CN101683458A - Application of a traditional Chinese medicine composition in preparation of medicament for treating vertigo - Google Patents
Application of a traditional Chinese medicine composition in preparation of medicament for treating vertigo Download PDFInfo
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Abstract
The invention provides application of a traditional Chinese medicine composition in preparation of medicament for treating vertigo, the traditional Chinese medicine composition is made of traditionalChinese medicine ginseng, ophiopogon tuber, cornus, danshen root, fried spiney date seed, Chinese taxillus herb, red peony root, ground beetle, nardostachys root etc., and the composition has an efficacy of boosting qi and nourishing yin, promoting blood circulation and removing obstruction in channels, purifying heart and tranquilization, clinical experiment shows that the traditional Chinese medicine composition has obvious curative effect for treating vertigo.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment vertigo medicament, belong to the Chinese herbal medicine application.
Background technology
Dizzy is dizzy and dizzy general name, is dizzy with dim eyesight, blurring of vision and dim blackout; Looking thing rotation, or as very dizzy can not standing to dizzy, simultaneously normal and see because of both, so title is dizzy.
Cause that dizzy kinds of Diseases are a lot, nearly hundreds of disease can cause that the reason of dizzy, different disease also is different.According to the difference of diseased region, roughly can be divided into peripheral vertigo and central vertigo two big classes.Central vertigo is to be caused by cerebral tissue, cranial nerve diseases, such as acoustic neuroma, cerebrovascular disease etc., accounts for 30% of dizzy patient's sum.Peripheral vertigo accounts for 70%, and most peripheral vertigos are relevant with the ear disease.In peripheral vertigo when outbreak, is many with cochlea symptom (change of audition, tinnitus) and autonomic nervous system symptom such as feel sick, vomit, be in a cold sweat.But part disease repeated relapsing is dizzy, spontaneous remission.
Commonly cause that dizzy disease has the untoward reaction of hypertension, hypotension, arteriosclerosis, cerebroma, cerebral thrombosis, anemia, hypothyroidism, hypomotility, disease of inner ear or some drugs medication period etc.
It is dizzy the closest with liver spleen kidney three dirty functional disorder relations that modern Chinese medicine is thought mostly.There is the scholar to think that primary disease is dirty impaired relevant with heart spleen kidney three, the person that undermines the heart, the heart-yin is deficient, hyperactivity of deficient fire; The person that undermines the spleen, insufficiency of the spleen failure of the spleen to transport and transform, the poly-wet expectorant that forms; The person that undermines the kidney suffers from a deficiency of the kidney and then can not conserve edema with the liver involved, and liver-yang is high and wind-transformation causes deficiency in origin and excess in superficiality, upper excess and lower deficiency.
Dizzy medicine commonly used has: 1, M cholinoceptor blocking agent, use scopolamine and Anisodamine more; 2, alpha receptor blocking medicine, phentolamine commonly used; 3, opiate receptor antagonistic, medicine commonly used such as naloxone; 4, cerebrocrast, common drug have nifedipine and flunarizine; 5 Chinese medicine injections are as ligustrazine injection, puerarin injection and Radix Et Caulis Acanthopanacis Senticosi injection etc.
Patent ZL02146572.X discloses a kind of pharmaceutical composition for the treatment of Coronary heart disease ventricular early throb and preparation method thereof, and present patent application quotes in full the content that patent ZL02146572.X is put down in writing.The application of unexposed this pharmaceutical composition of this patent in preparation treatment vertigo medicament.
Summary of the invention
The purpose of this invention is to provide the application of a kind of Chinese medicine composition in preparation treatment vertigo medicament;
Preferably, the present invention also provides the application of a kind of Chinese medicine composition in preparation treatment aural vertigo medicine.
Preferably, the present invention also provides the application of a kind of Chinese medicine composition in preparation treatment hypotension vertigo medicine.
Described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.
The weight ratio of crude drug is preferably in the Chinese medicine composition of the present invention:
89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
The weight ratio of crude drug also is preferably in the Chinese medicine composition of the present invention:
45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
The weight ratio of crude drug also is preferably in the Chinese medicine composition of the present invention:
90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.
In the application of the present invention, the active component of this Chinese medicine composition is made by the following step:
A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and concentrates, and oven dry is ground into fine powder;
B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters, and is standby;
C) Eupolyph aga sinesis Walker is broken into fine powder;
D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water 2 times, and merge extractive liquid, filters, and is standby;
E) with step b) and d) merging of gained extracting solution, reclaim ethanol, be condensed into extractum, add the fine drug powder of step c) gained, oven dry is ground into fine powder, adds step a) gained fine drug powder, and mixing promptly gets this Chinese medicine composition active component.
