CN104403737B - The production technology of CIT capsule releasing agents - Google Patents
The production technology of CIT capsule releasing agents Download PDFInfo
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- CN104403737B CN104403737B CN201410499405.4A CN201410499405A CN104403737B CN 104403737 B CN104403737 B CN 104403737B CN 201410499405 A CN201410499405 A CN 201410499405A CN 104403737 B CN104403737 B CN 104403737B
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Abstract
The invention discloses a kind of production technology of CIT capsules releasing agent, the raw materials by weight portion of capsule releasing agent includes：63~72 parts of paraffin, 120~140 parts of zinc stearate, 120~130 parts of stearic acid, 50~60 parts of soybean lecithin, 5 20 parts of fatty alcohol, 40 54 parts of vegetable oil, 5 10 parts of glycerine, 12 18 parts of silicone grease, it is first that vegetable oil, silicone grease, glycerine, fatty alcohol heating stirring is uniform, it is added into again in the reactor equipped with the paraffin melted, sequentially add zinc stearate, stearic acid, soybean lecithin, insulated and stirred is simultaneously filtered, and is described capsule releasing agent after filtrate cooling.The production technology of CIT capsule releasing agents in the present invention, raw material is simple and easy to get, technique is simple and convenient to operate, it is easy to large-scale production, the releasing agent of production while product qualification rate is improved for improving capsule transparency and finish, with good effect.
Description
Technical field
The present invention relates to technical field of mold release, more particularly to a kind of production technology of CIT capsules releasing agent.
Background technology
In pharmacy and health products trade, capsule is widely used in a kind of shell of protection medicine.The medicine of capsule dress, one
As be all to esophagus and gastric mucosa powder excitatory or particle, or mouthfeel it is bad, be easy to volatilization, in the oral cavity easily by saliva
Decompose, and the easily medicine of suction tracheae, if these medicines are loaded into capsule, both protected medicine property of medicine not to be destroyed, also protected
Digestive organs and respiratory tract.Remove capsule shells and be likely to result in drug wastage, drug waste, drug effect reduction.These capsules
In production process, the especially production process of Capsules, releasing agent be as one of which important component, it is essential.
Releasing agent is an a kind of interface coating for being used in two body surfaces for being easy to adhesion each other, and it can make object table
Face is easy to disengaging, smooth and cleaning, and capsule releasing agent mainly enables capsule smoothly to be come off from mould, and bad releasing agent will be made
Cracking wrinkle, influence product appearance and die life are produced into capsule body surface, and brings environmental pollution etc. is a series of to lack
Sunken appearance, releasing agent in the market can largely reduce the transparency and finish of capsule, influence capsule attractive in appearance and
Quality, it is therefore desirable to which a kind of efficient, safe and pollution-free and simple for production releasing agent solves the above problems.
The content of the invention
To solve technical problem present in background technology, the present invention proposes a kind of production technology of CIT capsules releasing agent,
Releasing agent in the production technology can efficiently solve it is bad be stripped cause utricule surface checking, reduce capsule transparency and
The problems such as finish.
A kind of production technology of CIT capsules releasing agent proposed by the present invention, the raw materials by weight portion bag of capsule releasing agent
Include：63~72 parts of paraffin, 120~140 parts of zinc stearate, 120~130 parts of stearic acid, 50~60 parts of soybean lecithin, fatty alcohol
5~20 parts, 40~54 parts of vegetable oil, 5~10 parts of glycerine, 12~18 parts of silicone grease；The production technology bag of the CIT capsules releasing agent
Include following processing step：
S1, under agitation, silicone grease, glycerine, fatty alcohol are sequentially added into vegetable oil, 50~60 DEG C are to slowly warm up to
Continue 1~4h of stirring afterwards and obtain material liquid；
S2, to paraffin carry out heat wait melt to liquid when start stirring, be slowly added under the conditions of 70~100 DEG C in S1
Material liquid, continue stir 8~14h obtain grease；
S3, the grease obtained in S2 is heated to after 80-110 DEG C, sequentially adds zinc stearate, stearic acid, soybean
Light yellow milk is obtained after lecithin, 2~6h of insulated and stirred；
S4, the milk obtained in S3 filtered, it is the capsule releasing agent that gained filtrate, which is cooled to after normal temperature,.
