CN101687117A

CN101687117A - A high capacity biological fluid filtration apparatus

Info

Publication number: CN101687117A
Application number: CN200780052584A
Authority: CN
Inventors: P·小祖克
Original assignee: Hemerus Medical LLC
Current assignee: Hemerus Medical LLC
Priority date: 2007-02-22
Filing date: 2007-02-22
Publication date: 2010-03-31
Anticipated expiration: 2027-02-22
Also published as: AU2007347456A1; EP2125135A4; CN101687117B; JP5329437B2; MX2009009035A; BRPI0721268A2; EA200901130A1; WO2008103142A1; EA016521B1; AU2007347456B2; CA2679044A1; EP2125135A1; JP2010518962A

Abstract

A biological fluid filtration device, system, and method, for filtering a biological fluid, the device comprising a housing having an inlet, a first outlet and a second outlet, with a first fluid flowpath defined between the inlet and the first outlet, with a second fluid flow path defined between the inlet and the second outlet, with a first biological fluid filtration media interposed between the inlet and the first outlet and across the first fluid flow path, with a second biological fluid filtration media interposed between the inlet and the second outlet and across the second fluid flowpath, the housing essentially lacking a solid partition wall between the first biological fluid filtration media and the second biological fluid filtration media, a first flow restriction may be addeddownstream of the first biological fluid filtration media, and a second flow restriction may be added downstream of the second biological fluid filtration media, in another embodiment, the device comprises a housing having an inlet an outlet with a flow path defined between the inlet and the outlet, with a biological fluid filtration media interposed between the inlet and the outlet and across the fluid flow path, the device further including a flow restriction downstream of the biological fluid filtration media.

Description

High capacity biological fluid filtration apparatus

Technical field

The present invention relates to filtration art, and more particularly, relate to improved low hold-up (lowhold up) biological fluid filtration system, comprise low hold-up bilateral Biolagical fluid filteration device, it does not have spaced walls, energy filtering biological fluid comprises from blood or blood product removing component or chemicals, comprises from Red Blood Cells Concentrate (packed red cell) removing leucocyte and removing prion from blood or blood product.

Background technology

The name of submitting in March 27 calendar year 2001 is called the U.S. Patent number 6 of " HIGH CAPACITY GRAVITYFEED FILTER FOR FILTERING BLOOD AND BLOODPRODUCTS ", 660, disclose bilateral Biolagical fluid filteration device among the 171B2, it comprises single inlet and single outlet and spaced walls.The name that body was submitted to September 3 in 2004 is called in the number of patent application 10/934,881 of " A BIOLOGICAL FLUID FILTRATIONAPPARATUS " and discloses the bilateral Biolagical fluid filteration device that comprises spaced walls.The name of submitting on September 7th, 2004 is called among the PCT application number PCT/US2004/02926 of " ABIOLOGICAL FLUID FILTRATION APPARATUS " and also discloses the bilateral Biolagical fluid filteration device that comprises spaced walls.Number of patent application 10/934,881 with number of patent application PCT/US2004/029026 bilateral Biolagical fluid filteration device is disclosed, it comprises two independent fluid flow paths that separated by spaced walls, and each fluid flow path comprises independent inlet and outlet, thereby allows independently the biofluid that comprises blood and blood product of two unit is filtered.

Patent No. US 6,231, and 770B1 has described the bilateral biological fluid filtration system in a kind of not interband next door, and it comprises single inlet and single outlet, and between inlet and outlet two fluid flow path arranged.The shortcoming of such device is: if the blood or blood product of two unit is filtered by this device, and be collected in two independent reception bags of blood, first module will be in the filter element that does not stain this device of (non-fouled) state relatively by the utilization of this device and be filtered so, and Unit second will be filtered by the filter element of this device that this device utilization is in the state of relative contamination.Therefore the flow rate by this device will be faster than the flow rate of Unit second for first module.Therefore, the filter efficiency of first module and Unit second can be different.Therefore, when this device was used to reduce leucocyte, first module was different with the leucocyte slip of Unit second.

Therefore the object of the present invention is to provide a kind of biological fluid filtration system, it comprises the Biolagical fluid filteration device, this Biolagical fluid filteration device does not have spaced walls, and comprise single inlet and two outlets, this device filters the biofluid that comprises blood or blood product of two unit, and two unit are all filtered and will move automatically and make the hold-up volume minimum simultaneously with flow rate much at one.The present invention also aims to provide single-pass gas filter, it can make two fluid flow path ventilations of the Biolagical fluid filteration device that comprises two independent fluid flow path.Another object of the present invention also is by comprise that in the downstream of Biolagical fluid filteration medium flow limiter limits the means of the flow rate of this device of flowing through in device.

Definition

Such filter below bilateral Biolagical fluid filteration device (being known as BFFD hereinafter) is represented as used herein: it comprises housing, housing comprises inlet and two outlets, and the first fluid flow path is defined between the inlet and first outlet, and second fluid flow path is defined between the inlet and second outlet; And the first Biolagical fluid filteration medium is inserted between inlet and first outlet and on the first fluid flow path, and the first Biolagical fluid filteration medium-tight to housing to prevent biofluid mobile between the housing and the first Biolagical fluid filteration medium; And the second Biolagical fluid filteration medium is inserted between inlet and second outlet and on second fluid flow path, and the second Biolagical fluid filteration medium to be sealed to housing mobile between the housing and the second Biolagical fluid filteration medium to prevent biofluid.The Biolagical fluid filteration device can filter the chemical reagent of biofluid to remove leucocyte, prion, other blood constitutent, cell from biofluid and to can be used for handling biofluid that comprises blood or blood product.BFFD also can be used as the writing a Chinese character in simplified form of Biolagical fluid filteration device of other type.

Biolagical fluid filteration medium (being known as BFFM hereinafter) represents that a kind of porous filter medium, this porous filter medium can filter the chemical reagent of biofluid to remove leucocyte, prion, other blood constitutent, cell from biofluid and to can be used for handling biofluid that comprises blood or blood product as used herein.Biolagical fluid filteration medium (BFFM) comprises at least one filter element, and each filter element comprises the porous filter material of one or more layers same type.The Biolagical fluid filteration medium can comprise more than a filter element, and each filter element comprises dissimilar filtering materials.As at number of patent application 10/934,881 or application number PCT/US2004/029026 in disclosed, comprise any Biolagical fluid filteration medium in all kinds Biolagical fluid filteration medium of one or more same type or dissimilar filter element and can be considered to Biolagical fluid filteration medium among the application.

The filter medium of ventilating as used herein is illustrated in used filter medium in the ventilation filter.The micropore filter material that medium can be served as reasons and be made such as polytetrafluoroethylene (PTFE) or the such material of PVDF, preferably have 0.2 μ rice or littler pore-size, perhaps medium can be depth media, such as cotton, spunbond polyester or such as the so molded depth media of Porex.

Housing represents that the inside is sealed with the capsule of filter medium as used herein.The housing of BFFD can comprise inlet and two outlets, and the first fluid flow path is defined between inlet and first outlet, and a BFFM be inserted in inlet export with first between and on the first fluid flow path and to be sealed to housing mobile between a housing and a BFFM to prevent biofluid; And second fluid flow path is defined between inlet and second outlet, and the 2nd BFFM be inserted in inlet export with second between and on second fluid flow path and to be sealed to housing mobile between housing and the 2nd BFFM to prevent biofluid.Housing does not comprise spaced walls.Housing can be made by rigid material, such as stainless steel or aluminium, is perhaps made by any rigid molded plastic material, such as acrylic acid, Merlon, polypropylene, polyethylene.The housing of ventilation filter comprises the breather port with big pneumatolytic fluid flow communication, with the system port that becomes fluid flow communication with biological fluid filtration system, and fluid flow path is defined between breather port and the system port, and the ventilation filter medium is inserted between breather port and the system port and on the fluid flow path and be sealed to housing and flow between ventilation filter medium and housing to prevent biofluid or gas.

Biofluid is represented the biofluid of any kind as used herein, comprises blood or blood product, and comprises the suspension that contains leukocytic suspension or contain prion.

Contain leukocytic suspension as used herein and represent wherein to be suspended with leukocytic liquid.The example that contains leukocytic suspension comprises: whole blood; Erythrocyte transfusion is such as the red blood cell, the Washed Red Blood Cells that concentrate, removed leukocytic cell, thawing (thawed) red blood cell concentrate and melted erythrocytic suspension; Blood plasma product is such as platelet poor plasma, be rich in hematoblastic blood plasma, bright frozen dry blood plasma, bright liquid blood plasma and cryoprecipitate; And, other contain leukocytic blood product, such as the platelet cell that concentrates, buffy coat (buffy coat) and removed the blood of buffy coat.Will be not limited to above-mentioned example by the leukocytic suspension that contains that device of the present invention and system are filtered.

