CN101731462B - Purely natural vegetality feed additive resisting gastrointestinal dysfunction and application thereof - Google Patents
Purely natural vegetality feed additive resisting gastrointestinal dysfunction and application thereof Download PDFInfo
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Abstract
The invention relates to a purely natural vegetality feed additive resisting gastrointestinal dysfunction and application thereof. The feed additive is characterized by comprising the following raw material components by weight percent: 9 to 11% of radix curcumae, 5 to 7% of rhizoma coptidis, 5 to 7% of phellodendron, 5 to 7% of radix scutellariae, 8 to 11% of gardenia, 4 to 6% of radix paeoniae alba, 4 to 6% of myrobalam, 5 to 7% of milk veteh, 5 to 7% of hawthorn and 36 to 40% of pine needle meal. The addition of the feed additive is 0.01g to 0.05g in one kilogram of piglet complete feed. Compared with other chemical additives, the invention has the advantages that the use level is low; 0.01g/kg to 0.05g/kg is added to the feed, toxic side effect can not be generated to animals, and the production cost can not be increased; and the use level of each natural vegetable is determined according to the property theory of the natural vegetable and the relationships among the vegetables, the drugs are reasonably mixed, and each natural vegetable is the common vegetable.
Description
Technical field
The invention belongs to a kind of animal feed additive, the feed addictive and the application of the anti-Gastrointestinal Tract of Weanling Piglets dysfunction of particularly a kind of Purely natural vegetality.
Background technology
Therefore intestines and stomach are the most important digestive organs of animal body, and that keeps the intestines and stomach 26S Proteasome Structure and Function is complete to the digesting and assimilating of food, body growth, grow most important.Body is suffering external or interiorly under the various factors spread effect, all can exert an influence to intestines and stomach, causes its 26S Proteasome Structure and Function to change, and makes the intestines and stomach function that a series of physiological and pathological take place and changes, and the gastrointestinal function obstacle occurs.In livestock and poultry breeding industry, gastrointestinal dysfunction is particularly common with diarrhoea with indigestion.Symptom show as ill domestic animal spirit depressed, lose the appetite, suffer from diarrhoea, make that Abwehrkraft des Koepers descends, production performance descends.The domestic in recent years statistics of certificate show: livestock and poultry are caused serious economy loss because the case load of the diarrhoeal diseases that gastrointestinal dysfunction causes accounts for 50-60% to aquaculture.
The feed that living environment is poor, the quality of searching for food is bad, drink poor into unclean water, cage house environmental sanitation, artificially stress wait factor all can reduce the body defence capability, make gastrointestinal barrier hypodynamia.Secondary bacterium, virus infections, common various infectious diseases also are the reasons that causes the gastrointestinal function obstacle.Domestic in recent years plant epidemic preventing working puts in place; Strong enterogastric diseases can not take place generally; Microbial gastrointestinal dysfunction happens occasionally but conditionity is caused a disease; The rare pathogen incidence of disease of past is on the rise, and some conditionity pathogenic bacteria such as Pasteurella, anthrax, Escherichia coli, proteus mirabilis, tubercle bacillus etc. will gradually become the pathogen of enteron aisle diarrhoea.When the weather cataclysm, often one or more germ mixed infections and be dispersed in morbidity when Abwehrkraft des Koepers descends.Mainly show as depressed, the anorexia of spirit or useless exhausted clinically, ruminate number of times and reduce or stop, drawing the water sample loose stool, and the clinical symptoms of in various degree " tenesmus " is arranged.The parasitic factor is arranged again; Mainly be owing to the feed that contains infective larvae and worm's ovum of having searched for food infects; Under the stable breeding condition, cause that the disorderly worm kind of herbivore function of intestinal canal is more, but much more comparatively to see with the enteron aisle diarrhoea that parasites such as the first nematode of hair, haemonchus, quasi-colubriformis, balantidium Coli, tapeworm, trypanosome cause; Show as clinically become thin, anaemia, diarrhoea and constipation alternately occur; Ight soil has blood and rheuminess thing, also is mixed with parasite polypide and worm's ovum sometimes, but appetite, body temperature are normal basically.
