CN101700244B - Novel wound paste constructed by water absorption pad of purely natural material - Google Patents
Novel wound paste constructed by water absorption pad of purely natural material Download PDFInfo
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- CN101700244B CN101700244B CN2009102232110A CN200910223211A CN101700244B CN 101700244 B CN101700244 B CN 101700244B CN 2009102232110 A CN2009102232110 A CN 2009102232110A CN 200910223211 A CN200910223211 A CN 200910223211A CN 101700244 B CN101700244 B CN 101700244B
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Abstract
The invention relates to a wound paste constructed by a water absorption pad of a purely natural material. The water absorption pad of the wound paste is completely prepared from the purely natural material. Compared with the water absorption pad of the traditional wound paste, the water absorption pad has uniform micro-pore structure, large specific surface area and strong adsorption capacity, so that the novel wound paste has very strong water absorption performance, has the performance of no wound adhesion and can act the functions of stopping bleeding, diminishing inflammation and recovering wounds. The wound paste constructed by the water absorption pad of the purely natural composite material has simple structure and low cost.
Description
Technical field
The invention belongs to medical instruments field.The present invention relates to a kind of adhesive bandage that makes up by pure natural composite adsorptive pads.
Background technology
" adhesive bandage " is usually used in hemostasis, the antiinflammatory of acute minor cut or wound or more creates.Be particularly useful for that otch is neat, cleaning, wound is less and the incised wound that need not sew up, scratch or stab.Because of it carries conveniently, easy to use, be fit to the fast pace of current society and receive the favor of consumer, thereby become family, hospital, the indispensable hygienic material of clinic first aid, belong to I class medical apparatus and instruments.
In principle, adhesive bandage has been stressed water absorption, inhales and has gone oozing of blood and wound sepage, reaches hemostasia effect through the physics compressing.What adhesive bandage played water sorption is adsorptive pads, but the material of adsorptive pads is mainly non-woven fabrics at present, and compound then layer of polyethylene porous membrane, this thin film mainly are to prevent that non-woven fabrics fiber and wound from adhering to each other.But polyethylene produces anaphylaxis to zest, the meeting of skin and wound.Therefore develop a kind of high-hydroscopicity that has, the adsorptive pads that does not adhere to wound simultaneously again is very necessary, can reduce the processing step of compound layer of polyethylene porous membrane like this.
The present invention adopts several kinds of natural medical polymers to prepare novel trauma exactly and uses adsorptive pads, thereby has developed a kind of novel adhesive bandage that is made up by pure natural material adsorptive pads.This adhesive bandage structure is simpler, and haemostatic effect is better, and cost is lower.
Summary of the invention
The object of the present invention is to provide a kind of adhesive bandage, this adhesive bandage is made up of base material, adsorptive pads and sealing coat three parts.
Wherein said adsorptive pads is to be processed by polysaccharide solution and protein solution.
Wherein polysaccharide is selected from: chitosan, alginic acid, glucosan, or hyaluronic acid macromolecule polysaccharide.
Albumen is selected from: fibroin albumen or collagen protein.
The concentration of polysaccharide solution is 1%～3% polysaccharide solution,
The concentration of protein solution is: 1%～5% protein solution.
Protein solution and polysaccharide solution are prepared into mixed solution, and the two concentration range in mixed solution is respectively 0.5%～5% and 0.5%-3%.
Consisting of of adsorptive pads wherein:
Adsorptive pads by fibroin albumen and the preparation of sodium alginate polysaccharide makes up novel adhesive bandage;
Adsorptive pads by fibroin albumen and Preparation of Chitosan makes up novel adhesive bandage;
Adsorptive pads by fibroin albumen and glucosan preparation makes up novel adhesive bandage;
Adsorptive pads by fibroin albumen and hyaluronic acid preparation makes up novel adhesive bandage;
Adsorptive pads by collagen protein and Preparation of Chitosan makes up novel adhesive bandage;
Adsorptive pads by collagen protein and glucosan preparation makes up novel adhesive bandage.
Another object of the present invention is to provide the method for preparing of adhesive bandage.
