CN106738516A - A kind of Capsules automatic production line releasing agent and preparation method thereof - Google Patents

Abstract

The present invention is a kind of for Capsules automatic production line demoulding agent prescription and preparation method；The releasing agent is constituted by raw material of pharmaceutical grade phosphatide, pharmaceutical grade atoleine and food-grade oleic acid；Each raw material is respectively by mass fraction：Pharmaceutical grade phosphatide：45~70 parts, pharmaceutical grade atoleine：25~35 parts, food-grade oleic acid：5~20 parts；It is well mixed after 20~30 DEG C, static 2~3 hours under the conditions of humidity 55~65%, is preserved after encapsulation.The present invention can efficiently solve releasing agent in use, easy carbonization, easy smoke, perishable, difficult smearing, the problems such as gamble pipeline, dirty equipment；Also, the brushing surface of product is wide, and equal amount is 1 times of general releasing agent brushing surface, and consumption is few, effect is good, and capsule appearance is intact, bright, the abrasion of equipment is reduced, increased the service life, reduce dimension rate, be difficult moldy metamorphism, do not produce poisonous and harmful substance.Medicine, food and health products production requirement are complied fully with, production process low cost is environment-friendly.

Description

A kind of Capsules automatic production line releasing agent and preparation method thereof

Technical field

The present invention relates to a kind of Capsules automatic production line releasing agent and preparation method.

Background technology

It is used to produce Capsules most equipment outside Current Domestic using automatic production line, used by full automatic line Releasing agent or releasing agent be generally natural type releasing agent, the overwhelming majority is by crude vegetal, natural plants wax and mineral oil Composition, such as：Animal fat, peanut oil, salad oil, palm oil, butter solid, white oil；There are the following problems in use：

（1）These natural releasing agents, it is different degrees of in use to add antioxidant, EP agent, oiliness Agent etc., these compositions often have certain toxicity, have a significant impact for product；

（2）Used under hot and humid environment, soon president bacterium, moldy metamorphism, poisonous and harmful substance is produced, so as to pollute Product；

（3）Smoke point is relatively low, and a large amount of cigarettes are produced in baking, influences production environment；

（4）Viscosity is big, and fusing point is high, is not easy to smearing and is not easy to cleaning equipment, if during using spraying apparatus, often blocking pipeline, makes With inconvenience；

（5）Component comparison is not pure, and containing sulphur and aromatic component, water content is oxidized easily and emulsifies.

It is therefore desirable to a kind of new releasing agent causes that above mentioned problem is addressed.

The content of the invention

It is an object of the present invention to provide a kind of high temperature resistant, viscosity is low, painting oil mass is few, component is pure, be difficult putrid and deteriorated food Grade hard shell capsules automatic production line releasing agent and preparation method.

The purpose of above-mentioned technical problem is solved to reach, the technical scheme is that：

A kind of Capsules automatic production line releasing agent, its each component mass fraction is：

5~70 parts of phosphatidase 4；

25~35 parts of liquid paraffin；

5~20 parts of oleic acid.

A kind of Capsules automatic production line releasing agent preparation method, including step：

A chooses phosphatide and is added in reactor according to the component of claim 1 by mass fraction, with the liquid less than recipe quantity Paraffin washing dress phosphatide container, the phosphatide of washing is poured into reactor in the lump；

B presses mass fraction and chooses atoleine according to the component of claim 1（Remove the amount of washing container）, oleic acid；

The atoleine of selection, oleic acid mixing are added in reactor, and are slowly heated to 40~45 DEG C of temperature by C in the lump, together When stir 35~45 minutes, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that it is saturating that product is presented yellow Prescribed liquid shape；

D static 2~3 hours under the conditions of humidity 55~65%, discharges bubble therein at 20~30 DEG C, obtains viscosity and exists The releasing agent of 245.0mPa.s~265.0mPa.s.

Beneficial effect：

1 releasing agent of the invention be yellowish-brown color oily liquids, it is uniform, without lamination.

2 releasing agent viscosity of the invention are low, are thus susceptible to smear, and equipment surface and internal residual amount are few, it is easy to clean, and use Amount is few, and stripping result more preferably, is increased operation rate.

3 release agent components of the invention are purer, and sulfur-bearing and aromatic component are few, and water content is few, be difficult be oxidized and Emulsification.

4 releasing agents of the invention can be reduced and set without antioxidant, EP agent, oiliness improver etc., long service life Standby abrasion, the service life of extension device, and reduce frequency of maintenance.

5 at 20~30 DEG C, processed under the conditions of humidity 55~65%, and the operation improves the stability problem of releasing agent, makes Obtain releasing agent and be difficult bacterium long, moldy metamorphism, produce poisonous and harmful substance.