Because the existence of above factor; Upset the normal stool function of animal gastrointestinal tract, various pathogenic pathogenic microorganisms are taken advantage of a weak point, and make the different variation of intestines and stomach 26S Proteasome Structure and Function occurrence degree; Influenced digestion and the absorption of food and caused production performance to descend, severe patient brings about great losses.
The control of gastrointestinal dysfunction is main with antibiotic therapy at present, but side effect is big, and medicament residue is difficult to resolve determines.Antibiotic use causes bacterium to produce drug resistance, in the medication process, causes the flora imbalance of enteron aisle to cause suprainfection simultaneously, and this phenomenon sees in that ruminant especially more, and often because due to the oral antibiotic.According to bibliographical information, long-time and heavy dose of antibiotic that uses can cause intestinal bacilli illness, cause some antibody-resistant bacterium growth and breeding on small intestine and colon, and the generation toxin causes pseudomembranous enteritis and watery diarrhea.Cause the medicine of pseudomembranous enteritis to mainly contain lincomycin, clindamycin, tetracycline, ampicillin, Amoxicillin, rifampin etc. at present, the prolonged application antibiotic also can cause intestinal canal fungus infection to cause fungal enteritis and diarrhoea occur in addition.Therefore in natural resources, seek the alternative antibiotics feed addictive of safe and effective natural antibacterial medicine and become the focus that animal and veterinary is already studied.
Natural plant feed addictive is little with its unique mode of action, toxic and side effect, noresidue, the no resistance to the action of a drug and characteristics such as pollution-free and favored.The application of natural plant feed addictive is to produce nuisance free feed, and then produces one of important step of pollution-free food.Natural plant feed addictive is to use traditional Chinese veterinarian's theory and the property theory of natural plant and the relation between medicine of China; The principles of formulating prescriptions according to Chinese medicine; In feed, add natural plant, be aided with modern scientific theories such as Animal nutrition and feed industry technology and the pure natural fodder additive processed.Natural plant feed addictive can guarantee the livestock and poultry body health, regulates stomach and intestine, strengthens resistance against diseases, improves the price of deed etc., promotes to grow, and increases animal products output.
Therefore, it is to make China's feed industry and aquaculture go on the demand on the road of sustainable sound development that the plant feed addictive of the anti-gastrointestinal dysfunction of pure natural is used in feed, is the wise move that improves social economy's ecological benefits.
Summary of the invention
The object of the invention: according to China traditional traditional Chinese medicine theory and modern medical theory, selected multiple natural plants forms according to certain proportioning is refining, to realize improving gastrointestinal function, improves piglet and digests and assimilates, thereby improve production performance.This additive avirulence is for the pork of producing safe green provides new method.
The present invention provides the anti-weanling pig gastrointestinal dysfunction of a kind of pure natural plant feed addictive, and the percentage by weight of its raw material components is: root tuber of aromatic turmeric 9-11%, coptis 5-7%; Golden cypress 5-7%, root of large-flowered skullcap 5-7%, cape jasmine 8-11%; Root of herbaceous peony 4-6%, myrobalan 4-6%, Radix Astragali 5-7%; Hawthorn 5-7%, pine needle meal 36-40%.
Preparation method: raw material weighed in proportion, pulverizes, sieved (100 order), mix, process powder, packing after the quality inspection.
