CN101668493A - Oral care compositions, methods, devices and systems - Google Patents

Abstract

Oral care treatments are provided, including multi-component oral care compositions and methods for delivering such compositions to the oral cavity. Oral care devices and systems for implementing suchoral care treatments are also provided.

Description

Oral care composition, methods, devices and systems

Technical field

The present invention relates to oral care composition, methods, devices and systems.

Background of invention

Although it is known that the purposes of two or more oral care compositions is people, but still be desirable to provide improved products and the method that is used for one or more compositionss are delivered to the oral cavity.

Summary of the invention

In general, the invention is characterized in the mouth care processing, described processing comprises: the multicomponent oral care composition; The method of mouth care comprises the scheme that is used for various ingredients is delivered to the oral cavity; And oral care appliance, external member and system.

Summary of drawings

Fig. 1 is the side perspective view of an oral care systems embodiment.

Fig. 2 A is the front perspective view of an oral care device embodiment.

Fig. 2 B is the back perspective view of the oral care appliance of Fig. 2 A.

Fig. 3 A is the transparent front view of the oral care appliance of Fig. 2 A.

Fig. 3 B is the transparent rearview of the oral care appliance of Fig. 2 A.

Fig. 4 A and 4B are respectively the head of another oral care device embodiment and the rearview and the front view of neck bar, and wherein the neck bar is shown as transparent.

Fig. 5 is the head of another oral care device embodiment and the rearview of neck bar, and wherein the neck bar is shown as transparent.

Fig. 6 and 7 is the front perspective view of two brush embodiments.

Fig. 8 A is the side perspective view of an embodiment of butt joint base.

Fig. 8 B is the transparent side perspective view of the butt joint base of Fig. 8 A.

Fig. 9 shows a butt joint base embodiment.

Figure 10 shows another butt joint base embodiment.

Figure 11 is the perspective view of an embodiment of oral care systems.

Figure 12 is the perspective view of the base part B of butt joint base shown in Figure 11.

Figure 13 is the profile that is applicable to of the present invention pair of compartment formula allotter.

Figure 14 is the profile that is applicable to two allotters of the present invention.

Figure 15 is the front view that is applicable to dispensing toothbrush of the present invention.

Figure 16 is the sketch map according to oral care systems of the present invention.

Figure 17 is the sketch map that is applicable to electric component of the present invention.

Detailed Description Of The Invention

Following text is set forth the broad description of the numerous different embodiments of the present invention.It only is exemplary illustration that this explanation should be regarded as, and do not address each possible embodiment, even if because describe each possible embodiment if possible, also be unpractical, and should be appreciated that any feature as herein described, characteristic, assembly, compositions, composition, dosage, product, step or method all can be deleted, whole or partly with any further feature as herein described, characteristic, assembly, compositions, composition, dosage, product, step or method is combined or replace with the latter.The technology that still belongs to these claims scope that can use present technique or develop after the submission date of this patent is implemented numerous alternative embodiments.All that this paper quoted are announced and patent is all incorporated this paper into way of reference.

Also be to be understood that, unless term clearly defines with sentence " as used herein; that term '------' is defined as being meant ... " or a similar sentence in this patent, otherwise be not intended with the implication of this term clearly or restriction impliedly exceed its usual or common implication, and this type of term should not be interpreted as being limited within the scope of any statement (except the language of claims) of having done in arbitrary part of this patent.Be absolutely necessary for the purpose of the present invention without any term, unless stipulate like this.When in this patent, mentioning arbitrary term of narrating in this patent appended claims in the mode that meets single meaning, be for clarity so that the reader is not caused confusion, and be not intended impliedly or in other words this claim term to be restricted to this single implication.At last, do not define, otherwise be not intention is explained arbitrary claim key element based on the utilization of the 6th section of 35U.S.C. § 112 scope unless the claim key element is described any structure by describing wording " device " and function.

In general, hereinafter discussion is related to the mouth care of following substance delivery in the oral cavity handled: two or more oral care compositions, many parts of compositionss, material, preparation or compositions (hereinafter being referred to as " component ").Specifically, mechanically isolating each other two kinds of components before sending hereinafter will be discussed.Described component can be sent from multiple oral care appliance such as manual toothbrush, electric toothbrush, packing or allotter.Described component can simultaneously or in a sequence be sent.In some cases, these two kinds of components (when mixing) are reacting between delivery period or in the oral cavity or are in other words interacting together to form oral care composition, for example United States Patent (USP) 6, the bi-component dentifrice of being discussed in " oral care composition and component " described in 375,933 and hereinafter part.In other cases, described component is certainly as complete oral care composition; For example, certain component can be dentifrice or collutory.We will at first discuss various executable mouth care and handle.Then, we are applicable to discussion the embodiment of the device of sending described component.At last, we will discuss the embodiment of the various components that can send.Described component can be any form that can be sent by required delivery apparatus, for example Newtonian fluid or non-Newtonian fluid, liquid, paste or gel.

Using method

In the following discussion, we will mention and send two kinds of mechanically isolating components.Yet, it is evident that the method for being discussed can be prolonged and is used for three kinds or more kinds of component.Following method can for example use the distributor with microprocessor controller to carry out.In toothbrush, can use fixed or movable head (or movable part of head).For example has head (or the part of head, comprise bristle or element) suitable toothbrush, described head is rotatable, swing, reciprocating motion, translation, vibration etc., as U.S. Patent application 09/993,167,10/036,613,10/114,870,10/128,018,10/208,213 and 10/830,693 and United States Patent (USP) 5,378, described in 153.In addition, also can use toothbrush with light emitting diode, comprise can luminous (comprising blue light) toothbrush, described in U.S. Patent application 10/832,168,10/847,429,10/842,302,10/887,644,10/887,667 and 10/888,206.Suitable toothbrush can comprise or can not comprise bristle or cleaning element.In another embodiment, allotter such as many compartments formula packing can be used for the present invention, such as further discussed.The embodiment of appropriate device will go through in " oral care appliance " part hereinafter.

Described component simultaneously or in a sequence can be delivered in the oral cavity.In the situation of delivery order, two kinds of components all can for example sent during scrubbing period or other single processing period (used, begun to end by specific user single, be generally about 0.1 minute to 5 minutes) single during single mouth care period; Or alternatively, described component is interim sending when a plurality of mouth care individually.Many combinations all are possible, and for example two kinds of components are all sent during first mouth care period, and only send a kind of in the described component during second mouth care period.The possible embodiment that sends sequence and scheme hereinafter is discussed.

Send simultaneously

The simplest situation for during single mouth care period simultaneously and send these the two kinds of components of equivalent or the described component of constant ratio continuously.In some cases, for example when a kind of in the described component was liquid such as collutory, this ratio can be between about 1: 20 and about 20: 1.For example, send mutual Fails To Respond but on dosage form during inconsistent two kinds of components, the solution of the present invention can be suitable when hope.For example, may expect to send needs different pH levels just to have active two kinds of components, such as inferior stannum of pyrophosphate (it has activity under low pH value) and sodium fluoride (it has activity under high pH value).These two kinds of components can provide with the adhesive composition with different pH levels independently, are delivered in the oral cavity simultaneously then.Scrubbing the persistent period can enough lack so that described component can inactivation.Another kind is used for simultaneously and the system of sending continuously is following system: they comprise two kinds of components that react lentamente relatively, and they will be retained in after scrubbing in the oral cavity to be absorbed by tooth and/or gingiva.

Alternatively, during scrubbing, send and can be the while and successive, but the ratio of these two kinds of components can change.In some cases, may expect first component of sending relative large crumb when initial, together with more a spot of second component (for example, 80: 20 ratio or between about 1: 20 and about 20: 1), during scrubbing, reduce the amount of first component then and increase the amount of second component, for example be reversed (for example, 20: 80 ratio) up to ratio.The variation of this relative quantity can be linear, or can be nonlinear, for example, a large amount of toothpaste of ejection so that begin to scrub with a spot of collutory, almost just reduces the amount of paste and the amount of increase collutory to have enough pastes then immediately significantly when initial.Also can select the ratio of described component and they to scrub experience to provide to user, described experience can soft mouthfeel become intensive cleaning/pure and fresh mouthfeel when initial.

In addition, two kinds of components can be during the single mouth care different time sections in period (for example, during 1 second to 5 seconds and 60 seconds to 65 seconds of mouth care periods of 120 seconds) send simultaneously, or two kinds of components can be sent in (for example, every a period) during different periods simultaneously.

