CN101743972A - High-effect bactericidal composites with epoxiconazole and difenoconazole - Google Patents
High-effect bactericidal composites with epoxiconazole and difenoconazole Download PDFInfo
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- CN101743972A CN101743972A CN201010002691A CN201010002691A CN101743972A CN 101743972 A CN101743972 A CN 101743972A CN 201010002691 A CN201010002691 A CN 201010002691A CN 201010002691 A CN201010002691 A CN 201010002691A CN 101743972 A CN101743972 A CN 101743972A
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Abstract
The invention discloses a group of high-effect bactericidal composites with epoxiconazole and difenoconazole and a preparation method and application thereof, and the bactericidal composites have the synergistic effect. The composites comprise two main active ingredients, namely epoxiconazole and difenoconazole and other additives, wherein the weight ratio of epoxiconazole to difenoconazole is 0.1-50:0.1-60 and the composites can be used for various diseases of cereal crops, melons, fruits, vegetables and the like. The composites have wide application range, low cost, good effect and obvious synergistic effect proved through laboratory experiments. The report about the combination of epoxiconazole and difenoconazole has not been found at home and abroad, thus the invention is provided.
Description
Technical field
The invention belongs to the agriculture chemical compounding field, relate to a kind of bactericidal composition and application thereof, especially a kind of is the bactericidal composition and the application thereof of main active with fluorine ring azoles and Difenoconazole.
Background technology
Using chemical agent is the most effectively means of control fungal diseases of plants.But long-term use single chemical bactericide continuously high dose, cause problems such as residual, the environmental pollution of medicament and anti-pesticide resistance fungi development easily.Reasonably chemical bactericide is composite or be mixed and have the expansion fungicidal spectrum, improve control efficiency, prolong the optimum period for applying fertilizer, reduce dosage, reduce poisoning, reduce residual, delay fungi drug resistance and positive characteristics such as drug-fast generation and development, bactericide compounded or to be mixed be one of the effective method the most that addresses the above problem.Exploitation new product bactericide price is constantly soaring, and by contrast, exploitation is efficient with research, low toxicity, low-residual composite be mixed have small investment, the lead time is short and be subjected to domestic and international attention, strengthens the development dynamics one after another.
Fluorine ring azoles: (2RS, 3RS)-1-[3-(2-chlorphenyl)-2,3-epoxy-2-(4-fluorophenyl) propyl group]-1 hydrogen-1,2, the 4-triazole
This product belongs to triazole bactericidal agent, the mechanism of action is for suppressing the synthetic of germ ergosterol, hinder the formation of germ cell wall, and fluorine ring azoles molecule has powerful compatibility to a kind of fungal enzyme (14-dencthylase), can improve all fourth matter enzymic activitys of crop, cause the contraction of fungi haustorium, suppress germ and invade, compare with at present known bactericide, can more effective inhibition germ fungal pathogens.To ten multiple diseases such as a series of cereal crops such as damping off, powdery mildew, eyeprint diseases, has good preventive and therapeutic effect, and can prevent and treat diseases such as sugar beet, peanut, rape, lawn, coffee, paddy rice and fruit tree, but, do not obtain excellent popularization and application because of costing an arm and a leg.
Difenoconazole: suitable, anti--3-chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1-yl methyl)-1,3-dioxolane-2-yl] phenyl 4-chlorphenyl ether
Difenoconazole is a sterol demethylation inhibitor, has good interior absorption.Fungicidal spectrum is wide, and leaf surface treatment or seed treatment can improve output and the guaranteed quality of crop.To Ascomycetes, Basidiomycetes and comprise Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball Cuo Pseudomonas, Phoma, Ramularia, Septoria, Venturia partly know germ, Erysiphaceae, Uredinales and some are planted and are passed pathogen lasting protection and therapeutic action are arranged.Also fine to bitter rot or anthracnose of grape, white rot effect.But because of a large amount of repeated uses of single agent, the resistance of germ produces gradually and strengthens.
Summary of the invention
The present invention be directed to the problems referred to above a bactericidal composition that contains fluorine ring azoles and Difenoconazole applied widely, that cost is low, effective is provided.
A further object of the invention provides the purposes of this bactericidal composition.
A kind of bactericidal composition, it contains fluorine ring azoles and Difenoconazole, and wherein the weight ratio of fluorine ring azoles and Difenoconazole is 0.1～50: 0.1～60.
Described bactericidal composition, wherein the more excellent weight ratio of fluorine ring azoles and Difenoconazole is 1～30: 1～40.
Described bactericidal composition, wherein active ingredient accounts for the weight ratio of preparation and is: 2～70%.
