CN101705593B - Shaping method of ultrafine fiber membrane - Google Patents
Shaping method of ultrafine fiber membrane Download PDFInfo
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- CN101705593B CN101705593B CN2009102095062A CN200910209506A CN101705593B CN 101705593 B CN101705593 B CN 101705593B CN 2009102095062 A CN2009102095062 A CN 2009102095062A CN 200910209506 A CN200910209506 A CN 200910209506A CN 101705593 B CN101705593 B CN 101705593B
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- fiber membrane
- ultrafine fiber
- temperature
- superfine fibre
- fibre film
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Abstract
The invention relates to a shaping method of an ultrafine fiber membrane, comprising the following steps: a) raising the temperature of a constant-temperature incubator to 50 DEG C and stabilizing for ten minutes; b) taking a partition plate and attaching gold membrane-polyimide on the periphery of the partition plate, wherein the thickness of the polyimide membrane is 80% of that of an ultrafine fiber membrane to be shaped; c) putting the ultrafine fiber membrane with the facade facing upward between two partition plates and pressing a weight on the partition plate according to the condition of 1g on per square centimeter of ultrafine fiber membrane; and d) putting the two partition plates into the constant-temperature incubator together with the ultrafine fiber membrane, setting the temperature of the incubator to be 40-50 DEG C and preserving the temperature for 20 minutes to 2 hours. The shaping method of the ultrafine fiber membrane has the advantages that the ultrafine fiber membrane obtains most excellent shaping by the regulation of hot pressing plate material, hot pressing temperature and hot pressing time, thereby guaranteeing that the product continuously has the characteristics of softness, high porosity, easy transmission of body fluid and the like as well as good adhesion prevention and wound repair effects; and the shaping method of the ultrafine fiber membrane provides a basis for boosting the clinical application process.
Description
Technical field
The present invention relates to a kind of method for shaping of the biodegradable and polylactic acid-based superfine fibre film that absorbs.
Background technology
The PLA synthetic material is one of up-to-date biological medical polymer material of polymer research; It can adapt with human body, and nontoxic, nonirritant can be hydrolyzed into lactic acid in human body; Participate in metabolism; Be applied in biomedical each field, at the carrier material of medicine, hormone, vaccine and Gene Handling delivery systme, fields such as bone support, repair materials and organizational project have a wide range of applications.
With polylactic acid-based macromolecular material is raw material; Through electrostatic spinning process; Can make on 26S Proteasome Structure and Function, similar with the n cell epimatrix and have better biocompatibility and have certain intensity and new bio medical material---the superfine fibre film of stability.This material is one of ideal material that body is implanted into and human organ reproduces.
Yet; Because the glass transition temperature of polylactic acid-based macromolecular material is lower; And the quick drawing process that electricity spins causes having strong ess-strain in the tunica fibrosa, in last handling process or use; When changing like external environments such as temperature, humidity, tunica fibrosa can shrink generation deformation.For this diaphragm is generalized to clinical use, guarantee simultaneously that product places between operation wound face and the body tissue to form barrier that reach the purpose of anti, the exterior appearance of product, microscopic fibers structure all can not be destroyed in processing and use.Therefore, product needed is through subsequent processes such as typing, sterilization, parsing, packing, transportations, and typing is particularly important.
Summary of the invention
Technical problem to be solved by this invention is, to above-mentioned prior art present situation, and provides a kind of in last handling process or use, can not shrink the method for shaping of the superfine fibre film that produces deformation.
The present invention solves the problems of the technologies described above the technical scheme that is adopted: a kind of method for shaping of superfine fibre film, it is characterized in that, and comprise the steps: a) temperature of constant incubator is risen to hot pressing temperature, be generally 40～50 ℃, and stablized 10 minutes; B) get a dividing plate, around said dividing plate, stick gold film-polyimides; Said polyimides thickness is 70%～90% of a superfine fibre film thickness to be shaped, is 20 microns～200 microns; C) with the facing up of superfine fibre film, be put on the said dividing plate; Another piece dividing plate is pushed down superfine fibre film, and a counterweight is pressed onto above the dividing plate; The weight of said counterweight is got 0.1～20g according to every square centimeter of superfine fibre film; D) above-mentioned two dividing plates and superfine fibre film are put into said constant incubator together, its temperature is set to 40～50 ℃, constant temperature 20min～2h;
In the step b), said polyimides thickness is 80% of a superfine fibre film thickness to be shaped; The material of said dividing plate is physics and chemistry plate, stainless steel or glass plate; The weight of said counterweight is got 1g according to every square centimeter of superfine fibre film; In the step d), said thermostat temperature is provided with 50 ℃, and constant temperature time is 20min.
