CN101687023B - 诊断方法 - Google Patents

诊断方法 Download PDF

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Publication number
CN101687023B
CN101687023B CN200880019915.XA CN200880019915A CN101687023B CN 101687023 B CN101687023 B CN 101687023B CN 200880019915 A CN200880019915 A CN 200880019915A CN 101687023 B CN101687023 B CN 101687023B
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CN
China
Prior art keywords
hbp
purposes
severe sepsis
wbc
individuality
Prior art date
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Active
Application number
CN200880019915.XA
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English (en)
Chinese (zh)
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CN101687023A (zh
Inventor
L·博乔克
贝蒂尔·克里斯汀森
海科·赫沃尔德
亚当·林德
波尔·艾克森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lufthansa Biopharmaceutical Co ltd
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Hansa Medical AB
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Publication of CN101687023A publication Critical patent/CN101687023A/zh
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
CN200880019915.XA 2007-06-12 2008-06-12 诊断方法 Active CN101687023B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0711327.7 2007-06-12
GBGB0711327.7A GB0711327D0 (en) 2007-06-12 2007-06-12 Diagnostic method
PCT/EP2008/004743 WO2008151808A1 (en) 2007-06-12 2008-06-12 Diagnostic method

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201310432428.9A Division CN103543271A (zh) 2007-06-12 2008-06-12 诊断方法

Publications (2)

Publication Number Publication Date
CN101687023A CN101687023A (zh) 2010-03-31
CN101687023B true CN101687023B (zh) 2016-04-20

Family

ID=38331957

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201310432428.9A Pending CN103543271A (zh) 2007-06-12 2008-06-12 诊断方法
CN200880019915.XA Active CN101687023B (zh) 2007-06-12 2008-06-12 诊断方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201310432428.9A Pending CN103543271A (zh) 2007-06-12 2008-06-12 诊断方法

Country Status (16)

Country Link
US (3) US8518648B2 (enExample)
EP (1) EP2129391B1 (enExample)
JP (1) JP5166522B2 (enExample)
KR (1) KR101563997B1 (enExample)
CN (2) CN103543271A (enExample)
AT (1) ATE548050T1 (enExample)
AU (1) AU2008261252B2 (enExample)
BR (1) BRPI0812875B8 (enExample)
CA (1) CA2690067C (enExample)
DK (1) DK2129391T3 (enExample)
ES (1) ES2380875T3 (enExample)
GB (1) GB0711327D0 (enExample)
PL (1) PL2129391T3 (enExample)
PT (1) PT2129391E (enExample)
SI (1) SI2129391T1 (enExample)
WO (1) WO2008151808A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0711327D0 (en) 2007-06-12 2007-07-25 Hansa Medical Ab Diagnostic method
US20100240049A1 (en) 2009-01-16 2010-09-23 Cepheid Methods of Detecting Cervical Cancer
JP5488885B2 (ja) * 2009-10-28 2014-05-14 国立大学法人 東京大学 感染症の疾患マーカー
GB201016161D0 (en) 2010-09-24 2010-11-10 Hansa Medical Ab Diagnostic method
AU2011334548B2 (en) * 2010-11-26 2016-06-09 Immunexpress Pty Ltd Diagnostic and/or screening agents and uses therefor
GB201102108D0 (en) * 2011-02-07 2011-03-23 Hansa Medical Ab Diagnostic method
CA2848873A1 (en) * 2011-09-16 2013-03-21 Cepheid Methods of detecting sepsis
US10260111B1 (en) 2014-01-20 2019-04-16 Brett Eric Etchebarne Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample
US10761093B2 (en) 2014-10-09 2020-09-01 Texas Tech University System Microdevice for cell separation utilizing activation phenotype
CN109541235A (zh) * 2018-08-19 2019-03-29 重庆早柒天生物科技股份有限公司 肝素结合蛋白和降钙素原二联检测试剂盒及其制备方法
US20220178932A1 (en) 2019-04-24 2022-06-09 Japanese Foundation For Cancer Research Cancer detection method and detection reagent
CN111208305B (zh) * 2020-02-16 2023-04-25 重庆翼锋生物科技有限公司 Hbp和pct在败血症诊断试剂制备中的用途
CN111951963B (zh) 2020-07-30 2022-09-02 中翰盛泰生物技术股份有限公司 Hbp在covid-19患者的预后风险预警中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1146724A (zh) * 1994-04-21 1997-04-02 诺沃挪第克公司 用于治疗脓毒症的肝素结合蛋白质及其制备方法
WO2005028512A1 (en) * 2003-09-19 2005-03-31 Leukotech A/S Pro-inflammatory and anti-inflammatory antibodies against the heparin-binding protein (hbp)

Family Cites Families (19)

