CN101732618A - Medicament for curing arthromeningitis and preparation process - Google Patents
Medicament for curing arthromeningitis and preparation process Download PDFInfo
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- CN101732618A CN101732618A CN200810177709A CN200810177709A CN101732618A CN 101732618 A CN101732618 A CN 101732618A CN 200810177709 A CN200810177709 A CN 200810177709A CN 200810177709 A CN200810177709 A CN 200810177709A CN 101732618 A CN101732618 A CN 101732618A
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Abstract
The invention relates to the technical field of Chinese medicinal herbs, in particular to a medicament for curing arthromeningitis and a preparation process. Most of conventional chemicals for curing joint diseases can only relieve pain, addresses the symptoms, not the cause, and easily causes relapse of disease, and has high cost and obvious side effect. The medicament comprises the following components in part by weight: 13.0 to 13.8 parts of common selfheal fruit-spike, 13.0 to 13.8 parts of coix seed, 8.5 to 9.3 parts of radix stephaniae tetrandrae, 8.5 to 9.3 parts of glabrous greenbrier rhizome, 6.3 to 7.1 parts of common St. Paulswort herb, 6.3 to 7.1 parts of fasciculus vascularis luffae, 4.1 to 4.9 parts of medicinal cyathula root, 3.6 to 4.4 parts of hiraute shiny bugleweed herb, 6.3 to 7.1 parts of danshen root, 4.1 to 4.9 parts of Chinese angelica, 8.5 to 9.3 parts of astragalus, 6.3 to 7.1 parts of glossy privet fruit, 6.3 to 7.1 parts of Chinese holly leaf and an appropriate amount of auxiliary materials. The information statistics of clinical use shows that medicament has the curative rate of 62 percent, and total effective rate of 97.2 percent.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, a kind of specifically medicine and preparation technology who treats synovitis.
Background technology
Doctor trained in Western medicine is the joint puncture drawing liquids that adopt when the treatment joint disease more, pressure dressing, and local braking, physical therapy and intraarticular injection steroid medicine etc., the course of treatment is long, and effect is undesirable.The chemical drugs majority that is used for the treatment of joint disease can only alleviating pain, cures the symptoms, not the disease, and easily repeatedly, and price is more expensive, and side effect is obvious.
Summary of the invention
The purpose of this invention is to provide a kind of medicine and preparation technology who treats synovitis, can effectively improve cure rate, and have no side effect.
Drug weight umber prescription of the present invention is: Spica Prunellae 13.0-13.8 part Semen Coicis 13.0-13.8 part Radix Stephaniae Tetrandrae 8.5-9.3 part Rhizoma Smilacis Glabrae 8.5-9.3 Fen Herba Siegesbeckiae 6.3-7.1 part Retinervus Luffae Fructus 6.3-7.1 part Radix Cyathulae 4.1-4.9 part Herba Lycopi 3.6-4.4 part Radix Salviae Miltiorrhizae 6.3-7.1 part Radix Angelicae Sinensis 4.1-4.9 part Radix Astragali 8.5-9.3 part Fructus Ligustri Lucidi 6.3-7.1 part Folium Ilicis Cornutae 6.3-7.1 part.Other has appropriate amount of auxiliary materials.
Medicine of the present invention has two kinds of dosage forms, is respectively granular pattern and capsule-type.
Preparation technology:
Granular pattern preparation technology:
13 flavor Chinese medicine selections are cleaned, add 8-10 and doubly measure purified water decoction 2 hours, medicinal residues add 4-6 again and doubly measure purified water and boil medicine and boil 1 hour, merge decoction liquor twice, it is 1.02-1.15 (65 ± 2 ℃ time survey) that hot reflux is concentrated into relative density, concentrated solution is added 95% ethanol reach the alcohol amount of containing 45%, leave standstill more than 24 hours, get supernatant and filter, continue to be concentrated into the concentrated solution of relative density 1.32-1.40 (25 ± 2 ℃ time survey) behind the filtrate recycling ethanol, add the Icing Sugar of 3 times of amounts of concentrated solution weight and the dextrin of 1 times of amount, mixing is granulated, granule is in 70 ℃ of-75 ℃ of dryings, with 12 order nylon mesh granulate, mixing, packing gets final product.
