CN101703487A - Codonopsis pilosula polysaccharide pill - Google Patents
Codonopsis pilosula polysaccharide pill Download PDFInfo
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- CN101703487A CN101703487A CN200910250358A CN200910250358A CN101703487A CN 101703487 A CN101703487 A CN 101703487A CN 200910250358 A CN200910250358 A CN 200910250358A CN 200910250358 A CN200910250358 A CN 200910250358A CN 101703487 A CN101703487 A CN 101703487A
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- radix codonopsis
- codonopsis polysaccharide
- polysaccharide
- drop pill
- codonopsis pilosula
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Abstract
The invention relates to a traditional Chinese medicine preparation, in particular to a codonopsis pilosula polysaccharide pill. The invention solves the problems of different disadvantages on clinical application of the current codonopsis pilosula polysaccharide preparation adopting tablets, oral liquid, parenteral soluation. The codonopsis pilosula polysaccharide pill comprises codonopsis pilosula polysaccharide and base material, wherein the weight ratio of the codonopsis pilosula polysaccharide to the base materials is 1:1 to 1:8, and the base material is any one of polyethyleneglycol 6000, polyethyleneglycol 4000, stearic acid, sodium stearate, glycerogelatin, polyoxyethylene monostearate and glycerin monostearate. The preparation method comprises the following steps: mixing the codonopsis pilosula polysaccharide and the base material in proportion; heating and melting the codonopsis pilosula polysaccharide and the base material in water bath with the temperature of 70 to 100 DEG C, and then dipping the mixture into condensing agent at the speed of 20 to 60 drops per minute; cooling the temperature to 10 to 15 DEG C, and forming; and removing the condensing agent. The traditional Chinese medicine preparation has the advantages of clean and bright appearance, beauty, portability, easy taking, quick deconcentration and good absorption in oral cavity and stomach, high bioavailability, stable preparation, few side effect, insurance of the quality of the medicine, high stability, quickness, high efficiency and controlled release.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specially a kind of Radix Codonopsis polysaccharide drop pill with immunoregulation effect and antitumor, anti-aging effects.
Background technology
The Chinese crude drug Radix Codonopsis is a Chinese medicine, is clinical first-selected invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting, and strengthening the body resistance, strengthening by means of tonics and antidotal medicine are applicable to all diseases of deficiency of both the splenic and pulmonary QI.The Chinese medicine ingredients complexity, pharmacological evaluation, Radix Codonopsis polysaccharide is the effective site active site of Radix Codonopsis, and it has following effect, and 1, immunoregulation effect: Radix Codonopsis polysaccharide can improve macrophage function that macrophage suppresses cyclophosphamide and hydrocortisone and E garland and be formed with and strengthen and restitution; 2, antitumor action: after giving mouse inoculation S180 sarcoma cell, adopt the Radix Codonopsis polysaccharide of variable concentrations to carry out the test of S180 tumor suppression, the result shows that Radix Codonopsis polysaccharide has inhibitory action to the S180 tumor; 3, anti-aging effects; 4, oxygen lack resistant function: be a kind of good oxygen free radical scavenger.The dosage form that with the Radix Codonopsis polysaccharide is main component at present has tablet, oral liquid, injection etc., through clinical verification, tablet exists that disintegration rate is slow, the effective ingredient rate of release is low causes that bioavailability is low, onset waits problem slowly, and the injection prolonged application has all proposed very high requirement to stability of formulation, safety and patient's tolerance degree, and oral liquid exists that medicament contg is low, taking dose big and taking dose is inaccurate, take inconvenient problem.At the problem of above existence, press for a kind of quick-acting, efficient, long lasting Radix Codonopsis polysaccharide preparation, to satisfy the needs of clinical practice.
Summary of the invention
All there is the problem of different shortcomings separately in the present invention in order to solve dosage forms such as existing polysaccharide tablet of asiabell, oral liquid, injection in clinical practice, a kind of Radix Codonopsis polysaccharide drop pill is provided.
The present invention adopts following technical scheme to realize: a kind of Radix Codonopsis polysaccharide drop pill, by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 1～1: 8, and described substrate is any one in polyethylene glycol 6000, Macrogol 4000, stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene monostearate, the glyceryl monostearate;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 70～100 ℃ the temperature, speed with 20～60 of per minutes splashes in the condensing agent, be cooled to 10～15 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.The water extract-alcohol precipitation method that described Radix Codonopsis polysaccharide can take this application people to obtain patent (patent No. 200710062520.5) is extracted; Described substrate is existing known products.Prepared Radix Codonopsis polysaccharide drop pill is yellowish drop pill, presses the regulation of the inspection method of regulation under an appendix IK of Chinese Pharmacopoeia version in 2005 the drop pill item, the different coefficient conformance with standard of the ball method of double differences of Radix Codonopsis polysaccharide drop pill; By " an appendix I of Chinese pharmacopoeia version in 2005 the drop pill item regulation of the inspection method of regulation is down measured, and the Radix Codonopsis polysaccharide drop pill is all molten loosing in 30min; Its content assaying method adopts the phenolsulfuric acid method to measure the polysaccharide total amount, is reference substance with the glucose.In the Radix Codonopsis polysaccharide drop pill polyoses content with glucose meter between 10% to 30%.
The optimum weight ratio of described Radix Codonopsis polysaccharide and substrate is 1: 3, to be the applicant get through test of many times and summary of experience for this. and the ball that substrates quantity directly has influence on this product heavily reaches dose, production cost etc., the substrate ratio is low excessively, then the medicinal liquid flowability is bad, cause a system difficulty, ball shape to differ greatly, the substrate ratio is too high, then can cause production cost to increase, and the patient takes too much adjuvant.
