CN101711808A - Soft capsule used for clearing away heat and toxic materials and preparation method thereof - Google Patents
Soft capsule used for clearing away heat and toxic materials and preparation method thereof Download PDFInfo
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- CN101711808A CN101711808A CN200910175947A CN200910175947A CN101711808A CN 101711808 A CN101711808 A CN 101711808A CN 200910175947 A CN200910175947 A CN 200910175947A CN 200910175947 A CN200910175947 A CN 200910175947A CN 101711808 A CN101711808 A CN 101711808A
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- powder
- soft capsule
- clear
- radix
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000463 material Substances 0.000 title abstract 2
- 231100000331 toxic Toxicity 0.000 title abstract 2
- 230000002588 toxic effect Effects 0.000 title abstract 2
- 239000000843 powder Substances 0.000 claims abstract description 59
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 11
- 239000008158 vegetable oil Substances 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 108010010803 Gelatin Proteins 0.000 claims abstract description 6
- 229920000159 gelatin Polymers 0.000 claims abstract description 6
- 239000008273 gelatin Substances 0.000 claims abstract description 6
- 235000019322 gelatine Nutrition 0.000 claims abstract description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000007766 cera flava Substances 0.000 claims description 11
- 239000008347 soybean phospholipid Substances 0.000 claims description 9
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 7
- 230000006837 decompression Effects 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 7
- 235000019198 oils Nutrition 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 17
- 229940079593 drug Drugs 0.000 abstract description 10
- 239000000375 suspending agent Substances 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 235000013871 bee wax Nutrition 0.000 abstract 3
- 239000012166 beeswax Substances 0.000 abstract 3
- 239000000725 suspension Substances 0.000 abstract 3
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 2
- 244000247747 Coptis groenlandica Species 0.000 abstract 2
- 244000068988 Glycine max Species 0.000 abstract 2
- 235000010469 Glycine max Nutrition 0.000 abstract 2
- 241000219061 Rheum Species 0.000 abstract 2
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 2
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 2
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 2
- 239000002612 dispersion medium Substances 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000000975 bioactive effect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 239000007902 hard capsule Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 231100000019 skin ulcer Toxicity 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000012846 chemical reference substance Substances 0.000 description 1
- 238000005314 correlation function Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a soft capsule used for clearing away heat and toxic materials and a preparation method thereof. The soft capsule is prepared by adopting a traditional preparation process after mixing and preparing clear extract powder, vegetable oil, soybean phosphatide and beeswax into suspension. The preparation method of the soft capsule comprises the following steps: decocting coptis root, rhubarb and baikal skullcap root, preparing a clear paste, then spraying, drying, preparing coptis root powder, rhubarb powder and baikal skullcap root powder and mixing evenly to obtain clear extract powder; mixing the clear extract powder, vegetable oil, soybean phosphatide and beeswax evenly according to the mixture ratio to prepare suspension; and taking gelatin, glycerol and water to prepare gum and then filling and pressing the suspension into the soft capsule. The invention adopts the natural type vegetable oil and the beeswax as a dispersion medium and a suspending agent respectively, enables the medicines to be evenly dispersed, has high utilization degree of the biologic active components of the medicines, enhances the stability of the medicines and the application safety and effectiveness effectively, enshrouds the discomfortable taste of the medicines, is easy to swallow, shortens the disintegration time limit of the soft capsule and enhances the quality standard of the medicines.
Description
Technical field
The present invention relates to a kind of soft capsule, specifically, is that a kind of mouth and nose that are used for the treatment of are given birth to clear soft capsule of diseases such as skin ulcer, the painful toothache of pharynx, dry mouth and tougue and preparation method thereof.
Background technology
The burning hot disease of institute's appellation in the traditional Chinese medical science, promptly " get angry ", it is a kind of common disease, this type of disease mainly is because after paathogenic factor acted on body, the human body correlation function presented a unusual excited class disease, is presented as that clinically mouth and nose give birth to skin ulcer, the painful toothache of pharynx, dry mouth and tougue, constipation, diseases such as yellowish or reddish urine.
