CN101690740B - Calculi dissolving agent for treating urologic calculi - Google Patents

Calculi dissolving agent for treating urologic calculi Download PDF

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Publication number
CN101690740B
CN101690740B CN2009100192369A CN200910019236A CN101690740B CN 101690740 B CN101690740 B CN 101690740B CN 2009100192369 A CN2009100192369 A CN 2009100192369A CN 200910019236 A CN200910019236 A CN 200910019236A CN 101690740 B CN101690740 B CN 101690740B
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calculi
calculus
dissolving agent
treatment
citric acid
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CN2009100192369A
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CN101690740A (en
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刘少鸽
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Abstract

The invention relates to a calculi dissolving agent for treating urologic calculi, belonging to the drugs for treating urologic calculi. The calculi dissolving agent comprises the following raw materials in percentage by weight: 5% of citric acid, 3% of ammonium molybdate, 2% of N-acetyl-D-glucosamine, 2% of panax notoginseng saponins, 20% of crystal sugar and the balance water. The calculi dissolving agent has the effects of softening calculi, dissolving calculi quickly, producing no simulation to urethra when the calculi are expelled, alleviating the pains of the patients and contributing to quick recovery and good treatment effects.

Description

A kind of litholytic for the treatment of urinary system calculus disease
Technical field
The present invention relates to a kind of litholytic for the treatment of urinary system calculus disease, belong to the medicine for the treatment of urinary system calculus.
Background technology
Urinary system calculus refers to that kidney, ureter, urethra, wing jump calculus, and the traditional Chinese medical science claims river renal calculus ", be one of common clinical, also do not have at present a kind of evident in efficacy, use wide medicine.
External supersonic ripple lithotripsy in treatment is difficult to effective radical cure, causes infection easily, and the recurrence of hepatolithiasis rate is higher, and human body and organ are caused certain damage.
Chinese medicine renal calculus is just on the books from ancient times, but many places are in through the clinical of proved recipe, folk prescription and drug efficacy study stage, and it is slow to take effect, and uncertain therapeutic efficacy is cut.
All there is the high deficiency of cost in above-mentioned Therapeutic Method.
A kind of medicine for the treatment of urinary system calculus disease is cheaply arranged at present, is to adopt oral citric acid to carry out the dissolving of calculus, takes for a long time, and it is dwindled, and peels off, and calculus is discharged from urethra.But the reaction that its shortcoming one is citric acid and calculus is slower, can not dissolve calculus apace, and treatment time is longer; The 2nd, when the calculus of dwindling is discharged, can stimulate urethra from urethra, produce huge painful.
Summary of the invention
The present invention is in order to overcome the deficiency of above technical elements, provides a kind of and made that litholysis is fast, calculus does not stimulate urethra when discharging, can alleviate the litholytic of the treatment urinary system calculus disease of patient's sufferings.
The present invention realizes by following measure:
The present invention relates to a kind of litholytic for the treatment of urinary system calculus disease, it is characterized in that containing following raw materials by weight percent: 5% citric acid, 3% ammonium molybdate, 2%N-acetyl-D-amino glucose, 2% arasaponin, 20% crystal sugar, surplus is a water.
Citric acid (citric acid) chemistry 2-hydroxy propane-1,2 by name, 3-tricarboxylic acids monohydrate.Colourless translucent crystallization, white granular or white crystalline powder; Odorless; Flavor is acid extremely; Little in dry air have air slaking; Aqueous solution shows acid reaction.
The inventor finds, a certain amount of arasaponin and ammonium molybdate are added in the citric acid, and the mixed liquor that is made into can promote the softening of calculus, shortens the calculus efflux time; Simultaneously, because calculus is softening, when calculus is discharged, can alleviate patient's pain.
Arasaponin (or Radix Notoginseng total arasaponins) is the total saponins that extracts in the Folium Notoginseng.Its preparation method is: get Folium Notoginseng, decoct with water twice, each 3 hours, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.2 (60 ℃), add ethanol and make that to contain alcohol amount be 60%, leave standstill and make precipitation, get supernatant, filter, decolouring, destaining solution reclaims ethanol, and being concentrated into relative density is the clear paste of 1.2 (60 ℃), drying, promptly.
In the prescription of the present invention, add a certain amount of N-acetyl-D-amino glucose, can effectively treat the inflammation of urinary system, have the effect of external microorganism field planting of antagonism and promotion local skin tissue repair, it is fast to have rehabilitation concerning the calculus patient, the advantage that therapeutic effect is good.
The invention has the beneficial effects as follows: can soften that calculus, litholysis are fast, calculus does not stimulate urethra when discharging, can alleviate patient's sufferings, rehabilitation is fast, therapeutic effect good, cost is low.
The specific embodiment:
Preparation: get the 5Kg citric acid, the 3Kg ammonium molybdate, 2Kg N-acetyl-D-amino glucose, the 2Kg arasaponin, the 20Kg crystal sugar adds in the 68Kg medical distilled water and dissolves, the bottling of sterilization back.
Usage and consumption: oral, three times on the one, each 30ml, seven days is a course of treatment, totally three courses of treatment.
Test: the present invention is by to system's clinical treatment observation of 100 routine urinary system calculus patients, and according to different signs such as different medical histories, age, sick times, divides into groups, treatment, and the observed result of its curative effect (being as the criterion with ultrasound diagnosis) is as following table:
Figure DEST_PATH_GSB00000489833100021
Model case:
Case 1: patient Zhao Jialin: the man, 45 years old, Tianqiao District Bei Yuan people from town, Jinan City, Shandong Province, ultrasound diagnosis, left renal calculus 0.7*0.6cm takes medicine of the present invention from January 15th, 2009, discharges the calculus of small rice grain size after 12 days with urine, during calculus, mild pain is arranged.Take medicine and check after three courses of treatment, the B ultrasonic result shows: left kidney is not seen calculus.
Case 2: patient Yuan Xiaojun: the woman, 42 years old, Licheng District Zhong Gong people from town, Jinan City, Shandong Province, ultrasound diagnosis urinary stone 0.7*0.5cm, on May 6th, 2009 was taken medicine of the present invention, discharged the calculus of small rice grain size after 10 days with urine, during calculus, mild pain was arranged.Take medicine and check after three courses of treatment, the B ultrasonic result shows: not seeing has calculus.