Delivery order-single mouth care period

The delivery order of carrying out during single mouth care period can adopt various forms.In a kind of situation, two kinds of components are alternately sent, send as circulation (ABAB) during scrubbing, or send with many rapid fire formula alternative forms (ABABABABAB...AB) with several relative long durations.The example that is highly suitable for the processing of this kind delivery type is the processing that Remineralization and use peroxide and the activator that is used for this peroxide carry out.Preferred circulation time will depend on used chemical substance, and can be at given chemical reaction optimization.For example, in the situation of peroxide and activator, circulation time can react to allow peroxide and activator relatively than long for example 15 seconds.Can with other chemical substance for example Remineralization system such as those (" compositions " parts that see below) as herein described be used for faster circulation time for example 5 seconds or shorter time.

In another kind of situation, two or more components were one after the other sent during single mouth care period, and do not carry out follow-up alternately sending (meeting B behind the A) period in this mouth care.For example, can send dentifrice when initial and scrub and provide cleaning with startup, after connect collutory, fluoridizer or temporarily sealing agent.Other option comprises and connects activator or dentifrice behind the peroxide to strengthen fluorination; Connect chlorous acid behind the copper dentifrice; Connect the antiinflammatory inorganic agent behind the gingivitis inorganic agent; Or a pair ofly have a differently flavoured component, to provide sensory signal to user.The variation of local flavor can be indicated: for example, user should be scrubbed the longer time and maybe can stop scrubbing, or user should change the pattern of scrubbing, and for example, becomes the higher or lower speed of scrubbing.

Delivery order-a plurality of mouth care period

Other sequential processing scheme relates to a plurality of mouth care period.In some concrete enforcements, delivery apparatus comprises time clock feature, and is programmed to send the predetermined process agent in scheduled time in the middle of one day or the time range.Depend on the time in the middle of one day, can send different components, different ratio or different component sequences.For example, can send a kind of component in the morning, and can send second kind of different component at night, for example two kinds of different dentifrice or collutory and dentifrice.And for example, can send two kinds of components in the morning, for example dentifrice and collutory, and can only send dentifrice at night.This way based on clock can allow user to scrub at one day to have two kinds of different sensory experience at twice o'clock, receives two kinds of different active component or only receive an active component (only morning or evening) in one day.

Similarly, some processing schemes can relate to according to specified processing scheme sends for example prescription drugs of special treating agent, for example, and only morning or evening, every other day (morning and/or evening) or jede Woche once (morning and/or evening).Delivery apparatus can be programmed for during scrubbing and send accurate dosage at required time.Can send toothpaste At All Other Times, and if desired, can send simultaneously with special treating agent.Special treating agent can be prescription toothpaste, and wherein the standard over-the-counter toothpaste can be distributed between the appointment of prescription toothpaste is used.

Another kind is applicable to that the way in a plurality of mouth care period is " counting " feature, and the mouth care that wherein delivery apparatus is programmed for every x number is just sent a kind of in the described component period.For example,, then delivery apparatus can be programmed for the replaceable toothbrush head of the specific user of identification, for example, discern, and only count the use age of this user by RFID if there are a plurality of user to use identical toothbrush handle part.

In some cases, may expect delivery apparatus is programmed for and comprise clock unit and volume monitoring component, the data in a plurality of mouth care of described monitoring component (for example) accumulative total period, so that only send in the section in preset time one or both (for example, in 24 hours time, send less than the x gram component A) in the described component of predetermined.Interim when single mouth care, the volume monitoring component also can be used to measure the accurate dosage of component.For example, when component caused toxicity or other safety problem because of the dosage that is higher than normal level, the volume monitoring was desired.For example, be used for child's fluoridizer situation,, importantly do not allowing the child receive too much fluoride owing to there is the risk of fluorosis.The dosage of being sent can be measured by any suitable method, such as calculating dosage indirectly based on the number of pumping circulation then by calibrating installation accurately.In some cases, delivery apparatus can be used to critically control the dosage of given activity material, can allow second compositions to send on demand such as standard dentifrice simultaneously.

For example, delivery apparatus can be programmed for accumulative total and distribute the data of the amount of every kind of component, with permission user and/or the odontologist of user or the concordance that other clinician follows the tracks of user and designated treatment scheme about time of scrubbing and/or institute.This information can be presented on the LCD display of delivery apparatus.

When delivery apparatus (for example, electric toothbrush) was used by a plurality of user, this device able to programme was chosen in the required component of using during mouth care period of this user to allow each user.For example, different user may be partial to select for use different toothpaste local flavors, maybe may need to have the particular characteristic attribute such as whitening or reducing the toothpaste of sensitivity.

In the situation of toothbrush, it can be configured to these two kinds of components are delivered on the different toothbrush heads.When first head (for example, the head of standard electric toothbrush) fix in position, send for example dentifrice of first component; And when second head (for example, toothpick (pic), tongue is scraped or the gums brush) fix in position, send for example collutory of another kind of component.Toothbrush can be configured to automatically discern different heads, for example, discerns or sets such as bearing pin by mechanical part by the RFID method of identification and discern.The oral care appliance of discerning various heads with RFID is described in the U.S. Patent application 2002/0129454 of announcement, and whole disclosures of this patent application are all incorporated this paper into way of reference.

Delivery parameter

All can be intermittently according to sending of doing of arbitrary processing scheme as herein described, that is, have the time out of not sending therebetween.Should be pointed out that in addition " successive " send also can be on following meaning for intermittently: the pumping mechanism of delivery apparatus can the pulse mode operation.Yet, can in processing scheme, comprise additional and/or longer time out by correspondingly programming delivery apparatus.

Can will about 0.05g from any delivery apparatus, 0.1g, 0.15g, 0.2g, 0.25g, 0.3g, 0.4g, 0.5g, 0.6g, 0.7g, 0.8g, 0.9g, 1g, 1.2g, 1.4g, 1.5g, 1.6g, 1.8g, or 2g (or about 0.05mL, 0.1mL, 0.15mL, 0.2mL, 0.25mL, 0.3mL, 0.4mL, 0.5mL, 0.6mL, 0.7mL, 0.8mL, 0.9mL, 1mL, 1.2mL, 1.4mL, 1.5mL, 1.6mL, 1.8mL, 2mL, 5mL, 7mL, 10mL, 12mL, 15mL, 20mL, 25mL, or 30ml) first component at about 0.2 second (s), 0.4s, 0.6s, 0.8s, 1s, 1.2s, 1.5s, 1.8s, 2s, 4s, 6s, 8s, 10s, 15s, 30s, 60s, 90s, or assign in the time of 120s, and can be with about 0.05g, 0.1g, 0.15g, 0.2g, 0.25g, 0.3g, 0.4g, 0.5g, 0.6g, 0.7g, 0.8g, 0.9g, 1g, 1.2g, 1.4g, 1.5g, 1.6g, 1.8g, or 2g (or about 0.05mL, 0.1mL, 0.15mL, 0.2mL, 0.25mL, 0.3mL, 0.4mL, 0.5mL, 0.6mL, 0.7mL, 0.8mL, 0.9mL, 1mL, 1.2mL, 1.4mL, 1.5mL, 1.6mL, 1.8mL, 2mL, 5mL, 7mL, 10mL, 12mL, 15mL, 20mL, 25mL, or 30ml) second component at about 0.2s, 0.4s, 0.6s, 0.8s, 1s, 1.2s, 1.5s, 1.8s, 2s, 4s, 6s, 8s, 10s, 15s, 30s, 60s, 90s, 120s, 180s, 240s, or assign in the time of 300s.(for example, two compartment formula allotters shown in Figure 13 in) the situation, first and/or second component can be by about 1 time of pump, and 2 times, 3 times, 4 times or 10 times or startup more frequently distribute at the delivery apparatus of manually pumping.In addition, first and second components can be about 90/10,80/20,70/30,60/40,50/50,40/60,30/70,20/80, or 10/90 ratio (first component/second component) distributes.Other ratio can be between about 1: 20 and about 20: 1.

As mentioned above, first and second components can distribute simultaneously or sequentially distribute (make second component can be after first component about 0.2s, 0.4s, 0.6s, 0.8s, 1s, 1.2s, 1.5s, 1.8s, 2s, 4s, 6s, 8s, 10s, 15s, 20s, 25s, 30s, 35s, 40s, 45s, 50s, 55s, 60s, 75s, 90s, 105s, or distribute during 120s).In addition, second component also can be connected on first and scrub after period second and distribute during scrubbing period, wherein have at least about 4 hours, and 6 hours, 8 hours, 10 hours, or that the end in period is scrubbed in second beginning and first of scrubbing period is spaced apart 12 hours time.In addition, second component also can be distributed during identical oral care regimen, but distributes after the interval between the use of the use of having passed through first component and second component.For example, dentifrice (first component) can use 2 minutes, and collutory (second component) can be after the use of finishing dentifrice several seconds or a few minutes use.