The suspension that contains prion as described herein represents wherein to be suspended with the liquid of prion.

Such device below diaphragm tapping equipment (the being known as DDD hereinafter) expression: it has housing, housing has the inlet and the outlet that becomes fluid flow communication with second device to be discharged with big pneumatolytic fluid flow communication, and diaphragm is inserted between inlet and the outlet, and housing comprises certain gas volume amount in its normal condition between diaphragm and outlet.

Summary of the invention

By using the Biolagical fluid filteration device (BFFD) and the system of constructed according to principles of the present invention, solve the foregoing problems of prior art and realize purpose of the present invention.Biological fluid filtration system of the present invention can the chemical reagent of filtering biological fluid (comprising blood or blood product) to remove leucocyte, prion, other blood constitutent, cell from biofluid and to can be used for handling biofluid.

Biological fluid filtration system comprises feeding container and one or more receiving vessel, this feeding container is generally the bags of blood that can collapse, this one or more receiving vessel is generally the bags of blood that one or more can be collapsed, and is plugged with BFFD between feeding bags of blood and reception bags of blood.BFFD comprises housing, housing there is no spaced walls, have an inlet and two outlets, and the first fluid flow path is defined between inlet and first outlet, and the first Biolagical fluid filteration medium (BFFM) be inserted in inlet and first export between and on the first fluid flow path; And second fluid flow path is defined between the inlet and second outlet, and the second Biolagical fluid filteration medium (BFFM) is inserted between the inlet and second outlet and on second fluid flow path.BFFM can comprise dissimilar a filter element or many filter elements.Housing also comprises the chamber between inlet and two BFFM upstream face.First flow limiter can be positioned at the downstream of a BFFM, and second flow limiter can be positioned at the downstream of the 2nd BFFM.Biological fluid filtration system also can comprise the mechanism of discharging BFFM upper reaches chamber automatically when circulation is finished when filtering.Discharging mechanism can comprise diaphragm tapping equipment (DDD), and it comprises built-in flow limiter.In the automatic discharging mechanism of number of patent application 10/934,881 and the various types of tandems (in line) disclosed in the number of patent application PCT/US2004/029026 any can be used as the automatic discharging mechanism among the application.

Among any embodiment in these embodiments, BFFM can comprise: first filter element, and it comprises one or more layers porous filter material of first pore-size; Be second filter element afterwards, it comprises one or more layers porous filter material of second pore-size, and second pore-size is less than first pore-size; Be the 3rd filter element afterwards, it comprises one or more layers porous filter material of the 3rd pore-size, and the 3rd pore-size is greater than second pore-size; Be the 4th filter element afterwards, it comprises one or more layers porous filter material of the 4th pore-size, and the 4th pore-size is less than the pore-size of second filter element.First filter element can comprise the mechanism that is used for removing from blood or blood product gel, second filter element can comprise the mechanism that is used for removing from blood or blood product microaggregate, the 4th filter element can comprise and be used for removing leukocytic mechanism from blood or blood product, and the 3rd filter element serves as the flow distribution layer.But BFFM is not limited to type mentioned above, can use the BFFM of any adequate types that is suitable for application-specific.

Description of drawings

When reading in conjunction with the accompanying drawings, can understand the present invention best with reference to detailed description of preferred embodiment herein, in the accompanying drawings:

Fig. 1 is the side view of first embodiment that can be used for the biological fluid filtration system of constructing according to the principle of the invention of filtering biological fluid, it comprises feeding bags of blood, first and receives bags of blood, the second reception bags of blood, and first embodiment of BFFD is inserted in the feeding bags of blood and receives between the bags of blood, and comprises that the diaphragm tapping equipment (DDD) of built-in flow limiter is inserted between feeding bags of blood and the BFFD;

Fig. 2 is the sectional view of first embodiment that can be used for the BFFD of constructed according to principles of the present invention that biofluid is filtered;

Fig. 3 is the isometric view of the each several part that is removed of DDD shown in Figure 1;

Fig. 4 is the enter the mouth isometric view of the each several part that half part is removed of the housing of BFFD shown in Figure 2;

Fig. 5 is the isometric view that first housing of BFFD shown in Figure 2 exports the each several part that half part is removed, and second housing exports half part and first housing, and to export half part identical;

Fig. 6 is the isometric view that the housing that comprises baffle plate exports the each several part that half part is removed, and it can be used for replacing housing shown in Figure 4 half part that enters the mouth.

Fig. 7 is the side view of second embodiment of biological fluid filtration system that can be used for the constructed according to principles of the present invention of filtering biological fluid, it comprises feeding bags of blood, first and receives bags of blood, the second reception bags of blood, and second embodiment of BFFD is inserted in the feeding bags of blood and receives between the bags of blood, and comprises that the diaphragm tapping equipment (DDD) of built-in flow limiter is inserted between feeding bags of blood and the BFFD.

Fig. 8 is the sectional view that can be used for the one-sided BFFD of constructed according to principles of the present invention that biofluid is filtered, and it is included in the flow limiter in the outlet.

The specific embodiment

An embodiment at the biological fluid filtration system of constructed according to principles of the present invention shown in Fig. 1 to Fig. 5.Biological fluid filtration system 1000 shown in Figure 1 comprises feeding blood 98, first and receives the bags of blood 99 and the second reception bags of blood 99a.Biolagical fluid filteration device (BFFD) 100 is inserted in feeding bags of blood 98 and two and receives between the bags of blood.Diaphragm tapping equipment (DDD 50) can be inserted between feeding bags of blood 98 and the BFFD 100.First segment pipe 81 is connected to the outlet of feeding bags of blood 98 the inlet base (tubesocket) 51 of DDD 50.The second segment pipe 81a is connected to the outlet base 52 of DDD 50 the inlet base 6 of BFFD100.The 3rd segment pipe 82 is connected to the first outlet base 28 of BFFD 100 inlet of the first reception bags of blood 99.The 4th segment pipe 82a is connected to the second outlet base 28a of BFFD 100 inlet of the second reception bags of blood 99a.Perhaps, the port of export of pipeline 82 can be connected to first port of T shape pipe or Y tube, and the port of export of pipeline 82a is connected to second port of T shape pipe or Y tube, and the 3rd port of T shape pipe or Y tube connects the common inlet that receives bags of blood.Pipeline 81 can comprise Tube vice 95, and pipeline 82 can comprise Tube vice 96, and pipeline 82a can comprise Tube vice 96a.Diaphragm tapping equipment 50 can utilize the ventilation filter to be replaced, and perhaps can be got rid of fully.

Referring to Fig. 2 to Fig. 5, BFFD 100 comprises stiff case, and this stiff case comprises and enters the mouth housing half part 1, first housing export half part 20, second housing exports half part 20a.The enter the mouth housing seal surface 19 of half part 1 of housing is attached to the housing seal surface 29 that first housing exports half part 20.The enter the mouth housing seal surface 19a of half part 1 of housing is attached to the housing seal surface 29a that second housing exports half part 20a.In conjunction with being preferably ultra-sonic welded, but can be also that thermal, gluing are closed, solvent in conjunction with or the antiseep combination of any other type.

Referring to Fig. 2, Fig. 4 and Fig. 5, housing half part 1 that enters the mouth comprises by the madial wall 8 and first filter trap 11 that defined by the plane of passing filter seal surface 7.Housing half part 1 that enters the mouth also comprises by madial wall 8a and passes the second filter trap 11a that the plane of filter seal surface 7a is defined.Upstream chamber 13 by housing enter the mouth half part 1 inwall 10 inner surface 10a and defined by the upstream face 16b of filter element 16 and the upstream face 16ab of filter element 16a.Therefore, upstream chamber is comprising the space between the upstream face of the upstream face of a BFFM and the 2nd BFFM, and the upstream face of the upstream face of a BFFM and the 2nd BFFM is vis-a-vis.The one BFFM and the 2nd BFFM be further definition hereinafter.Inlet 5 and 13 one-tenth fluid flow communications of upstream chamber.The port of export of passage 81a inserts and is attached to inlet base 6.Inlet 5 is illustrated the top place that is in upstream chamber 13 and on housing enters the mouth the vertical center line of half part 1, but its can between the top and bottom of upstream chamber 13 Anywhere, and also can be positioned at the right or the left side of vertical center line.

