CN101677863A - 移植面板 - Google Patents

移植面板 Download PDF

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Publication number
CN101677863A
CN101677863A CN200880013649A CN200880013649A CN101677863A CN 101677863 A CN101677863 A CN 101677863A CN 200880013649 A CN200880013649 A CN 200880013649A CN 200880013649 A CN200880013649 A CN 200880013649A CN 101677863 A CN101677863 A CN 101677863A
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CN
China
Prior art keywords
panel
anchor element
main body
transplanting
lock tab
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880013649A
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English (en)
Inventor
L·G·沃戈
J·A·艾迪
M·D·舒尔茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warsaw Orthopedic Inc
Original Assignee
Warsaw Orthopedic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc filed Critical Warsaw Orthopedic Inc
Publication of CN101677863A publication Critical patent/CN101677863A/zh
Pending legal-status Critical Current

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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
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Abstract

本发明涉及一种至少部分覆盖可移植元件中多个锚元件开口的面板，其包括尺寸适于至少部分交叠可移植元件的多个锚元件开口并被配置为阻止锚元件从多个锚元件开口退出的主体。锁定凸块可与主体关联，所述锁定凸块可形成至少部分弹性变形从而啮合可移植元件并将所述主体固定在适当位置。

Description

移植面板
技术领域
本发明一般涉及用医学移植替换部分人体解剖结构的领域。
背景技术
人体脊柱相邻椎骨(vertebrae)端板之间的椎盘(spinal discs)提供关键的支撑。但是，由于损伤、退化(degradation)、疾病或类似原因，这些椎盘可断裂、退变(degenerate)和/或突出至相邻椎骨间的椎间空间塌陷的程度，这是由于椎盘丧失至少部分支撑功能。这可引起神经根受到冲击和神经痛。在某些情况下，可能需要外科矫正。
某些外科矫正包括从相邻椎骨至之间除去非人工椎盘(natural spinaldisc)。为了保持椎间盘空间以便发挥正常脊柱功能，移植元件可插入到相邻椎骨间。
某些移植元件采用将移植元件固定在相邻椎骨间适当位置的锚元件。随着时间推移，由于椎骨相对于移植元件的微运动，锚元件可能变松并开始退出椎骨。
需要可减小或消除锚元件退出的移植件。本文公开的移植件解决了本技术领域中的一个或多个缺陷。
发明内容