Said method for preparing concrete steps are following:
(1). the polysaccharide solution of preparation 1%～3%;
(2). the protein solution of preparation 1%～5%;
(3). preparation albumen/polysaccharide mixed solution;
(4). the molding of adsorptive pads;
(5). the cured of adsorptive pads;
(6). adhesive bandage processing
The method for preparing of adhesive bandage of the present invention:
(1). the polysaccharide solution of preparation 1%～3%: get a certain amount of deionized water or certain density organic solvent, the polysaccharide (chitosan, or alginic acid, or glucosan, or hyaluronic acid) of dissolving certain mass obtains viscous solution.
(2). the protein solution of preparation 1%～5%: get a certain amount of deionized water or certain density organic solvent, the albumen (collagen protein or fibroin albumen) of dissolving certain mass obtains protein solution.
(3). preparation albumen/polysaccharide mixed solution: albumen/chitosan mixed solution that prepared composition is different, the two concentration range in mixed solution are respectively 0.5%～5% and 0.5%-3%.Mix homogeneously.
(4). the molding of adsorptive pads: albumen/polysaccharide mixed solution is poured in the mould, and die size can be selected as required.Sample behind-20 ℃ of freezing 24h, again lyophilization 48h (54 ℃, 80Pa).
(5). cured: the sample after the lyophilization is taken out from mould, in polar solvent, soak 2～6h after, remove solution, and lyophilization 48h is to remove residual solution.Obtain the adsorptive pads of needs at last.
Most preferred method for preparing in an embodiment.
Novel adhesive bandage of the present invention, its adsorptive pads has loose structure, and the average-size in aperture is 100 microns.The absorbability to water of this composite of unit mass is 10～40 times of quality of composite, and unit mass is 10～40 times of composite quality to the absorbability of blood, and pH value scope and physiology pH value are approaching, between 6.5～7.4.
Novel adhesive bandage of the present invention, its adsorptive pads can directly firm sticking on the base material, can be compatible with various medical glue commonly used.
Novel adhesive bandage of the present invention can carry out disinfection to it with the oxirane steam or with reference to relevant international standard.
Novel adhesive bandage of the present invention can adopt heat-sealing or cold envelope etc. to carry out following process.Its production and processing conditional request is not high, need not improve existing equipment and just can produce.
Adhesive bandage of the present invention can be designed to different sizes and different shapes as required, to be applicable to the wound at different sizes and position.The size and dimension of adsorptive pads also can be processed as required.
Adhesive bandage of the present invention has carried out the hemostatic test, and relevant data is following: the blood adsorbance of adhesive bandage be own wt 20-40 doubly, blood on adhesive bandage setting time less than 1 minute.
The adsorptive pads of adhesive bandage is formed by the pure natural material preparation, has loose structure, and water absorbing capacity is extremely strong, can stop blooding rapidly, and possess certain antiinflammation.Adhesive bandage of the present invention, structure is simpler, and cost is lower.Because adsorptive pads possesses and the NA performance of wound, therefore on adsorptive pads, do not need porous membrane to prevent the adhesion of adhesive bandage and wound.
The specific embodiment:
To combine exemplifying embodiment further to illustrate content of the present invention below, but not as restriction of the present invention.
Embodiment 1: the adsorptive pads by fibroin albumen and the preparation of sodium alginate polysaccharide makes up novel adhesive bandage
(1). the silk fibroin protein solution of preparation 5%.Get fibroin albumen 2.0g, dissolving deionized water 40ml obtains viscous solution.
(2). the sodium alginate polysaccharide solution of preparation 3%.Get the 40mL deionized water, dissolving 1.2g sodium alginate obtains viscous solution.
(3). preparation fibroin albumen/mixed solution of sodium alginate.Above-mentioned two kinds of solution are mixed, and both ratios are 1: 1, mix homogeneously.
(4). the lyophilization molding.Fibroin albumen/mixed solution of sodium alginate is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again.
(5). methanol treatment.Sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h is to remove residual methanol.Obtain fibroin albumen/alginic acid polysaccharide adsorptive pads at last.
(6). the adsorptive pads with preparation in (5) is processed into different sizes as required.