Now referring to Fig. 2 and Fig. 5, BFFD 100 comprises that first housing exports half part 20 and second housing exports half part 20a.Housing exports half part 20a and housing, and to export half part 20 identical.Housing exports half part 20 and comprises round exit passage 25 and go out 27.Outlet 27 can comprise as Fig. 2 and flow limiter shown in Figure 5.Round exit passage 25 with go out 27 one-tenth direct fluid flow communications, and the flow section that has in connection with the part of outlet 27 round exit passage 25 is greater than the flow section that goes out 27.Housing exports half part 20 and also comprises Vertical Channel 22 and the 22a that bottom closure is opened at a plurality of tops.Vertical Channel 22 and a 22a end separately and 25 one-tenth fluid flow communications of round exit passage.The width on the top of round exit passage 25 increases to hold flowing from the biofluid of Vertical Channel 22 and 22a.The width of the remainder of round exit passage (that is the bottom of round exit passage 25) preferably equals the width of Vertical Channel.Two outermost Vertical Channel that are labeled as Vertical Channel 22a are in connection with round exit passage 25, and wherein the width of round exit passage 25 equals the width of Vertical Channel.Exit passageway and Vertical Channel are combined, form to cut to housing and export filter covered conduit (under drain) structure in the wall 37 of half part 20, make the inner surface of all passages be positioned at inwall 21 belows that housing exports half part 20, as shown in Figure 5.The sectional area of exit passageway and Vertical Channel is limited by the inner surface of each passage and by the downstream surface of the BFFM that contacts with described wall.As shown in Figure 5, the distance between Vertical Channel 22 and the 22a is greater than the width of Vertical Channel 22 with 22a, and the distance between Vertical Channel 22 and the 22a is also much larger than the degree of depth of Vertical Channel 22 with 22a.For example, the distance between center line between the Vertical Channel can equal 0.150 inch, and the width of Vertical Channel equals 0.032 inch, and the degree of depth of Vertical Channel equals 0.025 inch.Housing exports half part 20 and also comprises filter seal surface 24.Do not include open chamber or pressure chamber (plenum) because housing exports half part 20, make the hold-up volume minimum of biofluid in the BFFM downstream.Comprise flow limiter except housing exports half part 20 in outlet, the application's housing exports the housing that discloses among half part 20 and number of patent application 10/934,881 and the application number PCT/US2004/029026, and to export half part 220 identical.

Referring to Fig. 2, the first Biolagical fluid filteration medium (BFFM) that is comprising at least one filter element is inserted in inlet 5 and first and goes out between 27, and is sealed to housing and prevents the unfiltered biofluid BFFM that makes a circulation to walk around to prevent that unfiltered biofluid stream from flowing between a housing and a BFFM.The second Biolagical fluid filteration medium (BFFM) that comprises at least one filter element is inserted between inlet 5 and the second outlet 27a, and is sealed to housing and prevents unfiltered biofluid the 2nd BFFM that makes a circulation to walk around to prevent that unfiltered biofluid from flowing between housing and the 2nd BFFM.A BFFM shown in Figure 2 comprises filter element 16 and 18.Filter element can all be identical type or can be dissimilar filter elements.For example, filter element 16 can be the microaggregate filter element, and filter element 18 can be that leucocyte removes filter element.Each filter element comprises upstream face, downstream surface and periphery surface, and for filter element 16, upstream face is noted as upstream face 16b, and downstream surface is noted as 16c, and periphery surface is noted as 16d.The BFFM downstream surface that is shown as filter element 18 downstream surface 18c contacts with the inwall 21 that housing exports half part 20.Because the downstream surface of BFFM is contacting the inwall 21 that housing exports half part 20, BFFD100 does not comprise open chamber or pressure chamber in the downstream of BFFM.The air or the liquid that are urged by BFFM must pass Vertical Channel and round exit passage, flow into the outlet 27 of BFFD 100 afterwards.As for shown in the filter element 18, this at least one filter element can utilize this at least one filter element periphery surface and housing enter the mouth between the madial wall 8 of half part 1 interference engagement and be sealed to housing; Perhaps as for shown in the filter element 16, the enter the mouth filter seal surface 7 of half part 1 of periphery that this at least one filter element can be by compressing this at least one filter element and housing utilizes compression seal to be sealed to housing; Perhaps, this at least one filter element can use the antiseep sealing of heat seal, ultra-sonic welded, glue sealing, solvent sealing, RF welding or any other type and be sealed to housing.Also can use the combination of some encapsulating methods that at least one filter element is sealed to housing.The 2nd BFFM is preferably identical with a BFFM and preferably to be sealed to the same way as of housing with a BFFM and to be sealed on the housing.Any combination in number of patent application 10/934,881 and the filter element disclosed in the application number PCT/US2004/029026 make up also can be used for the present invention.For example, can use the gel filtration element in the present invention, be the microaggregate filter element afterwards, is the flow distribution filter element afterwards, removes filter element for leucocyte afterwards.

Referring to Fig. 2 and Fig. 5, the first fluid flow path is defined between first outlet 27 of the inlet 5 of BFFD 100 and BFFD 100, and at least one filter element of a BFFM be inserted in inlet 5 and first export 27 between and on fluid flow path.The first fluid flow path 5 flows in the upstream chamber 13 from entering the mouth, at least one filter element by a BFFM flows in Vertical Channel 22 and the 22a, flow in the round exit passage 25, in the outlet 27 that can comprise flow limiter, first housing of promptly flowing through exports the whole of half part 20 then.Second fluid flow path is defined between the second outlet 27a of the inlet 5 of BFFD 100 and BFFD 100, and at least one filter element of the 2nd BFFM is inserted in inlet 5 and second and exports between the 27a and on second flow path.Second fluid flow path 5 flows in the upstream chamber 13 from entering the mouth, at least one filter element by the 2nd BFFM flows in Vertical Channel 22 and the 22a, in round exit passage 25, in the outlet 27a that can comprise flow limiter, second housing of promptly flowing through exports the whole of half part 20a then.

Fig. 1 and Fig. 3 illustrate diaphragm tapping equipment 50 (being known as DDD 50 hereinafter).DDD 50 comprises enter the mouth half part 58, stiff case of stiff case and exports half part 59 and flexible membrane 53.Housing exports half part 59 and is comprising inlet base 51, outlet base 52, first passage 54, second channel 55, third channel 56 and common node 60.Common node 60 (being shown as a little) is arranged in three passages each to become fluid flow communication with two other passages.Second channel 55 is comprising flow limiter, and this second channel is shown as than first passage and third channel is longer and diameter is littler passage.First passage can be known as inlet 54, and second channel can be known as outlet 55 and third channel can be known as side ports 56.Housing exports half part 59 and will export half part 1820 with housing at three tube connectors 1650 disclosed in number of patent application 10/934,881 and the application number PCT/US2004/029026 and be combined into individual devices.The shape of three tube connectors that are made of first passage 54, second channel 55 and third channel 56 is shown as T shape pipe, but is not limited to this shape, for example the form that it also can Y-shaped pipe.Fig. 3 illustrates DDD 50 and is in its normal condition, and housing half part 58 that enters the mouth is sealed to housing and exports half part 59.Sealing is preferably ultrasonic sealing, but also can be the sealing of heat seal, solvent, glue sealing or export compression seal between half part 59 or the antiseep of any other type seals at inlet half part 28 and housing.Flexible membrane 53 can be by such as molded the forming of the such flexible rubber material of silicone rubber, and perhaps it can be by such as the molded or hot forming of the such material of PVC, polyethylene or polypropylene, but is not limited to these materials.Flexible membrane 53 preferably is so shaped that in its normal condition, and outer surface 66 meets the enter the mouth inner surface 67 of half part 58 of housing.Flexible membrane 53 is comprising flange 68, and flange 68 can be attached to enter the mouth half part 58 or housing of housing and export half part 59.Thermal, combination of ultrasound, gluing are closed in conjunction with can be, solvent in conjunction with or the antiseep combination of any other type.Perhaps, flange 68 compressible seals export between half part 59 in enter the mouth half part 58 and housing of housing.Fig. 3 shows the DDD 50 that is in its normal condition, and the outer surface 66 of diaphragm 53 is contacting the enter the mouth inner surface 67 of half part 58 of housing.In its normal condition, DDD 50 comprises the chamber 63 with 56 one-tenth fluid flow communications of third channel.In normal condition, chamber 63 is full of the gas (being generally filtrated air) that is in atmospheric pressure.When diaphragm 53 is collapsed fully, the inner surface 69 of diaphragm 53 will contact the inner surface 70 that housing exports half part 59.