Described bactericidal composition, fluorine ring azoles and Difenoconazole and auxiliary agent, carrier etc. are processed into any one formulation that allows on the agricultural chemicals.
Described bactericidal composition is characterized in that the formulation that can be processed into is missible oil, suspending agent, aqueous emulsion, microemulsion, microcapsule formulations, wetting powder and water dispersible granules.
The application of described bactericidal composition aspect the multiple diseases of control cereal class and fruit tree, melon, vegetables etc.
Microbicide compositions with synergistic effect takes following measure to realize:
Contain two kinds of active components of fluorine ring azoles and Difenoconazole in the composition, wherein the weight ratio of fluorine ring azoles and Difenoconazole is 0.1～50: 0.1～60, more excellent weight ratio is 1～30: 1～40, and the active ingredient of composition adds auxiliary agent and filler can be processed into missible oil, aqueous emulsion, suspending agent, microcapsule formulations, wetting powder and water dispersible granules.
Specific embodiments of the present invention is as follows:
One of technical scheme of the present invention, described Pesticidal combination are cream preparation, and the percentage by weight of component is:
Fluorine ring azoles 0.1～50%
Difenoconazole 0.1～60%
Conventional emulsifier 10～30%
Conventional solvent 20～50%
Conventional synergist 1～5%
The concrete production stage of this cream preparation adds emulsifier, the synergist back that stirs after the dissolving fully again and becomes the oily liquids of transparent and homogeneous for earlier fluorine ring azoles, Difenoconazole being added in the solvent, can promptly makes the cream preparation that contains the bactericidal composition of fluorine ring azoles and Difenoconazole of the present invention.
Two of technical scheme of the present invention, described bactericidal composition are aqueous emulsion, and the percentage by weight of component is:
Fluorine ring azoles 0.1～50%
Difenoconazole 0.1～60%
Emulsifier 3～30%
Solvent 5～15%
Stabilizing agent 2～15%
Antifreezing agent 1～5%
Defoamer 0.1～8%
Thickener 0.2～2%
Water surplus
The concrete production stage of this aqueous emulsion is: at first former medicine fluorine ring azoles is added with Difenoconazole, solvent and emulsifier, cosolvent and be in the same place, make and be dissolved into uniform oil phase; With part water, antifreeze, other insecticides adjuvant such as antimicrobial mixes into uniform water; When the reactor high speed stirs, oil phase is added water, slowly add water, open clipper and carry out high speed shear, and add remaining water, shear half an hour approximately, form the aqueous emulsion of oil-in-water type until reaching the phase inversion point.Promptly make the aqueous emulsion of the bactericidal composition that contains fluorine ring azoles and Difenoconazole.
Three of technical scheme of the present invention, described bactericidal composition are suspending agent, and the percentage by weight of component is:
Fluorine ring azoles 0.1～50%
Difenoconazole 0.1～60%
Dispersant 5～20%
Antifreezing agent 1～5%
Thickener 0.1～2%
Defoamer 0.1～0.8%
Water surplus
The concrete production stage of this suspending agent is earlier other auxiliary agents to be mixed, mix through high speed shear, add fluorine ring azoles and Difenoconazole, abrading-ball is 2～3 hours in ball crusher, make a diameter all below 5mm, make the suspending agent preparation that contains the bactericidal composition of fluorine ring azoles and Difenoconazole of the present invention.
Four of technical scheme of the present invention, described bactericidal composition are microcapsule formulations, and the percentage by weight of component is:
Fluorine ring azoles 0.1～50%
Difenoconazole 0.1～60%
Urea 5～20%
Formaldehyde 5～20%
Emulsifying dispersant 5～20%
Antifreezing agent 1～5%
Thickener 0.1～2%
Defoamer 0.1～0.8%
Water surplus
In the there-necked flask of agitating device is housed, add urea and formaldehyde (amount of substance ratio be about 1: 1.5～2.0), about pH value to 8～9, be warming up to 70～80 ℃ then, react and obtain stable urea resin prepolymer with the sodium hydroxide solution regulator solution.The former medicine of getting a certain amount of fluorine ring azoles and Difenoconazole is dissolved in the cyclohexane, and adds emulsifying dispersant in solution, follows vigorous stirring, and being made into the aqueous solution that contains emulsifying dispersant is the O/W type stable emulsion of water.Above-mentioned urea resin prepolymer is added in the emulsion, regulate the pH value, polymerization reaction take place under the acid catalysis condition is wrapped oil phase substance, forms microcapsule granule.Slowly heat up, solidify, temperature is controlled at 40～50 ℃, hardening time 1h.Select to add an amount of auxiliary agent, the microcapsule suspending agent that gets final product stablely.