In releasing agent, paraffin is cheap in itself, and it is good to be deposited with performance, by coordinating with other releasing agents as lubricated lipid
In use, effect is more preferable.
Stearic acid, soybean lecithin have good hydrophilic and oleophylic performance, can be used as environment-friendly type surfactant, with stone
Wax can effectively improve the effect of releasing agent with the use of when making releasing agent.
Zinc stearate can be used as the releasing agent of clear plastic articles, can be effectively improved the transparency and light of demolded article
Degree.
Estersil is a kind of high polymer releasing agent, can be uniformly distributed film forming in die surface, simultaneously because surface tension is low, it is right
Various materials have prominent resistance to bond, that is, have good from film, be a kind of environmentally friendly, nontoxic releasing agent raw material.
Vegetable oil, fatty alcohol are a kind of interfacial agent system releasing agents, are characterized in that isolation performance is good.And glycerine, can be straight
Connect as releasing agent or curing bag lubricant.
The production technology of a kind of CIT capsules releasing agent in the present invention, by according to the technical recipe and step making
Into releasing agent, the efficiency and heat endurance of releasing agent can be substantially improved.It is tasteless and the releasing agent is colourless, it is nontoxic, do not hinder skin
Skin, it is harmless.
Heretofore described paraffin is preferably 65~No. 80 microcrystalline waxes.Such as described paraffin is No. 65, No. 70, No. 75
With No. 80 microcrystalline waxes etc..Microcrystalline wax is a kind of refined synthetic wax of approximate crystallite property, with good luster, and fusing point is high, color
The characteristics of pool is shallow, its close structure is hard and lubricious, can mutually be melted with various native paraffins, improve the performance of thick property wax.
The fatty alcohol is preferably one or more combinations in Decanol, n-octyl alcohol, laruyl alcohol.
The vegetable oil is preferably one or more combinations in linseed oil, soybean oil, peanut oil, corn oil, tung oil.
The silicone grease is preferably lubrication silicone grease.Lubrication silicone grease has splendid water resistance, can in wet condition provide and hold
Lubricate long and sealing property；Lubricating silicone grease also has excellent electrical insulation properties, anti-chemical mediator, anti-oxidant, dust-proof, resistance to spoke
Penetrate, ageing-resistant performance, and temperature in use scope is wide, under the great temperature difference performance can be maintained constant；Adaptability for materials is strong, and nothing
Poison, tasteless and nonirritant, comply fully with environmental requirement.
As optimal technical scheme, the raw materials by weight portion of capsule releasing agent of the present invention includes：It is 65~70 parts of paraffin, hard
125~136 parts of resin acid zinc, 124~128 parts of stearic acid, 54~58 parts of soybean lecithin, 9~16 parts of fatty alcohol, vegetable oil 45~
52 parts, 6~9 parts of glycerine, 13~16 parts of silicone grease.
As optimal technical scheme, the production technology of CIT capsules releasing agent of the present invention, it is comprised the technical steps that：
S1, by vegetable oil add the first reactor in, silicone grease, glycerine, fatty alcohol are sequentially added under agitation, slowly
It is warming up to after 52~58 DEG C and continues to stir 2~3h；
S2, by paraffin add the second reactor in, be heated to 65~75 DEG C using steam and paraffin heated, stone
Wax, which melts, starts stirring when being in a liquid state, the material liquid in S1 is slowly added under the conditions of 80~90 DEG C, continues 10~12h of stirring and obtains
To grease；
S3, the grease obtained in S2 is heated to 90~100 DEG C, sequentially adds zinc stearate, stearic acid, soybean ovum
Light yellow milk is obtained after phosphatide, 3~4h of insulated and stirred；
S4, the milk obtained in S3 filtered under the conditions of 50 DEG C, be the capsule after the cooling of gained filtrate
Releasing agent.
The production technology of CIT capsule releasing agents in the present invention, raw material is simple and easy to get, technique is simple and convenient to operate, it is easy to
Large-scale production；The releasing agent gumminess of production is good, adhesive force is strong, into mould stability is good, the demoulding easily and breakage rate is low, improve
Product qualification rate, simultaneously for capsule transparency and finish is improved, with good effect.