Referring to Fig. 1 to Fig. 3, the housing that the 3rd fluid flow path is defined in DDD 50 exports between the common node 60 and feeding bags of blood 98 of half part 59, and flowing in the 3rd fluid flow path flows in the inlet 54 of DDD 50 by pipeline 81 from feeding bags of blood 98, flows to common node 60.The 4th fluid flow path is defined between the inlet 5 of the common node 60 of DDD 50 and BFFD 100, and flowing from the outlet 55 (comprise flow limiter) of common node 60 by DDD 50 in the 4th fluid flow path flows into the inlet 5 of BFFD 100 by pipeline 81a.The 5th fluid flow path is defined between the chamber 63 of common node and DDD50, and flowing of the 5th fluid flow path flows to common node 60 from chamber 63 by third channel 56.

Referring to Fig. 1 to Fig. 5, biological fluid filtration system 1000 following working.The user has purchase the system of the bags of blood 98 of all devices as shown in Figure 1, less feeding.The user will make pipeline 81 be connected to the outlet 92 of feeding bags of blood 98 in mode as known in the art.Feeding bags of blood 98 can be hanging on the hook of bags of blood bar, and first receive bags of blood 99 and second and receive bags of blood 99a and will be positioned on the desktop or similar place, makes each device of system to locate as shown in Figure 1.Perhaps, feeding bags of blood 98 can be the part of the set that comprises all devices shown in Figure 1, in this case, will collect the feeding bags of blood 98 from the blood or blood product that donor is collected.Before being connected to feeding bags of blood 98, pipeline 81 answers closure tube clamp 95.Opening Tube vice 95 beginning biofluids (that is, liquid), should open Tube vice 96 and 96a by before the flowing of system.

When Tube vice 95 is opened, biofluid (that is liquid) will flow in the inlet 54 of DDD 50 from feeding bags of blood 98 by pipeline 81, outlet 55 by DDD 50, by pipeline 81a, flow in the inlet 5 of BFFD 100, enter the upstream chamber 13 of BFFD 100.Because the outlet 55 of DDD 50 is comprising flow limiter, will automatically limit the inlet downstream of DDD and flowing of side ports downstream, and will form normal pressure at common node 60 places of DDD 50.Also because flexible membrane 53 is sealed to DDD 50 with the sealing of impenetrable liquid/air, air can not be overflowed by the inlet 57 of DDD 50.Therefore the air in the chamber 63 of DDD 50 will pressurizedly make the side ports 56 of having only the biofluid of seldom measuring (if any) will enter DDD 50.

In case open Tube vice 95, a kind of situation in four kinds of situations can take place.First kind of situation is: if the volume of upstream chamber 13 is enough little, if and the initial pool flow rate of a BFFM and the 2nd BFFM and being no more than enters into the flow rate of the biofluid of inlet 5, the upstream chamber 13 of BFFD 100 will make progress from the bottom and promptly be full of biofluid so.Because upstream chamber 13 upwards is full of from the bottom, the initial air in upstream chamber 13 will be discharged by the biofluid displacement of filling upstream chamber 13.The part of air that displacement is discharged will be urged passes a BFFM in Vertical Channel 22 and 22a, and in round exit passage 25, in first outlet 27, first housing of promptly flowing through exports the whole of half part 20 then.The remainder of the air of discharging of replacing will be urged and pass the 2nd BFFM in Vertical Channel 22 and 22a, and in round exit passage 25, and then in the second outlet 27a, second housing of promptly flowing through exports the whole of half part 20a.Biofluid in upstream chamber 13 is with pressurized, and will be proportional to the distance of the bottom of upstream chamber 13, and will be proportional to the distance at the top of upstream chamber 13 with biofluid top from feeding bags of blood 98 at the pressure at the place, top of upstream chamber 13 with the top of biofluid from feeding bags of blood 98 at the pressure at place, the bottom of upstream chamber 13.Therefore, will be at the pressure at place, upstream chamber 13 tops less than the pressure of locating in the bottom of upstream chamber 13.Normal pressure in upstream chamber 13 will cause biofluid flow through a BFFM and the 2nd BFFM and utilize biofluid to replace the intrapore air of discharge at a BFFM and the 2nd BFFM on the whole surface area of a BFFM and the 2nd BFFM, thereby from upstream side to the BFFM of a BFFM and the 2nd BFFM and moistening BFFM in downstream and the 2nd BFFM of the 2nd BFFM.Along with BFFM is moistening, initial air in the BFFM hole will be discharged and flow into respective housings and export the Vertical Channel 22 and the 22a of half part and flow into the round exit passage 25 that respective housings exports half part by the biofluid displacement, outlet 27 and the housing that exports half part 20 to housing exports in the outlet 27a of half part 20a then, in pipeline 82, receive in the bags of blood 99 to first then, with in pipeline 82a, and receive in the bags of blood 99a to second then.Because greater than the pressure at place, upstream chamber 13 tops, then the primary rate of the biofluid by BFFM will be located greater than the top at BFFM at the place, bottom of BFFM at the pressure at upstream chamber 13 bottoms places.Therefore, BFFM at first will become moistening fully to the downstream surface at the BFFM of BFFM bottom from the upstream face of BFFM.If it is enough little that respective housings exports the width of the Vertical Channel 22 of half part and 22a, and the degree of depth of

Vertical Channel

22 and 22a is enough shallow, make that the flow section of Vertical Channel 22 and 22a is enough little, if and the distance between the Vertical Channel 22 is enough big, so the paths of least resistance that flows of the lasting biofluid by BFFM will in the horizontal direction and on the vertical direction all by the capillary of BFFM and do not pass through Vertical Channel; Because if the flow section of Vertical Channel is enough little, flow into so and the displacement of the Vertical Channel of flowing through is discharged air and will be formed sufficiently high normal pressure prevent that biofluid from entering into Vertical Channel in Vertical Channel.Therefore the downstream surface of BFFM will be upwards moistening from the bottom, and the displacement in BFFM discharges air and will continue to flow into Vertical Channel, and flow into the round exit passage, flow in the outlet then.When the downstream surface of corresponding BFFM becomes the height at moistening top to Vertical Channel 22a, because the downstream surface of the BFFM below the top of two most external Vertical Channel 22a is with wetted, then the air by these two most external Vertical Channel flows and will stop.Therefore the pressure in these two most external Vertical Channel will reduce, and allow biofluid upwards to enter into this two most external Vertical Channel from the bottom, thereby the air in two most external Vertical Channel be discharged in displacement.Simultaneously, the wetting level of the downstream surface of BFFM continues in the vertical direction wetting, make with respective circular exit passageway 25 in connection with the BFFM downstream surface moistening.Owing to the mobile reason of the air that passes through round exit passage 25, the flow section at round exit passage 25 tops is not to be small enough to form in them normal pressure, and biofluid will begin to flow into Vertical Channel 22 and along with the BFFM in the vertical direction continues moistening and flows into the top of round exit passage 25.The biofluid that flows into

Vertical Channel

22 and 22a and inflow round exit passage 25 will flow into corresponding outlet 27 and the 27a of BFFD 100, flow into then towards the pipeline 82 that receives blood bag 99, and flow into towards the pipeline 82a that receives blood bag 99a.Because biofluid begins to flow in outlet 27 and the 27a, a BFFM and the 2nd BFFM will continue moistening vertically.Therefore, by round exit passage 25 with by outlet 27 and the initial flow of 27a will at first be air, be the mixture of air and biofluid then, only be biofluid at last, make that the initial flow of

flow ipe

82 and 82a will at first be an air, being the alternately section that comprises biofluid and air then, is only to comprise biofluid at last.In case BFFM is by moistening, then is flowing on their the whole surface area and will will be uniformly, and make the whole surface area of BFFM will be used for the filtering biological fluid, thereby utilize BFFM most effectively by their biofluid.The present invention is not limited to filter covered conduit shown in Figure 5.For example, at number of patent application 10/934,881 or at application number PCT/US2004/029026 or in the patent No. 6,660, any filter covered conduit disclosed in 171 can be used for the present invention.And, also can use the supporting that provides enough to be used for BFFM and the filter covered conduit of any other type of the fluid flow mechanisms between BFFM downstream and corresponding outlet is provided.

