CN101721604B - Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases - Google Patents
Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases Download PDFInfo
- Publication number
- CN101721604B CN101721604B CN2008101751801A CN200810175180A CN101721604B CN 101721604 B CN101721604 B CN 101721604B CN 2008101751801 A CN2008101751801 A CN 2008101751801A CN 200810175180 A CN200810175180 A CN 200810175180A CN 101721604 B CN101721604 B CN 101721604B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- weight portions
- medicine composition
- foot
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to an application of a traditional Chinese medicine medicinal preparation, in particular to an application of a traditional Chinese medicine composition comprising antelope horn, ussuri fritillary, rhubarb, baikal skullcap root, lapis chloriti, raw gypsum, artificial ox gallstone and licorice in preparing a medicine for treating hand, mouth and foot diseases.
Description
Technical field:
The present invention relates to a kind of purposes of Chinese medicine pharmaceutical preparation, be specifically related to the application of a kind of Chinese medicine composition in preparation treatment hand, mouth and foot diseases medicine.
Technical background:
Hand-foot-mouth disease (Hand; Foot and mouth disease is the infectious disease that is caused by enterovirus HFMD), and pilosity is born in infant; Can cause the herpes at positions such as hands, foot, oral cavity, individual patient can cause complication such as myocarditis, pulmonary edema, AME.The enterovirus that causes hand-foot-mouth disease has kind more than 20 (type); 16,4,5,9,10 types of CA group; 2,5 types of B group; And enterovirns type 71 is the more common pathogen of hand-foot-mouth disease, and is wherein common with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV71).
The source of infection: the people is the source of infection of primary disease, and patient, inapparent infection person and asymptomatic carrier are the popular main source of infection of this disease.Epidemic period, the patient is the main source of infection.In acute stage, 3～5 weeks of patient's feces toxin expelling, pharyngeal 1～2 week of toxin expelling.Healthy carrier and light-duty Sporadic cases are the main sources of infection of popular intermittence and popular phase.Can not propagate mutually between humans and animals or the house pet.
The route of transmission: hand-foot-mouth disease mainly is to propagate through the close contact between the crowd.Virus in patient's throat secretions and the saliva can be passed through the air droplet transmission.The hands of saliva, herpes liquid, fecal pollution, towel, handkerchief, tooth cup, toy, tableware, milk tool and bedding, underwear etc., through daily contact transmission, but also per os is propagated.With the easy infection in the same chamber of patient.Contact is by the water source of viral pollution, but also peroral infection, and often cause popular.Outpatient service cross infection and dental instrument sterilization sternly can not cause propagation yet.
Spread path: hand-foot-mouth disease is dispersed in generation after often being outbreak of epidemic, and this disease epidemic period, kindergarten and nursery school are prone to take place group contagion.Also there is this type of morbidity aggregation phenomenon in family.The cross infection of hospital outpatient and dental instrument sterilization are not strict, can cause propagation yet.This disease transmission property is strong, and the route of transmission is complicated, and epidemic strength is big, propagates soon, can cause at short notice and be very popular.
Clinical manifestation: hand-foot-mouth disease is that a kind of enterovirus is sick, has the common trait of enterovirus infection.From modal asymptomatic or slight discomfort only arranged, all can take place to severe complications even death.Incubation period, general 2～7d did not have tangible prodrome; The unexpected onset of most patients.About half patient has heating in the time of premorbid 1～2d or morbidity, how about 38 ℃.Main hands, foot, mouth, four positions of buttocks invaded; So because measles unlike mosquito sting, unlike drug eruption, unlike lip gingiva herpes, claim milu again unlike chickenpox; And four characteristics not that more have not bitterly clinically, do not itch, do not form a scab, do not scab.Part patient has the slight sense symptom that goes up the initial stage, like cough, watery nasal discharge, feel sick, vomiting etc.Since oral ulcer pain, the refusing to eat of infant sialorrhea.The oral mucosa rash occurs relatively early, originally is Semen setariae appearance maculopapule or vesicle, and blush is arranged on every side, mainly is positioned at tongue and two buccals, and the lips and teeth side also often takes place.Flat or protruding class's pimple or herpes appear in distal site such as hands, foot, and erythra is not itched, and maculopapule is dark by red stain about 5d, disappears then; Rounded or the oval flat-ended protrusions of herpes, in turbid liquid is arranged, major diameter and dermatoglyph trend is consistent, differs in size like Semen Glycines, does not generally have pain and gargalesthesia, leaves no trace after the healing.