Principle of the present invention: root tuber of aromatic turmeric is a zingiberaceous plant in the side, has the effect of the cool serum heart, promoting qi circulation and removing obstruction in the collateral, stasis-dispelling and pain-killing, normalizing gallbladder to cure jaundice.Its active ingredient is right-tolyl-methyl methylol curcumin.Root tuber of aromatic turmeric water logging agent has inhibitory action to multiple pathomycete.Volatile oil can promote the secretion and the drainage of bile in the root tuber of aromatic turmeric.The root tuber of aromatic turmeric decoction can stimulate hydrochloric acid in gastric juice and duodenal juice secretion.The coptis is a Ranunculaceae perennial evergreen draft.Be used as medicine with root-like stock.Purging intense heat and detonicating is arranged, heat-clearing and damp-drying drug effect, diseases such as row heat poison, high heat agitation, dysentery, aphtha, ulcer serious case of furuncle in the time of can controlling when making Chinese medicine.The coptis contains multiple alkaloids such as jamaicin, coptisine, and other contains compositions such as obakunone, obakulactone.Pharmacological testing proves that the coptis has significant diuresis; And can bring high blood pressure down, coronary artery dilator reduces vasopermeability; Antibacterial and antiviral, antiprotozoan effect is arranged, staphylococcus aureus, shigella dysenteriae are had inhibitory action.Golden cypress is the dry bark of rutaceae wampee or cork tree.Has heat-clearing and damp-drying drug, purging intense heat and detonicating, the effect of clearind deficient heat.The root of large-flowered skullcap is the dry root of the labiate root of large-flowered skullcap.Scutellariae,radix contains baicalein, baicalin, wogonin, wogonoside and neobaicalein, also contains benzoic acid, cupreol etc.Contain scutellarin in the cauline leaf.Pharmacological evaluation shows that the root of large-flowered skullcap can the anti-inflammatory antiallergic action.The root of large-flowered skullcap has wider antimicrobial spectrum; Shigella dysenteriae, corynebacterium diphtheriae, Pseudomonas aeruginosa, staphylococcus, streptococcus, Diplococcus pneumopniae and meningococcus etc. all there is inhibitory action in vitro; Even the staphylococcus aureus to antibiotic such as penicillin have developed immunity to drugs still belongs to sensitivity to the root of large-flowered skullcap.The root of large-flowered skullcap has step-down, diuresis in addition.Cape jasmine is the fruit of madder wort mountain Cape jasmine.Contain flavonoids gardenin, pectin, tannin, crocin, crocetin, D-sweet mellow wine, nonacosane, cupreol.Other contains the glucoside of the smelly formaldehyde structure of multiple tool ring: gardenoside, geniposide pool element-1-glycoside, lattice Tegosept P-1-β-D-gentiobioside and shanzhiside in a small amount.Cape jasmine can be used for the jaundice that the biliary tract inflammation causes.Cape jasmine has calmness, hypotensive effect and anti-microbial effect.Cape jasmine is 27.45 gram/kilograms to chmice acute lumbar injection median lethal dose, and hypodermic injection is 31.79 gram/kilograms, belongs to the avirulence material.The root of root of herbaceous peony dicotyledon medicine ranunculaceae plant Chinese herbaceous peony (cultigen).The root of herbaceous peony has relexation in various degree to the stomach smooth muscle, so the effect of slow contraction pain relieving is arranged.The root of herbaceous peony has antibacterial action, and staphylococcus, hemolytic streptococcus, Diplococcus pneumopniae, shigella dysenteriae, typhoid bacillus, Escherichia coli and Pseudomonas aeruginosa etc. are had inhibitory action.The myrobalan is combretaceae plant myrobalan's a fruit.It is more that myrobalan's fruit contains tannin, and the general action of tannin is arranged, like convergence, antidiarrheal etc.In vitro test proves that the myrobalan is effective to 4～5 kinds of shigella dysenteriaes, is good with myrobalan's shell especially.Myrobalan's water decoction (100%) except that to various shigella dysenteriaes effectively; And stronger to Pseudomonas aeruginosa, corynebacterium diphtheriae effect, staphylococcus aureus, Escherichia coli, pneumococcus, hemolytic streptococcus, proteus, bacillus typhi murium also there are effect (paper disk method); Valid density to shigella dysenteriae, staphylococcus aureus, Pseudomonas aeruginosa was respectively 1: 32, and 1: 128,1: 64 (test tube method).The Radix Astragali is the root of legume Astragalus membranacus and astragalus mongholicus Bge.The Radix Astragali can invigorating qi for strengthening superficies, and diuresis holder poison has inhibitory action to shigella dysenteriae, golden yellow glucose coccus etc.The Radix Astragali can promote immune cell propagation, discharges lymphocyte factor, activates the B cell, generates immune globulin antibody; Promote to get rid of the decline cell, remove refuse.The astragaloside of the Radix Astragali mucous membrane that can stimulate digestion, reflectivity promotes the secretion of glandula digestive, it also can increase the absorption function of intestinal mucosa, promotes digesting and assimilating of nutriment.Hawthorn is the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn or hawthorn, is born in mountain valley or the mountain region bushes, and the tool appetite-stimulating indigestion-relieving, the effect of long-pending, promoting blood circulation to remove blood stasis, the promoting the circulation of qi of reducing phlegm of disappearing change to stagnate.Pine needle meal is that young shoot and the needle pruned on the pine tree form through super-dry, pulverizing.Green, the delicate fragrance of pine needle pink colour is the higher new type natural vegetalitas additive for farm animal feed of a kind of nutritive value developed of people in recent years.Its active chemical is volatile oil (australene and nopinene, an amphene etc.), flavonol (Quercetin, kaempferol etc.), resin etc.Not only contain rich nutrient substances in the pine needle (with alfalfa meal, green hay powder and Chinese scholartree leaf powder ratio; The content of the dry of pine needle meal, crude protein, crude fat, NFE all is the highest), also have bioactivators such as flavones, hormone, terpenoid.Pine needle is used as medicine, bitter, puckery, warm in nature, expelling wind and activating blood flow is arranged, makes eye bright, calms the nerves, detoxifcation, antipruritic effect.