Five of technical scheme of the present invention, described bactericidal composition are wetting powder, and the percentage by weight of component is:
Fluorine ring azoles 0.1～50%
Difenoconazole 0.1～60%
Dispersant 3～20%
Wetting agent 3～10%
Filler 10～70%
The concrete procedure of processing of this bactericidal composition wetting powder is: press above-mentioned prescription with fluorine ring azoles and Difenoconazole and dispersant, wetting agent and filler mixing, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder of the present composition.
Six of technical scheme of the present invention, described bactericidal composition are water dispersible granules, and the percentage by weight of component is:
Fluorine ring azoles 0.1～50%
Difenoconazole 0.1～60%
Dispersant 3～20%
Wetting agent 3～10%
Disintegrant 2～5%
Filler 10～70%
The concrete procedure of processing of this bactericidal composition water dispersible granules is: by above-mentioned prescription fluorine ring azoles, Difenoconazole and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis makes the water dispersible granules that contains the bactericidal composition of fluorine ring azoles and Difenoconazole of the present invention.
Described conventional emulsifier is selected from any one or more mixtures formed with arbitrary proportion in calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styryl phenol APEO, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, the polyoxyethylene aliphatic alcohol ether.
Described conventional solvent is any one or more mixed solvents formed with arbitrary proportion in dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), the water equal solvent.
Described conventional synergist is meant to have the medicament of enhancing penetration, wetting extended capability, knock down insect speed, improve the resistance of rainwater washing against power of agricultural chemicals, thereby improve a class safety, environmental protection of agricultural insecticide, bactericidal effect, the New-type adjuvant of nontoxic, noresidue, optional in organic silicon pesticide synergist ZC-650 or organic silicon pesticide bleeding agent spreading agent Agrowet810c, agricultural organic silicon pesticide synergist Silwet408, azone any.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
The choosing of described wetting agent is white: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., among the wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder one or more.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described stabilizing agent is selected from: a kind of in sodium citrate, the resorcinol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20Saturated fat acid compounds, C
8-10In the aliphatic alcohols compound one or more.
Described emulsifying dispersant comprises: wetting agent, dispersant, stabilizing agent, thickener, defoamer and antifreezing agent etc.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
The invention has the beneficial effects as follows:
1, two kinds of compound structures involved in the present invention, through evidence, being mixed mutually can not produce conflict, but Synergistic reduces dosage, reduces cost.And fluorine ring azoles and Difenoconazole composite do not have report as yet.
2, the pathogen that produces resistance is still had very high drug effect, but suspension of pesticide resistance generation.
3, reduced the agricultural chemicals usage amount, strengthened friendly environment.
4, reduce the agricultural chemicals usage amount, also reduced drug cost, strengthened the market competitiveness of this prescription.
Specific embodiment
Example of formulations 1:
Fluorine ring azoles 0.1g, Difenoconazole 60g, alkylphenol polyoxyethylene sulfosuccinate 15g, organosilicon 2g, the dimethylbenzene surplus makes 60.1% fluorine ring azoles Difenoconazole cream preparation according to above-mentioned missible oil processing way.
Example of formulations 2:
Fluorine ring azoles 5g, Difenoconazole 50g, alkylphenol polyoxyethylene sulfosuccinate 15g, organosilicon 2g, the dimethylbenzene surplus makes 55% fluorine ring azoles Difenoconazole cream preparation according to above-mentioned missible oil processing way.
Example of formulations 3:
Fluorine ring azoles 15g, Difenoconazole 35g, alkylphenol polyoxyethylene sulfosuccinate 15g, organosilicon 2g, the dimethylbenzene surplus makes 50% fluorine ring azoles Difenoconazole cream preparation according to above-mentioned missible oil processing way.
Example of formulations 4:
Fluorine ring azoles 25g, Difenoconazole 20g, alkylphenol polyoxyethylene sulfosuccinate 35g, organosilicon 2g, the dimethylbenzene surplus makes 45% fluorine ring azoles Difenoconazole cream preparation according to above-mentioned missible oil processing way.
Example of formulations 5:
Fluorine ring azoles 40g, Difenoconazole 10g, alkylphenol polyoxyethylene sulfosuccinate 10g, organosilicon 2g, the dimethylbenzene surplus makes 50% fluorine ring azoles Difenoconazole cream preparation according to above-mentioned missible oil processing way.
Example of formulations 6:
Fluorine ring azoles 50g, Difenoconazole 0.1g, alkylphenol polyoxyethylene sulfosuccinate 10g, organosilicon 2g, the dimethylbenzene surplus makes 50.1% fluorine ring azoles Difenoconazole cream preparation according to above-mentioned missible oil processing way.