在一个示例性方面，本公开涉及可移植医学装置，其可用锚元件(anchormember)连接到骨结构。该装置可包括移植元件，该移植元件包括尺寸适于接收锚元件的锚元件开口(aperture)，并可包括尺寸适于交叠至少一部分锚元件开口并且阻止锚元件从锚元件开口退出的面板。面板可被配置为咬合到可移植元件上。在另一个示例性方面，本公开涉及至少部分覆盖可移植元件中多个锚元件开口的面板。面板可包括主体，其尺寸适于至少部分交叠可移植元件的多个锚元件开口，并且被配置为阻止锚元件从多个锚元件开口中退出。锁定凸块(locking tab)可与主体关联，该锁定凸块可形成至少部分弹性变形从而啮合可移植元件并将主体固定在适当位置。
在又一个示例性方面，本公开涉及包括将移植元件引入脊椎段(vertebral segment)的方法，该脊椎段包括上椎骨和下椎骨。锚元件可穿过移植元件中锚元件开口而插入，所述锚元件穿透上椎骨和下椎骨。面板可被定向(oriented)从而至少部分交叠锚元件开口，并且面板可被推进直到其咬合到移植元件上从而阻止锚元件退出。
本发明进一步的方面、形式、实施方式、目的、特征、益处和优点可从本文提供的详细附图和说明书中显而易见地得出。
附图说明
图1是腰脊柱段的侧视示意图。
图2是由两个椎骨形成的脊柱段(spinal segment)的侧视示意图，其中示例性可移植装置位于这两个椎骨间。
图3是图2中所示的示例性移植件的透视示意图。
图4是图2中所示的示例性移植件的部分分解透视示意图。
图5是图2中所示的示例性移植件的示例性面板部分的透视示意图。
图6是可与图2中所示的示例性可移植装置一起使用的示例性插入工具的示意图。
图7是另一个示例性可移植装置的透视示意图。
图8是图7中示例性移植件的示例性面板部分的透视示意图。
图9是另一个示例性可移植装置的透视示意图，其中无锚元件。
图10是图9中示例性可移植装置的示例性面板部分的透视示意图。
图11是图10中示例性面板部分的顶视示意图。
图12是另一个示例性可移植装置的透视图，其中无锚元件。
图13是图12中示例性移植件的分解透视示意图。
图14是图9中所示的分解的示例性移植件的侧视示意图。
发明详述
为了促进对本发明原理的理解，用附图中所示的参考并且用特定语言来说明实施方式或实施例。但是应理解的是，该意图不是限制本发明的范围。所说明的实施方式中的任何改变和进一步改进以及本文所述的本发明原理的任何进一步应用都是可预期的，正如本发明相关领域的技术人员应通常想到的。
图1显示部分脊柱10的侧视图，其显示一组由非人工椎间盘D1、D2、D3隔开的相邻上椎骨和下椎骨V1、V2、V3、V4。四个椎骨的示意图的意图是仅作为例子。另一个例子是骶骨和一个椎骨。
作为进一步例子，将参考图2所示的脊柱段12来说明两个椎骨。上椎骨14和下椎骨16——可以是椎骨V1、V2、V3、V4中的任何一个——来确定脊柱段12。虽然图1和2的示意图一般地描述腰椎和腰椎段，但是可以理解的是，本公开的装置、系统和方法也可用于脊柱的所有区域，包括颈椎区和胸椎区。
椎盘关节造型术的某些类型要求位于两个椎骨14、16之间的一些或全部非人工椎盘经椎间盘切除术或类似外科手术方法去除。去除病变或退变的椎盘导致在上椎骨和下椎骨14、16之间形成椎间空间。一旦病变或退变的椎盘被去除，可移植的修复装置就可用来保持椎骨间隔并提供椎骨支撑。如图2所示，本文由标识号100表示的可移植装置位于椎骨空间内。其尺寸以类似非人工椎间盘如任一椎盘D1-D4的方式适配椎盘空间高度，可移植装置100提供对椎骨的支撑和稳定。
图3和4更详细显示可移植装置100。图3显示可移植装置100的透视示意图，而图4显示部分分解的可移植装置100。现在参考图3和4，可移植装置包括移植元件102、面板104和锚元件106。移植元件102可包括上表面108、下表面110、侧表面112a-b、后表面114和前表面116。上表面和下表面108、110被配置为与上椎骨和下椎骨14、16的负载支撑端板连接，而侧表面、后表面和前表面112a-b、114、116在上表面和下表面108、110之间延伸。中空中心118可以使骨生长材料如异体移植物的设置来促进可移植装置100与相邻椎骨的粘连(bonding)和融合。
