CN101705593A - Shaping method of ultrafine fiber membrane - Google Patents
Shaping method of ultrafine fiber membrane Download PDFInfo
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- CN101705593A CN101705593A CN200910209506A CN200910209506A CN101705593A CN 101705593 A CN101705593 A CN 101705593A CN 200910209506 A CN200910209506 A CN 200910209506A CN 200910209506 A CN200910209506 A CN 200910209506A CN 101705593 A CN101705593 A CN 101705593A
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- fiber membrane
- ultrafine fiber
- superfine fibre
- temperature
- fibre film
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Abstract
The invention relates to a shaping method of an ultrafine fiber membrane, comprising the following steps: a) raising the temperature of a constant-temperature incubator to 50 DEG C and stabilizing for ten minutes; b) taking a partition plate and attaching gold membrane-polyimide on the periphery of the partition plate, wherein the thickness of the polyimide membrane is 80% of that of an ultrafine fiber membrane to be shaped; c) putting the ultrafine fiber membrane with the facade facing upward between two partition plates and pressing a weight on the partition plate according to the condition of 1g on per square centimeter of ultrafine fiber membrane; and d) putting the two partition plates into the constant-temperature incubator together with the ultrafine fiber membrane, setting the temperature of the incubator to be 40-50 DEG C and preserving the temperature for 20 minutes to 2 hours. The shaping method of the ultrafine fiber membrane has the advantages that the ultrafine fiber membrane obtains most excellent shaping by the regulation of hot pressing plate material, hot pressing temperature and hot pressing time, thereby guaranteeing that the product continuously has the characteristics of softness, high porosity, easy transmission of body fluid and the like as well as good adhesion prevention and wound repair effects; and the shaping method of the ultrafine fiber membrane provides a basis for boosting the clinical application process.
Description
Technical field
The present invention relates to a kind of method for shaping of the biodegradable and polylactic acid-based superfine fibre film that absorbs.
Background technology
The PLA synthetic material is one of up-to-date biological medical polymer material of polymer research, it can adapt with human body, nontoxic, nonirritant, in human body, can be hydrolyzed into lactic acid, participate in metabolism, be applied in biomedical each field, at the carrier material of medicine, hormone, vaccine and gene control delivery systme, fields such as bone support, repair materials and organizational project have a wide range of applications.
With polylactic acid-based macromolecular material is raw material, through electrostatic spinning process, can make on 26S Proteasome Structure and Function, similar to the n cell epimatrix and have better biocompatibility and have certain intensity and new bio medical material---the superfine fibre film of stability.This material is one of ideal material that body is implanted into and human organ reproduces.
Yet, because the glass transition temperature of polylactic acid-based macromolecular material is lower, and the quick drawing process of electrospinning, cause existing in the tunica fibrosa strong ess-strain, in last handling process or use, when changing as external environments such as temperature, humidity, tunica fibrosa can shrink generation deformation.For this diaphragm is generalized to clinical use, guarantee simultaneously that product places between operation wound face and the body tissue to form barrier that reach the purpose of anti, the exterior appearance of product, the microscopic fibers structure all can not be destroyed in processing and use.Therefore, product needed is through subsequent processes such as typing, sterilization, parsing, packing, transportations, and typing is particularly important.
Summary of the invention
Technical problem to be solved by this invention is, at above-mentioned prior art present situation, and provides a kind of in last handling process or use, can not shrink the method for shaping of the superfine fibre film that produces deformation.
The present invention solves the problems of the technologies described above the technical scheme that is adopted: a kind of method for shaping of superfine fibre film, it is characterized in that, and comprise the steps: a) temperature of constant incubator is risen to hot pressing temperature, be generally 40～50 ℃, and stablized 10 minutes; B) get a dividing plate, around described dividing plate, stick gold film-polyimides; Described polyimides thickness is 70%～90% of a superfine fibre film thickness to be shaped, is 20 microns～200 microns; C) with the facing up of superfine fibre film, be put on the described dividing plate; Another piece dividing plate is pushed down superfine fibre film, and a counterweight is pressed onto above the dividing plate; The weight of described counterweight is got 0.1～20g according to every square centimeter of superfine fibre film; D) above-mentioned two dividing plates and superfine fibre film are put into described constant incubator together, its temperature is set to 40～50 ℃, constant temperature 20min～2h;
In the step b), described polyimides thickness is 80% of a superfine fibre film thickness to be shaped; The material of described dividing plate is physics and chemistry plate, stainless steel or glass plate; The weight of described counterweight is got 1g according to every square centimeter of superfine fibre film; In the step d), described thermostat temperature is provided with 50 ℃, and constant temperature time is 20min.
Compared with prior art, the invention has the advantages that, it is by the debugging to heating platen material, hot pressing temperature, hot pressing time, make polylactic acid-based composite superfine fibre membrane obtain optimized typing, guaranteed that product continues to have softness, porosity height, is easy to characteristics such as body fluid transmission, anti and wound repair are effective simultaneously, advance the clinical practice process to provide the foundation.Reach more than 80% without area contraction in the tunica fibrosa 37 degree water of hot-pressing processing, and handle and to control to below 10% through the present invention.