Example of formulations 7:
Fluorine ring azoles 0.1g, Difenoconazole 60g, lignosulfonates 15g, sodium citrate 0.5g, xanthans 0.3g, ethylene glycol 1g, Sodium Benzoate 0.6g, silicone oil 0.5g, water surplus.Make 60.1% fluorine ring azoles difenoconazole suspending agent according to above-mentioned suspending agent preparation method.
Example of formulations 8:
Fluorine ring azoles 5g, Difenoconazole 50g, lignosulfonates 10g, sodium citrate 0.5g, xanthans 0.3g, ethylene glycol 1g, Sodium Benzoate 0.6g, silicone oil 0.5g, water surplus.Make 55% fluorine ring azoles difenoconazole suspending agent according to above-mentioned suspending agent preparation method.
Example of formulations 9:
Fluorine ring azoles 15g, Difenoconazole 35g, lignosulfonates 7g, sodium citrate 0.5g, xanthans 0.3g, ethylene glycol 1g, Sodium Benzoate 0.6g, silicone oil 0.5g, water surplus.Make 50% fluorine ring azoles difenoconazole suspending agent according to above-mentioned suspending agent preparation method.
Example of formulations 10:
Fluorine ring azoles 25g, Difenoconazole 20g, lignosulfonates 7g, sodium citrate 0.5g, xanthans 0.3g, ethylene glycol 1g, Sodium Benzoate 0.6g, silicone oil 0.5g, water surplus.Make 45% fluorine ring azoles difenoconazole suspending agent according to above-mentioned suspending agent preparation method.
Example of formulations 11:
Fluorine ring azoles 40g, Difenoconazole 10g, lignosulfonates 10g, sodium citrate 0.5g, xanthans 0.3g, ethylene glycol 1g, Sodium Benzoate 0.6g, silicone oil 0.5g, water surplus.Make 50% fluorine ring azoles difenoconazole suspending agent according to above-mentioned suspending agent preparation method.
Example of formulations 12:
Fluorine ring azoles 50g, Difenoconazole 0.1g, lignosulfonates 10g, sodium citrate 0.5g, xanthans 0.3g, ethylene glycol 1g, Sodium Benzoate 0.6g, silicone oil 0.5g, water surplus.Make 50.1% fluorine ring azoles difenoconazole suspending agent according to above-mentioned suspending agent preparation method.
Example of formulations 13:
Fluorine ring azoles 0.1g, Difenoconazole 60g, polyoxyethylene nonylphenol ether 8g, n-butanol 10g, sodium citrate 0.5g, ethylene glycol 1g, silicone oil 0.5g, xanthans 0.3g, Sodium Benzoate 0.6g, water surplus.Make 60.1% fluorine ring azoles Difenoconazole aqueous emulsion according to above-mentioned method for producing aqueous emulsion.
Example of formulations 14:
Fluorine ring azoles 5g, Difenoconazole 50g, polyoxyethylene nonylphenol ether 5g, n-butanol 8g, sodium citrate 0.5g, ethylene glycol 1g, silicone oil 0.5g, xanthans 0.3g, Sodium Benzoate 0.6g, water surplus.Make 55% fluorine ring azoles Difenoconazole aqueous emulsion according to above-mentioned method for producing aqueous emulsion.
Example of formulations 15:
Fluorine ring azoles 15g, Difenoconazole 35g, polyoxyethylene nonylphenol ether 5g, n-butanol 8g, sodium citrate 0.5g, ethylene glycol 1g, silicone oil 0.5g, xanthans 0.3g, Sodium Benzoate 0.6g, water surplus.Make 50% fluorine ring azoles Difenoconazole aqueous emulsion according to above-mentioned method for producing aqueous emulsion.
Example of formulations 16:
Fluorine ring azoles 25g, Difenoconazole 20g, polyoxyethylene nonylphenol ether 5g, n-butanol 8g, sodium citrate 0.5g, ethylene glycol 1g, silicone oil 0.5g, xanthans 0.3g, Sodium Benzoate 0.6g, water surplus.Make 45% fluorine ring azoles Difenoconazole aqueous emulsion according to above-mentioned method for producing aqueous emulsion.
Example of formulations 17:
Fluorine ring azoles 40g, Difenoconazole 10g, polyoxyethylene nonylphenol ether 5g, n-butanol 8g, sodium citrate 0.5g, ethylene glycol 1g, silicone oil 0.5g, xanthans 0.3g, Sodium Benzoate 0.6g, water surplus.Make 50% fluorine ring azoles Difenoconazole aqueous emulsion according to above-mentioned method for producing aqueous emulsion.