Embodiment
The present invention proposes a kind of capsule releasing agent, and its raw materials by weight portion includes：63~72 parts of paraffin, zinc stearate
120~140 parts, 120~130 parts of stearic acid, 50~60 parts of soybean lecithin, 5~20 parts of fatty alcohol, 40~54 parts of vegetable oil,
5~10 parts of glycerine, 12~18 parts of silicone grease.
In a particular embodiment, the parts by weight of paraffin can for 64,65,65.2,66,67,67.8,68,69,70,70.5,
71 parts, the parts by weight of zinc stearate can for 122,124,125,125.8,127,128,130,130.5,131,134,136,
136.2nd, 137,138 parts, stearic parts by weight can for 121,123,123.3,124,124.4,125,127,127.6,
128th, 129 parts, the parts by weight of soybean lecithin can for 51,52,53,54.6,55,56,57.4,58,59.3 parts, fatty alcohol
Parts by weight can for 6,7,7.6,8,9.2,10,11.5,12,12.8,14,15,16.1,17,18,18.4,19 parts, vegetable oil
Parts by weight can for 41,42,44,45,45.5,47,48,48.6 parts, the parts by weight of glycerine can for 5.5,6.5,7,7.6,8,
8.2nd, 9 parts, the parts by weight of silicone grease can for 13,14,15.2,15.8,16,17.7,18,19 parts.
According to the raw material proportioning of above-mentioned capsule releasing agent, the production technology of the CIT capsules releasing agent includes following technique
Step：
S1, under agitation, silicone grease, glycerine, fatty alcohol are sequentially added into vegetable oil, 50~60 DEG C are to slowly warm up to
Continue 1~4h of stirring afterwards and obtain material liquid；
S2, to paraffin carry out heat wait melt to liquid when start stirring, be slowly added under the conditions of 70~100 DEG C in S1
Material liquid, continue stir 8~14h obtain grease；
S3, the grease obtained in S2 is heated to after 80-110 DEG C, sequentially adds zinc stearate, stearic acid, soybean
Light yellow milk is obtained after lecithin, 2~6h of insulated and stirred；
S4, the milk obtained in S3 filtered, it is the capsule releasing agent that gained filtrate, which is cooled to after normal temperature,.
Embodiment 1
A kind of capsule demoulding agent producing process that the embodiment of the present invention is proposed, the raw materials by weight portion bag of capsule releasing agent
Include：No. 65 63 parts of microcrystalline waxes, 140 parts of zinc stearate, 130 parts of stearic acid, 50 parts of soybean lecithin, 20 parts of Decanol, flax
54 parts of oil, 5 parts of glycerine, 12 parts of silicone grease of lubrication；
Matched according to above-mentioned raw materials, the production technology of the CIT capsules releasing agent is comprised the technical steps that：
S1, by linseed oil add the first reactor in, sequentially add under agitation lubrication silicone grease, glycerine, Decanol,
It is to slowly warm up to after 50 DEG C and stirs 3.5h；
S2, No. 65 microcrystalline waxes are added in 200L stainless steel cauldrons, 65 DEG C are heated to paraffin using steam
Heated, it is paraffin melting to start stirring when being in a liquid state, the material liquid in S1 is slowly added under the conditions of 75 DEG C, continues to stir
13h obtains grease；
S3, the grease obtained in S2 is heated to 100 DEG C, sequentially adds zinc stearate, stearic acid, soybean lecithin
Light yellow milk is obtained after fat, insulated and stirred 3h；
S4, the milk obtained in S3 filtered under the conditions of 50 DEG C, it is that capsule takes off that gained filtrate, which is cooled to after normal temperature,
Mould agent.