Described matrix optimization is any one in polyethylene glycol 6000 or the Macrogol 4000, this is that the applicant screens resulting optimum substrate adjuvant through science, result of the test shows that polyethylene glycol 6000 or Macrogol 4000 are as substrate, and be big to the medicine saturation, the good fluidity of medicinal liquid, drug loading is big, the drop pill good moldability, and outer light is smooth, mellow and full, drop pill is molten to loose comparatively fast.
Described condensing agent is any one in dimethicone, liquid paraffin or the vegetable oil, preferred dimethicone.
Radix Codonopsis polysaccharide drop pill of the present invention mixes the extract that contains active constituents of medicine mutually with molten matrix, splash in the not miscible condensed fluid and make, filled up the blank that the Radix Codonopsis polysaccharide medicine series still lacks drops, compared with prior art, the prepared drops of the present invention has overcome the defective of other dosage forms, outward appearance is bright and clean, attractive in appearance, is easy to carry and takes; In oral cavity and gastrointestinal, disperse fast, good absorbing, the bioavailability height, preparation stabilization, side effect reduces, and has guaranteed the quality of medicine, has increased stability, has quick-acting, efficient, long lasting advantages.
The specific embodiment
Embodiment 1:
A kind of Radix Codonopsis polysaccharide drop pill, by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 8, substrate is polyethylene glycol 6000;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 70 ℃ the temperature, speed with 20 of per minutes splashes in the dimethicone condensing agent, be cooled to 10 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.
Embodiment 2:
A kind of Radix Codonopsis polysaccharide drop pill, by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 1, substrate is Macrogol 4000;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 100 ℃ the temperature, speed with 60 of per minutes splashes in the liquid paraffin condensing agent, be cooled to 15 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.
Embodiment 3:
A kind of Radix Codonopsis polysaccharide drop pill, by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 3, described substrate is stearic acid;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 80 ℃ the temperature, speed with 40 of per minutes splashes in the vegetable oil condensing agent, be cooled to 12 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.
Embodiment 4:
A kind of Radix Codonopsis polysaccharide drop pill, by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 5, substrate is sodium stearate or glycerin gelatine;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 90 ℃ the temperature, speed with 50 of per minutes splashes in the dimethicone condensing agent, be cooled to 14 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.
Embodiment 5:
A kind of Radix Codonopsis polysaccharide drop pill, by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 7, substrate is in polyoxyethylene monostearate or the glyceryl monostearate;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 100 ℃ the temperature, speed with 20 of per minutes splashes in the dimethicone condensing agent, be cooled to 10 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.
Claims (4)
1. Radix Codonopsis polysaccharide drop pill, it is characterized in that by making as the Radix Codonopsis polysaccharide of Radix Codonopsis active constituents of medicine with as the substrate of adjuvant, the weight ratio of Radix Codonopsis polysaccharide and substrate is 1: 1～1: 8, and described substrate is any one in polyethylene glycol 6000, Macrogol 4000, stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene monostearate, the glyceryl monostearate;
The preparation method of Radix Codonopsis polysaccharide drop pill is as follows: with Radix Codonopsis polysaccharide and substrate according to the aforementioned proportion mix homogeneously, after heating in water bath fusion under 70～100 ℃ the temperature, speed with 20～60 of per minutes splashes in the condensing agent, be cooled to 10～15 ℃ then, molding, remove condensing agent, promptly make the Radix Codonopsis polysaccharide drop pill.
2. a kind of Radix Codonopsis polysaccharide drop pill according to claim 1, the weight ratio that it is characterized in that described Radix Codonopsis polysaccharide and substrate is 1: 3.
3. a kind of Radix Codonopsis polysaccharide drop pill according to claim 1 and 2 is characterized in that described substrate is any one in polyethylene glycol 6000 or the Macrogol 4000.
4. a kind of Radix Codonopsis polysaccharide drop pill according to claim 1 and 2 is characterized in that described condensing agent is any one in dimethicone, liquid paraffin or the vegetable oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910250358A CN101703487A (en) | 2009-12-04 | 2009-12-04 | Codonopsis pilosula polysaccharide pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910250358A CN101703487A (en) | 2009-12-04 | 2009-12-04 | Codonopsis pilosula polysaccharide pill |
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| CN101703487A true CN101703487A (en) | 2010-05-12 |
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| CN200910250358A Pending CN101703487A (en) | 2009-12-04 | 2009-12-04 | Codonopsis pilosula polysaccharide pill |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525950A (en) * | 2012-02-10 | 2012-07-04 | 兰州大学 | Method for preparing pellets of Se-polysaccharides in Codonopsis pilosula |
| CN108024909A (en) * | 2015-09-18 | 2018-05-11 | 天士力医药集团股份有限公司 | A kind of continuous intelligent preparation method of liquid cooling dripping pill |
-
2009
- 2009-12-04 CN CN200910250358A patent/CN101703487A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102525950A (en) * | 2012-02-10 | 2012-07-04 | 兰州大学 | Method for preparing pellets of Se-polysaccharides in Codonopsis pilosula |
| CN108024909A (en) * | 2015-09-18 | 2018-05-11 | 天士力医药集团股份有限公司 | A kind of continuous intelligent preparation method of liquid cooling dripping pill |
| CN108024909B (en) * | 2015-09-18 | 2020-07-10 | 天士力医药集团股份有限公司 | Continuous intelligent preparation method of liquid cooling dropping pills |
| US10813840B2 (en) | 2015-09-18 | 2020-10-27 | Tasly Pharmaceutical Group Co., Ltd. | Intelligent continuous manufacturing method via liquid cooling of dripping pills |
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Application publication date: 20100512 |