CN101693398B - Mould release agent used for producing empty capsule and preparation method thereof - Google Patents
Mould release agent used for producing empty capsule and preparation method thereof Download PDFInfo
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- CN101693398B CN101693398B CN2009101848708A CN200910184870A CN101693398B CN 101693398 B CN101693398 B CN 101693398B CN 2009101848708 A CN2009101848708 A CN 2009101848708A CN 200910184870 A CN200910184870 A CN 200910184870A CN 101693398 B CN101693398 B CN 101693398B
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- lecithin
- oleic acid
- calcium hydroxide
- cotton seed
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Abstract
The invention relates to a hard capsule, in particular to a mould release agent used for producing empty capsules and a preparation method thereof; the mould release agent used for producing empty capsules consists of cotton seed oil, salad oil, liquid paraffin, simethicone, oleic acid, calcium hydroxide and lecithin, and the components by mass ratio are as follows: 70 to 200 parts of the cotton seed oil, 50 to 300 parts of the salad oil, 10 to 200 parts of the liquid paraffin, 10 to 60 parts of the simethicone, 1 to 50 parts of the oleic acid, 10 to 70 parts of the calcium hydroxide and 10 to 110 parts of the lecithin; and by adopting the mould release agent, short bodies and short caps of single capsule sections and a series of B-type defects and C-type defects such as cracking of demoulding and insufficient cutting and the like can be reduced when producing the capsule, demoulding effect is better and the qualification rate of product can be obviously improved.
Description
One, technical field
The present invention relates to hard shell capsules, particularly the releasing agent of snap fit capsule and plant hard capsule production process.
Two, background technology
At pharmaceuticals industry and the health-product market capsule that has been widely used.Its main application is to be used for solid, semisolid, liquid, pill or herbal medicinal product as a kind of formulation.A main purpose of these formulations is the disintegratives that provide after the administration, can in the digestive organs that are fit to, active material effectively dissolved.So, during storing finished product before use, must keep the stable of this disintegrative.The traditional material that is used to form capsule shells is a gelatin; Because it has suitable and very desirable character, and do the production of Capsules, releasing agent is very important; When requirement is dipped in glue at mould; Glue has good cohesive, after glued membrane shaping drying, is easy to from mold separation again.The quality of the demoulding directly has influence on the qualification rate of product; The bad demoulding is prone to cause the short body of capsule single-unit, short cap; So that the appearance of splitting, cutting a series of defectives such as bad of the demoulding; Cause the qualification rate of product to be difficult to improve, so after needing a kind of new releasing agent, make the problems referred to above obtain.
Three, summary of the invention:
Technical purpose
The purpose of this invention is to provide a kind of releasing agent and preparation method thereof; The bad demoulding was prone to cause the short body of capsule single-unit, short cap during this releasing agent had solved effectively and produced; So that the appearance of splitting, cut a series of defectives such as bad of the demoulding, make the qualification rate raising of product.
Technical scheme
The present invention has following technical scheme to accomplish:
A kind of releasing agent that is used to produce Capsules is characterized in that being made up of cotton seed oil, salad oil, atoleine, dimethicone, oleic acid, calcium hydroxide, lecithin; Above-mentioned each components in mass portion number is respectively, cotton seed oil 70-200 part, salad oil 50-300 part, atoleine 10-200 part, dimethicone 10-60 part, oleic acid content 1-50 part, calcium hydroxide 10-70 part, lecithin 10-110 part.
A kind of method of releasing agent of preparation is characterized in that following steps:
A, with calcium hydroxide 10-70 part, cotton seed oil 70-200 part, salad oil 50-300 part, mixing with high-pressure sterilizing pot temperature 80-140 ℃ the sterilization 4-8 hour, for use;
B, atoleine 10-200 part, lecithin 10-110 part are added in the above-mentioned raw materials when 90 ℃ of the temperature, after stirring, get dimethicone 10-60 part, oleic acid 1-50 part and when 80 ℃ of temperature, add and stir, filter in the time of 50 ℃, obtain releasing agent.
Described cotton seed oil, salad oil, atoleine, lecithin, dimethicone are in the present invention as surfactant, and described calcium hydroxide, oleic acid are as anticorrisive agent.
Beneficial effect
1, adopt releasing agent of the present invention, can when producing capsule, significantly be reduced to the short body of capsule single-unit, short cap, down to the demoulding split, cut a series of category-B defectives and C class defectives such as bad, stripping result is better, can significantly improve the qualification rate of product.Corresponding standard is referring to seaweed plants Capsules standard Q/320683UAD01-2008.
2, preparation method's of the present invention technology is simple, and easy operating is with low cost.
3, adopting the invention component all is common product, and useful large-scale production reduces cost.
