CN101700243B - Novel medicine carrying woundplast with treating function - Google Patents
Novel medicine carrying woundplast with treating function Download PDFInfo
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- CN101700243B CN101700243B CN2009102232106A CN200910223210A CN101700243B CN 101700243 B CN101700243 B CN 101700243B CN 2009102232106 A CN2009102232106 A CN 2009102232106A CN 200910223210 A CN200910223210 A CN 200910223210A CN 101700243 B CN101700243 B CN 101700243B
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- adhesive bandage
- mixed liquor
- spray coating
- chitosan
- liquor
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Abstract
The invention relates to a novel medicine carrying woundplast with treating functions of stopping bleeding, diminishing inflammation, sterilization and suppuration, promoting granulation and the like. The woundplast can timely treat wound and seed up wound coalescene and broadens usage of the traditional woundplast, and meanwhile the processing technology of the water uptake of the woundplast adopts a method of spraying and laminating mixed solution of multiple medicines/high polymers layer by layer, the medicines are contained in the interior of the water uptake and can realize the functions of slow releasing medicine and prolonging effective action time of medicines, which is different from the technology that medicine is directly sprayed on gauze, bandage or absorbent cotton.
Description
Technical field
The invention belongs to technical field of medical instruments.The present invention relates to a kind of novel medicine carrying adhesive bandage that possesses the treatment function and preparation method thereof.
Technical background
Adhesive bandage is usually used in hemostasis, the antiinflammatory of acute minor cut or wound or more creates, and is easy to use, thereby becomes family, hospital, the indispensable hygienic material of clinic first aid, belongs to I class medical apparatus and instruments.In principle, adhesive bandage is to have stressed water absorption, inhales and goes oozing of blood and wound sepage, reaches hemostasia effect through the physics compressing.
Present most of adhesive bandages on the market, though can play certain emergency protection effect to wound, to wound or the big and deep slightly wound that has infected, the therapeutical effect of do not possess antibiotic, antiinflammatory, more creating.Therefore developing the novel medicine carrying adhesive bandage that possesses therapeutical effect has very big practical significance, especially can not get under the situation of medical aid timely in the long period, and this adhesive bandage is with the effect of playing protection and treatment simultaneously.
Through research for a long time; We have developed a kind of novel medicine carrying adhesive bandage that possesses treatment functions such as hemostasis, antiinflammatory, antibacterial suppuration, granulation promoting; Can in time treat wound like this, accelerating wound makes the isolation of wrapping, wound and the disposable completion of treatment ability of protection and wound.Widened the purposes of traditional adhesive bandage.Simultaneously; What the processing technique of this adhesive bandage adsorptive pads adopted is the method that multiple medicine/the macromolecule mixed liquor successively sprays; Medicine is comprised in the inside of adsorptive pads; Can play the function of slow releasing pharmaceutical, the effective acting time of prolong drug, be different from the technology of directly medicine being sent forth on gauze, binder or absorbent cotton (like number of patent application 02139346.X).
Summary of the invention
The object of the present invention is to provide a kind of novel medicine carrying adhesive bandage that possesses treatment functions such as hemostasis, antiinflammatory, antibacterial suppuration, granulation promoting.
Medicine contg. fabric bandage of the present invention is on the interior pad of existing adhesive bandage, to coat a kind of medicine that can play hemostasis, antiinflammatory, antibacterial, suppuration, granulation promoting to wound, makes the medicine on the adhesive bandage can directly cover wound contacting, accelerating wound healing.Adhesive bandage of the present invention be on adsorptive pads through successively spraying medicine and high molecular mixed liquor, dry, synergetic technology is processed repeatedly.
Wherein said medicine is to be selected from: nanometer silver; Silver ion; Gentamycin sulfate, the curative of one or more in Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture be selected from: the macromolecule of one or more in fibroin albumen, collagen protein, chitosan, hyaluronic acid, the alginic acid mixes.
Wherein curative and polymer substance mix with certain proportion.
The mass ratio value scope of curative and polymer substance is 0.005～0.00005: 1
Preferred ratio value scope is: 0.008～0.00001: 1
Most preferred ratio value is 0.0001: 1
Another object of the present invention is to provide a kind of method for preparing of novel medicine carrying adhesive bandage.