6 inside capsule walls reduce residual without mist of oil；To high-end transparent capsule and plant capsule more preferably, transparency is higher, takes off Imitate fruit more preferably.

Releasing agent prepared by the present invention is contrasted with existing releasing agent, and indices are as follows：

Commercially available prod demoulding agent prescription

Vegetable oil 80~90%

White oil 80~90%

Atoleine 10~20%

Project	Releasing agent prepared by the present invention	Vegetable oil	White oil	Atoleine
					Demoulding success rate	98.0%-99.0%	93.0%-95.0%	94.0%-97.0%	94.0%-96.0%
Brush oil mass	1 time	2 times	2 times	2 times
					Mould pin applies oil mass	0.001ml	0.002	0.003	0.003
Whether oil dripping phenomenon is had	Without oil dripping phenomenon	Occasionally there is oil dripping situation	There is oil dripping situation	There is oil dripping situation
					24 hours consumptions	220-240ml	350-400 ml	380-420 ml	400-450 ml
Product percent of pass	98%	95%	93%	94%
					Transparency and glossiness	Weak yellow liquid	Yellow oily liquid	Transparent oily liquid	Transparent oily liquid

The present invention has the advantages that compared with prior art as seen from the above table：

1 demoulding success rate improves 3~4%；

2 equipment residual quantities are greatly lowered, and consumption is few, and stripping result more preferably, is increased operation rate；

3 capsule production lines are average to be less than 2470ml per consumption per day, and inside capsule wall reduces residual without mist of oil；

4 product percents of pass improve 3-5%, and, transparency is higher, and stripping result is more to high-end transparent capsule and plant capsule more preferably It is good；

The process is simple of 5 preparation methods, it is easy to operate, it is with low cost, have and be easy to large-scale production, reduces cost.

6 releasing agents of the invention are not only applicable to gelatin hollow capsule, apply also for various plant hollow capsules, should It is wider with scope.

Brief description of the drawings

Fig. 1 preparation flow figures of the invention

Rhombus represents material in figure；Ellipse garden represents operation, and arrow represents flow, and rectangle represents operation, rectangle shadow representation Environment cleanliness.

Specific embodiment

Enough White Mineral Oils are added in reactor, isothermal holding 1~2 hour at a temperature of 90~100 DEG C, filtered；Together Be added to enough soybean lecithins in reactor by sample, and isothermal holding 1~2 hour, standby at a temperature of 90~100 DEG C.

Recipe quantity phosphatide is added in reactor, will be a small amount of（Less than recipe quantity）The appearance of phosphatide is contained in atoleine washing Device, it is standby in washing reactor.

Case study on implementation 1：

Grade phosphatidase 4 5Kg is taken food, pharmaceutical grade atoleine takes 35 Kg, food-grade oleic acid 20Kg respectively,

Food-grade phosphatide is added in reactor, isothermal holding 1 hour at a temperature of 40 DEG C, pharmaceutical grade atoleine is added To in reactor, equally be added to food-grade oleic acid in reactor by isothermal holding 1 hour at a temperature of 40 DEG C, in 40 DEG C of temperature The lower isothermal holding of degree 1 hour, it is standby；

To mix by the atoleine of pretreatment, phosphatide and oleic acid, and be slowly heated to 35 DEG C of temperature, while 45 points of stirring Clock, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that product is presented pale yellow liquid；

At 20 DEG C, static 2 hours under the conditions of humidity 55%, releasing agent of the viscosity in 375.5mPa.s is obtained.

Case study on implementation 2

Grade phosphatidase 4 5Kg is taken food, pharmaceutical grade atoleine takes 40 Kg, food-grade oleic acid 15Kg respectively,

Food-grade phosphatide is added in reactor, isothermal holding 1 hour at a temperature of 40 DEG C, pharmaceutical grade atoleine is added To in reactor, equally be added to food-grade oleic acid in reactor by isothermal holding 1 hour at a temperature of 40 DEG C, in 40 DEG C of temperature The lower isothermal holding of degree 1 hour, it is standby；

To mix by the atoleine of pretreatment, phosphatide and oleic acid, and be slowly heated to 35 DEG C of temperature, while 45 points of stirring Clock, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that product is presented pale yellow liquid；

At 20 DEG C, static 2 hours under the conditions of humidity 55%, releasing agent of the viscosity in 305.0mPa.s is obtained.