The Chinese medicine composition crude drug that the present invention relates to consists of: Cornu Saigae Tataricae, Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Lapis Chloriti, Gypsum Fibrosum, artificial Calculus Bovis and Radix Glycyrrhizae.Function cures mainly to: heat-clearing and toxic substances removing, dispels and cough only expectorant.Be used for the infantile acute bronchitis person that meets the phlegm-heat cough, show as heating, cough, cough and tell yellow sputum, cough and tell not well, red tongue, yellow and greasy fur etc.The content such as composition, method for preparing and dosage form and method of quality control that relates to this Chinese medicine composition has comparatively detailed description in Chinese invention patent 02129192.6,200410000911.0.
Hand-foot-mouth disease belongs to " epidemic febrile disease, eqpidemic disease " category in the traditional Chinese medical science, its disease is the diseases caused by exogenous pathogenic factor seasonal pathogen, in accumulate damp and hot due to.The traditional Chinese medical science is to the effective utilization and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of heat-clearing and toxic substances removing, removing dampness effectiveness principle; Make the unique curative effect of Chinese patent medicine tool in the early prevention and treatment of hand-foot-mouth disease; Doctor trained in Western medicine compared to still there not being specific drug has remarkable advantages, can also effectively remedy the defective that present Western medicine field does not still have vaccine.The Chinese patent medicine of the treatment hand-foot-mouth disease of generally using on the market mainly contains Radix Isatidis, Lonicerae and Forsythiae Powder etc.
The inventor is surprised to find that in clinical practice the Chinese medicine composition that the present invention relates to has extraordinary therapeutic effect to hand-foot-mouth disease, and this medicine has been carried out pharmacology and clinical experimental study, proves determined curative effect.
Summary of the invention:
Provide a kind of Chinese medicine composition of forming by Cornu Saigae Tataricae, Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Lapis Chloriti, Gypsum Fibrosum, artificial Calculus Bovis and Radix Glycyrrhizae to be used for treating the application of hand, mouth and foot diseases medicine in preparation.
Hand-foot-mouth disease mainly is popular in May～August, spring and summer time this moment, wind heat in season, children's's the lung being usually insufficient, the spleen tending to insufficiency usually, fur lose solid, pyretic toxicity is gone into from mouth and nose, warm spleen is wet to be combined, bring out in outside then heating; Wind-heat troubling is then swallowed the cheek redness; Lung Qi obstraction is then coughed; Pyretic toxicity combines damp and hot steaming to contain with spleen is wet, the evil lung spleen of violating, and spleen governing limbs is so see extremity brothers herpes.The Chinese traditional treatment principle, wind-dispelling heat-dissipating, eliminating damp, detoxifying.
This Chinese medicine composition mainly is made up of Cornu Saigae Tataricae, Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Lapis Chloriti, Gypsum Fibrosum, artificial Calculus Bovis and Radix Glycyrrhizae, and Cornu Saigae Tataricae is apt to the fire of liver heat removing, lung, and analgesic relieving convulsion is for controlling calentura, the key medicine of tetany; Bulbus Fritillariae Ussuriensis, Radix Glycyrrhizae clearing heat and moistening lung, preventing phlegm from forming and stopping coughing; Radix Et Rhizoma Rhei, Radix Scutellariae, Calculus Bovis heat-clearing and toxic substances removing, the pathogenic fire purging relieving constipation; Lapis Chloriti weighs down the expectorant therapeutic method to keep the adverse QI flowing downwards, and checking hyperfunction of the liver for relieving convulsion is controlled the pertinacious phlegm gluing, cough with dyspnea dyspnea with rapid respiration, convulsion with spasms; The Gypsum Fibrosum clearing away heat-fire, relieving restlessness is quenched the thirst, and all medicines share, the removing dampness of inducing sweat, heat-clearing and toxic substances removing, relieving exterior-interior syndrome is so obtain good curative effect.Experimentation shows; This Chinese medicine composition has tangible antiviral and antibacterial action; Various respiratory road Strain and enterovirus strain are caused the cultured cell pathological changes has the obvious suppression effect, and the growth of various bacteria bacterial strain is also had certain inhibitory action, and antiinflammatory, refrigeration function are preferably arranged; Can increase body's immunological function, disease resistance enhancemen effectively.
