CN101755044B - 通过冻干泡沫保存生物活性材料 - Google Patents

通过冻干泡沫保存生物活性材料 Download PDF

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Publication number
CN101755044B
CN101755044B CN200880025155.3A CN200880025155A CN101755044B CN 101755044 B CN101755044 B CN 101755044B CN 200880025155 A CN200880025155 A CN 200880025155A CN 101755044 B CN101755044 B CN 101755044B
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China
Prior art keywords
foam
preparation
temperature
active materials
biological active
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Expired - Fee Related
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CN200880025155.3A
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English (en)
Chinese (zh)
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CN101755044A (zh
Inventor
R·韦林
Y·奥
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MedImmune LLC
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MedImmune LLC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/34—Processes using foam culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200880025155.3A 2007-05-18 2008-05-06 通过冻干泡沫保存生物活性材料 Expired - Fee Related CN101755044B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93074607P 2007-05-18 2007-05-18
US60/930,746 2007-05-18
PCT/US2008/005840 WO2008143782A1 (en) 2007-05-18 2008-05-06 Preservation of bioactive materials by freeze dried foam

Publications (2)

Publication Number Publication Date
CN101755044A CN101755044A (zh) 2010-06-23
CN101755044B true CN101755044B (zh) 2014-06-11

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CN200880025155.3A Expired - Fee Related CN101755044B (zh) 2007-05-18 2008-05-06 通过冻干泡沫保存生物活性材料

Country Status (9)