During the period of scrubbing, can there be several sequences of the various combinations that comprise above-mentioned weight, volume and time.These sequences can be simultaneously or order, and can comprise aforesaid time out.For example, 2 minutes scrub in period, first sequence can comprise first component of certain volume that is distributed simultaneously and second component of certain volume, second sequence can comprise first component of certain volume that is assigned with then, time period that can not have distribution then, the 3rd sequence can comprise second component of certain volume that is assigned with then, can not have the time period of distribution then, and the 4th sequence can comprise first component of certain volume that is assigned with then.

Delivery apparatus

Can use various oral care appliances to distribute described component of the present invention, comprise manual toothbrush, electric toothbrush and multiple other packing (for example, hand pump etc.) and device.At first, we will discuss and can send the oral care appliance of two kinds of components simultaneously.

Referring to Fig. 1, shown an embodiment of mouth care system 10, it comprises oral care appliance 12 (being toothbrush in this example) and butt joint base 14, it makes oral care appliance 12 keep vertical position in the holding portion of butt joint base.Oral care appliance 12 is electric toothbrush, and it has the head of motorized, and is designed to scrubbing two kinds of components of cycle period discharging, such as dentifrice and collutory.Butt joint base 14 is designed to and can will be positioned at the battery recharge of oral care appliance, and recharges oral care appliance with described component.

Forward Fig. 2 A and 2B to, oral care appliance 12 comprises separable shell 16, and its assembly 152,154 and 156 by three interconnection is formed.After assembling, oral care appliance 12 comprises 20 distal part 18 and 24 portions of proximal 22 thereon of shank thereon of head.What connect shank 24 and head 20 is neck bar 26.The size of head 20 is made and is fit to be placed in the user mouth so that brush teeth, and shank 24 can be by user promptly and help in use handling head 20 simultaneously.

Referring to Fig. 2 B, shown the rearview of oral care appliance 12, inlet 28 is arranged to the end face 30 near portions of proximal 22 places of oral care appliance.Inlet 28 can cooperate with corresponding outlet 280 (Fig. 8 A), and described outlet is arranged on the butt joint base 14 that is used to recharge oral care appliance.

Referring now to Fig. 3 A and 3B,, shown the intraware of oral care appliance 12.Oral care appliance 12 comprises motor 34 and 36.Motor 34 drives pumping molectron 38, and described molectron transmits a pair of component edge passage (in the only described passage is that passage 40 is visible) separately in Fig. 3 A and 3B towards the distal part 18 of oral care appliance 12.Pumping molectron 38 can be by a part of coming compressed pipe 514 and 516 (Fig. 4 A) with compressing member via separately every kind of component of channel transfer, described in United States serial 10/861,253, whole disclosures of this patent are all incorporated this paper into way of reference.When compressing these pipes progressively with a row finger (as in USSN 10/861,253 described pump molectron like that), finger answer yardstick proper in case they can on the width of these two pipes, extend and so can compress these pipes simultaneously.

Motor 36 drives power transmission shafts 42, and it moves (as, rotation) head 20 again.In order to give motor 34,36 and 37 power supplies, rechargeable battery 44 can be electrically connected on the motor.Suitable rechargeable battery is lithium ion UR 14500P, derives from Sanyo.

Referring to Fig. 4 A and 4B, oral care appliance comprises that pair of pipes 514 and 516 is with these two fluid streams of guiding in oral care appliance.As shown in the figure, each in the pipe 514 and 516 all is connected on the head in the position of departing from longitudinal axis 531, and described longitudinal axis is perpendicular to the rotation axis 518 of movable punch head 20.In some embodiments, one in these pipes can be connected on the head at the rotation axis place, and another can connect in the position of departing from rotation axis.Referring to Fig. 5, shown a kind of modification, wherein manage 550 with 552 in upstream that head is in the downstream of pumping molectron and fluid issuing each other fluid be connected.If wish just to mix described component in certain time that is delivered to before scrubbing on the surface in passage, then this embodiment can be favourable.

We should point out, in Fig. 3 A to 3B, because the cause of the ratio of these pictures for clarity sake, has only shown single passage 40.Oral care appliance 12 generally comprises two passages, as mentioned above (for example, the pipe 514 and 516 among Fig. 4 A and the 4B).Yet, in some cases, can use single passage, for example, wherein these two kinds of components can be near the independently chamber of these two kinds of components of storage and in the combined upstream of head.

Referring to Fig. 3 A, oral care appliance 12 comprises control circuit or controller 400 again, and it is electrically connected on motor 34 and 36, and generally arranges the operation of motor.User interface 402 can provide the outside reciprocal action with controller 400.User interface 402 comprises and turns on and off button 404 and 406 and fluid levels switch 408 that they all can touch (seeing Fig. 2 A) from the outside of shell 16.

Although controller can be programmed on demand, as an example, controller is designed such that press push button 404 can starter 34 and 36, and press push button 406 can start in the motor only one such as motor 36.By press push button 404 or 405, head movement and fluid stream all can start, and wherein button 404 starts a stream, and button 405 starts another stream.By press push button 406, only in fluid stream and the head movement can start. Press push button 404 or 406 also can stop related motor after startup.Button 406 only starts and stops in the situation of motor 36 therein, and arbitrary component be scrubbed and do not sent to user can (for example), and can wash oral care appliance 12 when head rotates.Fluid levels switch 408,409 allow user at the fluid delivery rate of preliminary election such as at a high speed, select between middling speed and the low speed.Optionally light three LED 410 and send level to indicate selected fluid.Alternatively or in addition, can comprise that LCD display sends level to pass on fluid, and/or can be used to show the fluid levels in out of Memory such as the oral care appliance 12 and/or the charged state of battery.

Also controller 400 can be programmed at starter 34 back adjusting pastes and send level.For example, in some embodiments, with controller programming is to make that these two kinds of components of relative large crumb are promptly sent after motor 34 starts soon, begin to scrub so that have enough pastes, in scrubbing the whole remainder of circulation, the level of sending is reduced to for example lower level of sending then.For example, can and/or reduce paste by the speed that the fluid that slows down is sent and send level by ejecting fluid off and on.For example, can be with controller programming for providing three kinds to send setting, promptly low-grade, middle-grade and high-grade.In one embodiment, send when setting in low grade, with controller programming for sending agglomerate in about 7 seconds by starter 34.After about 7 seconds, controller is starter 34 about 0.75 second and inactive motors 34 about 2.4 seconds (that is, turning on and off motor at interval circularly with these) off and on.In identical embodiment, send when setting middle-grade, controller programming for sending agglomerate in about 7 seconds by starter 34, was connected motor then circularly about 0.75 second and turn-offed about 1.63 seconds.Send when setting at top grade, controller programming for sending agglomerate in about 7 seconds by starter 34, was connected motor then circularly about 0.75 second and turn-offed about 1.2 seconds.The required programming situation that depends on controller 400 can use more or less user Interface Control to start various functions.

Referring to Fig. 3 A, motor 36 moves (for example, translation linearly) pivot power transmission shaft 42 again, and described power transmission shaft moves (for example, swing rotatably) rotatable head 20 then.Power transmission shaft 42 uses offset design to be connected on the rotatable head 20, described design helps the fluid issuing and pipe 82 (or the pair of pipes at head 20 places, if these two kinds of flows of material are intended to keep isolating words) placement, described pipe forms the part of the fluid passage in the neck bar 26 of shell 16.This offset design is described in greater detail in the United States serial 10/861,253.Can partly realize the motion of rotatable head 20 in the following way: use cam and driven member system, described system is converted into the linear movement that drives power transmission shaft 42 with the rotation output of motor 36 with being used for front and back.This layout is described in above in the United States serial of incorporating into way of reference 10/861,253.

Referring now to Fig. 6 and 7,, head 20 comprises pedestal 136, and described pedestal has opening 124, valve 122 for example as shown in the figure duckbill valve by described opening protruding.In some embodiments, the far-end of pipe 82 forms fluid issuing and does not use the valve that is bonded on it.If keeping these two streams to separate up to them, expectation discharges head, can use two valves or twin duckbill valve such as the United States serial 11/114 that is filed on April 26th, 2005, the sort of described in 987, the complete disclosure of this patent is incorporated this paper into way of reference.What stretch out from pedestal 136 is a series of brushing cluster 138.Though each tuft 138 all is shown as entity in picture, in fact each constitutes by a large amount of individual plastic bristles tuft.For the more detailed discussion of toothbrush head, the applicant mentions the unsettled Application No. 10/666,497 of JIUYUE in 2003 submission on the 9th, and its disclosure is incorporated into way of reference in view of the above in full.