The specific embodiment:
In order to understand the present invention better, the inventor provides following research data, and technique effect of the present invention is described, is not limited to the present invention but following experiment and embodiment are used to further specify.
Embodiment 1:
This Chinese medicine composition oral liquid external to the inhibition of EV71 virus and the observation of inactivating efficacy
Study sample: this Chinese medicine composition oral liquid
The research purpose: this research is observed the effect of this Chinese medicine composition oral liquid to EV71 viral infection rhabdomyosarcoma passage cell (RD-A cell) through experiment in vitro.
1. material and method
1.1 material:
EV71 virus, RD-A cell, pancreatin (DT) 2.5mg/mL, DMEM culture medium, blue or green chain two anti-(P, 10
4IU/ml; S, 10
4Ug/ml), NaHCO
3(7.5%), glutamine (Glu, 0.03%), hyclone (available from GIBCO company).
1.2 method:
(1) cell culture goes down to posterity:
RD-A is with DMEM culture fluid (10% hyclone, 1%PS, 1%Glu, 1%NaHCO
3), 37 ℃, 5%CO
2Cultivate, went down to posterity in 5 days.Cell inserts 96 well culture plates, and 37 ℃, 5%CO
2Cultivated 48 hours, when cell is paved with 75% monolayer, changing 2%, to keep liquid for use.
(2) medicinal liquid is prepared:
Before using, this Chinese medicine composition oral liquid stock solution shakes up, adjustment pH value to 7.0, and it is subsequent use to put 4 ℃ of refrigerator storage.Experiment divides two groups:
The A group: this Chinese medicine composition oral liquid is kept liquid (DMEM culture fluid, 1%PS, 1%Glu, 1%NaHCO with serum-free before using
3), begin to carry out cell experiment from 1:100 with 2X doubling dilution (being 1:100,1:200,1:400,1:800,1:1600,1:3200,1:6400, totally 7 dilution factors).
The B group: this Chinese medicine composition oral liquid is kept liquid (DMEM culture fluid, 1%PS, 1%Glu, 1%NaHCO with serum-free before using
3), begin to carry out cell experiment from 1:10 with 2X doubling dilution (being 1:10,1:20,1:40,1:80,1:160,1:320,1:640, totally 7 dilution factors).
(3) Virus culture and suspension preparation
The cell culture multigelation 3 times that will contain EV71 virus, get 0.2ml add to above-mentioned finished changing 2% keep liquid the RD-A cell, 37 ℃, 5%CO
2Cultivate.Reach when pathological changes (CPE) appears in cell (+++) after, freeze thawing 3 times ,-70 ℃ are frozen subsequent use.
(4) tissue culture's ID 50, median infective dose (TCID50) is measured
Get the EV71 virus-culturing fluid, become 10 with the 10X doubling dilution with keeping liquid
-1, 10
-2, 10
-3, 10
-4, 10
-5, 10
-6Individual different dilution factor.Monolayer RD-A cell changes 2% and keeps liquid in 96 well culture plates, inserts different dilution viral liquid then, and 50 μ l are inoculated in every hole, and each dilution factor is inoculated 8 holes, and 37 ℃, 5%CO
2Cultivate 7d, every day the observation of cell pathological changes, result of determination behind the 7d.The viral liquid of getting 100TCID50 is used for test.
(5) medicinal liquid toxicity test
Get RD-A cell monolayer in 96 well culture plates, inhale and remove culture fluid, wash 2 times through Hank ' s liquid.Add different dilution Chinese medicine composition oral liquid 100 μ l respectively,, 37 ℃, 5%CO
2Cultivate, observe the influence of medicinal liquid pair cell.