Capsule-type preparation technology:
13 flavor Chinese medicine selections are cleaned; adding 8-10 doubly measures purified water and boils medicine and boil 2 hours; medicinal residues add the purified water that 4-6 doubly measures again and decocted 1 hour; merge decoction liquor twice; it is 1.02-1.15 (65 ± 2 ℃ time survey) that hot reflux is concentrated into relative density; concentrated solution is added 95% ethanol reach the alcohol amount 45% that contains; leave standstill more than 24 hours; getting supernatant filters; continue to be concentrated into the concentrated solution of relative density 1.20-1.25 (25 ± 2 ℃ time survey) behind the filtrate recycling ethanol, 8% dextrin that adds dry matter weight in the concentrated solution is done bed material, makes granule with multi-functional granulator spray drying method; 2% the lubricant that adds dry matter weight in the concentrated solution again; capsule charge behind the mixing, polishing, the plastic-aluminum packing gets final product; this dosage form sugar-free, suitable diabetic population is taken.
Technological parameter during spray-drying process:
Inlet temperature: 80-90 ℃
Leaving air temp: 50-70 ℃
Temperature of charge: 70-85 ℃
Atomizing pressure: 0.23-0.40Mpa.
Disease that medicine of the present invention is cured the disease is referred to as synovitis based on arthralgia in doctor trained in Western medicine, belongs to the arthromyodynia scope of the traditional Chinese medical science.Arthromyodynia be since be affected by the cold damp and hot, the impatency collaterals of human, QI-blood circulation is not smooth, muscle arteries and veins, joint produce ache, numbness, joint stuffiness, even clinical symptoms such as arthroncus is scorching hot.The present invention is based on Spica Prunellae, Semen Coicis, Radix Stephaniae Tetrandrae, and with clearing away heat-damp and promoting diuresis, current 12 warps are with pain relieving, detumescence.With Rhizoma Smilacis Glabrae, Herba Siegesbeckiae, Retinervus Luffae Fructus easing joint movement, treat quadriplegia, the dehumidifying of reason wind, relaxing muscles and tendons and activating QI and blood in the collateral.Invigorate blood circulation eliminating blood stasis to promote regeneration of blood with Radix Cyathulae, Herba Lycopi, Radix Salviae Miltiorrhizae, Chinese Angelica blood replonishing.With the Radix Astragali, Fructus Ligustri Lucidi, Folium Ilicis Cornutae boosting qi and nourishing yin, liver and kidney tonifying, settling five organs, strong waist knee joint.All medicines share, and gather clearing heat and expelling damp altogether, the effect of promoting blood circulation to remove obstruction in the collateral, thus reach the purpose of reducing swelling and alleviating pain, joint rehabilitation.
Clinical operating position:
This drug administration of clinical response is convenient, and is safe and effective, no side effects and untoward reaction.Acute and chronic, traumatic synovitis there is the effect of eliminating arthroedema, reducing swelling and alleviating pain and recovering function of joint.The Information Statistics of clinical use show cure rate 62%, total effective rate 97.2%.
Advantage of the present invention is that product is pure Chinese medicine, has no side effect, and eliminating symptom, eases the pain, recovers the function of joint aspect and all be better than chemicalses such as ibuprofen.
The specific embodiment:
Embodiment 1:
Take by weighing Spica Prunellae 13.4kg Semen Coicis 13.4kg Radix Stephaniae Tetrandrae 8.9kg Rhizoma Smilacis Glabrae 8.9kg Herba Siegesbeckiae 6.7kg Retinervus Luffae Fructus 6.7kg Radix Cyathulae 4.5kg Herba Lycopi 4.0kg Radix Salviae Miltiorrhizae 6.7kg Radix Angelicae Sinensis 4.5kg Radix Astragali 8.9kg Fructus Ligustri Lucidi 6.7kg Folium Ilicis Cornutae 6.7kg.13 flavor Chinese medicine selections are cleaned; add 8-10 and doubly measure purified water decoction 2 hours; medicinal residues add 4-6 again and doubly measure purified water and boil medicine and boil 1 hour; merge decoction liquor twice; it is 1.02-1.15 (65 ± 2 ℃ time survey) that hot reflux is concentrated into relative density, concentrated solution is added 95% ethanol reach and contain alcohol amount 45%, leaves standstill more than 24 hours; getting supernatant filters; continue to be concentrated into relative density 1.32-1.40 (25 ± 2 ℃ time survey) behind the filtrate recycling ethanol, concentrated solution 15kg, add the Icing Sugar of 45kg and the dextrin of 15kg; mixing; granulator is granulated, and granule is in 70 ℃ of-75 ℃ of dryings, and (with ebullated bed or oven drying) is with 12 order nylon mesh granulate; mixing, packing are the granular pattern dosage form.