Case study on implementation 3

Grade phosphatidase 4 5Kg is taken food, pharmaceutical grade atoleine takes 35 Kg, food-grade oleic acid 20Kg respectively,

Food-grade phosphatide is added in reactor, isothermal holding 1 hour at a temperature of 40 DEG C, pharmaceutical grade atoleine is added To in reactor, equally be added to food-grade oleic acid in reactor by isothermal holding 1 hour at a temperature of 40 DEG C, in 40 DEG C of temperature The lower isothermal holding of degree 1 hour, it is standby；

To mix by the atoleine of pretreatment, phosphatide and oleic acid, and be slowly heated to 35 DEG C of temperature, while 30 points of stirring Clock, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that product is presented pale yellow liquid；

At 20 DEG C, static 2 hours under the conditions of humidity 55%, releasing agent of the viscosity in 423.0mPa.s is obtained.

Case study on implementation 4

Grade phosphatidase 4 5Kg is taken food, pharmaceutical grade atoleine takes 40 Kg, food-grade oleic acid 15Kg respectively,

Food-grade phosphatide is added in reactor, isothermal holding 1 hour at a temperature of 40 DEG C, pharmaceutical grade atoleine is added To in reactor, equally be added to food-grade oleic acid in reactor by isothermal holding 1 hour at a temperature of 40 DEG C, in 40 DEG C of temperature The lower isothermal holding of degree 1 hour, it is standby；

To mix by the atoleine of pretreatment, phosphatide and oleic acid, and be slowly heated to 35 DEG C of temperature, while 50 points of stirring Clock, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that product is presented pale yellow liquid；

At 20 DEG C, static 2 hours under the conditions of humidity 55%, releasing agent of the viscosity in 285.0mPa.s is obtained.

Contrast case 1：

Grade phosphatidase 3 5Kg is taken food, pharmaceutical grade atoleine takes 45 Kg, food-grade oleic acid 20Kg respectively,

Food-grade phosphatide is added in reactor, isothermal holding 1 hour at a temperature of 40 DEG C, pharmaceutical grade atoleine is added To in reactor, equally be added to food-grade oleic acid in reactor by isothermal holding 1 hour at a temperature of 40 DEG C, in 40 DEG C of temperature The lower isothermal holding of degree 1 hour, it is standby；

To mix by the atoleine of pretreatment, phosphatide and oleic acid, and be slowly heated to 35 DEG C of temperature, while 45 points of stirring Clock, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that product is presented pale yellow liquid；

At 20 DEG C, static 2 hours under the conditions of humidity 55%, releasing agent of the viscosity in 255.5mPa.s is obtained.

Contrast case 2：

Grade phosphatidase 4 5Kg is taken food, pharmaceutical grade atoleine takes 40 Kg, food-grade oleic acid 15Kg respectively,

Food-grade phosphatide is added in reactor, isothermal holding 1 hour at a temperature of 40 DEG C, pharmaceutical grade atoleine is added To in reactor, equally be added to food-grade oleic acid in reactor by isothermal holding 1 hour at a temperature of 40 DEG C, in 40 DEG C of temperature The lower isothermal holding of degree 1 hour, it is standby；

To mix by the atoleine of pretreatment, phosphatide and oleic acid, and be slowly heated to 35 DEG C of temperature, while 40 points of stirring Clock, mixing speed 50r/min is well mixed it, to without colo(u)r breakup so that product is presented pale yellow liquid；

At 20 DEG C, static 2 hours under the conditions of humidity 55%, releasing agent of the viscosity in 265.0mPa.s is obtained.

Viscosity of the invention is to take appropriate releasing agent, is heated to 40-45 DEG C, is measured with NDJ-8S viscosity instruments Data.

The technical indicator of target level of product quality and product

Claims (2)

1. a kind of Capsules automatic production line releasing agent, it is characterised in that releasing agent is composed of the following components, each component Mass fraction is：

5~70 parts of phosphatidase 4；

25~35 parts of liquid paraffin；

5~20 parts of oleic acid；

Described thickener be phosphatide, one or more of soybean lecithin, meet pharmaceutical grade requirement；

Described diluent is one or more in atoleine, light liquid petrolatum, meets pharmaceutical grade requirement；

Described HBL values conditioning agent is oleic acid.

2. a kind of Capsules automatic production line releasing agent preparation method, including step：

A chooses phosphatide and is added in reactor according to the component of claim 1 by mass fraction, with the liquid stone less than recipe quantity Wax washing dress phosphatide container, the phosphatide of washing is poured into reactor in the lump；

B chooses atoleine (removing the amount of washing container), oleic acid according to the component of claim 1 by mass fraction；

The atoleine of selection, oleic acid mixing are added in reactor, and are slowly heated to 40~45 DEG C of temperature by C in the lump, together When stir 35~45 minutes, mixing speed 50.0r/min is well mixed it, to without colo(u)r breakup so that product is presented yellow Transparency liquid shape；

D static 2~3 hours under the conditions of humidity 55~65%, discharges bubble therein at 20~30 DEG C, obtains viscosity and exists The releasing agent of 245.0mPa.s~265.0mPa.s.