Natural plant additive provided by the invention relatively has remarkable advantages with other chemical addition agents:
1. consumption is little, only in feed, adds 0.01g/kg ~ 0.05g/kg, can not produce toxic and side effect to animal itself, also can not increase production cost simultaneously;
2. the dosage of each natural plants among the present invention is to confirm that according to the property theory and the relation between plant of natural plants compatibility of drugs is reasonable; And each natural plants is plant commonly used.
Description of drawings
Fig. 1 is a control group stomach section picture.
Fig. 2 is a natural plants group stomach section picture.
Fig. 3 is a control group small intestine section picture.
Fig. 4 is a natural plants group small intestine section picture.
The specific embodiment
Embodiment 1:
A kind of feed addictive of Purely natural vegetality resisting gastrointestinal dysfunction, its raw material components percentage by weight is: root tuber of aromatic turmeric 9%, the coptis 7%, golden cypress 6%, the root of large-flowered skullcap 5%, cape jasmine 10%, the root of herbaceous peony 4%, the myrobalan 5%, the Radix Astragali 7%, hawthorn 7%, pine needle meal 40%.
The preparation method: raw material is weighed by weight proportion, pulverize then, sieve (100 order), mixing are processed powder, packing after the quality inspection.
Use: the addition of this feed addictive in the piglet complete feed is 0.01 ~ 0.05g/kg feed.
Storage practice: this feed addictive powder should be deposited in aeration-drying place.3 months summers of shelf-life, spring, autumn, 6 months winters.
Embodiment 2:
A kind of feed addictive of Purely natural vegetality resisting gastrointestinal dysfunction, its raw material components percentage by weight is: root tuber of aromatic turmeric 11%, the coptis 6%, golden cypress 7%, the root of large-flowered skullcap 7%, cape jasmine 9%, the root of herbaceous peony 5%, the myrobalan 5%, the Radix Astragali 7%, hawthorn 6%, pine needle meal 37%.
Preparation method's and methods for using them is with embodiment 1.
Embodiment 3:
A kind of feed addictive of Purely natural vegetality resisting gastrointestinal dysfunction, its raw material components percentage by weight is: root tuber of aromatic turmeric 10%, the coptis 5%, golden cypress 7%, the root of large-flowered skullcap 7%, cape jasmine 11%, the root of herbaceous peony 6%, the myrobalan 5%, the Radix Astragali 6%, hawthorn 7%, pine needle meal 36%.
Preparation method's and methods for using them is with embodiment 1.
Embodiment 4:
A kind of feed addictive of Purely natural vegetality resisting gastrointestinal dysfunction, its raw material components percentage by weight is: root tuber of aromatic turmeric 11%, the coptis 6%, golden cypress 5%, the root of large-flowered skullcap 7%, cape jasmine 10%, the root of herbaceous peony 5%, the myrobalan 6%, the Radix Astragali 6%, hawthorn 6%, pine needle meal 38%.
Preparation method's and methods for using them is with embodiment 1.
Show below in conjunction with feeding experiment and clinical practice, the present invention done further description:
This experiment lasts 6 months, from microcosmic (GI institutional framework and anti-oxidation function) and macroscopic view (fungistatic effect, diarrhea rate, production performance etc.), evaluates the result of use of this natural plant feed addictive; And, evaluate the security of natural plant feed addictive of the present invention through the animal used as test toxicology test.