One clear preparation is that the primary raw material extraction is prepared from by Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Scutellariae, and wherein Rhizoma Coptidis has heat clearing and damp drying, the effect of eliminating fire and detoxication; Radix Et Rhizoma Rhei has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation; Radix Scutellariae has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.One clear preparation has anti-inflammatory antipyretic, and the effect of relieving constipation diuretic is evident in efficacy to all diseases due to the long-pending heat of three warmers, is used for diseases such as pharyngolaryngitis, tonsillitis, oral ulcer, swelling and aching of gum and acne seat skin ulcer clinically.In the present one clear preparation granule, hard capsule and soft capsule are arranged, granule is taken inconvenience, and the hard capsule mouthfeel is bad, and the bioactive ingredients availability of granule or hard capsule is low, sealing is poor, content is inaccurate etc.; Simultaneously existing granule quality standard has only with chemical reference substance on differentiating and compares, and unmatchfully compares according to medical material, lacks specificity; Assay does not have the assay index of monarch drug Rhizoma Coptidis in the prescription, be difficult to the quality of preparation is effectively controlled and estimated, though soft capsule has higher bioactive ingredients availability and sealing, but its disperse medium or suspending agent use chemical adjuvant, it mainly is polyethylene glycols, as PEG-400, PEG-4000, PEG-6000 etc.,, reduced the security reliability of medication easily to the generation harm of human body.
Summary of the invention
The object of the present invention is to provide a kind of one clear soft capsule and preparation method thereof, it adopts natural type vegetable oil, Cera Flava respectively as disperse medium and suspending agent, make dispersion of medicine, disintegrate is molten looses soon, medicine bioactive ingredients availability height has improved the safety in the pharmaceutical production, medicine stability, the safety of medication, effectiveness effectively.
The technical solution adopted in the present invention:
A kind of one clear soft capsule, be after being mixed and made into suspended matter, to adopt the traditional preparation process prepared to form by a clear extract powder, vegetable oil, soybean phospholipid and Cera Flava, wherein each components contents is by weight: 20 parts of clear extract powders, 20～50 parts of vegetable oil, 0.5～2 part of soybean phospholipid, 1～4 part in Cera Flava; Described one clear extract powder is to get Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Scutellariae respectively by weight 3.3: 10: 5.0 ratio to decoct with water secondary, collecting decoction, filter, it is 1.18 clear paste that filtrate decompression is concentrated into relative density, spray drying makes Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder then, with Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder mixing, promptly get a clear extract powder.
A kind of above-mentioned one clear preparation of soft capsule method, its concrete steps are as follows:
1, a clear extract powder produces
Respectively Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Scutellariae are decocted with water secondary by proportioning, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, it is 1.18 clear paste that filtrate decompression is concentrated into relative density, and spray drying makes Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder then, with Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder mixing, promptly get a clear extract powder.
2, preparation of soft capsule
By proportioning one clear extract powder, vegetable oil, soybean phospholipid and Cera Flava mix homogeneously are made suspended matter; Ratio by weight 0.35: 1: 1～0.50: 1: 1 is got gelatin, G ﹠ W, adopts traditional method to prepare rubber, suspended matter is irritated be pressed into soft capsule then, typing below 18～25 ℃, erase soft capsule appearance oil reservoir with no fiber rag,, get a clear soft capsule in dry below 28 ℃.
The present invention adopts natural type vegetable oil, Cera Flava respectively as disperse medium and suspending agent, make dispersion of medicine, medicine bioactive ingredients availability height, safety and the effectiveness of medicine stability, medication have been improved effectively, covered the uncomfortable taste of medicine, swallow easily, shortened the disintegration of soft capsule, improved drug standard.
The specific embodiment
The invention will be further described with indefiniteness embodiment below.
Embodiment one
With Rhizoma Coptidis 330g, Radix Et Rhizoma Rhei 1000g, Radix Scutellariae 500g decocts with water secondary respectively, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.18 (75 ℃), and spray drying is made Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder; With three kinds of extract powder mixings, promptly get a clear extract powder.