在所示实施方式中，上表面和下表面108、110包括骨啮合部件120，其被配置为减小移植元件102相对椎骨14，16的滑动或移动。在所示的示例性实施例中，骨啮合部件120为成角齿(angled teeth)，其可引入椎盘空间内并限制其移动(restrict removal)。这些可以是任何其他已知的骨啮合部件，包括凸起和骨脊(keel)等等。可选地，上表面和下表面108、110可以是相对平滑的。侧表面112a-b的每个都包括被配置为与插入工具(下文说明)配合的凹槽(recessed slot)122(图4最佳地显示)，该插入工具选择性连接到移植元件102。在槽122内，附着部件，如连接压痕(impression)124(图4)被配置为提供与面板104的紧固连接。
前表面116和/或上表面和下表面108，110包括锚元件开口126，其接收锚元件106以便将移植元件102连接到锥体14，16。在该示例性实施例中，锚元件106是骨锚元件。但是，其他锚元件也是可预期的。锚元件106穿过前表面116和上表明108及下表面110中的锚元件开口126延伸，延伸出中空中心118并进入椎骨14，16的支撑端板，因而牢固地将移植元件102完整地定位在椎盘空间内。在该示例性实施例中，移植元件102包括三个开口126——其中两个成角度以使锚元件106连接到上椎骨端板，一个成角度以使锚元件106连接到下椎骨端板。但是，在其他实施例中，也可使用其他数目和构型的锚元件106。
为了减小锚元件106随时间而退出锥体并引起移植元件102变松的机会，面板104被配置为横跨至少部分锚元件开口126延伸并物理阻挡锚元件退出。除了图3和4，图5也详细显示面板104。这些图中所示的示例性面板104包括主体128和与移植元件102配合的锁定部件，从而将主体128固定在锚元件开口126上适当的位置。在所示实施例中，锁定部件是适应性锁定凸块130，其从主体128伸出并啮合移植元件102。
主体128包括前表面132、接触表面(interfacing surface)134、各顶表面和底表面136、138，以及第一端和第二端140、142。接触表面134面对于移植元件102的前表面116设置并通过位于退出路径上的物理设置阻止锚元件106退出。在示例性实施例中，主体128以弧形从一侧表面112a到另一侧表面112b基本延伸前表面116的整个长度。其高度小于前表面116的高度，并且其仅交叠每个锚元件开口126的一部分，如图3所示。
在该示例性实施例中，锁定凸块130通常在形成U形的相同方向上，作为悬臂从主体128的第一和第二端140、142延伸。在其他实施例中，锁定凸块130从面板104的顶表面136和底表面138延伸。每个锁定凸块130包括体部144和从体部144延伸的锁定突起146。每个锁定凸块130的体部144被配置为与在移植元件102的侧表面112a-b中形成的相应凹槽122配合，并且锁定突起146被确定尺寸并被配置为与凹槽122中相应连接压痕124接界。在所示实施例中，锁定突起146是成角度突起，其具有引导渐细表面(leading taperedsurface)148和尾随锁定表面(trailing locking surface)150。
在所示实施例中，面板104被配置为连接到移植元件102的外侧112a-b。因此，面板104可定尺寸从而横越移植元件102的宽度，并可具有外部宽度W1。在其他实施例中，面板可被配置为连接到移植元件102上的位置而非外表面。
面板104可被配置为咬合到移植元件102上，以使一旦锚元件106在外科手术过程中被设置就可简易安装。如本文所用，术语“咬合，”和“咬合到”意图是表示使用不同组分的部件来连接，而不用独立扣件，如螺丝或钉(staple)。为了进行该目的，在所示实施例中，锁定凸块130可被配置为在将面板104设置在移植元件102上时弹性形变，并且然后咬合到适当位置，因而将面板104固定在移植元件102上并物理限制锚元件106从移植元件102退出。该例子进一步在下文提供。
如图2所示，当可移植装置100为间隔器(spacer)时，其能够整个包含在椎盘空间内。因此，减少锚元件退出机会的锚元件锁定部件，如锁定凸块130，也可完整地设置在椎盘空间内。这减少了产生额外的病人损伤的机会，这样的损伤可在器官和组织易于接触椎盘空间外可移植装置时发生。