Four, the specific embodiment
Embodiment 1
A kind of releasing agent that is used to produce Capsules is characterized in that being made up of cotton seed oil, salad oil, atoleine, dimethicone, oleic acid, calcium hydroxide, lecithin, by weight percentage; Described cotton seed oil 200g; Salad oil 300g, atoleine 200g, dimethicone 60g.Oleic acid 50g, calcium hydroxide 70g, lecithin 110g.
The method for preparing above-mentioned releasing agent:
1, gets cotton seed oil 200g, salad oil 300g, calcium hydroxide 70g mixing with high-pressure sterilizing pot high temperature 4-8 hour, select 80-140 ℃ of temperature;
2, atoleine 200g, lecithin 110g are added in the above-mentioned raw materials when 90 ℃ of the temperature, stir, get dimethicone 60g, oleic acid 50g after the interpolation, select temperature to add for 80 ℃ to stir, after filtering in the time of 50 ℃, finished product.
Referring to seaweed plants Capsules standard Q/320683UAD01-2008
Embodiment 2
A kind of releasing agent that is used to produce Capsules is characterized in that being made up of cotton seed oil, salad oil, atoleine, dimethicone, oleic acid, calcium hydroxide, lecithin, by weight percentage; Described cotton seed oil 180g; Salad oil 220g, atoleine 180g, dimethicone 50g.Oleic acid 40g, calcium hydroxide 60g, lecithin 100g.
The method for preparing above-mentioned releasing agent:
1, gets cotton seed oil 180g, salad oil 220g, calcium hydroxide 60g mixing with high-pressure sterilizing pot high temperature 4-8 hour, select 80-140 ℃ of temperature;
2, atoleine 180g, lecithin 100g are added in the above-mentioned raw materials when 90 ℃ of the temperature, stir, get dimethicone 50g, oleic acid 40g after the interpolation, select temperature to add for 80 ℃ to stir, after filtering in the time of 50 ℃, finished product.
| Project | Old mould oil | New mould oil |
| The category-A defective proportion | 2％ | 1.0％ |
| The category-B defective proportion | 7％ | 3％ |
| C class defective proportion | 10％ | 4.5％ |
| Stripping result | Generally | Better |
| Physical and chemical index | Not influence | Not influence |
| Product percent of pass | 80％ | 91％ |
Referring to seaweed plants Capsules standard Q/320683UAD01-2008
Embodiment 3
A kind of releasing agent that is used to produce Capsules is characterized in that by cotton seed oil, salad oil, liquid stone
| Project | Old mould oil | The present invention |
| The category-A defective proportion | 2％ | 1.5％ |
| The category-B defective proportion | 7％ | 2.1％ |
| C class defective proportion | 10％ | 4.1％ |
| Stripping result | Generally | Better |
| Physical and chemical index | Not influence | Not influence |
| Product percent of pass | 80％ | 92％ |
| Project | Old mould oil | New mould oil |
| The category-A defective proportion | 2％ | 1.0％ |
| The category-B defective proportion | 7％ | 5％ |
| C class defective proportion | 10％ | 5％ |
| Stripping result | Generally | Better |
| Physical and chemical index | Not influence | Not influence |
| Product percent of pass | 80％ | 89％ |
Wax, dimethicone, oleic acid, calcium hydroxide, lecithin are formed, by weight percentage, and described cotton seed oil 70g, salad oil 50g, atoleine 10g, dimethicone 10g.Oleic acid 1g, calcium hydroxide 10g, lecithin 10g.
Prepare above-mentioned Capsules and produce the method for releasing agent:
1, gets cotton seed oil 70g, salad oil 50g, calcium hydroxide 10g mixing with high-pressure sterilizing pot high temperature 4-8 hour, select 110 ℃ of temperature;
2, atoleine 10g, lecithin 10g are added in the above-mentioned raw materials when 90 ℃ of the temperature, stir, get dimethicone 10g, oleic acid 1g after the interpolation, select temperature to add for 80 ℃ to stir, after filtering in the time of 50 ℃, finished product.Referring to seaweed plants Capsules standard Q/320683UAD01-2008
Embodiment 4
A kind of releasing agent that is used to produce Capsules is characterized in that being made up of cotton seed oil, salad oil, atoleine, dimethicone, oleic acid, calcium hydroxide, lecithin, by weight percentage; Described cotton seed oil 120g; Salad oil 220g, atoleine 150g, dimethicone 40g.Oleic acid 40g, calcium hydroxide 50g, lecithin 90g.
The method for preparing above-mentioned releasing agent:
1, gets cotton seed oil 120g, salad oil 220g, calcium hydroxide 50g, mixing with high-pressure sterilizing pot high temperature 4-8 hour, select 110 ℃ of temperature.