(6) drug effect test
The A group: this Chinese medicine composition oral liquid suppresses the evaluation of pesticide effectiveness of EV71 virus replication in cell
RD inoculates 96 well culture plates with 200,000/ml concentration, cultivates for 37 ℃ and is cultured to cell monolayer in 48 hours, discards culture fluid, adds the EV71 viral dilution liquid of 100TCID50, establishes normal cell contrast and virus control simultaneously, and 37 ℃, 5%CO
2Adsorbed 1 hour, and discarded viral liquid, add the checking medicine of variable concentrations, medicine is with 2 times of dilutions of maximal non-toxic concentration of pair cell; 1:100～1:6400 is totally 7 dilution factors, every concentration 8 holes, every hole 100 μ l; Virus control and normal cell control wells are changed and are kept liquid simultaneously, and 37 ℃, 5%CO
2Cultivate; Per 24 hours under inverted microscope observation of cell CPE change the line item of going forward side by side and (be changed to "+" with 25% following cell CPE; 26%～50% following cell CPE is changed to " ++ ", and 51%～75% following cell CPE is changed to " +++", and 76%～100% following cell CPE is changed to " ++ ++ "); Change the checking medicine of fresh variable concentrations every day, continue 7 days.
B group: the outer evaluation of pesticide effectiveness of this Chinese medicine composition liquid oral to the viral deactivation of EV71
Mix with 100TCID50EV71 virus and variable concentrations checking medicine (1:10～1:640,2 times of dilutions, totally 7 dilution factors), set up the virus control group simultaneously, promptly with 100TCID50EV71 virus with keep liquid and mix, above-mentioned mixed liquor acts on 1h in 37 ℃.
Above-mentioned mixed liquor is added to the RD-A cell of having cultivated into monolayer in 96 orifice plates, 37 ℃ of 5%CO
2Absorption 1h.Abandon liquid subsequently, change and keep liquid (comprising virus control and cell matched group), in 37 ℃ of 5%CO
2Cultivated 7 days.Per 24 hours under inverted microscope observation of cell CPE change the line item (method is organized with A) of going forward side by side.
2. result
2.1 medicinal liquid is to the influence of passage cell
To not influence of passage cell growth, cellular morphology did not change after this Chinese medicine composition oral liquid was diluted to 320 times, and this research is decided to be the avirulence dilution factor with this dilution factor.
The effect of table 1 medicinal liquid pair cell
2.2A group: this Chinese medicine composition oral liquid suppresses the evaluation of pesticide effectiveness of EV71 virus replication in cell
Cell inoculation EV71 Strain behind the absorption 1h, adds different dilution factor medicines and keeps liquid, observes pathological changes 7 days, and this Chinese medicine composition oral liquid 1:200 occurs one day than virus control group delay pathological changes, but cell growth simultaneously is suppressed phase pair cell contrast rareness; 1:400 suppresses pathological development.
Table 2 medicine suppresses the effect of EV71 virus replication in cell
2.3B group: the outer evaluation of pesticide effectiveness of this Chinese medicine composition liquid oral to the viral deactivation of EV71
Different dilution Chinese medicine composition medicinal liquids (1:10,1:20,1:40,1:80,1:160,1:320,1:640), and behind EV71 strain 1:1 immixture 1h, inoculating cell, 1:10～1:160 postpones pathological changes than the virus control group and occurs one day.1:10～1:80 group cell growth is suppressed, and the contrast of cell phase pair cell is rare; The no significant change of 1:160 group phase pair cell contrast.
The external deactivation of table 3 medicine to EV71 virus
3. conclusion
1, this Chinese medicine composition oral liquid is in cell experiment, and 1:200～1:400 dilution factor has the effect that suppresses the EV71 virus replication;
2, this Chinese medicine composition oral liquid has the effect of part inactivation of viruses external 1:10～1:160 dilution factor and 100TCID50EV71 virus function 1 hour.
Embodiment 2:
This Chinese medicine composition oral liquid treatment child hand-foot-mouth disease 40 routine clinical observation on the therapeutic effect
In order to observe of clinical efficacy and the untoward reaction of this Chinese medicine composition oral liquid in treatment child hand-foot-mouth disease; To estimate interests and the risk that this Chinese medicine composition oral liquid uses in child's hand-foot-mouth disease, with the expansion indication clinical foundation is provided for improving medication.