One, test material and method
Test one
1. the selection that breeds experimental animals
Select the duroc * Landrace * Large White hybridization piglet of the health of 30 28 ± 1 age in days wean, initial body weight 6.83 ± 0.36kg.
2. the screening of natural plant feed addictive raw material and prerun
Natural plants weigh in proportion, pulverize, sieve (100 order).Mix according to proportioning, process powder.Carry out in test the record and the analysis of each parameter.
3. experimental design and grouping
Experimental animal feeding is in same house.Piglet is divided into two processed group at random, and (through statistical test, each organizes initial body weight difference not remarkable (P＞0.05), and 15 repetitions are established in each processing, and each repeats 1 pig.First group is control group, and second group is 1 group of natural plants.14 days experimental periods.
4. the composition of basal diet, natural plant feed addictive:
This experimental basis daily ration is main with corn-dregs of beans type:
Natural plants adds the 0.03g/kg natural plant feed additives for 1 group and (fills a prescription to shown in the embodiment 1: root tuber of aromatic turmeric 9%, the coptis 7%, golden cypress 6%, the root of large-flowered skullcap 5% in the piglet basal diet; Cape jasmine 10%, the root of herbaceous peony 4%, the myrobalan 5%; The Radix Astragali 7%, hawthorn 7%, pine needle meal 40%).
5. experimental index is measured
In test one, experimental period, finish, and butchers all piglets of two processing, gets stomach, small intestine (jejunum stage casing) tissue, routine paraffin wax section, H.E. dyeing.And, organize the antioxygenic property index in order to measure gastrointestinal mucosa with stomach, intestinal mucosa homogenate.
Test two
1. the selection that breeds experimental animals
The Landrace of 168 health of this experimental selection 28 ± 1 ages in days wean * Large White hybridization piglet, initial body weight 7.14 ± 0.49kg.
2. the screening of natural plant feed addictive raw material and prerun
Natural plants weigh in proportion, pulverize, sieve (100 order).Mix according to proportioning, process powder.Carry out in test the record and the analysis of each parameter.
3. experimental design and grouping
Experimental animal feeding is in same house.Piglet is divided into four groups at random, and (through statistical test, each organizes initial body weight difference not remarkable (P＞0.05), establishes 6 repetitions for every group, and each repeats 7 pigs.First group is control group, and second group is 2 groups of natural plants, and the 3rd group is 3 groups of natural plants (dividing according to different natural plant feed addictive prescriptions), and the 4th group is the antibiotic group.Measure the diarrhea rate and the production performance index of each group after the off-test.28 days experimental periods.
4. the composition of basal diet, natural plant feed addictive:
This experimental basis daily ration is with corn---and the dregs of beans type is main.
Natural plants adds the 0.03g/kg natural plant feed addictive for 2 groups and (fills a prescription to shown in the embodiment 2: root tuber of aromatic turmeric 11%, the coptis 6%, golden cypress 7%, the root of large-flowered skullcap 7% in basal diet; Cape jasmine 9%, the root of herbaceous peony 5%, the myrobalan 5%; The Radix Astragali 7%, hawthorn 6%, pine needle meal 37%).
Natural plants adds the 0.03g/kg natural plant feed addictive for 3 groups and (fills a prescription to shown in the embodiment 3: root tuber of aromatic turmeric 10%, the coptis 5%, golden cypress 7%, the root of large-flowered skullcap 7% in basal diet; Cape jasmine 11%, the root of herbaceous peony 6%, the myrobalan 5%; The Radix Astragali 6%, hawthorn 7%, pine needle meal 36%)
The antibiotic group is added 40mg/kg colistin sulfate (colistine sulfate)+20mg/kg effect U.S. plain (avilamycin).
5. test index is measured
The antibacterial situation of each feed addictive is measured in vitro test.Write down the diarrhoea situation of each experimental group piglet every day, calculate the back 28 days diarrhea rate of test, organic acid content and ammonia content in the excrement, and 28 days production performance.