When not in use, oral care appliance 12 can with dock base 14 and couple.Butt joint base 14 can be connected on electricity outlet (not shown) or other the suitable power supply.Referring to Fig. 8 A and 8B, butt joint base 14 is shaped as oral care appliance 12 is remained in the receiving portion 273 with vertical position.Receiving portion 273 comprises base plate 275, described base plate in being formed on shell 291 vertical groove 295 and shell extension 297 between extend.Groove 295 is circumvallate to admit the part of oral care appliance 12.Butt joint base 14 comprises for example pick off (not shown) of reaction unit, described pick off detects input when admitting oral care appliance by the butt joint base, and send signal in response to this input to controller, the details of described controller will be described in more detail below.

Referring now to Fig. 8 B and 9,, butt joint base 14 comprises multi-chamber fluid reservoir 274, and two chambers of described reservoir couple with the pipe 276 that leads to outlet 280.In some embodiments, for example as shown in Figure 9, fluid reservoir 274 is shaped as the integral part of the separable and replaceable part 301 of butt joint base 14.In other embodiment shown in Figure 10, replaceable two pouches 303 (in the only described pouch is shown among Figure 10) form fluid reservoir.In this case, the top 301 of butt joint base be removable, and with when the content of pouch is used up or user when wishing to use different products thereby need inserting the displacement pouch, permission consumer easily removes pouch 303.Referring to Fig. 8 B, for described component is moved to oral care appliance from fluid reservoir, the butt joint base comprises pump molectron 282.The details that recharges mechanism in the butt joint base is provided in the United States serial 10/861,253.

Referring to Fig. 8 B, pair of lead wires 336,338 is exposed in the receiving portion 273 of butt joint base 14 again.Lead-in wire 336,338 pair of contact 340,342 (Fig. 2 A) that are configured to when being placed on oral care appliance 12 in the receiving portion 173, can contact on the oral care appliance 12.This contact is with electric coupling oral care appliance 12 and butt joint base 14, so that the rechargeable battery in the butt joint power supply rechargeable oral care appliance that base connected.Contact 340,342 is electrically connected with rechargeable battery, thereby allows electric current to flow to battery from the butt joint base.

Be applicable to that the oral care systems 600 of sequentially sending two kinds of components is shown among Figure 11.Oral care systems 600 comprises oral care appliance 602 and the butt joint base 604 that is the toothbrush form.Oral care appliance 602 is connected on the butt joint base 604 by a segment pipe 605, and only the very little part of described pipeline is shown among Figure 11.Pipeline 605 is easily handled oral care appliance, for example about 2.5 feet to 3.5 feet long for flexible and long enough to allow user.Pipeline 605 can for example be connected on the oral care appliance at head or shank in any desired location, as hereinafter will discussing.

Oral care appliance 602 comprises shank 606 and dismountable head/neck bar part 608.Shank 606 does not comprise pumping mechanism or pump motor, because these assemblies can provide in the butt joint base, as hereinafter will discussing.But shank 606 comprises the necessary motor of drive head and other assembly, and can comprise two fluid passages.

Butt joint base 604 comprises turriform part T and base part B.Turriform partly comprises two reservoir (not shown), and can remove from base part, so that user can recharge or replacement reservoir.Base part B (at length being shown among Figure 12) carries two pumps 610,612, and they receive these two kinds of components and it is delivered to the downstream part 618,620 of pipe from reservoir by managing 614,616.After pipe withdraws from the butt joint base, can or in other words be included in the single crust their parcels to form pipeline shown in Figure 11 605. Pump 610 and 612 is driven independently by motor 622,624.The startup of motor is driven by for example one or more microprocessors of controller, and described controller can be installed on the printed circuit board (PCB) 626,628.

If pipeline 605 is at the pedestal place or enter oral care appliance in shank, then shank will comprise the pipeline that limits two fluid paths.If pipeline 605 enters oral care appliance at head, then can use the standard shank that only comprises the head driven unit.

The reservoir of any required type all can be used to comprise these the two kinds of components in the above-mentioned oral care appliance.Suitable reservoir is described in above in the United States serial of incorporating into way of reference 10/861,253.

In another embodiment, the form that delivery apparatus can two compartment formula allotters provides, and described allotter can use individually or be used in combination with aforesaid electric toothbrush.Referring to Figure 13, show two compartment formula allotters 700 with first outlet, 705 and second outlet 710.Allotter 700 has first compartment 715 of storage first component and second compartment 720 of storage second component.First compartment 715 is communicated with first outlet, 705 fluids by pipe 722, and second compartment 720 is communicated with second outlet, 710 fluids by pipe 724.In this embodiment, first and second compartments 715 and 720 are fluid communication with each other not in the downstream, so that first and second components can not mixed, mixing basically, blend or otherwise be distributed in together.Reciprocating pump 726 can be used to from first compartment, 715 pumpings, first component, and independently reciprocating pump 728 can be used to from second compartment, 720 pumpings, second component.Pump 726 and 728 can be by spring 730 and 732 biasings.Can provide one or more valves 736 to help the effect of reciprocating pump.Valve 736 can be provided as check-valves only advances in one direction to allow fluid.First and second compartments can have identical or similar capacity.In another embodiment, first and second compartments have different capacity, and this is applicable to the amount situation inequality of first and second components of wherein being distributed during oral care regimen.The dosage of first or second component that aperture 734 discharged with each stroke of metering piston pump can be provided.Dosage also can be controlled by the size (for example, internal diameter) and/or the stroke of piston pump.

First and second compartments 715 and 720 can be provided as replaceable tube, described tube meshes the shell 734 of allotter 700 releasedly.For example, compartment 715 and 720 can mesh shell 734 threadably.If there is different quantitative or meterings between first component and second component, then compartment 715 and 720 can have different screw thread (pitch or size), so that each compartment all can suitably match with piston pump or aperture.Although what illustrate is first outlet and second outlet, also can provide single reciprocating pump and outlet, wherein single reciprocating pump and outlet can be placed to optionally and be communicated with the first or second compartment fluid.Arbitrary described component as herein described, quantitatively or scheme all can be used for allotter 700 in whole or in part.Although allotter 700 for being applicable to a kind of distributor of the present invention, should be appreciated that other distributor also can use.

In a kind of method of the present invention, as the part of the scheme of scrubbing, user is assigned to first component on the toothbrush and follows first component applied in the oral cavity.After having used first component, as the part of the scheme of scrubbing, user sequentially be assigned to second component on the toothbrush and with second component applied in the oral cavity.Randomly, before being applied to second component on the toothbrush, the flushable brush of user and/or he/her oral cavity.Toothbrush can comprise intervalometer, described intervalometer at the fixed time section when having crossed enabling signal with the prompting user to this time that between first component and second component, switch or to finishing time of the use of second component.In one embodiment, about 15s after first component is applied on the toothbrush or is administered in the oral cavity, 30s, 45s, 60s, 120s, 180s, 240s, 300s, 360s, 420s or 10 minutes, 15 minutes, or be applied to second component on the toothbrush in 20 minutes or be administered in the oral cavity.

Although the allotter that has illustrated 700 comprises first and second compartments, should be appreciated that to provide to surpass two compartments.Allotter 700 can various shapes, size and configuration provide.

Referring to Figure 14, in another embodiment, first component and second component individual packages fully provide, and described packing can bundle becomes external member.For example, first component that is provided as dentifrice can provide in the first dentifrice allotter 800, and second component that is provided as dentifrice can independently provide in the dentifrice allotter 805 second.First and second allotters can be identical or different, and have been shown as for the sake of simplicity comprising and the identical structure of allotter 700 (Figure 13).User can be assigned to first amount on the toothbrush from first dentifrice packing, and after having scrubbed certain time period, from second dentifrice packing second component of certain amount is assigned on the identical toothbrush and with second component and finishes the scheme of scrubbing with first component.User first and second dentifrice packing can be provided as visually different shape, size or color, so that can easily be distinguished this two kinds of packings.First and second dentifrice packing also can have figure, literal, icon or numerical character, to distinguish this two packings.In some embodiments, first and second dentifrice are packed measurable first and second components so that send specific dosage, thereby can use the controlled rate between first and second components.