1. data and method:
1.1 clinical data 40 routine child's hand-foot-mouth disease derived from during May 15 to May 31 in 2008, the infant that hospital outpatient is gone to a doctor.
1.240 in the routine infant, male 25 examples, women 15 examples.14 years old 1 age example, 9.5 years old 1 example, remaining is 1 years old～5.5 years old infant.25 examples of generating heat, wherein hyperpyrexia 3 examples (body temperature >=39 ℃).There are not heating infant 15 examples.
2. the course of treatment, route of administration and method:
The course of treatment: 5～7 days.
Route of administration: oral administration, oral liquid specification of the present invention is every 10mL.
Consumption: oral.Six months extremely one-year-old, a 5ml, three times on the one; Two to three years old, a 10ml, three times on the one; Four years old to seven years old, a 10ml, three times on the one; Eight years old to 14 years old, a 15ml, three times on the one.5～7 days courses of treatment, the infant that has obvious oral cavity pain not take food, liquid make-up and electrolyte in case of necessity.
3. the evaluation of effectiveness and safety:
3.1 curative effect judging standard:
Recovery from illness: medication is after three days, and pimple, herpes and ulcer disappear basically, and temperature recovery is normal, and mucositis symptom (comprising upper airway symptoms such as cough, watery nasal discharge, sneeze, nasal obstruction) is basic to disappear.
Produce effects: medication is after three days, and pimple, herpes and ulcer take a turn for the better, and body temperature descends more than or equal to 1 ℃, and the mucositis symptom is most of to disappear.
Effectively: medication is after three days, and pimple, herpes and ulcer take a turn for the better, and body temperature descends more than or equal to 0.5 ℃, and the mucositis symptom partly disappears.
Invalid: as not reach above standard person.
3.2 safety evaluatio:
1 grade: safety, there is not any untoward reaction.
2 grades: compare safety,, need not do any processing and can continue administration if any untoward reaction.
3 grades: safety issue is arranged, moderate untoward reaction is arranged, can continue administration after processing.
4 grades: because of medication is ended in untoward reaction.
4. result:
40 routine child's hand-foot-mouth disease infants generate heat and how obviously to alleviate at 1～2 day through adopting this Chinese medicine composition oral liquid treatment, and herpes and mucositis symptom are many obviously to be alleviated at 2～3 days, 4～5 days transference cures, and nothing develops the disease of attaching most importance to and merges impaired cases such as heart and brain kidney.Cure 27 examples, account for 67.5%, produce effects 13 examples account for 32.5%.Total effective rate 100%.Treatment time is the shortest 4 days, and is the longest 7 days, average 5 days.
5. conclusion:
Through above-mentioned 40 routine Clinical analysis, this Chinese medicine composition oral liquid is brought down a fever obviously when treatment child hand-foot-mouth disease; Medication after 2～3 days herpes and mucositis symptom obviously alleviate; Explain that this Chinese medicine composition has tangible anti-enterovirus infection, prevent the effect of clinical complication, safety is good; Be the choice drug of child's hand-foot-mouth disease treatment, can be widely used in the Children's Infectious Diseases treatment.
Embodiment 3:
The 35 routine clinical observations of this Chinese medicine composition oral liquid treatment hand-foot-mouth disease
1. physical data
1.1 sex
Observation group's 35 examples: women 15 examples of man's 20 examples;
1.2 the age
Observation group's 35 examples: maximum 7 years old, minimum 10 months, 15 examples below 3 years old wherein, 20 examples more than 3 years old;
2. clinical data
2.1 body temperature
Observation group: 39.3 ℃ of high fevers, average 37.7 ℃;
2.2 herpes
Observation group: hands, foot herpes 35 examples all possess typical hand-foot-mouth disease Clinical symptoms;
2.3 the pharynx cheek is red and swollen
Observation group's 35 examples: pharynx cheek redness person 35 examples;
2.4 cough
Observation group's 35 examples: cough person's 12 examples;
2.5 nasal obstruction
Observation group's 35 examples: nasal obstruction person's 6 examples are arranged;
2.6 watery nasal discharge
Observation group's 35 examples: watery nasal discharge person's 10 examples;
2.7 complication
Observation group's 35 examples: do not have;
3. diagnostic criteria
Press hand-foot-mouth disease Western medicine diagnose standard:
(1) all can fall ill the whole year, good being sent out in summer and autumn, local nurseries and kindergartens mechanism and surrounding population have hand-foot-mouth disease popular, and the premorbid patient has direct or indirect contact history.