在所示实施方式中，面板104可全部或部分由不同类型的生物相容性材料构成。面板材料的例子包括但不限于非增强聚合物、碳增强聚合物复合物、PEEK和PEEK复合物、形状记忆金属、钛、钛合金、钴铬合金、不锈钢、陶瓷及其组合。如果面板104由射线透明材料制成，则x射线标记可定位在面板104上从而提供以x射线术或荧光检查来监视和确定椎盘空间内面板位置的能力。可再吸收材料也可使用。可使用的可再吸收材料的例子包括但不限于聚交酯、聚乙交酯、酪氨酸衍生聚碳酸酯、聚酐、聚原酸酯、聚磷腈、磷酸钙、羟基磷灰石、生物活性玻璃及其组合。
图6显示用于移植该移植元件102的插入工具152的端部。插入工具152包括体部(body portion)154和被配置为与移植元件侧表面112a-b上凹槽122接触的两个臂156。每个臂156上锁定突起158被定形和定尺寸从而与凹槽122中连接压痕124配合。因此，插入工具152和面板104可设计成与移植元件102上的相同部件配合。插入工具152的整个宽度W2可等于或大于面板104的整个宽度W1。这可确保移植元件102在用插入工具152引入并设置在病人体内后，面板104将适当配合在椎盘空间内。
在可选的实施方式中，锁定突起是在移植元件102和插入工具152上形成的，和/或面板104具有附着部件，如连接压痕，而不是在插入工具152和/或面板104上形成锁定突起146、158。此外，在某些示例性实施方式中，连接压痕124是开口，钩子或其他突出或凹陷特征。进一步，在某些示例性实施方式中，插入工具152和/或面板104连接到移植元件102上位置，而不是侧表面112a-b。例如，在某些示例性实施方式中，锁定凸块130延伸到邻近锚元件开口126的移植元件102的表面中形成的洞孔(bore)中。连接的其他类型和位置是可预期的。
此外，虽然公开的是在前表面116上，这里前表面是前部表面，但应该理解，面板104可设置来覆盖可移植装置102中的任何具有锚元件开口126的表面，从而阻止锚元件退出。例如，某些移植元件102可在后部移植并可包括在后侧114，或可选地在横侧112a-b上的锚元件开口126。在这些实施方式中，面板104可设置来与这些侧边上的开口配合并阻止锚元件从这些开口退出。
图7显示可移植装置的另一个示例性实施方式，其在本文由标识号200表示。可移植装置200可包括移植元件202、面板204和锚元件206。移植元件202、面板204和锚元件206可包括本文所述其他实施例的任意或所有特征，并且为了减少重复，许多这些特征都将不再针对可移植装置200讨论。
类似于可移植元件102，可移植元件202包括侧表面208a-b、后表面210和前表面212。锚元件开口214显示在前表面212中形成，并使其连接到图2中椎骨14，16的支撑端板。但是，在该实施方式中，侧表面208a-b和前表面212包括其中形成的凹口(与位于其中的面板204一起显示)，该凹口的尺寸适于接收面板204以便面板204与一个或所有侧表面208a-b及前表面212齐平设置。同其他实施方式一样，面板204与锚元件开口214交叠并阻止锚元件退出。
面板204的一个示例性实施方式在图8中显示。在该示例性实施方式中，面板204包括主体216和从主体216延伸的锁定凸块218。在该实施方式中，主体高度实质上与锁定凸块高度一样。锁定突起220(仅显示一个)从锁定凸块218向内延伸，通常彼此面对。在该示例性实施方式中，锁定突起220是圆柱形突出物(projections)，其被配置为装配到移植元件202上圆柱形连接压痕中。再次，如上所述，面板204被配置为咬合移植元件202并阻止锚元件退出。
图9显示可移植装置的另一个示例性实施方式，其由标识号300表示。可移植元件300可包括移植元件302、面板304和锚元件(未显示)。移植元件302、面板304和锚元件可包括本文所述其他实施例的任何或所有特征，为了减少重复，许多这些特征都将不再针对可移植装置300讨论。