In another embodiment, the form that delivery apparatus can oral care appliance provides, but described oral care appliance dispense liquid is such as collutory.Oral care appliance can toothbrush form provide, some case descriptions of described toothbrush are in USPN 6,331, in 088,6,047,429,6,689,078 and 6,739,782.Toothbrush can have movable bristle carrier and/or static or non-movable bristle carrier.Toothbrush head can be bonded on the toothbrush handle part releasedly.Referring to Figure 15, now description is applicable to an embodiment of fluid dispensing toothbrush of the present invention.Toothbrush 900 has shank 905, head 910 and is arranged on liquid storage device 915 in the shank.Liquid storage device 915 can be replaceable single use reservoir or can be recharged by the user of toothbrush.Liquid storage device 915 keeps fluid connection with the one or more outlets 920 that are arranged in the head 910.Outlet 920 is connected on the liquid storage device 915 by conduit 925.Provide pump 930 with the liquid 913 in the pumping liquid reservoir 915 or make liquid 913 superchargings in the liquid storage device 915.Pump 930 can various ways as known in the art provide.For example, can use 078 described piston pump as USPN 6,689.In one embodiment, pump 930 can be air pump, and it is used for making the liquid supercharging in the reservoir 915.In case be pressurized, liquid can be discharged reservoir when valve 935 is opened.Valve 935 can be opened or starts by depressing button (not shown) on the shank 905.

User can will preferably be on the brushing cluster 945 (or other cleaning of teeth element) of (though other form also can be used) first component of dentifrice form or the head 910 that compositions is applied to toothbrush 900.First component can comprise arbitrary composition as herein described (and their combination) and/or other composition known in the art.Then when using toothbrush, with first component applied in the sclerous tissues and/or soft tissue in oral cavity.Then tooth scrub scheme beginning, during or when finishing (or their combination), user can will preferably be second component of liquid or collutory form or compositions and optionally be administered on oral cavity all or part of by starting or opening valve 935 usefulness toothbrushes 900.Second component can comprise arbitrary composition as herein described (and their combination) and/or other composition known in the art.

Referring to Figure 16, one or more in the device described herein can use with the display 950 with screen 952.Various layouts also be described in more submission in 16,60/920,698 and 2007 on April that the US S/N that submitted on November 15th, 2006 March 29 in 60/859,226,2007 submitted 60/912,111 in.Show system 955, it comprises one or more oral care products, such as the dentifrice 960 of dispensing toothbrush 900, manual toothbrush or electric toothbrush 958, packing, collutory 965 and two compartment formula allotter 700 of packing.The case description that is applicable to manual toothbrushs more of the present invention or electric toothbrush 955 is in USPN 5,974, and 615,5,930,858,6,006,394,6,108,869,5,943,723,6,308,367,2003/0101,526,2003/0154,567,6,536,068, in 2002/0129454 and 5,987,688.Although Figure 16 shows some device and product for the sake of simplicity, should be appreciated that and multiple oral care appliance can be used for system 955, comprise other oral care appliance and the product described in the present patent application.Each oral care product can use with the data link 970,972,974,976 of display 950 and communicate by letter with 978, or use keeps the middle device of data communication to communicate by letter with display 950.One or more oral care products as herein described, display and/or system component can be bundled as external member and distribute or be sold to user.System 955 also can be connected on the network 982 by data link 984.Network 982 can comprise one or more computers, server and client computer or electronic installation 985.

The oral care product of system 955 and device can use several different methods and device to come storage between device/product and display 950, transmit and/or transmit data.Term " data " is intended to refer to be transmitted or transmit is any type of any numeral or analog information.Data can comprise by any data of data transmitter active transmission and/or by the passive detected data of data reader.If the data that transmitted are digital, then data can comprise one and zero.In another embodiment, data can be a series of numerals such as " 12345678 ", wherein each numeral (for example can be represented the information relevant with the characteristic of oral care appliance, for manual toothbrush, first digit can be represented the brushing time of Minute, on behalf of toothbrush, second digit can carry out metathetical month number, and the 3rd and fourth digit can be represented a kind of award of uniqueness etc.).Data can comprise the arrangement of the optical element (for example, bar code) of representative information.Data can comprise whether electromagnetic energy (for example, such as magnetic field) exists.986 pairs of data of available processor shown in Figure 17 are stored, explain, are decoded or analyze.For example, if data be a series of numerals such as " 12345678 ", then processor 986 and/or related memorizer 987 can comprise one group of instruction, described instruction can decode or decryption with the information of specified data representative.

Data transmitter is device or the assembly that an active is sent to data data reader.RFID tag or RFID label are an example of data transmitter.Data-phone is the device or the assembly that can or can not initiatively send data, yet it has the data that can be detected.Although data transmitter for example RFID tag is a kind of data-phone, data-phone needn't need initiatively to send data.The example that comprises the data that can be detected or read by data reader but initiatively do not send the data-phone of data comprises bar code (wherein said bar code reader is a data reader), point coding or Hall effect magnet (wherein hall effect sensor is a data reader).Therefore, just as is understood, phrase " data-phone ", " data transmitter " and " data reader " are intended to comprise and are used for sending, communicate by letter and/or detect multiple analog or digital the data various devices and the layout of (comprise and only detecting in the existing in of data-phone).Phrase " data communication " is intended to include and can supplies device of the present invention (comprising data reader, data transmitter, data-phone) to be used for sending, transmitting and/or detect all methods of data and the data communication between form and two assembly such as display and the arbitrary oral care product.

Data by RFID label or other data transmitter/communicator storage and/or transmission or transmission can be very extensive.Some data categories comprise that product identification data (for example, trade (brand) name or ProductName) and product usage or scheme data are (for example, service time such as the scheme of gargling 1 minute, use relevant text or picture specification with product, the relevant information etc. with using sequence), one or more award and assembly or product replacement data (for example, its spendable number of times or time span before assembly or product should be replaced).Instructional images, text or data can be particularly useful for the child aspect the suitable scheme of brushing teeth setting up.Data directly can be presented on the display 950, maybe can be with data with the function or the feature of input of doing processor 986 to be used for display 950.For example, each in the oral care product all can have RFID label 988, and described label can send usage or scheme data to the reader 990 that is associated with display 950.In one embodiment, can be with usage data as the input that increases progressively counter timer or countdown intervalometer that is presented on the display 950.In order to start the transfer of data from the RFID label to the data reader 990 that is associated with display 950, the oral care product that only needs to comprise the RFID label is placed to enough near reader 990 so that the RFID label is powered up.

In one embodiment, oral care regimen can comprise that (it can be any packing with dentifrice packing 960, comprise that the pipe that comprises dentifrice or outer package are such as carton) and collutory packing 965 be placed to display 950 (or keep the intermediate module of data communication with display 950) and keep data communication, (for example, dentifrice is administered in the oral cavity time quantum) sends display 950 to the data relevant with collutory so that data that will be relevant with dentifrice.Dentifrice is applied on the head 910 of toothbrush 900, and the liquid collutory is loaded in the liquid storage device 913.Then toothbrush 900 is placed to and display 950 maintenance data communication, described display starts intervalometer (its interval is presented on the display 950) and sets according to the data that transmitted by the RFID label that is associated with dentifrice packing 960.Display 950 can the beginning of interval, during or show when finishing or send one or more auditions and/or visual signal, send the data of reader 990 to based on the data-phone of collutory 965 by packing, the user of described signal indication toothbrush 900 should distribute collutory 965.In one embodiment, intervalometer can start second interval that is presented on the display 950, described display can transmit the interval that is used for collutory is assigned to the oral cavity, so that approach the quantitative of collutory, and/or can transmit the interval that in the oral cavity, uses collutory that approaches time of application.Second interval can be set according to the data that the RFID label that is associated with collutory packing 965 (or other data-phone) transmits.Dentifrice or the very first time at interval can be between about 30 seconds and 3 minutes, and liquid collutory or second interval can be between about 30 seconds and 3 minutes.Depend on the dentifrice of expection and the reciprocal action between the liquid collutory, the length of interval can change.Should be appreciated that step as herein described can be multiple sequence carry out, and have some steps can need not all to carry out for each mouth care or the circulation of brushing teeth.For example, can be at every turn equal re-filling liquid reservoirs 913, and can only need once dentifrice and the collutory packing is placed to and display 950 keeps data communication, such as when using dentifrice and collutory for the first time.Thereafter, can with the data storage that transmits by the RFID label in memorizer 987 up to deleted or displacement, such as when having bought that new dentifrice and collutory are packed and when using first.In addition, although the process that dentifrice and collutory are administered in the oral cavity is described to carry out in order, but also imagined described application (for example, dentifrice is administered in the oral cavity and promptly use soon thereafter collutory) can take place simultaneously or roughly simultaneously.Display 950 also can show out of Memory such as visually oriented, with help dentifrice or collutory is administered on four quadrants in oral cavity.For example, the diagrammatic sketch of each quadrant in oral cavity can be presented on the display 950 with indication should when or last long with dentifrice, collutory or scrub action and be administered on this quadrant in oral cavity.