2, atoleine 150g, lecithin 90g are added in the above-mentioned raw materials when 90 ℃ of the temperature, stir, get dimethicone 40g, oleic acid 40g after the interpolation, select temperature to add for 80 ℃ to stir, after filtering in the time of 50 ℃, finished product.
| Stripping result | Generally | Better |
| Physical and chemical index | Not influence | Not influence |
| Product percent of pass | 80％ | 89％ |
| Project | Old mould oil | New mould oil |
| The category-A defective proportion | 2％ | 1.0％ |
| The category-B defective proportion | 7％ | 2％ |
| C class defective proportion | 10％ | 2％ |
| Stripping result | Generally | Better |
| Physical and chemical index | Not influence | Not influence |
| Product percent of pass | 80％ | 95％ |
Referring to seaweed plants Capsules standard Q/320683UAD01-2008
Claims (2)
1. a releasing agent that is used to produce Capsules is characterized in that being made up of cotton seed oil, salad oil, atoleine, dimethicone, oleic acid, calcium hydroxide, lecithin; Above-mentioned each components in mass portion number is respectively, cotton seed oil 70-200 part, salad oil 50-300 part, atoleine 10-200 part, dimethicone 10-60 part, oleic acid content 1-50 part, calcium hydroxide 10-70 part, lecithin 10-110 part.
2. method for preparing the said releasing agent of claim 1 is characterized in that following steps:
A, get cotton seed oil 70-200 part, salad oil 50-300 part, calcium hydroxide 10-70 part mixing with high-pressure sterilizing pot temperature 80-140 ℃ of sterilization 4-8 hour, for use;
B, atoleine 10-200 part, lecithin 10-110 part are added in the above-mentioned raw materials when 90 ℃ of the temperature, after stirring, get dimethicone 10-60 part, oleic acid 1-50 part and when 80 ℃ of temperature, add and stir, filter in the time of 50 ℃, obtain releasing agent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101848708A CN101693398B (en) | 2009-10-16 | 2009-10-16 | Mould release agent used for producing empty capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009101848708A CN101693398B (en) | 2009-10-16 | 2009-10-16 | Mould release agent used for producing empty capsule and preparation method thereof |
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| CN101693398A CN101693398A (en) | 2010-04-14 |
| CN101693398B true CN101693398B (en) | 2012-02-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109551687A (en) * | 2018-11-06 | 2019-04-02 | 青岛聚大洋藻业集团有限公司 | A kind of preparation method of the dedicated mould oil of Capsules |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102248622B (en) * | 2011-06-30 | 2013-05-01 | 浙江大之医药胶囊有限公司 | Capsule mold release agent and preparation method thereof |
| CN103382409B (en) * | 2013-07-24 | 2014-11-26 | 湖北人福康华药用辅料有限公司 | Mould oil for pharmaceutical grade capsule and preparation method thereof |
| CN104403737B (en) * | 2014-09-25 | 2017-08-11 | 安徽华盛科技控股股份有限公司 | The production technology of CIT capsule releasing agents |
| CN104827611B (en) * | 2015-05-11 | 2017-01-25 | 江苏力凡胶囊有限公司 | Low-viscosity capsule mold release agent and preparation method thereof |
| CN105058644A (en) * | 2015-08-19 | 2015-11-18 | 湖北长江星医药股份有限公司 | Mold oil for medicinal hollow capsule production and preparation method thereof |
| CN106738516A (en) * | 2016-11-22 | 2017-05-31 | 湖北人福药用辅料股份有限公司 | A kind of Capsules automatic production line releasing agent and preparation method thereof |
| CN108972977A (en) * | 2018-07-05 | 2018-12-11 | 何治伟 | A kind of wood plastic composite release agent |
| CN110283647A (en) * | 2019-06-19 | 2019-09-27 | 江苏力凡胶囊有限公司 | A kind of preparation method of Capsules release agent |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002720A (en) * | 2000-03-01 | 2007-07-25 | Pvaxx研究和开发有限公司 | Method and apparatus for blowmolding capsules of polyvinylalcohol and blowmolded polyvinylalcohol capsules |
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- 2009-10-16 CN CN2009101848708A patent/CN101693398B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002720A (en) * | 2000-03-01 | 2007-07-25 | Pvaxx研究和开发有限公司 | Method and apparatus for blowmolding capsules of polyvinylalcohol and blowmolded polyvinylalcohol capsules |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109551687A (en) * | 2018-11-06 | 2019-04-02 | 青岛聚大洋藻业集团有限公司 | A kind of preparation method of the dedicated mould oil of Capsules |
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| CN101693398A (en) | 2010-04-14 |
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Address after: 226399 No. 8 Jinqiao West Road, Tongzhou Economic Development Zone, Jiangsu, Nantong Patentee after: Jiangsu Chenxing pharmaceutical Limited by Share Ltd Address before: 226300 No. 8 Jinqiao West Road, Tongzhou Economic Development Zone, Jiangsu, Nantong Patentee before: Jiangsu Zodiac Marine Biotechnology Co., Ltd. |