In the application of the present invention, described Chinese medicinal composition preparation dosage form is a capsule, tablet, granule, powder or oral liquid, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, the acetic acid chloroethene is fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.
Preferably, the preparation method of capsule of the present invention is:
A) people participates in 8 times of amount 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into 80 order fine powders;
B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 8 times of amount 70% alcohol reflux 3 times, and merge extractive liquid, filters, and reclaims ethanol;
C) TUBIECHONG is ground into 80 order fine powders;
D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis add 9 times of amount decoctions of water 2 times, merge extractive liquid,, filter, the extracting solution merging with the step b) gained is condensed into extractum, add step c) gained fine powder, oven dry is ground into 80 order fine powders, adds step a) gained fine powder, mixing, promptly encapsulated.
Clinical observation shows that Chinese medicine composition of the present invention can effectively be treated dizzy, and for aural vertigo and hypotension vertigo, curative effect is better, and no drug dependence and toleration also have no adverse reaction, and are easily accepted by the patient.
The consumption of Chinese medicine composition of the present invention by active component crude drug gross weight, is 7-28 gram/day, but takes every day once, preferably divides and takes for 2-4 time.
The specific embodiment
Following embodiment is used to illustrate the preparation of Chinese medicine composition of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1
Prescription:
Radix Ginseng 89g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 224g
Semen Ziziphi Spinosae (parched) 186g Herba Taxilli 186g Radix Paeoniae Rubra 89g Eupolyphaga Seu Steleophaga 75g
Radix Et Rhizoma Nardostachyos 89g Rhizoma Coptidis 45g Fructus Schisandrae Sphenantherae 67g Os Draconis 149g
Preparation method:
A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is standby;
B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is standby;
C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is standby;
D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters, and filtrate merges with step b) gained extracting solution, and concentrated extractum is standby;
E) with step d) gained extractum, add the fine drug powder oven dry of step c) gained, be ground into fine powder, add step a) gained fine drug powder, mixing, 1000 capsules of packing into.
Usage and consumption: oral.One time 2～4,3 times on the one.
Embodiment 2
Prescription:
Radix Ginseng 45g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 225g Semen Ziziphi Spinosae (parched) 186g
Herba Taxilli 186g Radix Paeoniae Rubra 89g Radix Et Rhizoma Nardostachyos 45g Eupolyphaga Seu Steleophaga 35g Rhizoma Coptidis 45g
Fructus Schisandrae Sphenantherae 67g Os Draconis 149g.
Preparation method:
A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is standby;
B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is standby;
C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is standby;
D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters, and filtrate merges with step b) gained extracting solution, and concentrated extractum is standby;
E) with step d) gained extractum, add the fine drug powder oven dry of step c) gained, be ground into fine powder, add step a) gained fine drug powder, mixing, preparation process is pressed into 1000 routinely.
Usage and consumption: oral.One time 2～4,3 times on the one.
Embodiment 3
Prescription:
Radix Ginseng 175g 192g Radix Ophiopogonis Fructus Corni 421g Radix Salviae Miltiorrhizae 440g Semen Ziziphi Spinosae (parched) 395g
Herba Taxilli 396g Radix Paeoniae Rubra 188g Eupolyphaga Seu Steleophaga 98g Radix Et Rhizoma Nardostachyos 188g Rhizoma Coptidis 85g
Fructus Schisandrae Sphenantherae 147g Os Draconis 278g.
Preparation method:
A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is standby;
B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is standby;
C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is standby;
D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters, and filtrate merges with step b) gained extracting solution, and concentrated extractum is standby;
E) with step d) gained extractum, add the fine drug powder oven dry of step c) gained, be ground into fine powder, add step a) gained fine drug powder, mixing is made 1000 bags of granules according to conventional formulation.
Usage and consumption: oral.One time 2～4 bags, 3 times on the one.
Experimental example
For illustrating the dizzy activity of traditional Chinese medicine composition for treating of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by the foregoing description 1 method to carry out following clinical trial.
1 data and method
1.1 physical data
All case all is selected from 2006.5～2008.2 Hebei Yi Ling hospital ward patients, amounts to 70 examples, and the patient is divided into treatment group and matched group at random.32 examples are organized in treatment, male 26 examples, women 6 examples, year at age (47 ± 8), individual month of the course of disease (13 ± 3), aural vertigo 20 examples, hypotension vertigo 12 examples.Matched group 38 examples, male 30 examples, women 8 examples, year at age (49 ± 7), individual month of the course of disease (14 ± 2), aural vertigo 23 examples, hypotension vertigo 15 examples.By statistics, two groups at aspect there was no significant differences (P＞0.05) such as sex, age, the course of disease, the state of an illness, has comparability.