如图9所示，移植元件302包括上表面308、下表面309、侧表面310a-b和前表面312。侧表面310a-b的每个都包括凹槽314，其被配置为与上述插入工具152配合，该插入工具选择性连接到移植元件302。在凹槽314内，连接压痕316被配置为提供与插入工具牢固连接。前表面312包括锚元件开口(未显示)，其接收锚元件以便将移植元件302连接到椎骨14、16。
面板304在图10和11中显示，并包括主体320、锁定凸块322和固定凸块324。主体320包括前表面326、接触表面328、以及各顶表面330和底表面332。在所示的示例性实施方式中，主体320包括观察端口(viewing port)334，其由横跨主体320延伸的凹槽形成。这些观察端口334使操作医师可观察先前穿过面板304插入的锚元件。接触表面328面对移植元件302的前表面312设置，并通过物理阻挡锚元件而阻止其退出。在该示例性实施方式中，面板304用固定凸块324和锁定凸块322连接到移植元件302。
在该示例性实施方式中，固定凸块324从主体320的侧边336延伸，并被配置为与移植元件302上的凹槽314接界并延伸到其中。这些固定凸块324用作导引件从而在组装过程中帮助定向和设置面板304。
在该示例性实施方式中，锁定凸块322从主体320的顶表面和底表面330、332延伸，并偏离中心线形成，如从图11中最佳看到的那样。每个锁定凸块322包括体部338和从体部338延伸的锁定突起340。每个锁定凸块322的体部338被配置为装配在移植元件302的上表面308和下表面309中形成的相应匹配沟槽342中(在图9中最佳显示)，锁定突起340被确定尺寸并配置为与匹配沟槽342中相应连接压痕(未显示)接界。锁定凸块322，如参考本文其他实施例描述的那样，可被配置为在将面板304设置在移植元件302上时弹性变形，并咬合到适当位置，因而在移植元件302上固定面板304并物理限制锚元件从移植元件302退出。
可移植元件的另一个示例性实施方式在图12-14中显示，其标识号为400。可移植装置400可包括移植元件402、面板404和锚元件(未显示)，其中每个都可包括本文所述其他实施例的任意和所有特征。为了减少重复，许多这些特征都将不再针对可移植装置400讨论。
如从图12-14中看到的那样，移植元件包括上表面408、下表面410、侧表面412a-b和前表面414。侧表面412a-b每个都包括凹槽416，其被配置为与上述插入工具152配合，该插入工具选择性连接到移植元件402。在凹槽416内，连接压痕424被配置为提供与插入工具和面板404牢固连接。前表面414和上表面408及下表面410包括锚元件开口420，其接收锚元件以便将移植元件402连接到椎骨14、16。
面板404包括具有主体422、锁定凸块424。主体422包括接触表面426、以及各顶表面428和底表面430。在图12-14所示的示例性实施方式中，突出的突起(projecting protuberance)432从主体422的接触表面426以与锁定凸块424相同的方向延伸。突出的突起432被定尺寸和成形从而至少部分穿入锚元件开口420并邻近锚元件装配。在某些示例性实施方式中，突出的突起432平贴于锚元件或与锚元件齐平设置从而实质上消除锚元件退出。在这些示例性实施方式中，锚元件被更紧密地保持在适当位置，并且它们的移动比前面的实施方式更受限制。在其他示例性实施方式中，突出的突起432没有平贴锚元件设置，但仍比仅有主体提供较小的退出空间。
现在参考图14，突出的突起432包括背离移植元件402定向的外表面434、被配置为面对锚元件的内表面436、以及轮廓边缘438。因为移植元件402中锚元件开口420有角度，所以内表面436也成角度从而与锚元件端部齐平设置并与其相邻。内表面436的角度取决于移植元件的设计和锚元件的角度以及锚元件开口420。在该示例性实施方式中，锚元件开口420延伸穿过前表面414和相应上表面408及下表面410。因此，在所示实施例中，外表面434定向在锚元件开口420外面并与相应上表面408或下表面410齐平设置。在其他实施例中，锚元件开口420仅穿过侧表面412、前表面414或后表面415安置，突出的突起432延伸到锚元件开口420中并可完全被其包围。