In another embodiment, two compartment formula allotters 700 and/or toothbrush 958 can be placed to and display 950 maintenance data communication.Two compartment formula allotters 700 can have one or more data-phones.In some embodiments, may there be a data communicator that is associated with each compartment.Can start intervalometer with the data communication of display 950.Based on the data that sent by the data-phone of toothbrush 958 and/or compartment formula allotter 700, display 950 can show the interval that increases progressively counting or countdown then.For example, data-phone such as RFID label 988 can transmit the data of the time quantum that the oral care composition of representing first compartment 715 should be used.RFID label 988 that is associated with second compartment 720 or the 2nd RFID label also can transmit the data of the time quantum that the oral care composition of representing second compartment should be used.For example, RFID label 988 can transmit the oral care composition of first compartment 715 should be administered in the oral cavity and continue 1 minute, and the oral care composition of second compartment 720 should be administered in the oral cavity and continue 2 minutes.When transmitting these data (or in some other data communication such as toothbrush 958 being placed to when keeping data communication with display 950, or even when manually booting the intervalometer of display by start button or touch screen element 953), display 950 can show that very first time interval or intervalometer continue 1 minute.When the very first time has crossed at interval, display 950 displayable signals or prompting (and/or are carried out additional move with indication on second compartment 720 is applied to second oral care composition on the head of toothbrush 958, such as Rinsing toothbrush and/or oral cavity etc. before using second oral care composition), after connect from second compartment 720 second oral care composition be administered to the oral cavity.Display 950 can show second interval or time period, and all being used for as the aforementioned is administered to 2 minutes of oral cavity with second oral care composition.By toothbrush 958 being placed to and display 950 keeps data communication, user by start on the display 950 or with display associated switch, button or other control piece, can start second interval; Or automatically start second interval after the section at the fixed time.When second interval had been crossed, display 950 can provide expression to pass through the audible signal and/or the visual signal of second interval.After having passed through second interval, can end the use of second oral care composition.Such as will be appreciated, display 950 can show out of Memory, described information and compartment formula packing 700 and/or be stored in wherein oral care composition be associated (for example, tutorial message, scheme or usage information (comprising historical user information), award, educational information, ticket etc.).In addition, although system 955 is described according to two compartment formula allotters 700 in this article for the sake of simplicity, but be to be understood that, method of the present invention can be used for comprising any packing or a plurality of individual packaging of one or more compartments and/or one or more oral care compositions, and each all comprises one or more oral care compositions described a plurality of individual packagings.

Oral care composition and component

Two component oral care compositions are described below.In some cases, two components being delivered to respectively in the user oral cavity, perhaps making two components of oral care composition keep separating until use, in that they are mixed, is useful or necessary then.This may be following situation, and for example, if be kept at together, then two components will be reacted and/or neutral situation each other, and perhaps the composition in two components has active situation under different pH value, as mentioned described in the method part.Be the embodiment of various two components compositions and their uses below.As described below, some described compositionss can be used as one-component in some cases and provide, and it is can be with the standard dentifrice discussed in all methods as mentioned of any other required component or the water of gargling continuous or send simultaneously.

Following argumentation focuses on two components compositions, uses said method and device, can advantageously send this based composition in whole or in part.Yet, notice that said method and device are equally applicable to send two kinds of uncorrelated components for example dentifrice and collutory, two kinds of differently flavoured dentifrice etc., and other two components composition of hereinafter not mentioning.

The stench inorganic agent

Oral hard tissue and soft tissue are coated with micropopulation, and described micropopulation comprises the antibacterial with different metabolic ability.In these micropopulations, gram positive bacteria is easy to make carbohydrate generation catabolism and generates acid, and oral hard tissue is attacked in described acid, causes forming dental caries and decreases (cavity).On the contrary, gram negative bacteria, especially anaerobe is easy to make each seed amino acid of comprising in the saliva (and make on less degree in the oral cavity other peptide and protein) catabolism to take place to form end product, and described end product helps causing oral malodor and periodontitis.

Oral malodor is called halitosis clinically, can be via these microorganism on the dental plaque, stick to the dead cell on the mucosa and the Putrefaction of saliva cellular elements, produce volatile sulfur compounds and cause--mainly be hydrogen sulfide, methanthiol and a small amount of methyl sulfide.

Some two component oral care compositions can reduce oral malodor, improve implication, and/or prevent that dental plaque from gathering.First component in the described oral care composition comprises slaine, mantoquita such as Cu (II) for example, and second component in the described oral care composition comprises oxidant, for example chlorite.For example, in all those two compartments as indicated above of delivery apparatus, described two components keep separating until use, or before being about to use.Described component can use device single step for example described herein to use by user, rather than uses with two-stage process, such as at first using dentifrice to brush teeth, uses the mouth care collutory then.

Not bound by theory, this based composition can reduce stench by double route.At first, slaine is precipitated out as metal sulfide by making volatile sulfur compounds (VSC), reduces the concentration of VSC.Use different chemistry routes, oxidant can be oxidized to non-volatile form with malodorous compound (comprising amine and sulfide), thereby is the odorlessness form.In addition, oxidant and slaine, especially Cu (II) salt has antibacterial activity, and they also can have the dental caries effect to user.

In some embodiments, with respect to using one pack system oral care product (for example single dentifrice or collutory), or even in some cases with respect to the oral care regimen that uses collutory behind the first dentifrice, described two components compositions can provide enhanced effect.Therefore, in some embodiments, with respect to the amount that is applied in the single-component system, the active component of less amount can be applied in described two components compositions, to obtain substantially the same effect, perhaps the active component of same amount will provide bigger effect conversely speaking.

The example of suitable metal salt comprises the salt of Cu, Zn, Ag, Sn, Mg, Fe and Mn.In some preferred embodiments, described first component comprises the mantoquita that Cu (II) ion can be discharged in the solution.The example of suitable mantoquita comprises copper gluconate, copper chlorate, copper chloride, copper fluoride and copper nitrate.In general, the concentration of mantoquita in described first component is about 50 to 10,000ppm, or about 200 to about 2000ppm, and for example 500 to about 1000ppm.

The example of suitable oxidant comprises chlorite, hydrogen peroxide and perborate, perchlorate, peroxy acid and perchlorate.In some preferred embodiments, described second component comprises the chlorite that chlorition can be discharged in the solution.Suitable chloritic example comprises sodium chlorite.In general, the concentration of chlorite in described second component is about 100 to 10,000ppm, or about 1000 to about 4000ppm, and for example about 1600 to about 2400ppm.

In described oral care composition two components each all can be mixed with dentifrice or collutory independently.In general, when every kind of component in the described oral care composition was formulated into dentifrice, described component can while or continuous mutually being delivered in the oral cavity of user.Can use delivery apparatus such as above-mentioned those, send first and second components.Every kind of component in the described oral care composition can single-dose ball form be sent, or alternatively, can during brushing teeth, send continuously user, for example during brushing teeth in two minutes, with about 0.01mL/min to about 20mL/min, or about 0.15mL/min is to about 1mL/min, or about 0.15mL/min extremely about 0.5mL/min speed send.

In another embodiment, two kinds of components in the described oral care composition are all sent as collutory.Every kind of component can be used separately, or alternatively, can before being about to use two components be mixed.In general, be 1: 1 o'clock for example at the component ratio, used about 30 seconds amounting to the collutory of about 15mL to about 30mL.

In another embodiment, a kind of component can be used as dentifrice, and another kind of component is used as collutory.Described component can while or continuous mutually using.In one embodiment, when described first and second components were used simultaneously, during described oral care composition was used, the ratio of first and second components can change.For example, can use oral care appliance described herein to use described oral care composition, make and initially use described oral care composition, and during using, the rate of change of first component and second component was to about 20: 80 with first about 80: 20 component and the second component ratio.