Adhesive bandage of the present invention is processed into through following steps:
(1) gets different types of spray coating liquor that medicament that adhesive bandage makes and polymer substance are configured to;
(2) on adsorptive pads, spray a kind of spray coating liquor of step (1), take lyophilization after having sprayed;
(3) and then the another kind of spray coating liquor processed of spraying step (1), freezing, dry;
(4) repeat to spray 0-2 time, the kind of each spray coating liquor is all inequality, spray last one deck and drying after, adhesion one deck antiadhesion barrier;
(5) this adsorptive pads can carry out cutting by direct needs according to production equipment, carries out the production of adhesive bandage; The last sealing of adhesive bandage production will be selected cold envelope or heat-sealing processing technique according to the character of medicine.
Wherein the described spray coating liquor of step (1) is that medicine and polymer substance mix the mixed liquor that obtains in water, and drug level is 0.001-10%.Described different types of spray coating liquor is meant: the ingredient in the spray coating liquor is inequality.
The method for preparing of preferred adhesive bandage of the present invention is following:
(1) the different types of spray coating liquor that thing and polymer substance be configured to of getting it filled;
(2) on adsorptive pads, spray a kind of spray coating liquor of step (1), take lyophilization after having sprayed;
(3) and then the another kind of spray coating liquor processed of spraying step (1), freezing, dry;
(4) adhere to one deck antiadhesion barrier;
(5) this adsorptive pads can carry out cutting by direct needs according to production equipment, carries out the production of adhesive bandage; The last sealing of adhesive bandage production will be selected cold envelope or heat-sealing processing technique according to the character of medicine.
Its prescription of spray coating liquor as in the step (2) is: chitosan and Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture; Compound method is: the mixed liquor for preparing chitosan and Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture according to the mass ratio of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and chitosan 1: 125～10000; Wherein Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture belongs to prior art, can prepare by official method.
Its prescription of another kind of spray coating liquor in the step (3) is: chitosan and nanometer silver, compound method is: the mixed liquor for preparing chitosan and nanometer silver according to the mass ratio of nanometer silver and chitosan 1: 125～10000.
The most preferred method for preparing of the present invention in an embodiment.
The processing technique of novel medicine carrying adhesive bandage adsorptive pads of the present invention makes medicine be comprised in the inside of adsorptive pads; Can play the function of slow releasing pharmaceutical; The time of prolong drug useful effect, be different from directly and send medicine forth on gauze, binder or absorbent cotton technology.
The water absorption of the adsorptive pads of novel medicine carrying adhesive bandage of the present invention and good air permeability, the adding technology of medicine does not influence the water absorption and the breathability of adsorptive pads.Its adsorptive pads can directly firm being attached on the base material, can be compatible with various medical glue commonly used.
The relevant international standard of novel medicine carrying adhesive bandage epoxy available ethane steam of the present invention or reference carries out disinfection to it, to the nothing influence of medicine.
Novel medicine carrying adhesive bandage of the present invention can also be used for big slightly, deep wound except the function that possesses general adhesive bandage, or the treatment of the wound that has infected.
Adhesive bandage of the present invention has carried out the test of anti-inflammation hemostasia, and relevant data is following: the time-to-live of antibacterial on adhesive bandage was less than 3 hours; The blood adsorbance of adhesive bandage be own wt 25-30 doubly, blood on adhesive bandage setting time less than 1 minute.
In sum, adhesive bandage of the present invention plays timely treatment to wound, and accelerating wound makes the effect of treatment of isolation and protection, the wound of wrapping, wound.And the adhesive bandage among the present invention, simple in structure, cost is low, and medicine can slowly discharge, and adsorptive pads adopts natural biomaterial to be prepared from fully, and this medicine carrying adhesive bandage production and processing technology is simple, does not need to improve significantly the equipment on the market.
The specific embodiment:
To combine embodiment further to illustrate content of the present invention below, but not as restriction of the present invention.