Example of formulations 18:
Fluorine ring azoles 50g, Difenoconazole 0.1g, polyoxyethylene nonylphenol ether 5g, n-butanol 8g, sodium citrate 0.5g, ethylene glycol 1g, silicone oil 0.5g, xanthans 0.3g, Sodium Benzoate 0.6g, water surplus.Make 50.1% fluorine ring azoles Difenoconazole aqueous emulsion according to above-mentioned method for producing aqueous emulsion.
Example of formulations 19:
Fluorine ring azoles 0.1g, Difenoconazole 60g, dimethyl sulfoxide (DMSO) 10g, aliphatic acid polyethenoxy ether 5g, sodium citrate 2g, organosilicon auxiliary agent 2g, water surplus according to above-mentioned microemulsion processing way, makes 60.1% fluorine ring azoles micro-emulsion of phenyl ether methyl cyclic-azole.
Example of formulations 20:
Fluorine ring azoles 5g, Difenoconazole 50g, dimethyl sulfoxide (DMSO) 8g, aliphatic acid polyethenoxy ether 5g, sodium citrate 2g, organosilicon auxiliary agent 2g, water surplus according to above-mentioned microemulsion processing way, makes 55% fluorine ring azoles micro-emulsion of phenyl ether methyl cyclic-azole.
Example of formulations 21:
Fluorine ring azoles 15g, Difenoconazole 35g, dimethyl sulfoxide (DMSO) 10g, aliphatic acid polyethenoxy ether 5g, sodium citrate 2g, organosilicon auxiliary agent 2g, water surplus according to above-mentioned microemulsion processing way, makes 50% fluorine ring azoles micro-emulsion of phenyl ether methyl cyclic-azole.
Example of formulations 22:
Fluorine ring azoles 25g, Difenoconazole 20g, dimethyl sulfoxide (DMSO) 10g, aliphatic acid polyethenoxy ether 5g, sodium citrate 2g, organosilicon auxiliary agent 2g, water surplus according to above-mentioned microemulsion processing way, makes 45% fluorine ring azoles micro-emulsion of phenyl ether methyl cyclic-azole.
Example of formulations 23:
Fluorine ring azoles 40g, Difenoconazole 10g, dimethyl sulfoxide (DMSO) 10g, aliphatic acid polyethenoxy ether 5g, sodium citrate 2g, organosilicon auxiliary agent 2g, water surplus according to above-mentioned microemulsion processing way, makes 50% fluorine ring azoles micro-emulsion of phenyl ether methyl cyclic-azole.
Example of formulations 24:
Fluorine ring azoles 0.1g, Difenoconazole 60g,, urea 8g, formaldehyde 10g, lignosulfonates 5g, lauryl sodium sulfate 5g, ethylene glycol 5g, xanthans 1g, silicone oil 0.5g, water surplus makes 60.1% fluorine ring azoles Difenoconazole microcapsule formulations according to above-mentioned microcapsule formulations processing way.
Example of formulations 25:
Fluorine ring azoles 5g, Difenoconazole 50g,, urea 8g, formaldehyde 10g, lignosulfonates 5g, lauryl sodium sulfate 5g, ethylene glycol 5g, xanthans 1g, silicone oil 0.5g, water surplus makes 55% fluorine ring azoles Difenoconazole microcapsule formulations according to above-mentioned microcapsule formulations processing way.
Example of formulations 26:
Fluorine ring azoles 15g, Difenoconazole 35g,, urea 8g, formaldehyde 10g, lignosulfonates 5g, lauryl sodium sulfate 5g, ethylene glycol 5g, xanthans 1g, silicone oil 0.5g, water surplus makes 50% fluorine ring azoles Difenoconazole microcapsule formulations according to above-mentioned microcapsule formulations processing way.
Example of formulations 27:
Fluorine ring azoles 25g, Difenoconazole 20g,, urea 8g, formaldehyde 10g, lignosulfonates 5g, lauryl sodium sulfate 5g, ethylene glycol 5g, xanthans 1g, silicone oil 0.5g, water surplus makes 45% fluorine ring azoles Difenoconazole microcapsule formulations according to above-mentioned microcapsule formulations processing way.
Example of formulations 28:
Fluorine ring azoles 40g, Difenoconazole 10g,, urea 8g, formaldehyde 10g, lignosulfonates 5g, lauryl sodium sulfate 5g, ethylene glycol 5g, xanthans 1g, silicone oil 0.5g, water surplus makes 50% fluorine ring azoles Difenoconazole microcapsule formulations according to above-mentioned microcapsule formulations processing way.