(2) be mostly infant below 5 years old.
(3) general 2～7 days of incubation period.
(4) typical maculopapule and herpetiform lesion appear in hands, foot, mouthful skin, mucosa, and with the Catarrhal symptom.
(5) complication: myocarditis, encephalitis, meningitis, speed a property paralysis, pulmonary edema etc.
4. therapeutic scheme
General treatment: have a rest polydipsia water, light diet, disinfection of indoor air;
Drug therapy: observation group's 35 examples: oral.Six months extremely one-year-old, a 5ml, three times on the one; Two to three years old, a 10ml, three times on the one; Four years old to seven years old, a 10ml, three times on the one; Eight years old to 14 years old, a 15ml, three times on the one.
5. result
5.1 herpes regression time and bringing down a fever the time
Herpes regression time (day) X ± S bring down a fever the time (hour)
3.05 ± 1.92 observation groups of observation group's (35 example) (8 example) 2.97 ± 0.75
5.2 the red and swollen regression time of pharynx cheek
Red and swollen regression time (day) X ± S of pharynx cheek
Observation group's (35 example) 3.75 ± 1.10
5.3 the cough-relieving time
Cough-relieving time (day) X ± S
Observation group's (12 example) 2.45 ± 2.35
5.5 complication
Do not have
6. conclusion
Clinical observation shows; This Chinese medicine composition bring down a fever, herpes is evident in efficacy aspect disappearing, and eliminating pharyngeal herpes, all obtaining better curative effect aspect red and swollen, this and Chinese traditional treatment principle match; Explain that this Chinese medicine composition has and bring down a fever; Suppress virus replication, prevent the effect of clinical complication, the treatment hand-foot-mouth disease has good potential applicability in clinical practice.
Embodiment 4:
This Chinese medicine composition oral liquid treatment child hand-foot-mouth disease 38 routine clinical observation on the therapeutic effect
In order to observe of clinical efficacy and the untoward reaction of this Chinese medicine composition oral liquid in treatment child hand-foot-mouth disease; To estimate interests and the risk that this Chinese medicine composition oral liquid uses in child's hand-foot-mouth disease, improve medication and clinical foundation is provided with the expansion indication.
1. data and method:
1.1 clinical data: 38 routine child's hand-foot-mouth disease derived from during May 8 to June 10 in 2008, the infant that outpatient service and in-patient department are gone to a doctor.
1.238 in the routine infant, male 18 examples, women 20 examples.Maximum age 7 years old, minimal ages 1 years old, the mean age is 3.5 years old, 15 examples of generating heat, 22 routine infants all have pharyngeal congestion and brothers' erythra in the clinical manifestation; Other 10 examples have the infant of pharyngeal ulcer that the hand erythra is only arranged, and biped does not have erythra.
2. the course of treatment, route of administration and method:
2.1 the course of treatment: 5～7 days.
2.2 route of administration: oral administration.
2.3 medication: oral.Six months extremely one-year-old, a 5ml, three times on the one; Two to three years old, a 10ml, three times on the one; Four years old to seven years old, a 10ml, three times on the one; Eight years old to 14 years old, a 15ml, three times on the one.
The infant that has obvious oral cavity pain not take food, liquid make-up and electrolyte in case of necessity.
3. the evaluation of effectiveness and safety:
3.1 curative effect judging standard:
Recovery from illness: medication is after three days, and pimple, herpes and ulcer disappear basically, and temperature recovery is normal, and the mucositis symptom disappears basically.
Produce effects: medication is after three days, and pimple, herpes and ulcer take a turn for the better, and body temperature descends more than or equal to 1 ℃, and the mucositis symptom is most of to disappear.