Every bag heavy 12g (quite primary crude drug amount 18g), every bag contains Radix Salviae Miltiorrhizae with protocatechualdehyde (C
7H
6O
3) meter, must not be less than 1.00mg.
Usage and consumption: warm boiled water, one time one bag, three times on the one.
Embodiment 2:
Take by weighing Spica Prunellae 13.4kg Semen Coicis 13.4kg Radix Stephaniae Tetrandrae 8.9kg Rhizoma Smilacis Glabrae 8.9kg Herba Siegesbeckiae 6.7kg Retinervus Luffae Fructus 6.7kg Radix Cyathulae 4.5kg Herba Lycopi 4.0kg Radix Salviae Miltiorrhizae 6.7kg Radix Angelicae Sinensis 4.5kg Radix Astragali 8.9kg Fructus Ligustri Lucidi 6.7kg Folium Ilicis Cornutae 6.7kg.13 flavor Chinese medicine selections are cleaned; add 8-10 and doubly measure purified water decoction 2 hours; medicinal residues add 4-6 again and doubly measure purified water and boil medicine and boil 1 hour; merge decoction liquor twice; it is 1.02-1.15 (65 ± 2 ℃ time survey) that hot reflux is concentrated into relative density; concentrated solution is added 95% ethanol reach the alcohol amount 45% that contains; leave standstill more than 24 hours, get supernatant and filter, continue to be concentrated into the concentrated solution of relative density 1.20-1.25 (25 ± 2 ℃ time survey) behind the filtrate recycling ethanol; take by weighing the 0.67kg dextrin and do bed material; make granule with multi-functional granulator spray drying method, add the lubricant of 0.17kg again, capsule charge behind the mixing; polishing, the plastic-aluminum packing is the capsule-type dosage form.
Every heavy 0.5g (quite primary crude drug amount 6g), every contains Radix Salviae Miltiorrhizae with protocatechualdehyde (C
7H
6O
3) meter, must not be less than 0.15mg.
Usage and consumption: warm water delivery service, one time 3, three times on the one.
Technological parameter during spray-drying process:
Inlet temperature: 80-90 ℃
Leaving air temp: 50-70 ℃
Temperature of charge: 70-85 ℃
Atomizing pressure: 0.23-0.40Mpa.
Claims (5)
1. medicine for the treatment of synovitis, comprise appropriate amount of auxiliary materials, it is characterized in that its drug weight umber prescription is: Spica Prunellae 13.0-13.8 part Semen Coicis 13.0-13.8 part Radix Stephaniae Tetrandrae 8.5-9.3 part Rhizoma Smilacis Glabrae 8.5-9.3 Fen Herba Siegesbeckiae 6.3-7.1 part Retinervus Luffae Fructus 6.3-7.1 part Radix Cyathulae 4.1-4.9 part Herba Lycopi 3.6-4.4 part Radix Salviae Miltiorrhizae 6.3-7.1 part Radix Angelicae Sinensis 4.1-4.9 part Radix Astragali 8.5-9.3 part Fructus Ligustri Lucidi 6.3-7.1 part Folium Ilicis Cornutae 6.3-7.1 part.
2. a kind of medicine for the treatment of synovitis as claimed in claim 1 is characterized in that two kinds of dosage forms, is respectively granular pattern and capsule-type.