Example of formulations 29:
Fluorine ring azoles 0.1g, Difenoconazole 60g, lignosulfonates 10g, calcium dodecyl benzene sulfonate 5g, Nekal BX 3g, the diatomite surplus according to above-mentioned wetting powder processing method, makes 60.1% fluorine ring azoles Difenoconazole wetting powder.
Example of formulations 30:
Fluorine ring azoles 5g, Difenoconazole 50g, lignosulfonates 6g, calcium dodecyl benzene sulfonate 5g, the diatomite surplus according to above-mentioned wetting powder processing method, makes 55% fluorine ring azoles Difenoconazole wetting powder.
Example of formulations 31:
Fluorine ring azoles 15g, Difenoconazole 35g, lignosulfonates 5g, calcium dodecyl benzene sulfonate 3g, Nekal BX 3g, the diatomite surplus according to above-mentioned wetting powder processing method, makes 50% fluorine ring azoles Difenoconazole wetting powder.
Example of formulations 32:
Fluorine ring azoles 25g, Difenoconazole 20g, lignosulfonates 6g, calcium dodecyl benzene sulfonate 3g, Nekal BX 3g, the diatomite surplus according to above-mentioned wetting powder processing method, makes 45% fluorine ring azoles Difenoconazole wetting powder.
Example of formulations 33:
Fluorine ring azoles 40g, Difenoconazole 10g, lignosulfonates 10g, calcium dodecyl benzene sulfonate 6g, Nekal BX 3g, the diatomite surplus according to above-mentioned wetting powder processing method, makes 50% fluorine ring azoles Difenoconazole wetting powder.
Example of formulations 34:
Fluorine ring azoles 0.1g, Difenoconazole 60g, sodium lignin sulfonate 10g, calcium dodecyl benzene sulfonate 8g, urea 3g, the bentonite surplus according to above-mentioned water dispersible granules processing method, makes 60.1% fluorine ring azoles difenoconazole water dispersible granule.
Example of formulations 35:
Fluorine ring azoles 5g, Difenoconazole 50g, sodium lignin sulfonate 8g, calcium dodecyl benzene sulfonate 5g, urea 3g, the bentonite surplus according to above-mentioned water dispersible granules processing method, makes 55% fluorine ring azoles difenoconazole water dispersible granule.
Example of formulations 36:
Fluorine ring azoles 15g, Difenoconazole 35g, sodium lignin sulfonate 5g, calcium dodecyl benzene sulfonate 5g, urea 3g, the bentonite surplus according to above-mentioned water dispersible granules processing method, makes 50% fluorine ring azoles difenoconazole water dispersible granule.
Example of formulations 37:
Fluorine ring azoles 25g, Difenoconazole 20g, sodium lignin sulfonate 8g, calcium dodecyl benzene sulfonate 5g, urea 3g, the bentonite surplus according to above-mentioned water dispersible granules processing method, makes 45% fluorine ring azoles difenoconazole water dispersible granule.
Example of formulations 38:
Fluorine ring azoles 50g, Difenoconazole 0.1g, sodium lignin sulfonate 10g, calcium dodecyl benzene sulfonate 3g, urea 3g, the bentonite surplus according to above-mentioned water dispersible granules processing method, makes 50.1% fluorine ring azoles difenoconazole water dispersible granule.
Biological Examples:
The different proportioning co-toxicities of fluorine ring azoles with Difenoconazole
1 materials and methods
The design 1.1 material and medicament are mixed
Test medicine is 90.5% epoxiconazole water dispersant, 97.6% Difenoconazole wetting powder.For the examination pathogen is banana tail spore bacterium (Cercospora mu-sae).Examination is made as 30% fluorine ring azoles according to fluorine ring azoles and Difenoconazole total active constituent content that is mixed: Difenoconazole was established 1: 3,1: 5,1: 1,3: 1,5: 1 by former medicine mass ratio, and promptly 5 ratios such as 7.5%+22.5%, 5%+25%, 15%+15%, 22.5%+7.5%, 25%+5% are mixed.
1.2 experimental scheme
Take by weighing the combination that is mixed of an amount of Difenoconazole, epoxiconazole raw drug, 5 fluorine ring azoles Difenoconazoles respectively, fully vibration makes its dissolving in the sterilization triangular flask that adds 3mL watery hydrochloric acid in advance, and adding an amount of sterile water, to make 500 each 50mL of μ g/mL mother liquor standby.On the basis of preliminary experiment, respectively be mixed combination and fluorine ring azoles, Difenoconazole of fluorine ring azoles Difenoconazole respectively to be established 5 concentration gradients, and make blank with the watery hydrochloric acid of same concentrations, each is handled and repeats 4 times.