Effectively: medication is after three days, and pimple, herpes and ulcer take a turn for the better, and body temperature descends more than or equal to 0.5 ℃, and the mucositis symptom partly disappears.
Invalid: as not reach above standard person.
3.2 safety evaluatio:
1 grade: safety, there is not any untoward reaction.
2 grades: compare safety,, need not do any processing and can continue administration if any untoward reaction.
3 grades: safety issue is arranged, moderate untoward reaction is arranged, can continue administration after processing.
4 grades: because of medication is ended in untoward reaction.
4. result:
38 routine child's hand-foot-mouth disease infants are through adopting this Chinese medicine composition oral liquid treatment, and treating back first day 15 example heating infant body temperature all has obvious decline, reduces to 11 examples that have of normal body temperature, and other 4 routine fever peak values also descend.The treatment back had 7 routine infant body temperature to reduce to normally again on the 3rd day.The 4th day body temperature in treatment back is all reduced to normally.Generate heat and how obviously to alleviate at 1～2 day, herpes and mucositis symptom are many obviously to be alleviated at 2～3 days, 4～5 days transference cures, and nothing develops the disease of attaching most importance to and merges impaired cases such as heart and brain kidney.Cure 26 examples, account for 68.42%, produce effects 12 examples account for 31.58%.Total effective rate 100%.Treatment time is the shortest 3 days, and is the longest 7 days, average 5 days.
5. conclusion:
Through above-mentioned 38 routine Clinical analysis; This Chinese medicine composition oral liquid is brought down a fever obviously when treatment child hand-foot-mouth disease, medication after 2～3 days herpes and mucositis symptom obviously alleviate; Simultaneously, during treating 38 routine infants all occur dizzy, shiver, untoward reaction such as erythra increases.Clinical treatment observation through 38 examples has confirmed that further this Chinese medicine composition is safely and effectively in the treatment of hand-foot-mouth disease.
Claims (1)
1. a Chinese medicine composition of being made up of Cornu Saigae Tataricae, Bulbus Fritillariae Ussuriensis, Radix Et Rhizoma Rhei, Radix Scutellariae, Lapis Chloriti, Gypsum Fibrosum, artificial Calculus Bovis, Radix Glycyrrhizae is used for treating the application of hand, mouth and foot diseases medicine in preparation; The ratio that it is characterized in that each crude drug in this Chinese medicine composition is: Cornu Saigae Tataricae 8～12 weight portions, Bulbus Fritillariae Ussuriensis 12～20 weight portions, Radix Et Rhizoma Rhei 20～35 weight portions, Radix Scutellariae 10～18 weight portions, Lapis Chloriti 10～18 weight portions, Gypsum Fibrosum 15～25 weight portions, artificial Calculus Bovis's 8～12 weight portions, Radix Glycyrrhizae 20～35 weight portions, perhaps Cornu Saigae Tataricae 9.45 weight portions, Bulbus Fritillariae Ussuriensis 47.45 weight portions, Radix Et Rhizoma Rhei 31.50 weight portions, Radix Scutellariae 15.75 weight portions, Lapis Chloriti 15.75 weight portions, Gypsum Fibrosum 23.62 weight portions, artificial Calculus Bovis's 9.45 weight portions, Radix Glycyrrhizae 31.50 weight portions.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101751801A CN101721604B (en) | 2008-10-28 | 2008-10-28 | Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases |
| HK10110633.0A HK1144076A1 (en) | 2008-10-28 | 2010-11-15 | Application of traditional chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101751801A CN101721604B (en) | 2008-10-28 | 2008-10-28 | Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101721604A CN101721604A (en) | 2010-06-09 |
| CN101721604B true CN101721604B (en) | 2012-11-28 |
Family
ID=42443554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101751801A Active CN101721604B (en) | 2008-10-28 | 2008-10-28 | Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101721604B (en) |
| HK (1) | HK1144076A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716245B (en) * | 2011-03-31 | 2014-05-28 | 丽珠医药集团股份有限公司 | Application of traditional Chinese medicine composition in preparing medicines for resisting enterovirus 71 |