3. a preparation technology who treats the medicine of synovitis is characterized in that 13 flavor Chinese medicine selections are cleaned, and adds 8-10 and doubly measures purified water decoction 2 hours, medicinal residues add 4-6 again and doubly measure purified water and boil medicine and boil 1 hour, merge decoction liquor twice, it is 1.02-1.15 that hot reflux is concentrated into relative density, concentrated solution is added 95% ethanol reach the alcohol amount 45% that contains, leave standstill more than 24 hours, get supernatant and filter, after continuing behind the filtrate recycling ethanol to concentrate, add appropriate amount of auxiliary materials, granulation, drying, packing gets final product.
4. a kind of preparation technology who treats the medicine of synovitis as claimed in claim 3, after it is characterized in that described concentrating, add appropriate amount of auxiliary materials, granulation, drying, be meant and be concentrated into relative density 1.32-1.40, add the Icing Sugar of 3 times of amounts of concentrated solution weight and the dextrin of 1 times of amount, mixing is granulated, granule is in 70 ℃ of-75 ℃ of dryings, with 12 order nylon mesh granulate, mixing, be distributed into bag and get final product.
5. a kind of preparation technology who treats the medicine of synovitis as claimed in claim 3, after it is characterized in that described concentrating, add appropriate amount of auxiliary materials, granulation, drying are meant to be concentrated into relative density 1.20-1.25,8% of dry matter weight dextrin is done bed material in the adding concentrated solution, make granule with multi-functional granulator spray granulation method, add 2% lubricant of dry matter weight in the concentrated solution again, capsule charge behind the mixing, polishing, the plastic-aluminum packing gets final product; Technological parameter during spray-drying process: inlet temperature: 80-90 ℃, leaving air temp: 50-70 ℃, temperature of charge: 70-85 ℃, atomizing pressure: 0.23--0.40Mpa.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810177709A CN101732618A (en) | 2008-11-11 | 2008-11-11 | Medicament for curing arthromeningitis and preparation process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810177709A CN101732618A (en) | 2008-11-11 | 2008-11-11 | Medicament for curing arthromeningitis and preparation process |
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| CN101732618A true CN101732618A (en) | 2010-06-16 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940823A (en) * | 2012-12-06 | 2013-02-27 | 神威药业（张家口）有限公司 | Synovitis treating medicine and preparation method thereof |
| CN102940822A (en) * | 2012-12-06 | 2013-02-27 | 神威药业（张家口）有限公司 | Synovitis treating medicine and preparation method thereof |
| CN106798865A (en) * | 2017-02-16 | 2017-06-06 | 成都市飞龙水处理技术研究所青白江第分所 | A kind of Chinese medicine composition for treating acute and chronic synovitis and preparation method thereof |
| CN112402565A (en) * | 2019-08-21 | 2021-02-26 | 盈科瑞（横琴）药物研究院有限公司 | Traditional Chinese medicine composition for tonifying qi, activating blood circulation, removing dampness and reducing swelling and preparation method thereof |
-
2008
- 2008-11-11 CN CN200810177709A patent/CN101732618A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940823A (en) * | 2012-12-06 | 2013-02-27 | 神威药业（张家口）有限公司 | Synovitis treating medicine and preparation method thereof |
| CN102940822A (en) * | 2012-12-06 | 2013-02-27 | 神威药业（张家口）有限公司 | Synovitis treating medicine and preparation method thereof |
| CN102940822B (en) * | 2012-12-06 | 2014-07-16 | 神威药业（张家口）有限公司 | Synovitis treating medicine and preparation method thereof |
| CN106798865A (en) * | 2017-02-16 | 2017-06-06 | 成都市飞龙水处理技术研究所青白江第分所 | A kind of Chinese medicine composition for treating acute and chronic synovitis and preparation method thereof |
| CN112402565A (en) * | 2019-08-21 | 2021-02-26 | 盈科瑞（横琴）药物研究院有限公司 | Traditional Chinese medicine composition for tonifying qi, activating blood circulation, removing dampness and reducing swelling and preparation method thereof |
| CN112402565B (en) * | 2019-08-21 | 2023-07-14 | 盈科瑞（横琴）药物研究院有限公司 | Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method thereof |
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Open date: 20100616 |