1.3 synergistic effect is measured
Adopt the mycelium dry weight determination method, every processing repeats 4 times, calculates relative inhibition, virulence regression equation, EC that each is handled
50, carry out the synergy determination method with (1985) methods such as Gisi and obtain the coefficient of synergism (SR) that each is handled, carry out the synergistic effect evaluation.Data see Table 1.
The fluorine ring azoles Difenoconazole mixture of the different proportionings of table 1 suppresses virulence and synergistic effect to banana tail spore bacterium
2 results and analysis
Each mixture synergism coefficient that fluorine ring azoles and Difenoconazole are mixed except 1: 3 o'clock less than 1 other all greater than 1, but fluorine ring azoles: 1: 1 combination S R value that is mixed of Difenoconazole is up to 1.73, greater than 1.5, show as synergistic function, remaining 3 be mixed combination S R value all less than 1.5 greater than 1, show as summation action.
3 field trials are surveyed rice sheath blight disease, rice green smut
3.1 test method
3.1.1 application method
Rice sheath blight disease: test dispenser twice altogether, check plot spray equivalent clear water.When making up a prescription, after with low amounts of water medicament fully being dissolved earlier, add suitable quantity of water again and carry out complete stool spraying processing, even spraying.All adopting power driven sprayer, operating pressure during the spray medicine is 2.0～2.3kg/cm
2, shower nozzle aperture 1.2mm.The sub-district spouting liquid is used by 675 liters/hectare, with the following droplet degree of being not of soup on moistening blade of soup and the branch.
Rice green smut: dispenser in 5～7 days is 1 time before the paddy rice cut, check plot spray equivalent clear water.When making up a prescription, after with low amounts of water medicament fully being dissolved earlier, add suitable quantity of water again and carry out complete stool spraying processing, even spraying.All adopting power driven sprayer, operating pressure during the spray medicine is 2.0～2.3kg/cm
2, shower nozzle aperture 1.2mm.The sub-district spouting liquid is used by 675 liters/hectare, with the following droplet degree of being not of soup on moistening blade of soup and the branch.
3.1.2 investigation method
Rice sheath blight disease: according to rice leaf sheath and blade damage symptom grading, with the strain is unit, 5 samplings of every sub-district diagonal, every some investigation links to each other 5 clumps, totally 25 clumps, write down total strain number, diseased plant number and sick progression, calculate the blade incidence of disease, disease index, refer to comparison with the contrast disease, calculate relative control effect.
State of an illness grade scale:
0 grade: complete stool is anosis;
1 grade: quaterfoil and following each leaf sheath thereof, blade morbidity (is first leaf with sword-like leave);
3 grades: the 3rd blade and following each leaf sheath thereof, blade morbidity;
5 grades: second blade and following each leaf sheath thereof, blade morbidity;
7 grades: sword-like leave blade and following each leaf essence thereof, blade morbidity;
9 grades: the complete stool morbidity, withered ahead of time.
Rice green smut: 1, disease survey method: 5 investigation in every sub-district, look into the sick fringe of 5 container made of bamboo, wicker, ratten, etc.s, look into 25 container made of bamboo, wicker, ratten, etc.s altogether for every;
2, paddy rice is copied kind of an investigation method: every sub-district is investigated number of productive ear, each spike length degree, total grain, real grain, blighted grain, infected seed, 2 thousand kernel weight in every sub-district, every cell measurement 10 root and stem of certain plants plant heights, every sub-district of 2 container made of bamboo, wicker, ratten, etc.s and is looked into 2m
2Effective container made of bamboo, wicker, ratten, etc.
3.1.3 control time and number of times
Rice sheath blight disease: investigate altogether 3 times,, carried out the 2nd, 3 investigation behind the 1st medicine behind 7 days and the 2nd medicine in 15 days respectively respectively at investigation state of an illness radix before the 1st dispenser.
Rice green smut: dispenser in 5～7 days is 1 time before the paddy rice cut, carries out efficacy survey after dispenser in 15 and 30 days.