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
Embodiment 2: the adsorptive pads by fibroin albumen and Preparation of Chitosan makes up novel adhesive bandage
(1). the silk fibroin protein solution of preparation 5%.Get fibroin albumen 2.0g, dissolving deionized water 40ml obtains viscous solution.
(2). the chitosan solution of preparation 3%.Get the acetic acid solution of 40mL0.2M, dissolving 1.2g chitosan obtains viscous solution.
(3). preparation fibroin albumen/chitosan mixed solution.Above-mentioned two kinds of solution are mixed, and both ratios are 1: 1, mix homogeneously.
(4). the lyophilization molding.Fibroin albumen/chitosan solution is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again.
(5). methanol treatment.Sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol.Obtain fibroin albumen/chitosan adsorptive pads at last.
(6). as required the adsorptive pads in (5) is processed into different sizes.
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
Embodiment 3: the adsorptive pads by fibroin albumen and glucosan preparation makes up novel adhesive bandage
(1). the silk fibroin protein solution of preparation 1%.Get fibroin albumen 0.4g, dissolving deionized water 40ml obtains viscous solution.
(2). the dextran solution of preparation 3%.Get the deionized water of 40mL, dissolving 1.2g glucosan obtains viscous solution.
(3). preparation fibroin albumen/glucosan mixed solution.Above-mentioned two kinds of solution are mixed, and both ratios are: 1: 1, and mix homogeneously.
(4). the lyophilization molding.Fibroin albumen/dextran solution is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again.
(5). methanol treatment.Sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol.Obtain fibroin albumen/glucosan adsorptive pads at last.
(6). as required the adsorptive pads in (5) is processed into different sizes.
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
Embodiment 4: the adsorptive pads by fibroin albumen and hyaluronic acid preparation makes up novel adhesive bandage
(1). the silk fibroin protein solution of preparation 5%.Get fibroin albumen 2.0g, dissolving deionized water 40ml obtains viscous solution.
(2). the hyaluronic acid solution of preparation 1%.Get the 40mL deionized water, dissolving 0.4g hyaluronic acid obtains viscous solution.
(3). preparation fibroin albumen/hyaluronic acid mixed solution.Above-mentioned two kinds of solution are mixed, and both ratios are 10: 1, mix homogeneously.
(4). the lyophilization molding.Fibroin albumen/hyaluronic acid solution is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again.
(5). methanol treatment.Sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol.Obtain fibroin albumen/hyaluronic acid adsorptive pads at last.
(6). as required the adsorptive pads in (5) is processed into different sizes.
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
Embodiment 5: the adsorptive pads by collagen protein and Preparation of Chitosan makes up novel adhesive bandage
(1). the collagen solution of preparation 5%.Get collagen protein 2.0g, dissolving deionized water 40ml obtains viscous solution.
(2). the chitosan solution of preparation 3%.Get the acetic acid solution of 40mL0.2M, dissolving 1.2g chitosan obtains viscous solution.
(3). preparation collagen protein/chitosan mixed solution.Above-mentioned two kinds of solution are mixed, and both ratios are 1: 1, mix homogeneously.
(4). the lyophilization molding.Collagen protein/chitosan solution is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again.
(5). methanol treatment.Sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol.Obtain collagen protein/chitosan adsorptive pads at last.
(6). as required the adsorptive pads in (5) is processed into different sizes.
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
Embodiment 6: the adsorptive pads by collagen protein and glucosan preparation makes up novel adhesive bandage
(1). the collagen solution of preparation 1%.Get collagen protein 0.4g, dissolving deionized water 40ml obtains viscous solution.
(2). the dextran solution of preparation 1%.Get the 40mL deionized water, dissolving 0.4g glucosan obtains viscous solution.
(3). preparation collagen protein/glucosan mixed solution.Above-mentioned two kinds of solution are mixed, and both ratios are 0.1: 1, mix homogeneously.
(4). the lyophilization molding.Collagen protein/dextran solution is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again.
(5). methanol treatment.Sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol.Obtain collagen protein/glucosan adsorptive pads at last.
(6). as required the adsorptive pads in (5) is processed into different sizes.