Embodiment 2
A kind of capsule demoulding agent producing process that the embodiment of the present invention is proposed, the raw materials by weight portion bag of capsule releasing agent
Include：No. 75 72 parts of microcrystalline waxes, 120 parts of zinc stearate, 120 parts of stearic acid, 60 parts of soybean lecithin, 5 parts of laruyl alcohol, soybean oils
40 parts, 10 parts of glycerine, lubrication 18 parts of silicone grease；
Matched according to above-mentioned raw materials, the production technology of the CIT capsules releasing agent is comprised the technical steps that：
S1, by soybean oil add the first reactor in, sequentially add under agitation lubrication silicone grease, glycerine, laruyl alcohol,
2.5h is stirred after being slowly warmed up 60 DEG C；
S2, No. 75 microcrystalline waxes are added in 200L stainless steel cauldrons, 75 DEG C are heated to paraffin using steam
Heated, it is paraffin melting to liquid when start stirring, the material liquid stirred in S1 is slowly added under the conditions of 90 DEG C, is stirred
Mix 12h and obtain grease；
S3, the material liquid obtained in S2 is heated to 90 DEG C, sequentially adds zinc stearate, stearic acid, soybean lecithin,
Light yellow milk is obtained after insulated and stirred 4h；
S4 filters the milk obtained in S3 under the conditions of 50 DEG C, is capsule releasing agent after the cooling of gained filtrate..
Embodiment 3
A kind of capsule demoulding agent producing process that the embodiment of the present invention is proposed, the raw materials by weight portion bag of capsule releasing agent
Include：No. 70 72 parts of microcrystalline waxes, 136 parts of zinc stearate, 125 parts of stearic acid, 56 parts of soybean lecithin, 12 parts of n-octyl alcohol, corns
47 parts of oil, 8 parts of glycerine, 15 parts of silicone grease of lubrication；
Matched according to above-mentioned raw materials, the production technology of the CIT capsules releasing agent is comprised the technical steps that：
S1, by corn oil add the first reactor in, sequentially add under agitation lubrication silicone grease, glycerine, n-octyl alcohol,
58 DEG C are slowly warmed up, 3h is stirred；
S2, No. 70 microcrystalline waxes are added in 200L stainless steel cauldrons, 70 DEG C are heated to paraffin using steam
Heated, it is paraffin melting to liquid when start stirring, be slowly added to the material liquid in S1 under the conditions of 85 DEG C, continue to stir
12h obtains grease；
S3, by what is obtained in S2 80 DEG C are heated to, sequentially add zinc stearate, stearic acid, soybean lecithin, insulation is stirred
Mix and light yellow milk is obtained after 6h；
S4 filters the milk obtained in S3 under the conditions of 50 DEG C, and it is the capsule demoulding that gained filtrate, which is cooled to after normal temperature,
Agent.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (4)
1. a kind of production technology of capsule releasing agent, it is characterised in that the raw materials by weight portion of capsule releasing agent includes：Paraffin
63~72 parts, 120~140 parts of zinc stearate, 120~130 parts of stearic acid, 50~60 parts of soybean lecithin, fatty alcohol 5~20
Part, 40~54 parts of vegetable oil, 5~10 parts of glycerine, 12~18 parts of silicone grease；The production technology of the capsule releasing agent includes following work
Skill step：
S1, under agitation, silicone grease, glycerine, fatty alcohol are sequentially added into vegetable oil, be to slowly warm up to 50~60 DEG C it is follow-up
1~4h of continuous stirring obtains material liquid；
S2, to paraffin carry out heat wait melt to liquid when start stirring, the original in S1 is slowly added under the conditions of 70~100 DEG C
Feed liquid, continues 8~14h of stirring and obtains grease；
S3, the grease obtained in S2 is heated to after 80-110 DEG C, sequentially adds zinc stearate, stearic acid, soybean lecithin
Light yellow milk is obtained after fat, 2~6h of insulated and stirred；
S4, the milk obtained in S3 filtered, it is the capsule releasing agent that gained filtrate, which is cooled to after normal temperature,；
And paraffin is 65~No. 80 microcrystalline waxes；And vegetable oil be in linseed oil, soybean oil, peanut oil, corn oil, tung oil one
Plant or multiple combinations；Fatty alcohol is one or more combinations in Decanol, n-octyl alcohol, laruyl alcohol.
2. the production technology of capsule releasing agent according to claim 1, it is characterised in that the silicone grease is lubrication silicone grease.
3. the production technology of the capsule releasing agent according to any one of claim 1~2, it is characterised in that capsule releasing agent
Raw materials by weight portion include：65~70 parts of paraffin, 125~136 parts of zinc stearate, 124~128 parts of stearic acid, soybean ovum
4~58 parts of phosphatidase 5,9~16 parts of fatty alcohol, 45~52 parts of vegetable oil, 6~9 parts of glycerine, 13~16 parts of silicone grease.
