CN101744930B - Chinese medicinal atomizing preparation for treating chronic bronchitis - Google Patents
Chinese medicinal atomizing preparation for treating chronic bronchitis Download PDFInfo
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- CN101744930B CN101744930B CN2010101071133A CN201010107113A CN101744930B CN 101744930 B CN101744930 B CN 101744930B CN 2010101071133 A CN2010101071133 A CN 2010101071133A CN 201010107113 A CN201010107113 A CN 201010107113A CN 101744930 B CN101744930 B CN 101744930B
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Abstract
The invention discloses a Chinese medicinal atomizing preparation for treating chronic bronchitis, which is prepared from the following pure Chinese medicinal herbs with functions of clearing away heat and toxic material, regulating qi and strengthening the spleen, eliminating dampness and eliminating phlegm, and removing heat from the lung to relieve cough: liquoric root, heartleaf houttuynia herb, tangerine peel, ephedra herb, ajuga decumbens, almond and wild chrysanthemum. When being used for atomization inspiration of the patient, the Chinese medicinal atomizing preparation is beneficial for the mucous membrane of the respiratory tract to discharge secretions, sanies and pathogenic bacteria and has effect of provoking self-cleaning of the respiratory tract. The Chinese medicinal atomizing preparation can relieve bronchospasm, reduce mucous edema and liquefying bronchial secretions, promotes the control of the bronchial inflammatory process and the improvement of the ventilation function, and has good treatment effect and no side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially relate to a kind of Chinese medicine composition for the treatment of chronic bronchitis.
Background technology
Chronic bronchitis is common respiratory system disease.It is because infection or non-infective agent cause the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Its pathological characteristic is a bronchus body of gland hypertrophy, and mucous secretion increases, clinical have continuous more than 2 years, the annual a kind of disease that continues the symptoms such as cough, expectoration or asthma more than 3 months.Bronchitis is normal to be sent out in winter-spring season, cough with copious phlegm, and it is difficult to show effect repeatedly, delay, because the course of disease is long, the most of patients physical weakness is insufficiency of lung-QI body constitution, and is the most typical with the senile chronic bronchitis symptom especially.At present, the medicine of treatment chronic bronchitis is more, but all exists therapeutic effect undesirable, the problem that the side effect that has is bigger.
Summary of the invention
The objective of the invention is at the chronic bronchitis pathogeny, selected heat-clearing and toxic substances removing, regulating qi-flowing for strengthening spleen, a kind of propellant that the pure Chinese herbal medicine of drying dampness to eliminate phlegm, clearing away lung-heat to relieve cough is made has the advantage that therapeutic effect is good, have no side effect.
The objective of the invention is to be achieved through the following technical solutions, the Chinese herbal aerosol agent of this treatment chronic bronchitis is made up of following bulk drugs: Radix Glycyrrhizae 30-50, Herba Houttuyniae 30-40, Pericarpium Citri Reticulatae 20-30, Herba Ephedrae 20-30, Herba Ajugae 10-20, Semen Armeniacae Amarum 10-20, Flos Chrysanthemi Indici 20-30.
The Chinese herbal aerosol agent of this treatment chronic bronchitis is made up of the crude drug of following optimum weight part: Radix Glycyrrhizae 40, Herba Houttuyniae 35, Pericarpium Citri Reticulatae 25, Herba Ephedrae 25, Herba Ajugae 15, Semen Armeniacae Amarum 15, Flos Chrysanthemi Indici 25.
Its preparation method is: extracting liquorice 400 grams, Herba Houttuyniae 350 grams, Pericarpium Citri Reticulatae 250 grams, Herba Ephedrae 250 grams, Herba Ajugae 150 grams, Semen Armeniacae Amarum 150 grams, Flos Chrysanthemi Indici 250 grams, add 2 distillations behind the water, collect 1000 milliliters of distillates, little shaking up, add sodium chloride 8 grams, pass through filtration, packing, seal, standby.