Other example that can improve the oral care composition of oral malodor comprises U.S. Patent Publication 6,375, the two component dentifrice of describing in 933, and described document is incorporated this paper into way of reference in full.These dentifrice comprise the discharged zinc that is contained in the independent semi-solid aqueous components and the chemical compound of chlorition.In some embodiments, first component comprises zinc salt as zinc ion source in having the oral area acceptable carrier of neutral pH basically, and comprises chlorite as the chlorition source, and described pH is about 6.0 to 7.5, for example about 6.8.Second component has about 2.0 to about 6.0, preferred about 4.0 to about 5.5 acid pH.Two components of described oral care composition are mixed and combination, can provide and be not more than 6.5, preferred about 5.8 to about 6.4 final products pH, thus produce chlorine dioxide.Described two components are preferably formulated together having similar physical characteristic with water, wetting agent, surfactant and grinding agent, and acid compound be added in the acidic components with pH regulator to required acidity.

Suitable zinc ion can discharge chemical compound and be generally water-soluble zinc salt, comprises zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, bicarbonate zinc and zinc oxalate, preferred zinc nitrate.Described zinc salt generally with by weight about 0.25% to about 10%, and preferred about 0.5% to about 2.0% concentration by weight is incorporated in the dentifrice component of neutral pH.Chlorition can discharge chemical compound and comprise alkali metal chlorite, alkaline-earth metal chlorite and any other transition metal chlorite, interior transition metal chlorite and/or polymer salt.Preferred water dissolubility chlorite.The chloritic example of suitable metal comprises calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite.Also can use the mixture of two or more chlorous acid Yanyuans.But chlorition release property salt generally with by weight about 0.5% to about 5%, and preferred about 0.1% to about 1% concentration by weight is incorporated in the dentifrice component of neutral pH.

When before use with two combination of components, the acid dentifrice component in the dentifrice composition comprises acid or acid blend, thereby activates the chlorite chemical compound that is present in the neutral dentifrice component with acidify, discharges chlorine dioxide.

The acid compound that is present in the acid dentifrice component of the present invention comprises mineral acid and organic acid, such as sulphuric acid, hydrochloric acid, malic acid, alginic acid, citric acid, succinic acid, lactic acid, tartaric acid, potassium hydrogen tartrate, sodium acid citrate, phosphoric acid and sodium acid phosphate.The preferred acid acid phosphate comprises phosphoric acid or comprises PO ₄Ionic phosphate because this type of acid or its acid salt such as sodium dihydrogen phosphate not only provide required acidity, but also provides any dentium nitor demineraliting of phosphate anion to suppress may occur when tooth is used two component dentifrice.Preferred acid, phosphoric acid, liquid that can 85% concentration is commercially available.A certain amount of acid is joined in the dentifrice component, so that the pH of dentifrice is maintained at about 2.0 to about 6.0, and preferred about 4.0 to about 5.5 pH, when neutrality of the present invention and acid dentifrice combination of components, the pH of the compositions of combination is between about 5.8 to about 6.4.

Described compositions also can comprise the pyrophosphate with anti-dental calculus effect, and for example water soluble salt such as two alkali metal or four alkali metal pyrophosphates are such as Na ₄P ₂O ₇(TSPP), K ₄P ₂O ₇, Na ₂K ₂P ₂O ₇, Na ₂H ₂P ₂O ₇And K ₂H ₂P ₂O ₇Polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate).Described pyrophosphate can about by weight 0.05% to about 2.0%, and preferred about 0.5% mix to about 2% concentration by weight, and polyphosphate can about by weight 1.0% mixes to about 7.0% concentration.

The tooth whitening compositions

The case description of two component oral care compositions that can be used for tooth whitening is in U.S. Patent Publication 6,174,516 for example, and described document is incorporated this paper into way of reference in full.

Wash component by at first using moisture gargling, then use peroxide dentifrice, can significantly improve the tooth whitening effect of the dentifrice component that comprises peroxide to tooth with alkaline pH to tooth.The alkalescence collutory is tending towards activating and promotes that rapid release comes out the peroxide of oxygen in being contained in dentifrice.Can adopt said method and device to implement that this kind is continuous mutually to be used.For example, but the described delivery apparatus of programme-control, in the mode of disposable employed dentifrice behind the disposable employed collutory of elder generation, perhaps with alternative mode (collutory, dentifrice, collutory, dentifrice etc.), continuous mutually alkaline collutory and the peroxide dentifrice sent.

In some embodiments, moisture gargling washed component and comprised about 70% to about 95% water or water and alcoholic acid combination, and preferred about water of 65% to 95% and about ethanol of 0% to 35%.

Comprise a certain amount of peroxide compound,, reach the purpose that it is whitened to be enough to during brushing teeth, can discharge the oxygen of capacity.The content of described peroxide compound is preferably about 5% to about 15% by the weight of described component.The example that is used for preparing the suitable peroxide compound of the dentifrice component that the present invention's practice uses comprises calper calcium peroxide, hydrogen peroxide, and the peroxide that comprises urea peroxide, peroxidating glycerol, benzoyl peroxide etc.Preferred peroxide compound is a urea peroxide.

In the time of in being contained in peroxide dentifrice component, metal ion chelation agent can help the chemical stability of peroxide component when grinding agent such as calcined alumina or calcium pyrophosphate also are present in the described dentifrice.The example of suitable metal ion chelating agent comprises alkali metal stannate, such as sodium stannate and potassium stannate, ethylenediaminetetraacetic acid (EDTA) and salt thereof.Described metal ion chelation agent is incorporated in the described dentifrice component with about 0.01% to about 1% concentration by weight.

When the described peroxide dentifrice component of preparation, with acid such as phosphoric acid with pH regulator between about 3.0 to about 8, and preferred between about 5 to about 7 scope.

Flavoring agent

Can promote the example of the oral care composition that local flavor improves to comprise U.S. Patent Publication 6,696, those that describe in 047, described document is incorporated into way of reference in view of the above in full.Comprise more chloritic two component oral composition and can stably tolerate the chlorite minimizing that causes via being transformed into chlorine dioxide, and the degraded that can stably tolerate other composition components such as flavoring agent and sweeting agent.Except keeping specifying the chlorition of content for reaching effect, for oral care composition, the particularly important is, flavor components is not degraded, and this is because consumer's acceptance of product significantly is subjected to the influence of product special flavour and taste.

In some embodiments, under alkaline pH, prepare aqueous components, do not change so that significant pH not to take place between the storage life.In some embodiments, when described two components were mixed, resulting composition did not show yet and will change the pungent of product special flavour characteristic and make us unhappy chlorine dioxide abnormal smells from the patient.

Described first component can comprise chlorition; And described second component can comprise pharmaceutically useful local with oral carrier and do not comprise chlorite.Described first component also can comprise pharmaceutically useful part oral carrier, and described carrier can be compatible with chlorition.Described first component preferably also comprises a kind of (or multiple) compatible binding agent, buffer agent and/or antiseptic.Do not comprise chloritic described second component and preferably comprise flavouring agent, surfactant, fluorion, wetting agent and/or grinding agent.

Described two components can be sent simultaneously, and can during distribution make up, and for example with 1: 1 volume: volume ratio makes up to form described compositions.

Since compositions on the efficient of contact tissue and tooth difference and because the common used amount of described compositions, so the concentration of chlorition in described compositions depends on the type (for example toothpaste or collutory) that is used for chlorition is administered to the compositions on gums/mucosal tissue and/or the tooth.Described concentration also depends on disease to be treated or situation.

It is general preferred about 0.02% to about 0.5% by the weight of described compositions to take in chlorition concentration that the collutory in the oral cavity has, and more preferably from about 0.10% to about 0.30% scope.When using about 15mL collutory, collutory compositions of the present invention preferably can be to about 3.75 to about 30.0mg the chlorition of oral delivery.For dentifrice (comprising toothpaste and gutta-percha) and non-abrasiveness gel, the concentration of chlorition by the weight of described compositions preferred about 0.5% to about 3.0% scope.On behalf of component, the above-mentioned concentration of chlorition mix to form the concentration of chlorition after the described compositions.Therefore, the concentration of chlorition in comprising chloritic component will be according to treating and comprising chloritic component and mix with second component that obtains final composition or the amount of annexing ingredient and change.

The holistic health state

In some embodiments, the one pack system or the local oral cavity composition of using of two components that comprise safety and effective dose chlorition and pharmaceutical carrier mixture by use, can promote human and animal's holistic health state, described compositions can be controlled disease and the disease that is present in the bacteria mediated in the oral cavity effectively, and suppresses the bacteriotoxin of oral pathology substance antibacterial and association and gained inflammatory cytokine and amboceptor and be diffused in the blood flow.These compositionss can be locally applied in the oral cavity, and the chlorition of its safe in utilization and effective dose is to promote and/or to strengthen the holistic health state of human and other animal.