The specific embodiment
According to embodiment the present invention is described in further detail below.
A kind of method for shaping of superfine fibre film comprises the steps: a) temperature of constant incubator is risen to 50 ℃, and stablized 10 minutes; B) get a dividing plate, around described dividing plate, stick gold film-polyimides; Described polyimides thickness is 80% of a superfine fibre film thickness to be shaped; C) with the facing up of superfine fibre film, be put on the described dividing plate; Another piece dividing plate is pushed down superfine fibre film, and a counterweight is pressed onto above the dividing plate; The weight of described counterweight is got 1g according to every square centimeter of superfine fibre film; D) above-mentioned two dividing plates and superfine fibre film are put into described constant incubator together, its temperature is set to 50 ℃, and constant temperature time is 20min.
Kapton is done the limit, is to play a supportive role, so the polyimides thickness is optional, from 20 microns～200 microns, decides on tunica fibrosa thickness.
Claims (4)
1. the method for shaping of a superfine fibre film is characterized in that, comprises the steps:
A) temperature with constant incubator rises to 40～50 ℃, and stablizes 10 minutes;
B) get a dividing plate, around described dividing plate, stick gold film-polyimides; Described polyimides thickness is 70%～90% of a superfine fibre film thickness to be shaped;
C) with the facing up of superfine fibre film, be put on the described dividing plate; Another piece dividing plate is pushed down superfine fibre film, and a counterweight is pressed onto above the dividing plate; The weight of described counterweight is got 0.1～20g according to every square centimeter of superfine fibre film;
D) above-mentioned two dividing plates and superfine fibre film are put into described constant incubator together, its temperature is set to 40～50 ℃, constant temperature 20min～2h.
2. the method for shaping of superfine fibre film as claimed in claim 1 is characterized in that, in the step b), described polyimides thickness is 80% of a superfine fibre film thickness to be shaped; The material of described dividing plate is physics and chemistry plate, stainless steel or glass plate.
3. the method for shaping of superfine fibre film as claimed in claim 2 is characterized in that, in the step c), the weight of described counterweight is got 1g according to every square centimeter of superfine fibre film.
4. as the method for shaping of the described superfine fibre film of the arbitrary claim of claim 1 to 3, it is characterized in that in the step d), described thermostat temperature is set to 50 ℃, constant temperature time is 20min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102095062A CN101705593B (en) | 2009-10-29 | 2009-10-29 | Shaping method of ultrafine fiber membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102095062A CN101705593B (en) | 2009-10-29 | 2009-10-29 | Shaping method of ultrafine fiber membrane |
Publications (2)
| Publication Number | Publication Date |
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| CN101705593A true CN101705593A (en) | 2010-05-12 |
| CN101705593B CN101705593B (en) | 2012-07-11 |
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| CN2009102095062A Active CN101705593B (en) | 2009-10-29 | 2009-10-29 | Shaping method of ultrafine fiber membrane |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611180A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN104645420A (en) * | 2014-12-29 | 2015-05-27 | 深圳迈普再生医学科技有限公司 | Soft tissue repairing patch and preparation method thereof |
| WO2016107522A1 (en) * | 2014-12-29 | 2016-07-07 | 深圳迈普再生医学科技有限公司 | Soft tissue repair patch and preparation method thereof, and tension-free hanging belt system |
| CN112406244A (en) * | 2020-11-10 | 2021-02-26 | 长春工业大学 | High-performance laminated glass intermediate polymer film material and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101418520B (en) * | 2008-12-12 | 2010-12-01 | 林楠 | Method for manufacturing plane cocoon fiber nonwoven sheet material |
| CN101424049B (en) * | 2008-12-22 | 2012-12-05 | 贵州大自然科技有限公司 | Heat pressing and sulfuration integrated method and device for natural fabric elastic material |
-
2009
- 2009-10-29 CN CN2009102095062A patent/CN101705593B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611180A (en) * | 2013-11-21 | 2014-03-05 | 无锡中科光远生物材料有限公司 | Preparation method of self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN103611180B (en) * | 2013-11-21 | 2015-02-18 | 无锡中科光远生物材料有限公司 | Preparation method of self-adhesion hemostasis anti-adhesion corpus fibrosum |
| CN104645420A (en) * | 2014-12-29 | 2015-05-27 | 深圳迈普再生医学科技有限公司 | Soft tissue repairing patch and preparation method thereof |
| WO2016107522A1 (en) * | 2014-12-29 | 2016-07-07 | 深圳迈普再生医学科技有限公司 | Soft tissue repair patch and preparation method thereof, and tension-free hanging belt system |
| CN112406244A (en) * | 2020-11-10 | 2021-02-26 | 长春工业大学 | High-performance laminated glass intermediate polymer film material and preparation method thereof |
| CN112406244B (en) * | 2020-11-10 | 2023-02-21 | 长春工业大学 | High-performance laminated glass intermediate polymer film material and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101705593B (en) | 2012-07-11 |
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