CN101678212A - 用于治疗急性躁狂的氨甲酰基-环己烷类 - Google Patents

用于治疗急性躁狂的氨甲酰基-环己烷类 Download PDF

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Publication number
CN101678212A
CN101678212A CN200880017360A CN200880017360A CN101678212A CN 101678212 A CN101678212 A CN 101678212A CN 200880017360 A CN200880017360 A CN 200880017360A CN 200880017360 A CN200880017360 A CN 200880017360A CN 101678212 A CN101678212 A CN 101678212A
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CN
China
Prior art keywords
chemical compound
effective dose
treatment effective
described method
formula
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Pending
Application number
CN200880017360A
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English (en)
Chinese (zh)
Inventor
I·拉兹洛维斯基
G·尼梅斯
G·安道尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
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Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to CN201510549993.2A priority Critical patent/CN105193807A/zh
Publication of CN101678212A publication Critical patent/CN101678212A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880017360A 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类 Pending CN101678212A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510549993.2A CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0700370A HUP0700370A2 (en) 2007-05-24 2007-05-24 Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
HUP0700370 2007-05-24
PCT/HU2008/000052 WO2008142463A2 (en) 2007-05-24 2008-05-19 Carbamoyl-cyclohexanes for treating acute mania

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510549993.2A Division CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Publications (1)

Publication Number Publication Date
CN101678212A true CN101678212A (zh) 2010-03-24

Family

ID=89987541

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880017360A Pending CN101678212A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类
CN201510549993.2A Pending CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510549993.2A Pending CN105193807A (zh) 2007-05-24 2008-05-19 用于治疗急性躁狂的氨甲酰基-环己烷类

Country Status (26)

Country Link
US (1) US20100197704A1 (cg-RX-API-DMAC7.html)
EP (1) EP2164572B2 (cg-RX-API-DMAC7.html)
JP (1) JP2010527985A (cg-RX-API-DMAC7.html)
KR (1) KR20150076266A (cg-RX-API-DMAC7.html)
CN (2) CN101678212A (cg-RX-API-DMAC7.html)
AU (1) AU2008252621B2 (cg-RX-API-DMAC7.html)
CA (1) CA2687528C (cg-RX-API-DMAC7.html)
CY (1) CY1113566T1 (cg-RX-API-DMAC7.html)
DK (1) DK2164572T4 (cg-RX-API-DMAC7.html)
EA (1) EA021936B1 (cg-RX-API-DMAC7.html)
ES (1) ES2397962T5 (cg-RX-API-DMAC7.html)
GE (1) GEP20135731B (cg-RX-API-DMAC7.html)
HR (1) HRP20130092T4 (cg-RX-API-DMAC7.html)
HU (1) HUP0700370A2 (cg-RX-API-DMAC7.html)
IL (1) IL202048A (cg-RX-API-DMAC7.html)
MX (1) MX2009012752A (cg-RX-API-DMAC7.html)
MY (1) MY148955A (cg-RX-API-DMAC7.html)
NZ (1) NZ582284A (cg-RX-API-DMAC7.html)
PL (1) PL2164572T5 (cg-RX-API-DMAC7.html)
PT (1) PT2164572E (cg-RX-API-DMAC7.html)
RS (1) RS52613B2 (cg-RX-API-DMAC7.html)
SI (1) SI2164572T2 (cg-RX-API-DMAC7.html)
TW (1) TWI428130B (cg-RX-API-DMAC7.html)
UA (1) UA101323C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008142463A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200908283B (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
AU2009270823B2 (en) 2008-07-16 2014-07-17 Richter Gedeon Nyrt. Pharmaceutical formulations containing dopamine receptor ligands
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
US9610274B2 (en) * 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8912197B2 (en) 2012-08-20 2014-12-16 Forest Laboratories Holdings Ltd. Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829703A (zh) * 2003-08-04 2006-09-06 匈牙利吉瑞大药厂 作为d3/d2受体拮抗剂的(硫代)氨基甲酰基－环己烷衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60223506T2 (de) * 2001-02-27 2008-09-18 Ortho-Mcneil Pharmaceutical, Inc. Carbamatverbindungen zur vorbeugung oder behandlung bipolarer erkrankungen
MY148643A (en) * 2007-05-11 2013-05-15 Richter Gedeon Nyrt Solvate and crystalline forms of carbamoyl-cyclohexane derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829703A (zh) * 2003-08-04 2006-09-06 匈牙利吉瑞大药厂 作为d3/d2受体拮抗剂的(硫代)氨基甲酰基－环己烷衍生物

Also Published As

Publication number Publication date
GEP20135731B (en) 2013-01-25
WO2008142463A3 (en) 2009-03-05
PL2164572T5 (pl) 2016-02-29
MY148955A (en) 2013-06-14
EP2164572A2 (en) 2010-03-24
JP2010527985A (ja) 2010-08-19
HRP20130092T1 (en) 2013-02-28
DK2164572T4 (en) 2016-01-04
TWI428130B (zh) 2014-03-01
DK2164572T3 (da) 2013-02-11
ES2397962T5 (es) 2016-01-08
NZ582284A (en) 2012-07-27
AU2008252621A1 (en) 2008-11-27
WO2008142463A2 (en) 2008-11-27
AU2008252621B2 (en) 2013-09-19
MX2009012752A (es) 2010-03-15
TW201002326A (en) 2010-01-16
HU0700370D0 (en) 2007-07-30
CN105193807A (zh) 2015-12-30
EA200971087A1 (ru) 2010-04-30
ZA200908283B (en) 2010-08-25
HK1136984A1 (en) 2010-07-16
PL2164572T3 (pl) 2013-04-30
KR20150076266A (ko) 2015-07-06
CA2687528C (en) 2016-07-05
PT2164572E (pt) 2013-01-28
SI2164572T1 (sl) 2013-02-28
RS52613B (sr) 2013-04-30
HRP20130092T4 (hr) 2016-01-01
CA2687528A1 (en) 2008-11-27
EP2164572B1 (en) 2012-11-14
RS52613B2 (sr) 2018-05-31
EP2164572B2 (en) 2015-09-16
ES2397962T3 (es) 2013-03-12
SI2164572T2 (sl) 2016-01-29
CY1113566T1 (el) 2016-06-22
UA101323C2 (en) 2013-03-25
EA021936B1 (ru) 2015-10-30
IL202048A0 (en) 2010-06-16
US20100197704A1 (en) 2010-08-05
IL202048A (en) 2014-11-30
HUP0700370A2 (en) 2009-04-28

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Application publication date: 20100324