The procedure of processing that implement 1, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and gentamycin sulfate on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of gentamycin sulfate is 0.0003%, and is freezing rapidly, dry;
(2) mixed liquor of spraying Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and collagen protein, collagen concentration is 2% in the mixed liquor, the concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage
The procedure of processing that implement 2, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and nanometer silver on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of nanometer silver is 0.0003%, and is freezing rapidly, dry;
(2) spraying Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and chitosan mixed liquor, the concentration of chitosan is 3% in the mixed liquor, the concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage
The procedure of processing that implement 3, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and nanometer silver on adsorptive pads, the concentration of chitosan is 1% in the mixed liquor, the concentration of nanometer silver is 0.0003%, and is freezing rapidly, dry;
(2) mixed solution of spraying gentamycin sulfate and collagen protein, collagen concentration is 2% in the mixed liquor, the concentration of gentamycin sulfate is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage
The procedure of processing that implement 4, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.003%, and is freezing rapidly, dry;
(2) spraying gentamycin sulfate and collagen protein mixed solution, collagen concentration is 2% in the mixed liquor, the concentration of gentamycin sulfate is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage
The procedure of processing that implement 5, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.0003%,
(2) mixed liquor of spraying nanometer silver and collagen protein, collagen concentration is 2% in the mixed liquor, the concentration of nanometer silver is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage
The procedure of processing that implement 6, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and gentamycin sulfate mixture on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of gentamycin sulfate mixture is 0.008%,
(2) spraying nanometer silver and collagen protein mixed liquor, collagen concentration is 2% in the mixed liquor, the concentration of nanometer silver is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage
The procedure of processing that implement 7, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed liquor of spraying chitosan and gentamycin sulfate mixture on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of gentamycin sulfate mixture is 0.0003%,
(2) spraying gentamycin sulfate; The mixed liquor of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and collagen protein, collagen concentration is 2% in the mixed liquor, the concentration of gentamycin sulfate is 0.0002%; The concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage.
The procedure of processing that implement 8, a kind of novel medicine carrying adhesive bandage that possesses the treatment function is concrete is following:
(1) mixed solution of spraying chitosan and gentamycin sulfate mixture on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of gentamycin sulfate mixture is 0.005%,
(2) spraying Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and collagen solution, collagen concentration is 2% in the mixed liquor, the concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, can directly be used for the production of adhesive bandage.
(5) the cold envelope of adhesive bandage.
Claims (7)
1. a medicine carrying adhesive bandage that possesses hemostasis, antiinflammatory, antibacterial suppuration, granulation promoting function is characterized in that, the adsorptive pads of adhesive bandage is through successively spraying medicine and high molecular mixed liquor, and is dry, synergetic technology is processed repeatedly; Wherein said medicine is to be selected from: nanometer silver; Silver ion; Gentamycin sulfate, the curative of one or more in Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture be selected from: the polymer substance of one or more in fibroin albumen, collagen protein, chitosan, hyaluronic acid, the alginic acid mixes; Wherein curative and polymer substance are mixedly configured into spray coating liquor; The mass ratio value scope of curative and polymer substance is 0.005～0.00005: 1.
2. medicine carrying adhesive bandage according to claim 1 is characterized in that, the mass ratio value scope of curative and polymer substance is: 0.008～0.0001: 1.
3. medicine carrying adhesive bandage according to claim 1; It is characterized in that; Consisting of of spray coating liquor: chitosan and gentamycin sulfate mixed liquor; Or Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and collagen protein mixed liquor, or chitosan and nanocrystalline silver-colored granule mixed liquor, or Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and chitosan mixed liquor.
4. medicine carrying adhesive bandage according to claim 1 is characterized in that, the consisting of of spray coating liquor: chitosan and nanocrystalline silver-colored granule mixed liquor, or Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and chitosan mixed liquor, its mass ratio is 1: 125～10000.