4. the production technology of the capsule releasing agent according to any one of claim 1~2, it is characterised in that the capsule takes off
The production technology of mould agent is comprised the technical steps that：
S1, vegetable oil added in the first reactor, silicone grease, glycerine, fatty alcohol are sequentially added under agitation, slow heating
Continue to stir 2~3h after to 52~58 DEG C；
S2, by paraffin add the second reactor in, be heated to 65~75 DEG C using steam and paraffin heated, paraffin melts
Change starts stirring when being in a liquid state, the material liquid in S1 is slowly added under the conditions of 80~90 DEG C, continues 10~12h of stirring and obtains oil
Shape thing；
S3, the grease obtained in S2 is heated to 90~100 DEG C, sequentially adds zinc stearate, stearic acid, soybean lecithin
Light yellow milk is obtained after fat, 3~4h of insulated and stirred；
S4, the milk obtained in S3 filtered under the conditions of 50 DEG C, be the capsule demoulding after the cooling of gained filtrate
Agent.
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| CN201410499405.4A CN104403737B (en) | 2014-09-25 | 2014-09-25 | The production technology of CIT capsule releasing agents |
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| CN201410499405.4A CN104403737B (en) | 2014-09-25 | 2014-09-25 | The production technology of CIT capsule releasing agents |
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| CN104403737B true CN104403737B (en) | 2017-08-11 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104827611B (en) * | 2015-05-11 | 2017-01-25 | 江苏力凡胶囊有限公司 | Low-viscosity capsule mold release agent and preparation method thereof |
| CN106553295A (en) * | 2016-11-01 | 2017-04-05 | 广西大学 | A kind of releasing agent of polyurethane elastomer material |
| CN107118833A (en) * | 2017-06-04 | 2017-09-01 | 李家友 | A kind of preparation method of compound releasing agent for concrete demoulding |
| CN108972977A (en) * | 2018-07-05 | 2018-12-11 | 何治伟 | A kind of wood plastic composite release agent |
| CN109551687A (en) * | 2018-11-06 | 2019-04-02 | 青岛聚大洋藻业集团有限公司 | A kind of preparation method of the dedicated mould oil of Capsules |
| CN110154284B (en) * | 2019-06-14 | 2021-04-06 | 江苏力凡胶囊有限公司 | Release agent for hollow hard capsules and preparation method thereof |
| CN110281431A (en) * | 2019-06-17 | 2019-09-27 | 江苏力凡胶囊有限公司 | A kind of Capsules release agent of low viscosity and preparation method thereof |
| EP3845622A1 (en) | 2020-01-03 | 2021-07-07 | Indian Oil Corporation Limited | High temperature zinc complex grease |
| CN114085701B (en) * | 2021-11-23 | 2022-07-05 | 科之杰新材料集团有限公司 | Water-based concrete release agent and preparation method thereof |
| CN116144415A (en) * | 2022-12-28 | 2023-05-23 | 刘艳平 | Composite modified emulsified lubricating oil |
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| CN101693398A (en) * | 2009-10-16 | 2010-04-14 | 江苏辰星海洋生物科技有限公司 | Mould release agent used for producing empty capsule and preparation method thereof |
| CN102248622A (en) * | 2011-06-30 | 2011-11-23 | 浙江大之医药胶囊有限公司 | Capsule mold release agent and preparation method thereof |
| CN102284675A (en) * | 2010-06-17 | 2011-12-21 | 霍山县诚胜金属制品有限公司 | Lubricating oil for die-casting and de-molding |
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2014
- 2014-09-25 CN CN201410499405.4A patent/CN104403737B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101693398A (en) * | 2009-10-16 | 2010-04-14 | 江苏辰星海洋生物科技有限公司 | Mould release agent used for producing empty capsule and preparation method thereof |
| CN102284675A (en) * | 2010-06-17 | 2011-12-21 | 霍山县诚胜金属制品有限公司 | Lubricating oil for die-casting and de-molding |
| CN102248622A (en) * | 2011-06-30 | 2011-11-23 | 浙江大之医药胶囊有限公司 | Capsule mold release agent and preparation method thereof |
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