为了便于解释，面板404仅显示单个突出的突起432。但是，在其他实施例中，主体422包括与移植元件402中每个锚元件开口420相应的突出的突起432。因此，具有突出的突起432的主体422通过物理阻挡锚元件而阻止其退出。如本文所示的其他实施例，在该示例实施例中，面板404用锁定凸块424连接到移植元件402。
类似于针对本文其他实施方式所述，锁定凸块424可被配置为在将面板设置在移植元件402上时弹性变形，然后咬合到适当位置，从而将面板404固定到移植元件402上，并物理限制锚元件从移植元件402退出。
以下描述了移植方法，其参考本文公开的可移植装置100的第一实施方式。但是，移植方法的意图是可应用于所有公开的实施方式。
可用任何常用方法在椎骨14，16之间移植间隔器，常用方法包括前路手术(anterior approach)、后路手术(posterior approach)、经椎间孔入路手术(posterior transforaminal approach)、远外侧入路手术(far lateralapproach)、直接外侧入路手术(direct lateral approach)等等。根据这些方法中的至少一个，切口例如中线切口(midline incision)可在病人背部形成，并且部分或全部受影响椎盘和周围组织可经孔口除去。椎骨14的端板表面可碾磨、打磨或被切除从而匹配移植元件102的上表面108的轮廓，进而规格化椎骨14端板表面上的应力分布，和/或在骨头长到肉中前提供初始固定。椎骨14的端板的制备可导致变平的表面或表面等高线，如凹穴、凹槽，或可与上表面108上骨头啮合部件120匹配的其他等高线。椎骨16的端板可类似地制备从而啮合移植元件102的下表面110至离开神经根和背神经后根中枢的程度。在某些过程中，椎骨14，16的非人工脊椎面关节(facet joint)可修整或切除从而提供对椎盘空间的接触。
然后移植元件102可连接到插入工具152并引入到上椎骨和下椎骨14，16间的椎间盘空间中。一旦适当定位，插入工具152可从移植元件102除去，并且锚元件106可被驱动通过锚元件开口126进入椎骨端板。可选地，锚元件106可在除去插入工具152之前被驱动进入锚元件开口126。一旦锚元件106被驱动进入骨头，锚元件开口126可以面板104覆盖从而防止锚元件退出。
面板104可引入到移植元件102中，因此锁定凸块130与凹槽122对准。在推进面板104时，锁定突起146的渐细表面148接触移植元件102并被迫弹性地分开。进一步，推进沿凹槽122滑动锁定突起146直到锁定突起146达到连接压痕124。一旦到达这里，面板104咬合到移植元件102中，因为随着锁定突起146至少部分咬合到连接压痕124中，锁定凸块130向其原始位置变形。锁定突起146上锁定表面150贴着连接压痕124啮合并抵抗面板104从移植元件102分开。现在定向面板102的主体128从而交叠至少部分锚元件开口126，并且外科手术过程可以本领域已知的方式完成。
随着时间推移，由于椎骨和移植元件102的微运动，锚元件106可稍微松开。但是，锚元件106可能因为与面板104的主体128接触而不能退出。因此，锚元件退出被面板104阻止。在一些实施方式中，在面板104咬合移植元件102后，额外的锁定部件，如螺丝紧固件可用来进一步将面板104连接到移植元件102上。
在某些实施方式中，移植元件或可移植元件的个别组件由骨实心段、其他组织或可再吸收材料的构造。组织材料包括但不限于合成或非人工自体移植物，异体移植物或异种移植物，并可以是天然可再吸收的或不可再吸收的。其他组织材料的例子包括但不限于硬组织、结缔组织、去矿物质骨基质及其组合。可使用的可再吸收材料的例子包括但不限于聚交酯、聚乙交酯、酪氨酸衍生聚碳酸酯、聚酐、聚原酸酯、聚磷腈、磷酸钙、羟基磷灰石、生物活性玻璃及其组合。可移植装置可以是固体的、多孔的、海绵状的、打孔的、钻孔的和/或开放的。
在某些情况下，以合适的生骨材料或治疗组合物将移植元件的所有或部分中空中心包裹是有利的。生骨材料包括但不限于自体移植物、异体移植物、异种移植物、去矿物质骨、合成和非人工骨移植替代品如生物陶瓷和聚合物、以及骨生成诱导因子(osteoinductive factor)。也可使用将材料保持在装置内的独立载体。这些载体可包括基于胶原的载体、生物陶瓷材料如