Second kind of situation that may take place after Tube vice 95 is opened is: BFFD 100 is will be as mentioned moistening as described in first kind of situation, and primary rate (that is, at BFFM by the flow rate before moistening) is as described under first kind of situation.In case but BFFM is moistening by biofluid, thereby the flow rate by BFFM can increase and makes the flow through combination flow rate of a BFFM and the 2nd BFFM will surpass 5 flow rates that enter the biofluid of chamber 13 that enter the mouth of flowing through.In the case, biofluid will be full of chamber 13 at first from bottom to top, and after BFFM is moistening, the liquid level in chamber 13 will drop to the height below chamber 13 tops then.Therefore, in case BFFM is by moistening, flow rate by the biofluid partly of the BFFM below the liquid level top of chamber 13 will make that the BFFM above liquid level partly will suitably not utilized much larger than the flow rate of the BFFM that passes through liquid level over top in the chamber 13 biofluid partly.If BFFD 100 is used for removing leucocyte from blood or blood product, when comparing when measuring with above first situation, under second kind of situation, the leucocyte of BFFM removes ability will be weakened so.Therefore, under second kind of situation, the leucocyte that blood or blood product comprised that has filtered in receiving bags of blood may be more than receive the leucocyte that is comprised in the blood or blood product that has filtered in the bags of blood under first kind of situation.As shown in Figure 2, correct second kind of situation by adding flow limiter to first outlet, the 27 and second outlet 27a.Flow limiter is shown as long minor diameter outlet in Fig. 2.The size of flow limiter should make biofluid by a BFFM and the 2nd BFFM and therefore be less than or equal to biofluid by 5 flow rates that enter into chamber 13 that enter the mouth by exporting 27 with the combination flow rate of 27a.The downstream that flow limiter can be positioned at BFFM Anywhere.For example, first flow limiter can be in outlet 27 and first receives pipeline 82 between the bags of blood 99, and second flow restriction can be in the pipeline 82a between the outlet 27a and the second reception bags of blood 99a.Perhaps, pipeline 82 and pipeline 82a all or part of has than the littler internal diameter of pipeline 81 and pipeline 81a and forms limiter with the downstream at a BFFM and the 2nd BFFM respectively.Because just described identical, flow limiter also can use in the downstream of BFFM in one-sided BFFD.Can in any device of the one-sided device disclosed in number of patent application 10/934,881 or the number of patent application PCT/US2004/029026, add flow limiter in the downstream of BFFM.

The third situation that may occur after Tube vice 95 is opened is: if the volume of upstream chamber 13 is enough big, then by the liquid flow of BFFM and the moistening combination of capillary above liquid level of below the liquid level of upstream chamber 13, flowing through, BFFM will be in upstream chamber liquid level arrive before the top of upstream chamber 13 moistening, thereby allow to remove air from BFFM.In case BFFM is by moistening, the air in upstream chamber 13 above the liquid level will be trapped within the upstream chamber 13, because moistening BFFM will not allow to remove these air from upstream chamber 13.In case BFFM is by moistening, flow rate by the biofluid partly of the BFFM below the liquid level top in the chamber 13 will make that the BFFM of liquid level top is partly utilized inadequately much larger than the flow rate of the BFFM that passes through liquid level over top in the chamber 13 biofluid partly.If BFFD 100 is used for removing leucocyte from blood or blood product, so, when recently measuring mutually with first condition above, under the third condition, the leucocyte of BFFM removes ability may be weakened.Therefore, under the third condition, the leucocyte that blood or blood product comprised that has filtered in receiving bags of blood can be more than the leucocyte that blood or blood product comprised that has filtered in the reception bags of blood under the first condition.Can correct the third situation by the volume that reduces upstream chamber 13.Referring to Fig. 4, to such an extent as to if make inlet 5 sectional area enough do not limit greatly biofluid pass through enter the mouth 5 mobile, then must make the enter the mouth width (that is the distance between filter seal surface 7 and the filter seal surface 7a) of inner surface 10a of half part 1 of housing enough wide.In the case, can add the volume minimum that baffle plate 12 makes upstream chamber 13 by the inwall 10 of the half part 1a that enters the mouth to housing, as shown in Figure 6.Baffle plate 12 extends from the opposite side of a lateral inner wall 10 of inwall 10.Baffle plate 12 can comprise filter support ribs sheet 15 that is positioned on its first surface 9 and the filter support ribs sheet 15a that is positioned on its second surface 9a, as shown in Figure 6.The sectional area that adds baffle plate 12 and inlet 5a except the half part 1a that enters the mouth to housing increases makes the sectional area of inlet 5a and the width of inwall 10a to be increased more than or equal to the sectional area of as shown in Figure 1 pipeline 81a inside, and housing half part 1a and housing half part 1 that enters the mouth that enters the mouth is identical.But because baffle plate 12 and filter support ribs sheet 15 and the occupied volume of 15a, housing enters the mouth the volume of upstream chamber 13 of half part 1a will be less than the enter the mouth volume of upstream chamber 13 of half part 1 of housing.Because at the gap 14 and the 14a of the above and below of baffle plate 12 tops and bottom, baffle plate 12 does not serve as spaced walls upstream chamber 13 is divided into two differences and independent chamber respectively.The compound section in two gaps is long-pending should be enough big to prevent that upstream chamber 13 is divided into two independent and different chambers.The sectional area in each gap be defined in pass the baffle plate center and be parallel to filter seal surface 7 and the plane of filter seal surface 7a in the sectional area in measured gap.Enter the mouth purpose that half part adds baffle plate 12 just for the volume that reduces upstream chamber 13 with add filter support ribs sheet 15 and 15a to housing, and filter support ribs sheet 15 and 15a provide a kind of mechanism in order to keep two BFFM suitably to separate.Can utilize filter fulcrum post array or other mechanism to replace the filter support ribs sheet.Although baffle plate shown in Figure 6 has in first gap at place, top and second gap of locating in the bottom, at the top or bottom place or locating Anywhere between top and bottom, it also is feasible with the single gap that upstream chamber 13 is divided into two differences and independent chamber that anti-baffle plate serves as spaced walls.The gap also can be known as the aperture.

The 4th kind of situation that may take place after Tube vice 95 is opened is: if the initial pool flow rate of a BFFM and the 2nd BFFM surpasses the flow rate of the biofluid that enters into inlet 5, so by the liquid flow of BFFM and the moistening combination of capillary above liquid level of below the liquid level of upstream chamber 13, flowing through, BFFM will be in upstream chamber liquid level arrive before the top of upstream chamber 13 moistening, thereby allow to remove air from BFFM.In case BFFM is by moistening, the air in the upstream chamber 13 above liquid level will be trapped within the upstream chamber 13, because moistening BFFM will not allow to remove these air from upstream chamber 13.In case BFFM is by moistening, flow rate by the biofluid partly of the BFFM below the liquid level top in the chamber 13 will make that the BFFM of liquid level top is not partly suitably utilized much larger than the flow rate of the BFFM that passes through liquid level over top in the chamber 13 biofluid partly.If BFFD is used for removing leucocyte from blood or blood product, when recently measuring mutually with first kind of situation above, under the 4th kind of situation, the leucocyte of BFFM removes ability may be weakened so.Therefore, under the 4th kind of situation, the leucocyte that blood or blood product comprised that the leucocyte that blood or blood product comprised that has filtered in receiving bags of blood has filtered in can be more than the reception bags of blood under first kind of situation.Primary rate that can be by the BFFM that reduces to flow through, by reducing the surface area of BFFM, or by increasing the resistance that flows to the BFFM that flows through, or this two correct the 4th kind of situation.Perhaps, add flow limiter in the downstream of BFFM, all flow limiters in outlet 27,27a are as shown in Figure 2 corrected the 4th kind of situation.By adding flow limiter, need not to reduce the surface area of BFFM, thereby allow the bigger total throughput of the blood or blood product that filtered and the leucocyte that can not impair the product that has filtered reduces.

