CN101711279A - Tp调节剂在阿司匹林敏感群体以及其他群体中治疗心血管疾病的用途 - Google Patents

Tp调节剂在阿司匹林敏感群体以及其他群体中治疗心血管疾病的用途 Download PDF

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Publication number
CN101711279A
CN101711279A CN200880014605A CN200880014605A CN101711279A CN 101711279 A CN101711279 A CN 101711279A CN 200880014605 A CN200880014605 A CN 200880014605A CN 200880014605 A CN200880014605 A CN 200880014605A CN 101711279 A CN101711279 A CN 101711279A
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Prior art keywords
aspirin
conditioning agent
individuality
adp receptor
cox
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Pending
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CN200880014605A
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Chinese (zh)
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大卫·R·菲利普斯
帕特里克·安德烈
查尔斯·J·和穆西
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Portola Pharmaceuticals LLC
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Portola Pharmaceuticals LLC
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200880014605A 2007-05-03 2008-05-02 Tp调节剂在阿司匹林敏感群体以及其他群体中治疗心血管疾病的用途 Pending CN101711279A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US91578407P 2007-05-03 2007-05-03
US91578507P 2007-05-03 2007-05-03
US60/915,785 2007-05-03
US60/915,784 2007-05-03
US94728907P 2007-06-29 2007-06-29
US94731607P 2007-06-29 2007-06-29
US60/947,289 2007-06-29
US60/947,316 2007-06-29
PCT/US2008/062565 WO2008137791A1 (en) 2007-05-03 2008-05-02 Use of tp modulators for the treatment of cardiovascular disorders in aspirin sensitive and other populations

Publications (1)

Publication Number Publication Date
CN101711279A true CN101711279A (zh) 2010-05-19

Family

ID=39943967

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880014605A Pending CN101711279A (zh) 2007-05-03 2008-05-02 Tp调节剂在阿司匹林敏感群体以及其他群体中治疗心血管疾病的用途
CN200880019332A Pending CN101686668A (zh) 2007-05-03 2008-05-02 用血栓烷受体拮抗剂治疗和预防血栓形成的单位剂量制剂和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200880019332A Pending CN101686668A (zh) 2007-05-03 2008-05-02 用血栓烷受体拮抗剂治疗和预防血栓形成的单位剂量制剂和方法

Country Status (10)

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US (2) US20090012115A1 (enExample)
EP (2) EP2144999A4 (enExample)
JP (2) JP2010527331A (enExample)
KR (2) KR20100037029A (enExample)
CN (2) CN101711279A (enExample)
AU (2) AU2008247439A1 (enExample)
CA (2) CA2688319A1 (enExample)
IL (2) IL201885A0 (enExample)
MX (2) MX2009011745A (enExample)
WO (2) WO2008137793A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114569608A (zh) * 2015-06-30 2022-06-03 坎伯兰医药品股份有限公司 Aerd/哮喘中的血栓烷受体拮抗剂

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100168137A1 (en) * 2006-12-20 2010-07-01 Johan Raud Combination for use in the treatment of inflammatory disorders
WO2008087371A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
KR20130026504A (ko) * 2010-07-14 2013-03-13 큠버랜드 에멀징 테크놀로지스 아이앤씨 트롬복산-a2 수용체 길항제를 이용한 간신증후군 및 간성뇌증의 치료방법
US10016417B2 (en) 2011-11-07 2018-07-10 Diakron Pharmaceuticals, Inc. Extended release formulation of a direct thrombin inhibitor
JP6183459B2 (ja) * 2012-08-06 2017-08-23 Jnc株式会社 合成コラーゲンを用いる二重抗血小板薬／アスピリン応答および反応性試験
US12161632B2 (en) 2014-05-16 2024-12-10 Cumberland Pharmaceuticals Inc. Compositions and methods of treating cardiac fibrosis with ifetroban
JP6273072B2 (ja) * 2014-05-16 2018-01-31 カンバーランド ファーマシューティカルズ，インコーポレーテッド イフェトロバンにより心臓線維症を治療する組成物及び方法
ES2984026T3 (es) * 2015-06-16 2024-10-28 Atxa Therapeutics Ltd Antagonistas del receptor de tromboxano
EP3454850B1 (en) 2016-05-11 2023-06-21 Cumberland Pharmaceuticals Inc. Compositions and methods of treating muscular dystrophy with thromboxane-a2 receptor antagonists
AU2021246444A1 (en) * 2020-03-31 2022-10-20 Martin Ogletree Methods and pharmaceutical compositions of thromboxane A2 receptor antagonist for the treatment of COVID-19

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3895115A (en) * 1974-03-01 1975-07-15 Serono Ist Farm Method of inhibiting platelet aggregation
US5071866A (en) * 1989-07-31 1991-12-10 Bristol-Myers Squibb Company Arylpyrazole derivatives as anti-platelet agents
US5506248A (en) * 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
US5605917A (en) * 1994-12-22 1997-02-25 Bristol-Myers Squibb Company Method of treating dysmenorrhea employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog
US6509348B1 (en) * 1998-11-03 2003-01-21 Bristol-Myers Squibb Company Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination
JP2005533830A (ja) * 2002-07-09 2005-11-10 ビー．エム．アール．エイ． コーポレイション ベスローテン フェンノートシャップ トロンボキサンａ２受容体アンタゴニストおよびｃｏｘ−２阻害剤の薬剤の組み合わせ
WO2006066008A2 (en) * 2004-12-14 2006-06-22 Portola Pharmaceuticals, Inc. Device and methods for identifying and treating aspirin non-responsive patients
US7381536B2 (en) * 2005-03-01 2008-06-03 Gurbel Paul A Assessment of cardiac health and thrombotic risk in a patient

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114569608A (zh) * 2015-06-30 2022-06-03 坎伯兰医药品股份有限公司 Aerd/哮喘中的血栓烷受体拮抗剂

Also Published As

Publication number Publication date
KR20100037029A (ko) 2010-04-08
MX2009011745A (es) 2010-02-12
IL201886A0 (en) 2010-06-16
CA2688317A1 (en) 2008-11-13
EP2146573A4 (en) 2012-11-21
JP2010527331A (ja) 2010-08-12
US20090012115A1 (en) 2009-01-08
EP2144999A4 (en) 2010-06-16
AU2008247441A1 (en) 2008-11-13
JP2010526104A (ja) 2010-07-29
US20090012136A1 (en) 2009-01-08
CN101686668A (zh) 2010-03-31
KR20100032854A (ko) 2010-03-26
MX2009011744A (es) 2010-02-12
IL201885A0 (en) 2011-08-01
WO2008137793A1 (en) 2008-11-13
AU2008247439A1 (en) 2008-11-13
EP2144999A1 (en) 2010-01-20
WO2008137791A1 (en) 2008-11-13
CA2688319A1 (en) 2008-11-13
EP2146573A1 (en) 2010-01-27

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Application publication date: 20100519