Two, test result analysis
1. stomach and intestine microsection
In this test, gastric tissue section shows: foveolae gastricae is less in control group (Fig. 1) the gastric mucosa mucous layer, and 1 group of (Fig. 2) ruga gastrica of natural plants is more, can secreting mucus, and the protection gastric mucosa.And 1 group of submucous tissue of natural plants is very thick, helps mucous membrane stretching, extension and displacement.The disorder of control group (Fig. 3) intestinal villi is irregular, 1 group of (Fig. 4) intestinal villi of natural plants marshalling, the dense finger-like that is.
This feed addictive of this result of the test explanation effectively prevents the damage of gastrointestinal mucosa institutional framework, guarantees gastrointestinal tissue's structural integrity, thereby has promoted digesting and assimilating of feed.This mechanical barrier of being made up of gastrointestinal mucosa can stop enteric bacteria and endotoxic invasion simultaneously, in preventing the displacement of pathogenic bacterium, has important function.
2. the anti-oxidant index of gastrointestinal mucosa
Table 1 different disposal is to the influence of the anti-oxidant index of weanling pig stomach
The different lowercase persons of same row shoulder mark are significant difference (P＜0.05), and identical lowercase person is difference not remarkable (P＞0.05).
Table 2 different disposal is to the influence of the anti-oxidant index of weanling pig small intestine
Annotate: the different lowercase persons of same row shoulder mark are significant difference (P＜0.05), and identical lowercase person is difference not remarkable (P＞0.05).
This result of the test shows that 1 group of piglet stomach of natural plants glutathion inside content (P＜0.05), catalase activity are higher than control group (P＞0.05), and 1 group of MDA content of natural plants is lower than control group (P＞0.05).Glutathione content and CAT activity all are higher than control group (P＜0.05) significantly in the small intestine, and mda content is markedly inferior to control group (P＞0.05).The content of nitric oxide of 1 group of stomach of natural plants, small intestine all is higher than control group (P＜0.05) significantly.This result of the test explanation, this feed addictive can improve the antioxygenic property of gastrointestinal mucosa, reduces enterocyte film and cells injury, reduces and to the infringement of antioxidant radical to intestinal mucosa.
3. bacteriostatic test
Table 3 extracorporeal bacteria inhibitor test result (antibacterial circle diameter mm)
This test shows (table 3), and each additive group all has inhibitory action to Escherichia coli.The antibiotic group is less than the natural plants group to colibacillary inhibition zone, and the antibiotic group also has inhibitory action to bacillus in addition.Explain that this natural plant feed addictive can suppress pernicious bacteria-Escherichia coli in the enteron aisle, but profitable strain-bacillus is not had effect.And Antibiotic Additive is inhibited to Escherichia coli and bacillus.Therefore can explain that this natural plant feed addictive has corrective action to gut flora.
4. index in the excrement
Table 4 natural plant feed addictive is to organic acid influence (28 days) in diarrhea of weaned piglets rate and the excrement
Annotate: the different lowercase persons of same row shoulder mark are significant difference (P＜0.05), and identical lowercase person is difference not remarkable (P＞0.05).
In this test, organic acid content is higher than control group and antibiotic group significantly in 2 groups of natural plants and 3 groups of excrement of natural plants.This is because the Purely natural vegetality feed addictive has prevented the intestinal mucosa atrophy effectively, promotes the intestinal villi growth, keeps normal intestinal mucosa weight, strengthens the intestinal cell activity; Therefore promote field planting, growth and the propagation of profitable strain; Its decomposed substance produces a large amount of organic acids, and sour environment has improved proteinase activity, promotes the digestion of amino acid, protein; Thereby the raising production performance reduces the generation of diarrhoea.
The one of the main reasons of grice diarrhoea is that Escherichia coli utilize protein and amino acid in the enteron aisle to produce ammonia, stimulates intestinal mucosa, causes the endotoxin of intestinal secretion, ectotoxic absorption, and osmotic pressure raises in the intestines, and osmotic diarrhea takes place.In this test, ammonia content is markedly inferior to control group (P＜0.05) in 2 groups of natural plants and 3 groups of excrement of natural plants, with antibiotic group difference not significantly (P＞0.05).This is because the Purely natural vegetality feed addictive has reduced the quantity of pernicious bacteria, has promoted the absorption of body protein, thereby promotes nitrogen deposition in vivo, reduces the discharge of fecaluria ammonia.