| CN106344574B (en) * | 2016-08-16 | 2019-03-15 | 江苏康缘药业股份有限公司 | Application of the black dragon peimine in the drug of preparation prevention and/or treatment hand-foot-and-mouth disease |
| CN108704058B (en) * | 2018-08-21 | 2021-05-04 | 江苏康缘药业股份有限公司 | Composition for treating pharyngitis and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476855A (en) * | 2002-08-20 | 2004-02-25 | 江苏康缘药业股份有限公司 | Chinese medicine composition and its preparation method |
| CN1488380A (en) * | 2003-08-16 | 2004-04-14 | 江苏康缘药业股份有限公司 | Use of chinese medicine composition in preparing medicine for anti SARS virus |
-
2008
- 2008-10-28 CN CN2008101751801A patent/CN101721604B/en active Active
-
2010
- 2010-11-15 HK HK10110633.0A patent/HK1144076A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476855A (en) * | 2002-08-20 | 2004-02-25 | 江苏康缘药业股份有限公司 | Chinese medicine composition and its preparation method |
| CN1488380A (en) * | 2003-08-16 | 2004-04-14 | 江苏康缘药业股份有限公司 | Use of chinese medicine composition in preparing medicine for anti SARS virus |
Non-Patent Citations (1)
| Title |
|---|
| 殷子斐等.手足口病的中医治疗.《中医儿科杂志》.2008,第4卷(第01期),51-55. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101721604A (en) | 2010-06-09 |
| HK1144076A1 (en) | 2011-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102258105B (en) | Health-care tea for treating chronic pharyngitis and preparation method thereof | |
| CN101721604B (en) | Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases | |
| CN100579557C (en) | Cough-stopping granule with honeysuckle flower and bulbus fritilariae | |
| CN104013846A (en) | Traditional Chinese medicine composition for treating dental ulcer and application thereof | |
| CN101721515B (en) | Application of traditional Chinese medicine composition in preparing medicine for treating hand, mouth and foot diseases | |
| CN102416067A (en) | Traditional Chinese medicine for preventing and treating influenza | |
| CN103041030B (en) | Pharmaceutical composition for treating fever with swollen head, as well as preparation method and application thereof | |
| CN1836697A (en) | Candy for larynx | |
| CN102698158A (en) | Traditional Chinese medicine for preventing and treating infectious bronchitis, preparation method thereof and feed | |
| CN102416060A (en) | Traditional Chinese medicine for preventing influenza | |
| CN103417639A (en) | Quick-acting sore throat powder | |
| CN105311251A (en) | Snuffing type Chinese herbal medicine for preventing influenza and preparation method thereof | |
| CN104524253B (en) | A kind of Chinese medicine composition for treating pregnancy period and women breast-feeding their children's toothache | |
| CN102205048A (en) | Pharmaceutical composition with function of moistening throat | |
| CN103656416B (en) | One treats parotitic Chinese medicine composition and preparation method thereof | |
| CN103341151B (en) | Traditional Chinese medicine for treating chronic bronchitis | |
| CN102406748B (en) | Chinese medicinal composition for treating child bronchitis | |
| CN104324080B (en) | The injection for the treatment of upper respiratory tract infection and preparation method | |
| CN107137689A (en) | A kind of Chinese medicine composition for treating menopausal syndrome | |
| CN105250774A (en) | Traditional Chinese medicine composition for treating chronic influenza | |
| CN105233048A (en) | traditional Chinese medicine for treating verumontanitis | |
| CN105031379A (en) | Traditional Chinese medicine preparation used for treating upper respiratory tract infection and preparation method | |
| CN105396071A (en) | Traditional Chinese medicine formula for treating children pneumonia | |
| Hiremath | A Comparative Clinical Study to Evaluate Efficacy of Dhanyaka Kashaya (Coriandrum Sativum) and Dhanyaka Phanta on Tundikere Shoth WSR to Tonsillitis a Folkore Claim | |
| CN105168847A (en) | Traditional Chinese medicine for treating helicobacter pylori infected peptic ulcer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1144076 Country of ref document: HK |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1144076 Country of ref document: HK |