Compared with prior art; The invention has the advantages that; It makes polylactic acid-based composite superfine fibre membrane obtain optimized typing through to the debugging of heating platen material, hot pressing temperature, hot pressing time, guaranteed product continue to have softness, porosity high, be easy to characteristics such as body fluid transmission; Anti and wound repair are effective simultaneously, advance the clinical practice process to provide the foundation.Reach more than 80% without area contraction in the tunica fibrosa 37 degree water of hot-pressing processing, and handle and to control to below 10% through the present invention.
The specific embodiment
According to embodiment the present invention is done further explain below.
A kind of method for shaping of superfine fibre film comprises the steps: a) temperature of constant incubator is risen to 50 ℃, and stablized 10 minutes; B) get a dividing plate, around said dividing plate, stick gold film-polyimides; Said polyimides thickness is 80% of a superfine fibre film thickness to be shaped; C) with the facing up of superfine fibre film, be put on the said dividing plate; Another piece dividing plate is pushed down superfine fibre film, and a counterweight is pressed onto above the dividing plate; The weight of said counterweight is got 1g according to every square centimeter of superfine fibre film; D) above-mentioned two dividing plates and superfine fibre film are put into said constant incubator together, its temperature is set to 50 ℃, and constant temperature time is 20min.
Kapton is done the limit, is to play a supportive role, so the polyimides thickness is optional, from 20 microns～200 microns, looks tunica fibrosa thickness and decides.
Claims (3)
1. the method for shaping of a superfine fibre film is characterized in that, comprises the steps:
A) temperature with constant incubator rises to 40～50 ℃, and stablizes 10 minutes;
B) get a dividing plate, around said dividing plate, stick gold film-polyimides; Said gold thickness is 80% of a superfine fibre film thickness to be shaped; The material of said dividing plate is physics and chemistry plate, stainless steel or glass plate;
C) with the facing up of superfine fibre film, be put on the said dividing plate of step b); With another piece dividing plate superfine fibre film is pushed down, and a counterweight is pressed onto above the dividing plate; The weight of said counterweight is got 0.1～20g according to every square centimeter of superfine fibre film;
D) above-mentioned two dividing plates and superfine fibre film are put into said constant incubator together, its temperature is set to 40～50 ℃, constant temperature 20min～2h.
2. the method for shaping of superfine fibre film as claimed in claim 1 is characterized in that, in the step c), the weight of said counterweight is got 1g according to every square centimeter of superfine fibre film.
3. according to claim 1 or claim 2 the method for shaping of superfine fibre film is characterized in that in the step d), said thermostat temperature is set to 50 ℃, and constant temperature time is 20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102095062A CN101705593B (en) | 2009-10-29 | 2009-10-29 | Shaping method of ultrafine fiber membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102095062A CN101705593B (en) | 2009-10-29 | 2009-10-29 | Shaping method of ultrafine fiber membrane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101705593A CN101705593A (en) | 2010-05-12 |
| CN101705593B true CN101705593B (en) | 2012-07-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009102095062A Active CN101705593B (en) | 2009-10-29 | 2009-10-29 | Shaping method of ultrafine fiber membrane |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611180B (en) * | 2013-11-21 | 2015-02-18 | 无锡中科光远生物材料有限公司 | Preparation method of self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN104645420B (en) * | 2014-12-29 | 2017-04-12 | 深圳迈普再生医学科技有限公司 | Soft tissue repairing patch and preparation method thereof |
| WO2016107522A1 (en) * | 2014-12-29 | 2016-07-07 | 深圳迈普再生医学科技有限公司 | Soft tissue repair patch and preparation method thereof, and tension-free hanging belt system |
| CN112406244B (en) * | 2020-11-10 | 2023-02-21 | 长春工业大学 | High-performance laminated glass intermediate polymer film material and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101418520A (en) * | 2008-12-12 | 2009-04-29 | 林楠 | Method for manufacturing plane cocoon fiber nonwoven sheet material |
| CN101424049A (en) * | 2008-12-22 | 2009-05-06 | 南方汇通股份有限公司 | Heat pressing and sulfuration integrated method and device for natural fabric elastic material |
-
2009
- 2009-10-29 CN CN2009102095062A patent/CN101705593B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101418520A (en) * | 2008-12-12 | 2009-04-29 | 林楠 | Method for manufacturing plane cocoon fiber nonwoven sheet material |
| CN101424049A (en) * | 2008-12-22 | 2009-05-06 | 南方汇通股份有限公司 | Heat pressing and sulfuration integrated method and device for natural fabric elastic material |
Non-Patent Citations (3)
| Title |
|---|
| JP特开2009-57407A 2009.03.19 |
| 李金宝等.聚乳酸纤维染整加工的进展.《印染》.2004,(第9期),36-43. * |
| 王立新等.静电纺PLGA纤维膜的体外降解性能研究.《合成纤维》.2009,(第4期),26-29. * |
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| Publication number | Publication date |
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| CN101705593A (en) | 2010-05-12 |
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