3.1.4 drug effect computational methods
The banded sclerotial blight computing formula:
Disease index=∑ (the sick numbers of sheets at different levels * relative level numerical value)/(investigating total number of sheets * 9) * 100
Control efficiency (%)=(1-(disease index behind disease index before the blank district medicine * treatment region medicine)/(disease index before disease index behind the blank district medicine * treatment region medicine)) * 100
The false smut computing formula:
Disease tassel yield (%)=(sick spike number ÷ investigates total spike number) * 100
Infected seed rate (%)=(infected seed is counted hundred numbers of ÷ investigation) * 100
Disease tassel yield preventive effect (%)=((check plot disease tassel yield-treatment region disease tassel yield) * 100)/contrast disease tassel yield
Infected seed preventive effect (%)=((contrasting hundred fringe infected seed numbers-processing hundred fringe infected seed numbers) * 100)/contrast hundred fringe infected seed numbers
3.1.5 poisoning investigation method
Continuous 7d range estimation medicament does not have poisoning to crop after the dispenser.
3.2 result of the test and analysis
3.2.1 each handles the effect (seeing Table 2) of preventing and treating rice sheath blight disease
Each processing of table 2 prevents and treats rice sheath blight disease field control effectiveness test table as a result
As shown in Table 2,30% fluorine ring azoles: it is remarkable that Difenoconazole makes up the effect of preventing and treating rice sheath blight disease with 1: 1 be mixed, and its preventive effect is better than 30% Difenoconazole missible oil, more is better than 12.5% epoxiconazole suspension concentrate; Have good quick-acting and lasting effect, the effect of 15 its high concentration treatment regions obviously is better than the low concentration treatment region under the same proportioning behind its 2 medicines, and preventive effect reaches as high as 85%.Simultaneously, compare with single agent, its complex preparation has obvious synergistic effect.According to field observation, each treatment region paddy growth is normal under recommended dose, and no poisoning produces, and is safe to paddy rice.
3.2.2 each handles the effect (seeing Table 3) of control rice green smut
Each handles control rice green smut field control effectiveness test table as a result table 3
As shown in Table 3,30% fluorine ring azoles: Difenoconazole is remarkable with the effect of 1: 1 the combination control rice green smut that is mixed, and its preventive effect is better than 30% Difenoconazole missible oil, more is better than 12.5% epoxiconazole suspension concentrate; Investigation in 30 days behind its 2nd medicine, the highest preventive effect can reach 88%.Simultaneously, its complex preparation has obvious synergistic effect.Under recommended dose, use, be suitable for promoting demonstration crop safety.At the rice green smut initial stage of origination, the control of dispenser in time can obtain ideal effect.Should be used alternatingly with other bactericide in use, to delay the drug-fast generation of germ.
Claims (6)
1. a bactericidal composition is characterized in that containing fluorine ring azoles and Difenoconazole, and wherein the weight ratio of fluorine ring azoles and Difenoconazole is 0.1～50: 0.1～60;
2. bactericidal composition according to claim 1 is characterized in that: the weight ratio of fluorine ring azoles and Difenoconazole is 1～30: 1～40;
3. bactericidal composition according to claim 1 is characterized in that: the percentage by weight that active ingredient accounts for preparation is 2～70%;
4. bactericidal composition according to claim 1, fluorine ring azoles and Difenoconazole and auxiliary agent and cosolvent are re-dubbed any one formulation that allows on the agricultural chemicals;
5. bactericidal composition according to claim 4 is characterized in that formulation is missible oil, suspending agent, aqueous emulsion, microemulsion, microcapsule formulations, wetting powder and water dispersible granules;
6. bactericidal composition according to claim 1 at control cereal class and melon, really, the application on the vegetables aspect the disease.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102754649A (en) * | 2012-08-01 | 2012-10-31 | 杭州宇龙化工有限公司 | Sterilizing composition containing phenylate bi (imidazole) and epoxiconazole |
| CN104237047A (en) * | 2014-08-27 | 2014-12-24 | 广东省农业科学院植物保护研究所 | Method for detecting toxicity of bactericide on bacteria of sigatoka disease of bananas |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101262767A (en) * | 2005-09-14 | 2008-09-10 | 巴斯夫欧洲公司 | Triazole-based fungicidal mixtures |
| CN101779676A (en) * | 2009-12-16 | 2010-07-21 | 陈章艳 | Sterilization composition containing epoxiconazole |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101262767A (en) * | 2005-09-14 | 2008-09-10 | 巴斯夫欧洲公司 | Triazole-based fungicidal mixtures |
| CN101779676A (en) * | 2009-12-16 | 2010-07-21 | 陈章艳 | Sterilization composition containing epoxiconazole |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102754649A (en) * | 2012-08-01 | 2012-10-31 | 杭州宇龙化工有限公司 | Sterilizing composition containing phenylate bi (imidazole) and epoxiconazole |
| CN104237047A (en) * | 2014-08-27 | 2014-12-24 | 广东省农业科学院植物保护研究所 | Method for detecting toxicity of bactericide on bacteria of sigatoka disease of bananas |
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