Figure G200880013649XD00111
羟基磷灰石和磷酸钙复合物。载体材料可以海绵体、块体、折叠片、灰泥、浆糊、移植材料或其他合适形式提供。生骨组合物可包括有效量的骨形态发生蛋白质(bone morphogenetic protein)、转化生长因子(transforming growth factor)β1、胰岛素样生长因子(insulin-like growth factor)1、血小板源生长因子(platelet-derived growth factor)、成纤维细胞生长因子(fibroblast growthfactor)、LIM矿化蛋白质(LMP)及其组合，或其他治疗或抗感染药剂，这些成分独立地或保持在合适载体材料内。
可以理解，所有空间参照，如“顶”、“内”、“外”、“底”、“左”、“右”、“前部”、“后部”、“上方”、“下方”、“中”、“侧”、“上”、“下”、“前”和“后”仅用于说明目的，并可在本公开的范围内改变。
虽然本公开详细说明并描述了本发明实施例，但本公开应被认为是说明性的而不是在特征上限制的。本发明精神内的所有变化和修改都被认为是在本公开的范围内。

Claims (13)

1.一种可用锚元件连接到骨结构的可移植医学装置，包括：
移植元件，其包括尺寸适于接收所述锚元件的锚元件开口；以及
面板，其尺寸适于交叠至少一部分锚元件开口并阻止所述锚元件从所述锚元件开口退出，所述面板被配置为咬合到所述可移植元件上。
2.根据权利要求1所述的装置，其中所述移植元件包括面板附着部件，并且所述面板包括咬合到所述面板附着部件上的适应性锁定凸块。
3.根据权利要求2所述的装置，其中所述面板附着部件是所述移植元件中的连接压痕。
4.根据权利要求3所述的装置，其中所述移植元件包括在其中形成的凹口，并且所述连接压痕在所述凹口中形成。
5.根据权利要求3所述的装置，其中所述面板附着部件被配置为与插入工具配合用于所述移植元件的移植。
6.根据权利要求1所述的装置，其中所述面板包括交叠所述锚元件开口的主体，并且包括从所述主体延伸的适应性锁定凸块。
7.根据权利要求6所述的装置，其中所述适应性锁定凸块是第一和第二锁定凸块，其中所述主体和所述第一及第二锁定凸块形成U形，并且其中所述锁定凸块被配置为沿所述可移植元件的相对侧边延伸。
8.根据权利要求1所述的装置，其中所述移植元件包括凹陷部分，并且其中所述面板包括交叠锚元件开口的主体，并且其中所述主体装配在所述凹陷部分内。
9.根据权利要求1所述的装置，其中所述面板包括：
主体；以及
从所述主体向所述移植元件延伸的突出的突起，所述突出的突起至少部分延伸到所述锚元件开口中。
10.根据权利要求9所述的装置，其中所述突出的突起具有内表面，其被配置为位于邻近所述锚元件。
11.根据权利要求10所述的装置，其中所述内表面相对于所述主体成角度。
12.根据权利要求1所述的装置，其中所述面板包括：
主体；
从所述主体延伸的锁定凸块，所述锁定凸块被配置为将所述面板固定到所述移植元件上；以及
固定从所述主体延伸的凸块，所述固定凸块被配置为将所述面板导引并定向到所述移植元件上。
13.根据权利要求12所述的装置，其中所述主体包括观察端口，其穿过所述主体延伸并定位以进行所述锚元件开口的视觉观察。
CN200880013649A 2007-04-03 2008-03-31 移植面板 Pending CN101677863A (zh)

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WO2008124355A1 (en) 2008-10-16
AU2008237452A1 (en) 2008-10-16
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US20080249569A1 (en) 2008-10-09
EP2131791A1 (en) 2009-12-16
EP2131791B1 (en) 2012-08-01

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