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
Claims (3)
1. adhesive bandage; Constitute by base material, adsorptive pads and sealing coat three parts; It is characterized in that: adsorptive pads is mixed and made into by polysaccharide solution and protein solution; After protein solution and polysaccharide solution mixed, the concentration range of albumen and polysaccharide was respectively 0.5%～5% and 0.5%-3%, and wherein concrete adsorptive pads is selected from:
Adsorptive pads by fibroin albumen and sodium alginate preparation;
Adsorptive pads by fibroin albumen and Preparation of Chitosan;
Adsorptive pads by fibroin albumen and glucosan preparation;
Adsorptive pads by fibroin albumen and hyaluronic acid preparation;
Adsorptive pads by collagen protein and Preparation of Chitosan;
Adsorptive pads by collagen protein and glucosan preparation;
The preparation process of above-mentioned adhesive bandage is following:
(1). the polysaccharide solution of preparation 1%～3%: get a certain amount of deionized water or certain density organic solvent, the polysaccharide of dissolving certain mass obtains viscous solution,
(2). the protein solution of preparation 1%～5%: get a certain amount of deionized water or certain density organic solvent, the albumen of dissolving certain mass obtains protein solution,
(3). the mixed solution of preparation albumen and polysaccharide: protein solution mixes with polysaccharide solution, and the mixing afterwards concentration range of albumen and polysaccharide is respectively 0.5%～5% and 0.5%-3%,
(4). the molding of adsorptive pads: the mixed solution of albumen and polysaccharide is poured in the mould, and die size is selected as required, sample behind-20 ℃ of freezing 24h, lyophilization 48h again,
(5). cured: the sample after the lyophilization is taken out from mould, in polar solvent, soak 2～6h after, remove solution, and lyophilization 48h obtains adsorptive pads to remove residual solution,
(6). adhesive bandage processing.
2. adhesive bandage according to claim 1 is characterized in that, the preparation process of adhesive bandage is following:
(1). the silk fibroin protein solution of preparation 5%, get fibroin albumen 2.0g, be dissolved in deionized water 40ml, obtain viscous solution,
(2). prepare 3% chitosan solution, get the acetic acid solution of 40mL0.2M, dissolving 1.2g chitosan obtains viscous solution,
(3). the mixed solution of preparation fibroin albumen and chitosan, above-mentioned two kinds of solution to be mixed, both ratios are 1: 1, mix homogeneously,
(4). the mixed solution of fibroin albumen and chitosan is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again,
(5). the sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol, obtain fibroin albumen/chitosan adsorptive pads at last,
(6). as required the adsorptive pads in (5) is processed into different sizes,
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
3. adhesive bandage according to claim 1 is characterized in that, the preparation process of adhesive bandage is following:
(1). the collagen solution of preparation 5%, get collagen protein 2.0g, be dissolved in deionized water 40ml, obtain viscous solution,
(2). prepare 3% chitosan solution, get the acetic acid solution of 40mL0.2M, dissolving 1.2g chitosan obtains viscous solution,
(3). the mixed solution of preparation collagen protein and chitosan, above-mentioned two kinds of solution to be mixed, both ratios are 1: 1, mix homogeneously,
(4). the mixed solution of collagen protein and chitosan is poured in the mould, the mould that sample is housed behind-20 ℃ of freezing 24h, lyophilization 48h again,
(5). the sample after the lyophilization is taken out from mould, after methanol soaks 2～6h, fall nor-alcohol, and lyophilization 48h removes residual methanol, obtain collagen protein/chitosan adsorptive pads at last,
(6). as required the adsorptive pads in (5) is processed into different sizes,
(7). with the adsorptive pads adhesive bandage production equipment of packing into, can produce.
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| CN2009102232110A CN101700244B (en) | 2009-11-20 | 2009-11-20 | Novel wound paste constructed by water absorption pad of purely natural material |
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| CN2009102232110A CN101700244B (en) | 2009-11-20 | 2009-11-20 | Novel wound paste constructed by water absorption pad of purely natural material |
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| CN106279749A (en) * | 2016-09-22 | 2017-01-04 | 大连工业大学 | A kind of alginate and the preparation method of fibroin albumen composite sponge |
| CN106913911B (en) * | 2017-02-23 | 2020-02-18 | 福建吉特瑞生物科技有限公司 | Medical collagen membrane for plastic surgery |
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