By weight, get 20 parts of clear extractum, 20 parts of Oleum Arachidis hypogaeae semen, 0.5 part of soybean phospholipid, 1 part of mix homogeneously of Cera Flava is made suspended matter; Ratio by weight 0.35: 1: 1 is got gelatin, G ﹠ W, adopts traditional method to prepare rubber, suspended matter is irritated be pressed into 1000 soft capsules then, typing below 20 ℃, erase soft capsule appearance oil reservoir with no fiber rag,, promptly get product in dry below 28 ℃.
Embodiment two
With Rhizoma Coptidis 3.3kg, Radix Et Rhizoma Rhei 10.0kg, Radix Scutellariae 5.0kg decocts with water secondary respectively, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.18 (75 ℃), and spray drying is made Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder; With three kinds of extract powder mixings, promptly get a clear extract powder.
By weight, get 20 parts of clear extractum, 50 parts of Semen Maydis oil, 2 parts of soybean phospholipids, 4 parts of mix homogeneously of Cera Flava are made suspended matter; Ratio by weight 0.45: 1: 1 is got gelatin, G ﹠ W, adopts traditional method to prepare rubber, suspended matter is irritated be pressed into 10000 soft capsules then, typing below 23 ℃, erase soft capsule appearance oil reservoir with no fiber rag,, promptly get product in dry below 28 ℃.
Embodiment three
With Rhizoma Coptidis 1.6kg, Radix Et Rhizoma Rhei 5.0kg, Radix Scutellariae 2.5kg decocts with water secondary respectively, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.18 (75 ℃), and spray drying is made Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder; With three kinds of extract powder mixings, promptly get a clear extract powder.
By weight, get 20 parts of clear extractum, 35 parts of Petiolus Trachycarpi oils, 1.2 parts of soybean phospholipids, 2.5 parts of mix homogeneously of Cera Flava are made suspended matter, ratio by weight 0.50: 1: 1 is got gelatin, G ﹠ W, adopts traditional method to prepare rubber, suspended matter is irritated be pressed into 10000 soft capsules then, typing below 25 ℃, erase soft capsule appearance oil reservoir with no fiber rag,, promptly get product in dry below 28 ℃.
Claims (2)
1. clear soft capsule, it is characterized in that: be after being mixed and made into suspended matter, to adopt the traditional preparation process prepared to form by a clear extract powder, vegetable oil, soybean phospholipid and Cera Flava, wherein each components contents is by weight: 20 parts of clear extract powders, 20～50 parts of vegetable oil, 0.5～2 part of soybean phospholipid, 1～4 part in Cera Flava; Described one clear extract powder is to get Rhizoma Coptidis, Radix Et Rhizoma Rhei, Radix Scutellariae respectively by weight 3.3: 10: 5.0 ratio to decoct with water secondary, collecting decoction, filter, it is 1.18 clear paste that filtrate decompression is concentrated into relative density, spray drying makes Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder then, with Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder mixing, promptly get a clear extract powder.