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US5627262A (en) 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
US5962241A (en) * 1989-07-28 1999-10-05 The University Of Arizona Monoclonal antibody detection of proteins on sperm related to fertility
US5314804A (en) * 1992-03-24 1994-05-24 Serim Research Corporation Test for Helicobacter pylori
US5976536A (en) 1995-08-09 1999-11-02 Emory University Neisseria mutants, lipooligosaccharides and immunogenic compositions
US5778895A (en) 1997-01-29 1998-07-14 Uab Research Foundation Method of discriminating bacterial from aseptic meningitis
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7655480B2 (en) 2002-03-08 2010-02-02 The Board Of Regents Of The University Of Oklahoma Method for predicting sepsis or an acute infectious inflammatory response
US20030170745A1 (en) * 2002-03-08 2003-09-11 Pereira Heloise Anne Early detection marker for chronic inflammatory associated diseases
EP1581556A2 (en) 2002-08-15 2005-10-05 Leukotech A/S Bactericidal, anti-apoptotic, pro-inflammatory and anti-inflammatory peptides of heparin-binding protein (hbp)
JP2006515227A (ja) * 2003-02-24 2006-05-25 ジーティーシー バイオセラピューティックス インコーポレイテッド 十字流濾過の方法およびそのための装置
US7191068B2 (en) * 2003-03-25 2007-03-13 Proteogenix, Inc. Proteomic analysis of biological fluids
CA2529503A1 (en) * 2003-06-20 2004-12-29 Royer Biomedical, Inc. Drug polymer complexes
US20050196817A1 (en) 2004-01-20 2005-09-08 Molecular Staging Inc. Biomarkers for sepsis
US20070092911A1 (en) 2005-10-03 2007-04-26 Buechler Kenneth F Methods and compositions for diagnosis and /or prognosis in systemic inflammatory response syndromes
EP1869463A4 (en) * 2005-04-15 2010-05-05 Becton Dickinson Co SEPSIS DIAGNOSIS
FR2894675B1 (fr) 2005-12-14 2008-06-27 Assist Publ Hopitaux De Paris Distinction des meningites bacteriennes et virales
GB0711327D0 (en) 2007-06-12 2007-07-25 Hansa Medical Ab Diagnostic method
GB201016161D0 (en) 2010-09-24 2010-11-10 Hansa Medical Ab Diagnostic method
GB201102108D0 (en) 2011-02-07 2011-03-23 Hansa Medical Ab Diagnostic method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1146724A (zh) * 1994-04-21 1997-04-02 诺沃挪第克公司 用于治疗脓毒症的肝素结合蛋白质及其制备方法
WO2005028512A1 (en) * 2003-09-19 2005-03-31 Leukotech A/S Pro-inflammatory and anti-inflammatory antibodies against the heparin-binding protein (hbp)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
赵明辉等.原发性小血管炎和抗中性粒细胞胞浆抗体靶抗原的系列研究.《北京大学学报(医学版)》.2002,第34卷(第1期), *
辛岗等.抗中性粒细胞胞质抗体的检出率及其靶抗原研究.《中华风湿病学杂志》.2003,第7卷(第1期), *
郭晓蕙等.抗甲状腺药物引起抗中性粒细胞胞质抗体相关血管炎的临床分析.《中华医学杂志》.2003,第83卷(第11期), *

Also Published As

Publication number Publication date
JP5166522B2 (ja) 2013-03-21
US9784741B2 (en) 2017-10-10
BRPI0812875B1 (pt) 2017-12-05
CA2690067A1 (en) 2008-12-18
KR20100021578A (ko) 2010-02-25
CN101687023A (zh) 2010-03-31
AU2008261252B2 (en) 2013-03-14
JP2010529468A (ja) 2010-08-26
GB0711327D0 (en) 2007-07-25
CN103543271A (zh) 2014-01-29
EP2129391B1 (en) 2012-03-07
CA2690067C (en) 2023-09-19
US20100305185A1 (en) 2010-12-02
SI2129391T1 (sl) 2012-07-31
DK2129391T3 (da) 2012-06-11
US8518648B2 (en) 2013-08-27
KR101563997B1 (ko) 2015-10-28
AU2008261252A1 (en) 2008-12-18
ES2380875T3 (es) 2012-05-21
EP2129391A1 (en) 2009-12-09
ATE548050T1 (de) 2012-03-15
PL2129391T3 (pl) 2012-09-28
WO2008151808A1 (en) 2008-12-18
BRPI0812875A2 (pt) 2014-12-09
BRPI0812875B8 (pt) 2022-07-12
US20140187503A1 (en) 2014-07-03
US20130252347A1 (en) 2013-09-26
PT2129391E (pt) 2012-06-06

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP01 Change in the name or title of a patent holder

Address after: Lund, Sweden

Patentee after: Lufthansa biopharmaceutical Co.,Ltd.

Address before: Lund, Sweden

Patentee before: Hansa Medical AB

CP01 Change in the name or title of a patent holder
IP01 Partial invalidation of patent right

Commission number: 4W110802

Conclusion of examination: On the basis of claims 1-14 submitted by the patentee on September 4, 2020, the invention patent right No. 200880019915. X is maintained valid

Decision date of declaring invalidation: 20201211

Decision number of declaring invalidation: 46928

Denomination of invention: diagnostic method

Granted publication date: 20160420

Patentee: Lufthansa biopharmaceutical Co.,Ltd.

IP01 Partial invalidation of patent right