Claims (1)

1. litholytic for the treatment of urinary system calculus disease is characterized in that being made up of following raw materials by weight percent: 5% citric acid, and 3% ammonium molybdate, 2%N-acetyl-D-amino glucose, 2% arasaponin, 20% crystal sugar, surplus is a water;
Described arasaponin preparation method is: get Folium Notoginseng, decoct with water twice, each 3 hours, collecting decoction filters, and relative density was 1.2 clear paste when filtrate was concentrated into 60 ℃, add ethanol and make that to contain alcohol amount be 60%, leave standstill and make precipitation, get supernatant, filter, decolouring, destaining solution reclaims ethanol, and relative density is 1.2 clear paste when being concentrated into 60 ℃, drying, promptly.
CN2009100192369A 2009-10-13 2009-10-13 Calculi dissolving agent for treating urologic calculi Expired - Fee Related CN101690740B (en)

Priority Applications (1)

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CN101690740B true CN101690740B (en) 2011-07-20

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4893864B2 (en) * 2010-07-21 2012-03-07 三浦工業株式会社 Determination of total phosphorus
ES2486442B1 (en) * 2014-04-02 2015-06-11 Universitat De Les Illes Balears Combined preparations of urinary basifiers and crystallization inhibitors and their application for the treatment or prevention of uric acid or uric acid induced renal lithiasis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061721A (en) * 1990-11-27 1992-06-10 沈阳铁路局中心医院 A kind of preparation method of litholytic
CN1322530A (en) * 2000-05-09 2001-11-21 詹炳炎 Niaoshijiang as medicine for preventing and treating urinary tract infection
CN1416868A (en) * 2002-11-26 2003-05-14 邓运想 Medicine for treating urinary calculus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061721A (en) * 1990-11-27 1992-06-10 沈阳铁路局中心医院 A kind of preparation method of litholytic
CN1322530A (en) * 2000-05-09 2001-11-21 詹炳炎 Niaoshijiang as medicine for preventing and treating urinary tract infection
CN1416868A (en) * 2002-11-26 2003-05-14 邓运想 Medicine for treating urinary calculus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
易延华等.枸橼酸钾防治泌尿系结石的研究新进展.《广西医学》.2007,第29卷(第9期),第1379-1381页. *
邓芳等.植物药抑制泌尿系结石形成的化学基础.《化学研究》.2007,第18卷(第3期),第99-103页. *

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