The pharmacological properties of selected Chinese medicine:
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, grow and to cough lung moistening, the spasmolytic of eliminating the phlegm, the effect of emergency antidotal, and can be in harmonious proportion hundred medicines: herba houttuyniae: heat-clearing and toxic substances removing, main lung abscess vomiting pus; The expectorant dyspnea of heat type is coughed; When the treatment chronic tracheitis, Sodium Houttuyfonate can make patient's leukocyte that the staphylococcic phagocytic activity of white is obviously improved; Pericarpium Citri Reticulatae: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Cure mainly phlegm-damp and stop up the cough and asthma of lung; Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing.Be used for bronchial asthma, can open lung qi dispersing gas, dispersing wind and cold and relievining asthma; Herba Ajugae: clearing away lung-heat to relieve cough cures mainly tracheitis.The active ingredient flavonoid glycoside that includes has antiasthmatic effect preferably, and the effect of diastole bronchial smooth muscle is arranged with the alkaline ether extract of guinea pig in vitro broncho-pulmonary perfusion method proof Herba Ajugae; Semen Armeniacae Amarum: expelling phlegm for arresting cough, the intestine moistening of relievining asthma, following air to open numbness has the anabolic effect of the pulmonary surfactant of promotion; Flos Chrysanthemi Indici: heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver.
By the aerosol that above Chinese medicine is made, help the mucosa of respiratory tract to discharge secretions, pus and pathogen after atomizing sucks, and the effect that stimulates respiratory tract self cleaning is arranged.Can remove bronchospasm, reduce myxedema and liquefaction bronchial secretion, promote the control of bronchitis process and the improvement of ventilatory function.
Clinical data:
1, physical data: case 240 examples are selected in this clinical trial, and all cases all derive from the chronic bronchitis patient of my institute's prescription on individual diagnosis over the past two years, and all cases all meet the chronic bronchitis diagnostic criteria that " practical internal medicine " formulated.Case is divided into treatment group and matched group at random, and 120 examples are organized in treatment, male's 90 examples wherein, and women's 30 examples make 51-69 year year, and average year makes 60.2 years old; Matched group 120 examples, male's 83 examples wherein, women's 37 examples make 53-71 year year, and average year makes 61.4 years old.Two groups of cases have comparability not having statistically-significant difference aspect sex, pro ratione aetatis, the course of disease.
2, Therapeutic Method
The treatment group: with Chinese herbal aerosol agent of the present invention, adopt atomizing instrument oral cavity atomization inspiration treatment, 5 days was 1 course of treatment, every day 2 times, each 20 minutes, 10 milliliters of each consumptions.
Matched group: select for use terbutaline to suck, 10 milligrams of each terbutalines add that atomizing sucks in 20 milliliters of 0.9% sodium chloride injections, and every day twice, each 20 minutes, 5 days was a course of treatment.As no special circumstances, all do not add other symptomatic treatment Drug therapy in two groups of treatments.For further observe the curative effect, before the medication, in the treatment and finish the back course of treatment and check hematuria routine, hepatic and renal function, arterial blood gas analysis etc., and do the Chest X-rays inspection, observed and recorded clinical symptoms, sign change in detail.
3, curative effect determinate standard
Formulate curative effect determinate standard according to " new Chinese medicine clinical research guideline ".Produce effects: cardinal symptom, sign are obviously alleviated or are disappeared substantially, and objective indicator is near normal; Effectively: cardinal symptom, sign take a turn for the better, and objective indicator makes moderate progress; Invalid: cardinal symptom, sign no change, objective indicator change not obvious or increase the weight of.
4, therapeutic effect
(1) two group therapeutic outcome compares, and the total effective rate of treatment group is significantly higher than matched group (P＜0.05), sees Table 1
The efficacy result of table 1 liang group relatively
| Group | Produce effects | Effectively | Invalid | Total effective rate % |
| The treatment group | 56(53.7) | 49 | 5 | 95.8％ |
| Matched group | 24(20.0) | 70 | 26 | 78.3％ |
(2) two groups of arterial blood gas analysis are relatively treated relatively there was no significant difference of preceding two groups of partial pressure of oxygens, partial pressure of carbon dioxide.Before the partial pressure of oxygen of treatment back treatment group is significantly higher than treatment, before partial pressure of carbon dioxide significantly is lower than treatment.Relatively, after finishing, the treatment of the partial pressure of oxygen of treatment group is significantly higher than matched group (P＜0.05) between two groups; Partial pressure of carbon dioxide then significantly is lower than matched group (P＜0.05).Result before and after two groups partial pressure of oxygen, the partial pressure of carbon dioxide treatment is relatively as table 2
Table 2 liang group arterial blood gas analysis result comparison (x ± s)
This group studies have shown that the total effective rate of treatment group is 95.8%, all is significantly higher than 78.3% of matched group, and simultaneously, the obvious effective rate of treatment group is 53.7%, all is higher than 20% of matched group.