5. the method for preparing of described any one medicine carrying adhesive bandage of claim 1 is characterized in that method for making is following:
(1) different types of spray coating liquor of being mixedly configured into of medicament that adhesive bandage makes and polymer substance;
(2) on adsorptive pads, spray a kind of spray coating liquor that step (1) is processed, take lyophilization after having sprayed;
(3) and then the another kind of spray coating liquor processed of spraying step (1), freezing, dry;
(4) repeat to spray 0-2 time, the kind of each spray coating liquor is all inequality, spray last one deck and drying after, adhesion one deck antiadhesion barrier;
(5) this adsorptive pads can carry out cutting by direct needs according to production equipment, carries out the production of adhesive bandage, and the last sealing of adhesive bandage production will be selected cold envelope or heat-sealing processing technique according to the character of medicine;
6. method for preparing according to claim 5 is characterized in that method for making is following:
(1) the different types of spray coating liquor that thing and polymer substance be configured to of getting it filled;
(2) on adsorptive pads, spray a kind of spray coating liquor of step (1), take lyophilization after having sprayed;
(3) and then the another kind of spray coating liquor processed of spraying step (1), freezing, dry;
(4) adhere to one deck antiadhesion barrier;
(5) this adsorptive pads can carry out cutting by direct needs according to production equipment, carries out the production of adhesive bandage; The last sealing of adhesive bandage production will be selected cold envelope or heat-sealing processing technique according to the character of medicine;
Wherein the described spray coating liquor of step (1) is that medicine and polymer substance mix the mixed liquor that obtains in water, and drug level is 0.001-10%, and described different types of spray coating liquor is meant: the ingredient in the spray coating liquor is inequality.
7. method for preparing according to claim 6 is characterized in that method for making is following:
(1) mixed liquor of spraying chitosan and gentamycin sulfate on adsorptive pads, the concentration of chitosan is 3% in the mixed liquor, the concentration of gentamycin sulfate is 0.0003%, and is freezing rapidly, dry;
(2) mixed liquor of spraying Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture and collagen protein, collagen concentration is 2% in the mixed liquor, the concentration of Gypsum Fibrosum Preparatum/Hydrargyri Oxydum Rubrum mixture is 0.0002%, takes lyophilization after having sprayed;
(3) adhere to one deck antiadhesion barrier;
(4) after this adsorptive pads cutting, directly be used for the production of adhesive bandage,
(5) the cold envelope of adhesive bandage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102232106A CN101700243B (en) | 2009-11-20 | 2009-11-20 | Novel medicine carrying woundplast with treating function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102232106A CN101700243B (en) | 2009-11-20 | 2009-11-20 | Novel medicine carrying woundplast with treating function |
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| CN101700243A CN101700243A (en) | 2010-05-05 |
| CN101700243B true CN101700243B (en) | 2012-05-02 |
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| CN2009102232106A Expired - Fee Related CN101700243B (en) | 2009-11-20 | 2009-11-20 | Novel medicine carrying woundplast with treating function |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102120043B (en) * | 2011-02-23 | 2013-09-11 | 中国人民解放军军事医学科学院基础医学研究所 | Absorbent cotton gauze containing nanometer silver and chitosan, preparation device as well as method thereof |
| CN103784968B (en) * | 2012-11-02 | 2016-12-21 | 西北农林科技大学 | A kind of antibiotic-chitosan covalent complex and its preparation method and application |
| CN106333939A (en) * | 2016-10-09 | 2017-01-18 | 常州亚环环保科技有限公司 | Method for preparing medicinal transdermal material |
| CN109674771A (en) * | 2019-02-22 | 2019-04-26 | 陈仁奇 | A kind of erythromycin adhesive bandage |
| CN112057437B (en) * | 2019-12-10 | 2021-08-06 | 江苏一全药业有限公司 | Pharmaceutical preparation containing hyaluronic acid, pharmaceutical transdermal patch and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1473628A (en) * | 2002-08-06 | 2004-02-11 | 杨志洪 | New strong anti-infectious medical dressing |
| CN1679825A (en) * | 2005-01-14 | 2005-10-12 | 西北大学 | Powdery wound paste with instant soluble seal and production thereof |
| CN201161002Y (en) * | 2008-01-29 | 2008-12-10 | 上海高纯生物材料股份有限公司 | Chitin containing adhesive bandage |
-
2009
- 2009-11-20 CN CN2009102232106A patent/CN101700243B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1473628A (en) * | 2002-08-06 | 2004-02-11 | 杨志洪 | New strong anti-infectious medical dressing |
| CN1679825A (en) * | 2005-01-14 | 2005-10-12 | 西北大学 | Powdery wound paste with instant soluble seal and production thereof |
| CN201161002Y (en) * | 2008-01-29 | 2008-12-10 | 上海高纯生物材料股份有限公司 | Chitin containing adhesive bandage |
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| CN101700243A (en) | 2010-05-05 |
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