Referring to Fig. 1 to Fig. 5, in case the first fluid flow path and second fluid flow path in BFFD 100 have been removed all air, biofluid will continue to export 27 by the first fluid flow path to first of BFFD 100 from the inlet 5 of BFFD 100, and entering first by pipeline 82 then receives in the bags of blood 99, and from the inlet 5 of BFFD 100 by the second outlet 27a of second fluid flow path to BFFD 100, enter second by pipeline 82a then and receive in the bags of blood 99a biofluid in the feeding bags of blood 98 that soared.As shown in Figure 2, to guarantee that to outlet 27 and 27a interpolation flow limiter mobile by the biofluid of a BFFM and the 2nd BFFM is balance, and therefore two BFFM will suitably be utilized, and the biofluid that filters in receiving bags of blood 99 and receiving bags of blood 99a will have identical quality.In case feeding bags of blood 98 is emptied, feeding bags of blood 98 will be collapsed, and seal the top of pipeline 81 effectively, thereby prevent that biofluid from flowing in pipeline 81.Receive the height that bags of blood 99a is positioned to be lower than fully BFFD 100 if first receives bags of blood 99 and second, will bear at the pressure in a BFFM and the 2nd BFFM downstream so.In case feeding bags of blood 98 is collapsed and biofluid stops by first fluid flow path and the mobile of second fluid flow path, then stride across pressure reduction on a BFFM and the 2nd BFFM and will become zero, therefore in upstream chamber 13 and the pressure in and outlet 55, side ports 56 and the chamber 63 inner at DDD 50 at pipeline 81a will become negative.Because the outer surface 66 of flexible membrane 53 is in atmospheric pressure via the inlet 57 of DDD 50, suction force (promptly, negative pressure) will be automatically from the side ports 56 of DDD 50 with from exporting 55, with from pipeline 81a with from upstream chamber 13, by BFFM, by outlet 27 and the 27a of BFFD100, make biofluid be discharged into by

pipeline

82 and 82a and receive in bags of blood 99 and the 99a.Suction force will automatically make flexible membrane 53 collapse, thereby makes the air in the chamber 63 that is in DDD 50 that the biofluid displacement of discharging from the BFFM upstream will be discharged.As long as the volume of the chamber 63 of DDD 50 is more than or equal to the volume of the biofluid that is discharged, all biofluids all will automatically discharge as described in just now.If the volume of the chamber 63 of DDD 50 is greater than the volume of the biofluid that is discharged, flexible membrane 53 will partly be collapsed so.When filtering circulation when finishing, biofluid will be stayed in the BFFM, and export in the filter covered conduit structure that half part and second housing export half part and in

pipeline

82 and 82a at first housing.Although DDD 50 is used as automatic discharging mechanism in biological fluid filtration system 1000, also can use any other automatic discharging mechanism, be included in any automatic discharging mechanism disclosed in number of patent application 10/934,881 or the application number PCT/US2004/029026.Perhaps, can get rid of automatic discharging mechanism, in this case, feeding bags of blood 98 soar by after will not discharge upstream chamber 13.

Can be of value to one-sided BFFD by adding flow limiter in the downstream of BFFM, one-sided BFFD has single inlet and single outlet, and fluid flow path is defined between inlet and the outlet, and BFFM is inserted between inlet and the outlet and on fluid flow path.If (for example) use one-sided BFFD to come to remove leucocyte from biofluid, the primary rate of the biofluid by BFFM will begin higher and reduce along with BFFM stains so.If primary rate is too high, the leucocyte of BFFM removes ability and will weaken so, the situation after therefore initial leucocyte from the biofluid that has filtered of the per unit volume that biofluid removed will be less than flow rate owing to stain and decreased.In the case, on whole filtration cycle, obtain flow rate uniformly by flowing of BFFD, remove rate thereby increase leucocyte by BFFM by use limiter to limit biofluid in the downstream of BFFM.In the case, one-sided BFFD will have single inlet and single outlet, and fluid flow path is defined between inlet and the outlet, and BFFM is inserted between inlet and the outlet and on fluid flow path, and flow limiter is positioned at the downstream of BFFM, and fluid flow path flows by flow limiter.

Add flow limiter in the downstream of BFFM and can be of value to one-sided BFFD, all BFFD 300 as shown in FIG. 8, it comprises single inlet 105 and single outlet 127, and fluid flow path is defined between inlet and the outlet, and BFFM 118 is inserted between inlet and the outlet and on the fluid flow path that is comprising upstream chamber 113.BFFD 100 in the replaceable biological fluid filtration system 1000 shown in Figure 1 of BFFD 300, and single reception bags of blood is connected to outlet 127.In case open Tube vice 95, if the volume of upstream chamber 113 is enough little, if and the primary rate of BFFM 118 is no more than biofluid and enters into inlet 105 flow rate, the upstream chamber 113 of BFFD 200 will make progress from the bottom and promptly be full of biofluid so.Along with upstream chamber 113 upwards is full of from the bottom, the biofluid that is full of upstream chamber 113 will be replaced the initial air of discharging in the upstream chamber 113.The air of discharging of replacing will be urged and pass BFFM 118 in outlet 127.But, if in case BFFM 118 is moistening by biofluid, thus the flow rate then by BFFM will increase the flow rate that makes by BFFM will be above biofluid by 105 flow rates that enter into chamber 113 that enter the mouth.In the case, biofluid is full of chamber 113 at first to the top from the bottom, then at BFFM by after moistening, the liquid level in chamber 113 will be reduced to the height that is lower than chamber 113 tops.Therefore, in case BFFM is by moistening, the flow rate of the biofluid of the BFFM part by liquid level top below in the chamber 113 will be much larger than the flow rate of the biofluid of the BFFM part by liquid level over top in the chamber 113, thereby makes that the BFFM above liquid level partly will suitably not utilized.If BFFD 300 is used for removing leucocyte from blood or blood product, to compare with situation about in whole filtration cycle, remaining full of so as if upstream chamber, the leucocyte of BFFM removes ability will be weakened.Therefore, the leucocyte that can should comprise more than the blood or blood product that has filtered of the leucocyte that filtering blood or blood product comprised in receiving bags of blood.As shown in Figure 8, can correct this problem by adding flow limiter to outlet 127.Flow limiter is shown as long minor diameter outlet in Fig. 8.Therefore the size of flow limiter should make by BFFM and be less than or equal to by 105 flow rates that enter into the biofluid of chamber 113 that enter the mouth by the flow rate that exports 127 biofluid.Flow limiter can be positioned at the BFFM downstream Anywhere.For example, flow limiter can be in the pipeline 82 between outlet 127 and the reception bags of blood.Perhaps, pipeline 82 all or part of has than pipeline 81 and the littler internal diameter of pipeline 81a and forms limiter with the downstream at BFFM.

Second kind of situation that one-sided BFFD may occur after opening Tube vice 95 is: if the primary rate of BFFM 118 surpasses the flow rate that biofluid enters into inlet 105, by the liquid flow of BFFM and the moistening combination of capillary above liquid level of flowing through below the liquid level in upstream chamber 113, BFFM will be in upstream chamber liquid level arrive before the top of upstream chamber 113 moistening, thereby allow to remove air from BFFM.In case BFFM is moistening, then the air in the upstream chamber above liquid level 113 will be trapped within the upstream chamber 113, because moistening BFFM will not allow to remove these air from upstream chamber 113.In case BFFM is by moistening, the flow rate of the biofluid of the BFFM part by liquid level top below in the chamber 113 will be much larger than the flow rate of the biofluid of the BFFM part by liquid level over top in the chamber 113, thereby makes that the BFFM part above liquid level is not suitably utilized.If use BFFD 300 to come to remove leucocyte from blood or blood product, in the case, the leucocyte of BFFM removes ability may be weakened.Therefore, in the case, the blood or blood product that has filtered in receiving bags of blood can comprise than required more leucocyte.Can by reduce by BFFM primary rate, by reducing the surface area of BFFM, perhaps by increasing to the resistance that flows by BFFM, or this two correct this situation.Perhaps, add flow limiter in the downstream of BFFM, all flow limiters in outlet 27 are as shown in Figure 8 corrected the 4th kind of situation.If added flow limiter, will need not to reduce the surface area of BFFM, thereby allow the bigger total throughput of the blood or blood product that filtered and the leucocyte that can not impair the product of filtration reduces.

Can be of value to bilateral BFFD by adding flow limiter in the downstream of a BFFM and the 2nd BFFM, bilateral BFFD does not have spaced walls, it comprises single inlet and single outlet, and the first fluid flow path is defined between inlet and the outlet, and a BFFM is inserted between inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between inlet and the outlet, and the 2nd BFFM is inserted between inlet and the outlet and on second fluid flow path.If (for example) this bilateral BFFD is used for removing leucocyte from biofluid, the primary rate of the biofluid by BFFM will begin higher and reduce along with BFFM stains so.If primary rate is too high, the leucocyte of BFFM removes ability may be weakened, thus make at first from the leucocyte of the filtering biological fluid of the per unit volume that biofluid removed will be less than flow rate by BFFM owing to stain the situation after having decreased.In the case, come the flowing of biofluid of restricted passage BFFD, will on whole filtration cycle, produce the more uniform flow rate of passing through BFFM, remove rate thereby increased leucocyte by using limiter in two BFFM downstreams.In the case, the bilateral BFFD that does not have spaced walls will have single inlet and single outlet, and the first fluid flow path is defined between inlet and the outlet, and a BFFM is inserted between inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between inlet and the outlet, and the 2nd BFFM is inserted between inlet and the outlet and on second fluid flow path, and flow limiter is positioned at the two downstream of a BFFM and the 2nd BFFM, and first fluid flow path and second fluid flow path flow limiter of flowing through.