All do not see obvious toxic-side effects for two groups.Hepatic and renal function is all normal before and after all case treatments.
5, model case
Patient Wang, the man, 56 years old, the worker of enterprise after the trouble influenzas in 1992, left over cough, pants.Took dexamethasone, multiple Chinese medicine and western medicine such as China, SHANSHEN drop pill, various antibiotics, all inefficacy.Use Chinese herbal aerosol agent of the present invention, every day, atomizing took a favorable turn two the cough with asthma complete obiterations course of treatment after sucking twice, one course of treatment.
The specific embodiment
Embodiment 1: extracting liquorice 400 gram, Herba Houttuyniae 350 grams, Pericarpium Citri Reticulatae 250 grams, Herba Ephedrae 250 grams, Herba Ajugae 150 grams, Semen Armeniacae Amarum 150 grams, Flos Chrysanthemi Indici 250 grams, add 2 distillations behind the water, and collect 1000 milliliters of distillates, little shaking up, add sodium chloride 8 grams, pass through filtration, packing, seal, standby.
Embodiment 2:
Extracting liquorice 500 gram, Herba Houttuyniae 300 grams, Pericarpium Citri Reticulatae 200 grams, Herba Ephedrae 300 grams, Herba Ajugae 100 grams, Semen Armeniacae Amarum 100 grams, Flos Chrysanthemi Indici 300 grams add 2 distillations behind the water, collect 900 milliliters of distillates, little shaking up, add sodium chloride 7.5 grams, pass through filtration, packing, seal, standby.
Embodiment 3:
Radix Glycyrrhizae 300 gram, Herba Houttuyniae 400 grams, Pericarpium Citri Reticulatae 300 grams, Herba Ephedrae 200 grams, Herba Ajugae 200 grams, Semen Armeniacae Amarum 200 grams, Flos Chrysanthemi Indici 200 grams add 2 distillations behind the water, collect 1000 milliliters of distillates, little shaking up, add sodium chloride 8.5 grams, pass through filtration, packing, seal, standby.
Claims (2)
1. Chinese herbal aerosol agent for the treatment of chronic bronchitis is characterized in that used crude drug is made up of the component of following weight portion: Radix Glycyrrhizae 30-50, Herba Houttuyniae 30-40, Pericarpium Citri Reticulatae 20-30, Herba Ephedrae 20-30, Herba Ajugae 10-20, Semen Armeniacae Amarum 10-20, Flos Chrysanthemi Indici 20-30.
2. a kind of Chinese herbal aerosol agent for the treatment of chronic bronchitis according to claim 1 is characterized in that used crude drug is made up of the component of following weight portion: Radix Glycyrrhizae 40, Herba Houttuyniae 35, Pericarpium Citri Reticulatae 25, Herba Ephedrae 25, Herba Ajugae 15, Semen Armeniacae Amarum 15, Flos Chrysanthemi Indici 25.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101071133A CN101744930B (en) | 2010-01-30 | 2010-01-30 | Chinese medicinal atomizing preparation for treating chronic bronchitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101071133A CN101744930B (en) | 2010-01-30 | 2010-01-30 | Chinese medicinal atomizing preparation for treating chronic bronchitis |
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| Publication Number | Publication Date |
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| CN101744930A CN101744930A (en) | 2010-06-23 |
| CN101744930B true CN101744930B (en) | 2011-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101071133A Expired - Fee Related CN101744930B (en) | 2010-01-30 | 2010-01-30 | Chinese medicinal atomizing preparation for treating chronic bronchitis |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727802B (en) * | 2012-07-17 | 2013-09-18 | 盛春正 | Chinese herbal medicine composition for treating cold, trachitis and dry cough |
| CN105311322A (en) * | 2014-07-30 | 2016-02-10 | 陈立云 | Chinese herbal compound for treating chronic bronchitis |
| CN105078888A (en) * | 2015-08-31 | 2015-11-25 | 王淮南 | Traditional Chinese medicine for nebulization |
| CN114796453A (en) * | 2022-02-25 | 2022-07-29 | 中科梅奥(杭州)生物工程有限公司 | Method for applying BMAP (BMAP) derived peptide to respiratory system cough antiphlogosis |
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Granted publication date: 20111109 Termination date: 20120130 |