1.2 case is selected
Inclusion criteria: (1) meets the clinical diagnosis standard: have a dizzy spell, look thing rotation, the lighter closes order and promptly ends, and weight person is as ship by bus, even falls in a swoon suddenly, can be with headache, and nausea and vomiting, tinnitus, antiperspirant goes out; (2) hypotension medical history or auditory vertigo medical history are arranged.Exclusion standard: get rid of other reasons, as vertebral-basilar artery insufficiency, hypertension etc. cause dizzy.
1.3 Therapeutic Method
Matched group uses betahistine 20mg, adds dead point among the 5% glucose injection 250ml, 1 time/day.The treatment group adds on the matched group basis uses medicine of the present invention, and 4/time, 3 times/day.Be 7 days the course of treatment.
1.4 curative effect determinate standard
(1) produce effects: dizzy symptom complete obiteration, follow up a case by regular visits to no recidivist of 1 week; (2) effective: dizzy symptom obviously alleviates, and idol has ictal increasing the weight of, dizzy and (or) slight levitation; (3) invalid: as not reach effective standard person though dizzy symptom has obvious improvement or has to improve.
1.5 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation
2Check.
2 results
2.1 clinical efficacy more by statistics, treatment group patient total effective rate is apparently higher than matched group (P＜0.05).The results are shown in Table 1.
Table 1 liang group patient clinical efficacy is (%) relatively
Annotate: * and # compare, P＜0.05.
3 conclusions
This research is on the basis of doctor trained in Western medicine conventional therapy, add Drug therapy of the present invention, all being better than simple western medical treatment aspect the raising clinical efficacy, fully confirm medicine of the present invention to dizzy, especially have significant clinical efficacy for aural vertigo and hypotension vertigo.
Claims (9)
1, the application of a kind of Chinese medicine composition in preparation treatment vertigo medicament is characterized in that this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.
2, application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
3, application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.
4, application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.
5, as the arbitrary described application of claim 1-4, it is characterized in that the active component of this Chinese medicine composition is made by the following step:
A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and concentrates, and oven dry is ground into fine powder;
B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters, and is standby;
C) Eupolyph aga sinesis Walker is broken into fine powder;
D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water 2 times, and merge extractive liquid, filters, and is standby;
E) with step b) and d) merging of gained extracting solution, reclaim ethanol, be condensed into extractum, add the fine drug powder of step c) gained, oven dry is ground into fine powder, adds step a) gained fine drug powder, and mixing promptly gets this Chinese medicine composition active component.
As each described application among the claim 1-4, it is characterized in that 6, the preparation formulation of described Chinese medicine composition is capsule, tablet, granule, powder or oral liquid.
7, as the preparation method of medicine capsule as described in the claim 6, it is characterized in that this medicine is made by following steps:
A) people participates in 8 times of amount 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into 80 order fine powders;
B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 8 times of amount 70% alcohol reflux 3 times, and merge extractive liquid, filters, and reclaims ethanol;
C) TUBIECHONG is ground into 80 order fine powders;
D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis add 9 times of amount decoctions of water 2 times, merge extractive liquid,, filter, the extracting solution merging with the step b) gained is condensed into extractum, add step c) gained fine powder, oven dry is ground into 80 order fine powders, adds step a) gained fine powder, mixing, promptly encapsulated.
8, as each described application among the claim 1-4, it is characterized in that, described dizzy be aural vertigo.
9, as each described application among the claim 1-4, it is characterized in that, described dizzy be hypotension vertigo.
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| CN103505687A (en) * | 2013-10-10 | 2014-01-15 | 孙丽 | Traditional Chinese medicine for treating vertigo with syndrome of heart-Qi deficiency |
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| CN1188159C (en) * | 2002-10-24 | 2005-02-09 | 河北以岭医药研究院有限公司 | Medicines composition for treating coronary heart disease ventricular premature beat and its prepn |
| CN101234169B (en) * | 2007-02-01 | 2012-05-23 | 河北以岭医药研究院有限公司 | Application of Chinese medicine composition in preparing medicament for adjusting cardiac muscle cell potassium ion channel |
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| CN103505687A (en) * | 2013-10-10 | 2014-01-15 | 孙丽 | Traditional Chinese medicine for treating vertigo with syndrome of heart-Qi deficiency |
| CN103505687B (en) * | 2013-10-10 | 2015-04-08 | 王玉光 | Traditional Chinese medicine for treating vertigo with syndrome of heart-Qi deficiency |
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