Can be of value to bilateral BFFD by adding flow limiter in the downstream of a BFFM and the 2nd BFFM, such as at U.S. Patent number 6,660,171 and Application No. 10/934, bilateral BFFD disclosed in 881, it comprises spaced walls, and it comprises single inlet and single outlet, and the first fluid flow path is defined between inlet and the outlet, and a BFFM is inserted between inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between inlet and the outlet, and the 2nd BFFM is inserted between inlet and the outlet and on second fluid flow path.If (for example) use this bilateral BFFD to come to remove leucocyte from biofluid, then the primary rate of the biofluid by BFFM will begin higher and along with the BFFM contamination reduces.If primary rate is too high, the leucocyte of BFFM removes ability and may weaken so, thereby makes at first the leucocyte of the fluid of filtering biological of the per unit volume that can remove from biofluid be less than the flow rate by BFFM owing to stain situation after decreasing.In the case, come the flowing of biofluid of restricted passage BFFD by the limiter that uses two BFFM downstreams, will in whole filtration cycle, obtain more uniform flow rate, remove rate thereby increase leucocyte by BFFM.In the case, the bilateral BFFD that comprises spaced walls will have single inlet and single outlet, and the first fluid flow path is defined between inlet and the outlet, and a BFFM is inserted between inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between inlet and the outlet, and the 2nd BFFM is inserted between inlet and the outlet and on second fluid flow path, and flow limiter is positioned at the two downstream of a BFFM and the 2nd BFFM, and first fluid flow path and second fluid flow path flow by flow limiter.

Can be by being of value to bilateral BFFD at a BFFM and the 2nd BFFM downstream interpolation flow limiter, such as in Application No. 10/693, BFFD disclosed in 757, it comprises spaced walls, and it comprises single inlet and two outlets, and the first fluid flow path is defined between the inlet and first outlet, and a BFFM is inserted between the inlet and first outlet and on the first fluid flow path, and second fluid flow path is defined between the inlet and second outlet, and the 2nd BFFM is inserted between the inlet and second outlet and on second fluid flow path.If (for example) use this bilateral BFFD to come to remove leucocyte from biofluid, the primary rate of the biofluid by BFFM will begin higher and along with the BFFM contamination reduces.If primary rate is too high, the leucocyte of BFFM removes ability and may weaken so, thereby makes at first the leucocyte of biofluid after filtration of the per unit volume that removes from biofluid be less than the flow rate by BFFM owing to stain situation after decreasing.In the case, come the flowing of biofluid of restricted passage BFFD, will on whole filtration cycle, produce more uniform flow rate, thereby the increase leucocyte removes rate by BFFM by using limiter in these two BFFM downstreams.In the case, the bilateral BFFD that comprises spaced walls will have single inlet and first outlet and second outlet, and the first fluid flow path is defined between the inlet and first outlet, and a BFFM is inserted between the inlet and first outlet and on the first fluid flow path, and second fluid flow path is defined between the inlet and second outlet, and the 2nd BFFM is inserted between the inlet and second outlet and on second fluid flow path, and flow limiter is positioned at the two downstream of a BFFM and the 2nd BFFM, and the first fluid flow path flows by first flow limiter, and second fluid flow path flows by second flow limiter.

Add flow limiter in the downstream of a BFFM and the 2nd BFFM and will be of value to bilateral BFFD, such as in Application No. 10/693, bilateral BFFD disclosed in 757, it comprises spaced walls, and it comprises two inlets and single outlet, and the first fluid flow path is defined between first inlet and the outlet, and a BFFM is inserted between first inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between second inlet and the outlet, and the 2nd BFFM is inserted between second inlet and the outlet and on second fluid flow path.If (for example) this bilateral BFFD is used for removing leucocyte from biofluid, the primary rate of the biofluid by BFFM will begin higher and reduce along with BFFM stains so.If primary rate is too high, the leucocyte of BFFM removes ability and may weaken so, thereby makes at first the leucocyte of the fluid of filtering biological of the per unit volume that removes from biofluid be less than the flow rate by BFFM owing to stain situation after reducing.In the case, come the flowing of biofluid of restricted passage BFFD, will on whole filtration cycle, produce more uniform flow rate, thereby the increase leucocyte removes rate by BFFM by using limiter in two BFFM downstreams.In the case, the bilateral BFFD that comprises spaced walls will have two inlets and single outlet, and the first fluid flow path is defined between first inlet and the outlet, and a BFFM is inserted between first inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between second inlet and the outlet, and the 2nd BFFM is inserted between second inlet and the outlet and on second fluid flow path, and flow limiter is positioned at the two downstream of a BFFM and the 2nd BFFM, and first fluid flow path and second fluid flow path flow by flow limiter.Perhaps, BFFD can comprise at first flow limiter between the first BFFM downstream and the outlet with at the downstream of second BFFM and second flow limiter between the outlet.

Can be of value to bilateral BFFD by adding first flow limiter in the downstream of a BFFM and adding second flow limiter in the downstream of the 2nd BFFM, such as in Application No. 10/934,881 or at the bilateral BFFD disclosed in the application number PCT/US2004/029026, it comprises solid spaced walls, and it comprises two inlets and two outlets, and the first fluid flow path is defined between first inlet and first outlet, and a BFFM is inserted between first inlet and first outlet and on the first fluid flow path, and second fluid flow path is defined between second inlet and second outlet, and the 2nd BFFM is inserted between second inlet and second outlet and on second fluid flow path.If (for example) use this bilateral BFFD come from single or two independently the biofluid source remove leucocyte, the primary rate of one or more biofluids by a BFFM and the 2nd BFFM will begin higher and along with the BFFM contamination reduces.If the primary rate by arbitrary BFFM among the BFFM is too high, the leucocyte of BFFM removes ability and may weaken so, makes at first to be less than flow rate by the BFFM situation after lowering to some extent owing to stain by the leucocyte of arbitrary fluid flow path from the biofluid that has filtered of the per unit volume that one or more biofluids removed.In the case, flowing of first flow path that first flow limiter by using a BFFM downstream and second flow limiter in the 2nd BFFM downstream come restricted passage BFFD and one or more biofluids of second flow path, to on whole filtration cycle, produce more uniform flow rate, thereby the leucocyte that increases by these two BFFM removes rate by these two BFFM.In the case, the bilateral BFFD that comprises solid spaced walls has first inlet and first outlet, and first fluid flows and is defined between first inlet and first outlet, and a BFFM is inserted between first inlet and first outlet and on the first fluid flow path, and second fluid flow path is defined between second inlet and second outlet, and the 2nd BFFM is inserted between second inlet and second outlet and on second fluid flow path, and first flow limiter is positioned at the downstream of a BFFM, and second flow limiter is positioned at the downstream of the 2nd BFFM, and the first fluid flow path flows by first flow limiter, and second fluid flow path flows by second flow limiter.

As shown in Figure 7, add two flow limiters in the downstream of outlet and can be of value to bilateral BFFD, it has or does not have spaced walls, it comprises single inlet and single outlet, and the first fluid flow path is defined between inlet and the outlet, and a BFFM is inserted between inlet and the outlet and on the first fluid flow path, and second fluid flow path is defined between inlet and the outlet, and the 2nd BFFM be inserted in enter the mouth and export between and on second fluid flow path.Referring to Fig. 7, bilateral BFFD 200 can comprise spaced walls or can not comprise spaced walls.The outlet of BFFD 200 becomes fluid flow communication via pipeline 82b with the inlet of T shape pipe 70.The side arm 70a of T shape pipe 70 becomes fluid flow communication via pipeline 82c with the inlet that receives bags of blood 99, and the side arm 70b of T shape pipe 70 becomes fluid flow communication via pipeline 82d with the inlet that receives bags of blood 99a.First limiter can be included among the side arm 70a or among the pipeline 82c, and second limiter can be included among side arm 70b or the pipeline 82d.Provide equal back-pressure (back pressure) if first limiter and second limiter flow to the biofluid from pipeline 82b, the biofluid that has filtered of equivalent will flow in two reception bags of blood so.And under superincumbent situation, two limiters will limit biofluid and pass through flowing of BFFD, thereby produce more uniform flow rate on whole filtration cycle, remove rate thereby increase leucocyte.

Although in BFFD illustrated in figures 1 and 2 100, use filter covered conduit structure shown in Figure 5, also can use the filter covered conduit structure that any other type of suitable support is provided to BFFM.

Although show and described the present invention about concrete preferred embodiment, it will be understood by a person skilled in the art that variation and the modification that to make the inventive concept that does not depart from described herein and instruction.These variations and modification are considered to be in the scope of these inventive concepts.Any combination of the various characteristics of described embodiment is considered to be in the scope of these inventive concepts.