5. diarrhea rate
Table 5 natural plant feed addictive is to the influence of grice diarrhoea rate
Annotate: the different lowercase persons of same row shoulder mark are significant difference (P＜0.05), and identical lowercase person is difference not remarkable (P＞0.05).
In this experiment (table 5), 2 groups of diarrhea rates with 3 groups of natural plants of natural plants are markedly inferior to control group and antibiotic group (P＜0.05).Explain that Chinese medicine is remarkable to control post-weaning diarrhea in piglet effect.
6. production performance index
Table 6 Chinese herbal feed additive influences situation (28 days experimental periods) to the weanling pig production performance
Annotate: the different lowercase persons of same row shoulder mark are significant difference (P＜0.05), and identical lowercase person is difference not remarkable (P＞0.05).
Table 6 shows; Compare the production performance that 2 groups of natural plants and 3 groups of natural plants can improve behind the weaned piglet 28 days significantly with control group: can make behind the weaned piglet 28 days average daily gain improve 16.59% and 15.29% respectively, with control group significant difference (P＜0.05).The also corresponding raising of daily ingestion amount, but compare difference not significantly (P＞0.05) with control group.In addition, 2 groups of feedstuff-meat ratios with 3 groups of natural plants of natural plants are lower than control group (P＜0.05).Though the antibiotic group has also improved production performance, its effect is lower than the natural plants group.
Six, safety testing result
Toxicity test: carry out clinical testing with karber's method, the result of rat oral shows, the median lethal dose (LD of this natural plant feed addictive
50) be 16.84g/kg, belong to the avirulence material, pair cell is harmless.
Though this project implementation does not obtain to apply on a large scale so far; But show through small-scale feeding experiment result; This plant feed addictive can resist the animal intestines and stomach dysfunction: keep the complete of gastrointestinal tissue's structure, improve anti-oxidation function, promote the balance of intestinal microecology.The present invention can effectively suppress pernicious bacteria in the intestines, reduces the diarrhea rate of animal significantly, guarantees the quantity of beneficial bacterium simultaneously, promotes to digest and assimilate, and then reaches the purpose that has improved production performance.The as fired basis instinct of this achievement among a small circle guarantees that plant increases by 10% economic benefit, considers that from the angle of producing green pork industrialization the social benefit of this project and ecological benefits are significant.
The present invention can drive the development of China's feed industry, and the antibiotic situation of the long-term use of adjustment China additive industry can be widened China green feed additive market.
Claims (2)
1. the feed addictive of the anti-Gastrointestinal Tract of Weanling Piglets dysfunction of Purely natural vegetality is characterized in that the percentage by weight of raw material components is: root tuber of aromatic turmeric 9-11%, coptis 5-7%; Golden cypress 5-7%, root of large-flowered skullcap 5-7%, cape jasmine 8-11%; Root of herbaceous peony 4-6%, myrobalan 4-6%, Radix Astragali 5-7%; Hawthorn 5-7%, pine needle meal 36-40%.
2. the feed addictive of the anti-Gastrointestinal Tract of Weanling Piglets dysfunction of Purely natural vegetality as claimed in claim 1 is as the application of piglet complete feed; It is characterized in that: additive is added in the piglet complete feed, and addition is 0.01～0.05g/kg feed.
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| CN111066957A (en) * | 2019-12-19 | 2020-04-28 | 无锡三智生物科技有限公司 | High-efficiency natural plant feed additive for repairing intestinal injury of aquatic animals |
| CN111972540A (en) * | 2020-07-22 | 2020-11-24 | 内蒙古自治区农牧业科学院 | Antidiarrheal fattening feed additive and preparation and use methods thereof |
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| CN1275386A (en) * | 2000-06-05 | 2000-12-06 | 塔志丽 | Pure traditional Chinese medicine fodder additives |
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|---|---|---|---|---|
| CN1275386A (en) * | 2000-06-05 | 2000-12-06 | 塔志丽 | Pure traditional Chinese medicine fodder additives |
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|---|---|
| CN101731462A (en) | 2010-06-16 |
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