2. claim 1 described one clear preparation of soft capsule method is characterized in that concrete steps are as follows:
1), a clear extract powder produces
Respectively Rhizoma Coptidis, Radix Et Rhizoma Rhei and Radix Scutellariae are decocted with water secondary by proportioning, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, it is 1.18 clear paste that filtrate decompression is concentrated into relative density, and spray drying makes Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder then, with Rhizoma Coptidis powder, Radix Et Rhizoma Rhei powder, Radix Scutellariae powder mixing, promptly get a clear extract powder;
2), preparation of soft capsule
By proportioning one clear extract powder, vegetable oil, soybean phospholipid and Cera Flava mix homogeneously are made suspended matter; Ratio by weight 0.35: 1: 1～0.50: 1: 1 is got gelatin, G ﹠ W, adopts traditional method to prepare rubber, suspended matter is irritated be pressed into soft capsule then, typing below 18～25 ℃, erase soft capsule appearance oil reservoir with no fiber rag,, get a clear soft capsule in dry below 28 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101759475A CN101711808B (en) | 2009-09-11 | 2009-09-11 | Soft capsule used for clearing away heat and toxic materials and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101759475A CN101711808B (en) | 2009-09-11 | 2009-09-11 | Soft capsule used for clearing away heat and toxic materials and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101711808A true CN101711808A (en) | 2010-05-26 |
| CN101711808B CN101711808B (en) | 2011-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009101759475A Active CN101711808B (en) | 2009-09-11 | 2009-09-11 | Soft capsule used for clearing away heat and toxic materials and preparation method thereof |
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| Country | Link |
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| CN (1) | CN101711808B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101890087A (en) * | 2010-07-27 | 2010-11-24 | 李钢 | Composition containing coptis root, rhubarb and baikal skullcap root |
| CN103163260A (en) * | 2011-12-16 | 2013-06-19 | 成都康弘制药有限公司 | Fingerprints of drugs and determination method thereof |
| CN106615184A (en) * | 2015-11-04 | 2017-05-10 | 泰喜物产株式会社 | Tofu coagulator composition and preparation method of tofu by using it |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1199671C (en) * | 2002-04-12 | 2005-05-04 | 成都康弘科技实业（集团）有限公司 | Improved process for preparing Chinese medicine capsule for treating constipation |
| CN1640428A (en) * | 2004-01-15 | 2005-07-20 | 北京市圣普华医药科技开发有限公司 | One-time-clearing soft capsule and its preparing process |
| CN1291734C (en) * | 2004-04-30 | 2006-12-27 | 成都优他制药有限责任公司 | Method for preparing and controlling the quality of Chinese medicinal soft capsule |
| CN1634427A (en) * | 2004-11-01 | 2005-07-06 | 辽宁大生药业有限公司 | Soft capsule containing rhubarb, goldthread root and scutellaria root and preparation technique thereof |
| CN1698774A (en) * | 2004-11-26 | 2005-11-23 | 温光辉 | Chinese medicinal soft capsule with heat-clearing toxin-removing function and its preparation process |
| CN101274025B (en) * | 2007-03-27 | 2010-12-15 | 北京亚东生物制药有限公司 | Quality control method of Chinese medicinal composition with functions of reducing fever, purging the intense heat and detoxification |
-
2009
- 2009-09-11 CN CN2009101759475A patent/CN101711808B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101890087A (en) * | 2010-07-27 | 2010-11-24 | 李钢 | Composition containing coptis root, rhubarb and baikal skullcap root |
| CN103163260A (en) * | 2011-12-16 | 2013-06-19 | 成都康弘制药有限公司 | Fingerprints of drugs and determination method thereof |
| CN103163260B (en) * | 2011-12-16 | 2014-12-24 | 成都康弘制药有限公司 | Determination method of fingerprints of drugs |
| CN106615184A (en) * | 2015-11-04 | 2017-05-10 | 泰喜物产株式会社 | Tofu coagulator composition and preparation method of tofu by using it |
| CN106615184B (en) * | 2015-11-04 | 2021-01-29 | 泰喜物产株式会社 | Coagulant composition for tofu and method for producing tofu using the same |
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| Publication number | Publication date |
|---|---|
| CN101711808B (en) | 2011-08-24 |
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Application publication date: 20100526 Assignee: ANHUI HISHEN SHOUCHUN PHARMACEUTICAL CO.,LTD. Assignor: HAINAN HISHEN TONGZHOU PHARMACEUTICAL Co.,Ltd. Contract record no.: 2012460000001 Denomination of invention: Soft capsule used for clearing away heat and toxic materials and preparation method thereof Granted publication date: 20110824 License type: Exclusive License Record date: 20120416 |
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Denomination of invention: Soft capsules for clearing heat and detoxifying and their preparation method Granted publication date: 20110824 Pledgee: Industrial Bank Co.,Ltd. Haikou Branch Pledgor: HAINAN HISHEN TONGZHOU PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980020578 |