Claims

1. Biolagical fluid filteration device, it comprises:

Housing, it has inlet, first outlet and second outlet, and limiting the first fluid flow path between the inlet and first outlet and between the inlet and second outlet, limiting second fluid flow path, its middle shell does not have solid spaced walls in fact between the first fluid flow path and second fluid flow path

The first Biolagical fluid filteration medium, it has upstream face and downstream surface, is inserted between described inlet and described first outlet and on described first fluid flow path,

The second Biolagical fluid filteration medium, it has upstream face and downstream surface, is inserted between described inlet and described second outlet and on described second fluid flow path,

Upstream chamber, it comprises the space between described first Biolagical fluid filteration medium and the described second Biolagical fluid filteration medium, and the upstream face of the upstream face of the described first Biolagical fluid filteration medium and the described second Biolagical fluid filteration medium is vis-a-vis.

2. Biolagical fluid filteration device according to claim 1, wherein said first Biolagical fluid filteration medium and the described second Biolagical fluid filteration medium can remove leucocyte from biofluid.

3. Biolagical fluid filteration device according to claim 1, wherein first flow limiter is positioned at the downstream of the described first Biolagical fluid filteration medium, and wherein second flow limiter is positioned at the downstream of the described second Biolagical fluid filteration medium.

4. Biolagical fluid filteration device according to claim 3, wherein said first flow limiter are placed in described first outlet, and wherein said second flow limiter is placed in described second outlet.

5. Biolagical fluid filteration device according to claim 1, wherein said housing comprises baffle plate, described baffle plate is placed in the described upstream chamber and is inserted between the described first Biolagical fluid filteration medium and the second Biolagical fluid filteration medium, and wherein said baffle plate comprises at least one aperture, and the sectional area in described aperture is enough greatly preventing that described upstream chamber is divided into two differences and independent chamber, thereby described baffle plate reduces the volume of described upstream chamber.

6. method that is used to handle biofluid, it comprises:

Biofluid is delivered in the filter for installation, described filter for installation comprises housing, described housing has inlet, first outlet and second outlet, and limiting the first fluid flow path between described inlet and described first outlet and between described inlet and described second outlet, limiting second fluid flow path, wherein said housing does not have solid spaced walls in fact between described first fluid flow path and described second fluid flow path;

Transmit the part of described biofluid by the first Biolagical fluid filteration medium along described first fluid flow path, the described first Biolagical fluid filteration medium has upstream face and downstream surface, and the described first Biolagical fluid filteration medium is inserted between described inlet and described first outlet and on described first fluid flow path

Transmit another part of described biofluid by the second Biolagical fluid filteration medium along described second fluid flow path, the described second Biolagical fluid filteration medium has upstream face and downstream surface, and the described second Biolagical fluid filteration medium is placed between described inlet and described second outlet and on described second fluid flow path.

7. method according to claim 6, wherein said first Biolagical fluid filteration medium and the described second Biolagical fluid filteration medium can remove leucocyte from biofluid.

8. method according to claim 6, wherein first flow limiter is positioned at the downstream of the described first Biolagical fluid filteration medium, and wherein second flow limiter is positioned at the downstream of the described second Biolagical fluid filteration medium.

9. method according to claim 6, wherein said housing comprises baffle plate, described baffle plate is placed in the described upstream chamber and is inserted between described first Biolagical fluid filteration medium and the described second Biolagical fluid filteration medium, and wherein said baffle plate comprises at least one aperture, and the sectional area in described aperture is enough greatly preventing that described upstream chamber is divided into two differences and independent chamber, thereby described baffle plate reduces the volume of described upstream chamber.

10. method according to claim 9, wherein said baffle plate comprise at least one the filter support ribs sheet that is positioned on its first surface, and are positioned at least one the filter support ribs sheet on its second surface.

11. method according to claim 6, wherein automatic discharge device is positioned at the upstream of described inlet, and after mobile the stopping by the described first fluid flow path and second fluid flow path, described automatic discharge device automatically is emitted on the biofluid of the upstream of described first Biolagical fluid filteration medium and the described second Biolagical fluid filteration medium thus.

12. a biological fluid filtration system comprises:

Feeding blood bag,

Be positioned at the Biolagical fluid filteration device in described feeding bags of blood downstream, it has inlet and outlet, and between described inlet and described outlet, limit fluid flow path, and the Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described inlet and the outlet and on described fluid flow path

Receive bags of blood,

One segment pipe, its outlet with described Biolagical fluid filteration device become fluid flow communication and become fluid flow communication with described reception bags of blood,

Flow limiter, it is positioned at the downstream of described Biolagical fluid filteration medium.

13. biological fluid filtration system according to claim 12, wherein said flow limiter are positioned at described Biolagical fluid filteration device.

14. biological fluid filtration system according to claim 12, described flow limiter are positioned at the downstream of described outlet of described biological fluid filtration system and the upstream of described reception bags of blood.

15. biological fluid filtration system according to claim 12, wherein said Biolagical fluid filteration device also comprises second outlet, and second fluid flow path is defined between described inlet and described second outlet, and the second Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described inlet and described second outlet and on described second fluid flow path

And described biological fluid filtration system comprises that also second receives bags of blood,

Second segment pipe, it exports into fluid flow communication with second of described Biolagical fluid filteration device, and becomes fluid flow communication with the described second reception bags of blood,

And second flow limiter that is positioned at the described second Biolagical fluid filteration medium downstream.

16. Biolagical fluid filteration device according to claim 15, wherein said Biolagical fluid filteration device also comprises spaced walls, and first the outlet be positioned on first side of described spaced walls, and second the outlet be positioned on second side of described spaced walls.

17. biological fluid filtration system according to claim 15, wherein said Biolagical fluid filteration device does not have solid spaced walls in fact between described first fluid flow path and described second fluid flow path.

18. biological fluid filtration system according to claim 12, wherein said Biolagical fluid filteration device also comprises second inlet and second inlet, and second fluid flow path is defined between described second inlet and described second outlet, and the second Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described second inlet and described second outlet and on described second fluid flow path

Second segment pipe, it exports into fluid flow communication and becomes fluid flow communication with the described second reception bags of blood with second of described Biolagical fluid filteration device,

19. biological fluid filtration system according to claim 18, wherein said Biolagical fluid filteration device also comprises the solid spaced walls between described first fluid flow path and described second fluid flow path, thereby makes described first fluid flow path be independent of described second fluid flow path.

20. biofluid flow filtration according to claim 12 system, wherein said Biolagical fluid filteration device also comprises second outlet, and second fluid flow path is defined between described inlet and described second outlet, and the second Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described inlet and described second outlet and on described second fluid flow path

Second segment pipe, it exports into fluid flow communication with second of described Biolagical fluid filteration device, and becomes fluid flow communication with described reception bags of blood,

21. biological fluid filtration system according to claim 20, wherein said Biolagical fluid filteration device also comprises spaced walls, and first outlet is positioned on first side of described spaced walls and second outlet is positioned on second side of described spaced walls.

22. biological fluid filtration system according to claim 20, wherein said Biolagical fluid filteration device does not have solid spaced walls in fact between described first fluid flow path and described second fluid flow path.

23. biological fluid filtration system according to claim 12, wherein said Biolagical fluid filteration device also comprises second inlet and second outlet, and second fluid flow path is defined between described second inlet and described second outlet, and the second Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described second inlet and described second outlet and on described second fluid flow path

Second segment pipe, it exports into fluid flow communication and becomes fluid flow communication with described reception bags of blood with second of described Biolagical fluid filteration device,

24. biological fluid filtration system according to claim 23, wherein said Biolagical fluid filteration device also is included in the solid spaced walls between described first fluid flow path and described second fluid flow path, thereby makes described first fluid flow path be independent of described second fluid flow path.

25. biological fluid filtration system according to claim 12, wherein said Biolagical fluid filteration device also comprises second inlet, and second fluid flow path is defined between described second inlet and the described outlet, and the second Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described second inlet and the described outlet and on described second fluid flow path

And described flow limiter is positioned at the downstream of the described first Biolagical fluid filteration medium and the second Biolagical fluid filteration medium.

26. biological fluid filtration system according to claim 12, wherein said Biolagical fluid filteration device also comprises second inlet, and second fluid flow path is defined between described second inlet and the described outlet, and the second Biolagical fluid filteration medium has upstream face and downstream surface, is inserted between described second inlet and the described outlet and on described second fluid flow path

And described first flow limiter is between the downstream and described outlet of the described first Biolagical fluid filteration medium, and second flow limiter is between the downstream and described outlet of the described second Biolagical fluid filteration medium.