Country Link
US (1) US8617576B2 (cg-RX-API-DMAC10.html)
EP (1) EP2148923B1 (cg-RX-API-DMAC10.html)
JP (2) JP5307801B2 (cg-RX-API-DMAC10.html)
KR (1) KR101557169B1 (cg-RX-API-DMAC10.html)
CN (1) CN101755044B (cg-RX-API-DMAC10.html)
BR (1) BRPI0811161A2 (cg-RX-API-DMAC10.html)
DK (1) DK2148923T3 (cg-RX-API-DMAC10.html)
ES (1) ES2393160T3 (cg-RX-API-DMAC10.html)
WO (1) WO2008143782A1 (cg-RX-API-DMAC10.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1631496B1 (en) 2003-04-28 2014-02-26 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
WO2007079147A2 (en) 2005-12-28 2007-07-12 Advanced Bionutrition Corporation A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
WO2007127286A2 (en) 2006-04-24 2007-11-08 Medical Instill Technologies, Inc. Needle penetrable and laser resealable lyophilization device and related method
JP5285617B2 (ja) 2006-12-18 2013-09-11 アドバンスド バイオニュートリション コーポレーション 生きたプロバイオティクスを含む乾燥食物製品
EP3266448B1 (en) 2009-03-27 2022-02-16 Intervet International B.V. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
SG176253A1 (en) 2009-05-26 2011-12-29 Advanced Bionutrition Corp Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
NZ601017A (en) 2010-01-28 2014-07-25 Advanced Bionutrition Corp Dry glassy composition comprising a bioactive material
CN102753975B (zh) 2010-02-19 2015-05-20 卡帝拉药物有限公司 基本上保留免疫原性的被杀死细胞的药物组合物
WO2012018628A1 (en) 2010-07-26 2012-02-09 Board Of Regents, The University Of Texas System Methods for inducing an immune response via buccal and/or sublingual administration of a vaccine
CL2011001984A1 (es) 2010-08-13 2012-06-29 Advanced Bionutrition Corp Composicion seca estabilizadora para material biologico que comprende carbohidrato, proteinas hidrolizadas de animal o de planta y un componente de acido carboxilico; metodo de preparacion; y formulacion de entrega oral que comprende la composicion seca estabilizadora.
EP2841408A4 (en) * 2012-04-22 2016-06-22 Cargill Inc METHODS OF MAINTAINING AND IMPROVING CELL BIOLOGICAL FUNCTION AND ACTIVITY
US20140017318A1 (en) * 2012-07-10 2014-01-16 Kevin O'Connell Method to produce a medicinal product comprising a biologically active protein and the resulting product
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US20140193456A1 (en) * 2013-01-09 2014-07-10 Hristem Mitkov Dyanov Method for Drying-Conservation of Natural Substances
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
EP3057978B1 (en) 2013-10-16 2022-09-14 Merck Sharp & Dohme LLC Method of microwave vacuum drying spherical-shaped pellets of biological materials
WO2015057541A1 (en) 2013-10-16 2015-04-23 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
WO2015057548A1 (en) 2013-10-16 2015-04-23 Merck Sharp & Dohme Corp Thermostable respiratory synctial virus (rsv) vaccine compositions
AR099470A1 (es) 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
US12558395B2 (en) 2015-07-29 2026-02-24 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
EP3328215B1 (en) 2015-07-29 2021-07-07 Advanced BioNutrition Corp. Stable dry probiotic compositions for special dietary uses
WO2017073752A1 (ja) 2015-10-30 2017-05-04 株式会社ヤクルト本社 微生物乾燥菌体の製造方法
EP3383435A4 (en) 2015-11-30 2019-07-10 Medimmune, LLC OPTIMIZED RATES OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS HAVING HIGH CONCENTRATIONS IN PROTEIN-BASED THERAPEUTICS
US11447738B2 (en) * 2016-10-28 2022-09-20 Vedanta Biosciences, Inc. Methods and compositions for preserving bacteria
TWI719220B (zh) * 2017-06-13 2021-02-21 英屬維爾京群島商大利緯眾生物科技股份有限公司 用於血清蛋白的活性保存的新穎方法
DE112017007639T5 (de) * 2017-06-13 2020-06-04 Chung Chin SUN Neues verfahren zum blutplasmaprotein-aktivitätserhalt
JP7198264B2 (ja) * 2017-07-11 2022-12-28 ユニバーサル スタビリゼイション テクノロジーズ，インコーポレイテッド バイオ医薬品を保存するための方法
JP7284156B2 (ja) * 2017-09-19 2023-05-30 アドバクシス， インコーポレイテッド 細菌またはＬｉｓｔｅｒｉａ株の凍結乾燥のための組成物および方法
JP7384347B2 (ja) * 2017-10-27 2023-11-21 クミアイ化学工業株式会社 微生物凍結乾燥組成物
KR102649069B1 (ko) 2018-05-31 2024-03-19 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물
WO2019231134A1 (ko) * 2018-05-31 2019-12-05 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 안면 홍조 개선용 조성물
CN112261871B (zh) 2018-07-28 2022-05-17 韩国外泌体生技有限公司 用于使外排体冻干的方法
KR102163806B1 (ko) 2018-07-30 2020-10-07 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피지분비 감소용 조성물
US11243028B2 (en) * 2018-12-14 2022-02-08 Fortunata, LLC Systems and methods of cryo-curing
CN111214392B (zh) * 2020-01-08 2021-02-26 江苏悦智生物医药有限公司 一种球形化妆品冻干泡及其制备方法
AU2021297245A1 (en) 2020-06-23 2023-02-02 Illumina Software, Inc. Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes
CN116585724A (zh) * 2023-05-25 2023-08-15 广州和实生物技术有限公司 玻璃化真空干燥试剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423252B1 (en) * 2000-06-23 2002-07-23 Ethicon, Inc. Methods of making micropatterned foams
US20030219475A1 (en) * 2002-04-11 2003-11-27 Medlmmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766520A (en) 1996-07-15 1998-06-16 Universal Preservation Technologies, Inc. Preservation by foam formation
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6306345B1 (en) 1998-05-06 2001-10-23 Universal Preservation Technologies, Inc. Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures
US7094412B2 (en) * 2001-12-10 2006-08-22 Bavarian Nordic A/S Poxvirus containing formulations and process for preparing stable poxvirus containing compositions
CA2503871C (en) * 2002-11-01 2012-12-11 Glaxosmithkline Biologicals S.A. An immunogenic composition for generating an immune response against polio virus
ES2319527T3 (es) * 2003-02-20 2009-05-08 Centro Nacional De Investigaciones Cientificas (Cnic) Cepas atenuadas de vibrio cholerae y vacunas liofilizadas que las contienen.
WO2005067460A2 (en) 2003-12-24 2005-07-28 Medimmune, Inc. Epha2 vaccines
EP1937800A4 (en) 2005-09-26 2009-11-18 Aeras Global Tb Vaccine Found METHOD FOR STABILIZING BACTERIAL CELLS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423252B1 (en) * 2000-06-23 2002-07-23 Ethicon, Inc. Methods of making micropatterned foams
US20030219475A1 (en) * 2002-04-11 2003-11-27 Medlmmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam

Also Published As

Publication number Publication date
KR20100028561A (ko) 2010-03-12
JP2013177473A (ja) 2013-09-09
EP2148923A1 (en) 2010-02-03
JP2010528003A (ja) 2010-08-19
EP2148923A4 (en) 2010-11-24
ES2393160T3 (es) 2012-12-19
US8617576B2 (en) 2013-12-31
WO2008143782A1 (en) 2008-11-27
BRPI0811161A2 (pt) 2014-10-07
KR101557169B1 (ko) 2015-10-02
JP5307801B2 (ja) 2013-10-02
CN101755044A (zh) 2010-06-23
EP2148923B1 (en) 2012-08-22
DK2148923T3 (da) 2012-12-03
US20100297231A1 (en) 2010-11-25

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Granted publication date: 20140611

Termination date: 20170506