, the hydroxyethyl-cellulose.
6. the method for preparing chewable tablet as claimed in claim 1, tabletting behind employing direct powder compression or the wet granulation is characterized in that: must be with raw material drying before the employing direct powder compression.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910230082 CN101757057B (en) | 2009-11-13 | 2009-11-13 | Whiteflower leadword root chewable tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910230082 CN101757057B (en) | 2009-11-13 | 2009-11-13 | Whiteflower leadword root chewable tablet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101757057A true CN101757057A (en) | 2010-06-30 |
| CN101757057B CN101757057B (en) | 2013-11-06 |
Family
ID=42488539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910230082 Expired - Fee Related CN101757057B (en) | 2009-11-13 | 2009-11-13 | Whiteflower leadword root chewable tablet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101757057B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973870A (en) * | 2012-12-14 | 2013-03-20 | 安徽农业大学 | Decanting chewable tablet and preparation method thereof |
| CN103301463A (en) * | 2013-06-13 | 2013-09-18 | 广西南宁市桃源兽药厂 | Compound composition containing plumbago zeylanica for treating livestock and poultry escherichia coli infection diseases |
| CN103356933A (en) * | 2013-07-18 | 2013-10-23 | 苏州市天灵中药饮片有限公司 | Stomach-nourishing spleen-strengthening chewing tablets and preparation method thereof |
| CN104027368A (en) * | 2013-06-13 | 2014-09-10 | 广西南宁市桃源兽药厂 | Plumbago zeylanica and doxycycline containing compound composition for livestock and poultry |
| CN107260778A (en) * | 2017-08-16 | 2017-10-20 | 长沙天卓生物科技有限公司 | A kind of Chinese medicine composition of cure scapulohumeral periarthritis cervical spondylopathy pain in waist and lower extremities and preparation method thereof |
| CN109512847A (en) * | 2018-12-29 | 2019-03-26 | 广州医科大学附属第医院 | Plumbago zeylanica is in the purposes being used to prepare in treatment pulmonary fibrosis disease drug |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626168A (en) * | 2003-12-08 | 2005-06-15 | 西南民族大学 | Leadwort (white snowflake) preparation |
-
2009
- 2009-11-13 CN CN 200910230082 patent/CN101757057B/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973870A (en) * | 2012-12-14 | 2013-03-20 | 安徽农业大学 | Decanting chewable tablet and preparation method thereof |
| CN102973870B (en) * | 2012-12-14 | 2014-04-16 | 安徽农业大学 | Decanting chewable tablet and preparation method thereof |
| CN103301463A (en) * | 2013-06-13 | 2013-09-18 | 广西南宁市桃源兽药厂 | Compound composition containing plumbago zeylanica for treating livestock and poultry escherichia coli infection diseases |
| CN104027368A (en) * | 2013-06-13 | 2014-09-10 | 广西南宁市桃源兽药厂 | Plumbago zeylanica and doxycycline containing compound composition for livestock and poultry |
| CN103356933A (en) * | 2013-07-18 | 2013-10-23 | 苏州市天灵中药饮片有限公司 | Stomach-nourishing spleen-strengthening chewing tablets and preparation method thereof |
| CN103356933B (en) * | 2013-07-18 | 2015-05-27 | 苏州市天灵中药饮片有限公司 | Stomach-nourishing spleen-strengthening chewing tablets and preparation method thereof |
| CN107260778A (en) * | 2017-08-16 | 2017-10-20 | 长沙天卓生物科技有限公司 | A kind of Chinese medicine composition of cure scapulohumeral periarthritis cervical spondylopathy pain in waist and lower extremities and preparation method thereof |
| CN109512847A (en) * | 2018-12-29 | 2019-03-26 | 广州医科大学附属第医院 | Plumbago zeylanica is in the purposes being used to prepare in treatment pulmonary fibrosis disease drug |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101757057B (en) | 2013-11-06 |
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Inventor after: Qin Dawei Inventor after: Liu Shuqing Inventor after: Zhuang Chaohui Inventor after: Liu Wentao Inventor before: Qin Dawei Inventor before: Liu Wentao |
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Free format text: CORRECT: INVENTOR; FROM: QIN DAWEI LIU WENTAO TO: QIN DAWEI LIU SHUQING ZHUANG CHAOHUI LIU WENTAO Free format text: CORRECT: ADDRESS; FROM: 250022 JINAN, SHANDONG PROVINCE TO: 250353 JINAN, SHANDONG PROVINCE |
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Effective date of registration: 20140108 Address after: 250353 Ji'nan University, Changqing, Shandong Road, No. 3501 Patentee after: Qilu University of Technology Address before: Nanxinzhuang street in Huaiyin District of Ji'nan city of Shandong Province, No. 70 250022 Patentee before: Qin Dawei |
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