Be effective to promote the example of the oral care composition of holistic health state for example to be found among the U.S. Patent Publication US 6,846,478, described document is incorporated into way of reference in full.In some embodiments, the local holistic health state that can be used for promoting the human and animal with oral cavity composition, described compositions comprises the chlorition of safety and effective dose and the mixture of pharmaceutical carrier, and can control the disease and the disease that are present in the bacteria mediated in the oral cavity effectively, and suppress the bacteriotoxin of pathogen antibacterial, association and gained inflammatory cytokine and amboceptor and be diffused in the blood flow.

Some embodiments comprise by use the using method that these compositionss promote and/or strengthen human and other integral animal health status to oral cavity partial.More particularly, described compositions can be used for the risk that cardiovascular disease, apoplexy, atherosclerosis, diabetes, serious respiratory tract infection, premature labor and low birth weight (and puerperal is neural and the growth dysfunction) takes place in reduction, and reduces the mortality risk of following.In a preferred method, described compositions can be used for treatment and prevention oral disease and disease, comprises periodontal disease, thereby promotes and/or promote the raising of individual holistic health state to be treated, as being confirmed by following health index or biological marker:

1) reduce have a heart attack, apoplexy, diabetes, respiratory tract infection, LBWI and puerperal nerve/growths dysfunction risk, and the risk of the mortality rate increase followed of reduction;

The generation of the blood coagulation incident of the generation of the generation of fibrous cap attenuation, atherosclerotic plaque rupture and secondary on the generation of the 2) generation of the generation of the fatty tremulous pulse speckle of minimizing, atherosclerotic plaque, dental plaque formation, the atherosclerotic plaque;

3) reduce carotid artery (inner membrance) wall thickness (as identifying) with ultrasonic technique;

4) reduce blood and contact oral cavity pathogen and/or their toxic component with systemic circulation, specifically, cause and reduce oral cavity bacterium, the content of lipopolysaccharide (LPS) in blood, and/or reduce occur oral pathology substance and/or its be present in arterial plaque, artery structure and/or be far apart organ (as, heart, liver, pancreas, kidney) in component;

5) reduce the bacterial pathogens that the lower respiratory tract contact is sucked, and reduce the secondary of pneumonia and/or the deterioration of chronic obstructive pulmonary disease;

6) variation of minimizing circulation hematocrit, hematochrome, white blood cell count and/or platelet counts;

7) reduce the generation that inflammatory mediators/cytokine such as TNF-α, IL-6, CD-14 and IL-1 content are lacked of proper care in blood/serum;

8) reduce the generation of the acute phase reactant content imbalance that comprises C-reactive protein, Fibrinogen and haptoglobin in blood/serum;

9) reduce comprise homocysteine, glycosylated hemoglobin, 8-different-generation of Metabolic disorder blood/blood serum designated object imbalance of PGF-2-α and uric acid;

10) glucose metabolism imbalance (being identified by the glucose tolerance abnormality test usually) appears in minimizing, the fasting blood glucose content increases and fasting insulin content abnormality; With

11) minimizing comprises the imbalance of the blood lipid levels of blood or serum cholesterol, triglyceride, LDL, HDL, VLDL, apolipoprotein B and/or aPoA-I specifically.

Not bound by theory, it is believed that described compositions is present in the disease and the disease of the bacteria mediated in the oral cavity by control, prevent that antibacterial, bacteriotoxin and endotoxin and inflammatory mediators/cytokine are diffused in blood flow and other position of health, thereby promote the holistic health state.

In some embodiments, described oral care composition comprises the therapeutic collutory, especially collutory, and toothpaste, gutta-percha, dentifrice, non-abrasiveness gel (comprising gel under the gum), and described compositions comprises:

(a) chlorition reagent safe and effective amount, preferred minimal effective dose; With

(b) pharmaceutically useful part oral carrier; Wherein said final composition is substantially free of chlorine dioxide or chlorous acid, and wherein said compositions is substantially free of hypochlorite ion or hypochlorite, and has greater than 7, is preferably greater than 7.5, and even 8 to 12 final pH more preferably from about.Preferably a certain amount of chlorition reagent is incorporated in the present composition, to comprise about by weight 0.02% to about 6.0% chlorition.

As used herein, " being substantially free of chlorous acid or chlorine dioxide " is meant, use is used to measure chlorine dioxide or chlorous known analysis methods, comprise high degree of specificity electron spin resonance (ESR) spectrum, compositions comprises utmost point low content for example less than about 2ppm, preferably less than chlorine dioxide or the chlorous acid of about 1ppm.

Compositions of the present invention also preferably comprises one or more additional treatment agent, and described therapeutic agent is selected from the group of being made up of following: antimicrobial/antiplaque agent, biomembrane inhibitor, antiinflammatory (comprising cyclooxygenase-2 inhibitor and lipoxidase inhibitor), H2-antagonist, inhibitors of metalloproteinase, cytokine receptor antagonist, lipopolysaccharide chelating agent, tissue growth factor, immunostimulant, cellular oxidation reduction regulator (antioxidant), analgesic, hormone, vitamin and mineral.

In some embodiments, for example, when described compositions comprised the additional treatment agent, described compositions can comprise first component that contains chlorition and second component that contains the additional treatment agent.

The chlorition source

In some embodiments, chlorition is the neccessary composition in described compositions and the method.Described chlorition can be from the chlorite of any kind.Example comprises alkali metal chlorite, alkaline-earth metal chlorite and any other transition metal chlorite, interior transition metal chlorite and/or polymer salt.Preferred water dissolubility chlorite.The chloritic example of suitable metal comprises calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite.Preferred sodium chlorite and potassium chlorite.Especially preferred sodium chlorite.Also can use the mixture of two or more chlorous acid Yanyuans.

For dentifrice composition, the content of chlorition by the weight of described compositions greater than about 0.005%, 0.01%, 0.02%, 0.4%, 0.6%, 0.75%, and/or less than about 2%, 1.5% or 1%.

For the collutory compositions, the content of chlorition by the weight of described compositions greater than about 0.02%, be preferably greater than about 0.075%, more preferably greater than about 0.15%.

For the method for treatment or prevention gingivitis, described compositions preferably comprises the chlorition by the weight of described compositions about 0.1% to about 6%.

Chlorite can the sodium chlorite form derive from a plurality of suppliers.Sodium chlorite can be used as technical grade powder or thin slice, and commercially available as the liquid, aqueous concentrated solution of finite concentration scope.The example in sodium chlorite source comprises: the sodium chlorite that derives from Aragonesas and Vulcan.These are originated generally to have equally and are no more than 4% sodium chlorite.

The chlorition source for example preferably has 70% or higher high-purity.In addition, compositions of the present invention preferably is substantially free of hypochlorous acid slaine or hypochlorite ion, dichlord isocyanurice acid or its salt.

Preferably by use derive from Dionex Corporation (Sunnyvale, Ion Pac ASII exchange column Calif), the inorganic and organic anion of gradient separations, thus measure chlorition content.

Final composition of the present invention preferably comprises the chlorine dioxide or the chlorous acid of low content, or is substantially free of chlorine dioxide or chlorous acid (promptly containing less than about 2ppm, preferably less than chlorine dioxide or the chlorous acid of about 1ppm).

For two-component composition, after mixing, two components in about 2 to 3 minutes, measure chlorine dioxide or chlorous content.

The pH of described final composition is preferably greater than 7.5 generally greater than 7, and more preferably 8 to 12; Described pH also more preferably 9 to 10.

Organoleptic feature through improving

Dentifrice case description with the organoleptic feature through improving is in for example U.S. Patent Publication No.5, and in 820,854, described document is incorporated this paper into way of reference in full.These dentifrice can be used as one-component, or provide and send as two components compositions.

Having promptly about 1, the 000 μ mho of high ionic strength can come sense organ to improve by adding polyoxyethylene to the organoleptic feature of the dentifrice of about 50,000 μ mho.Described dentifrice provides the foam volume of increase, the foam viscosity that increases, and tooth smooth feeling.In bi-component dentifrice, polyoxyethylene can be present in the second dentifrice component, and the dentifrice component of described second dentifrice component and high ionic strength is parallel distributes.Alternatively, polyoxyethylene can be contained in the dentifrice component of high ionic strength, and can be different components by second liquid stream that delivery apparatus distributes, for example the dentifrice of collutory or another type.Polyoxyethylene has about 100,000 to about 10,000,000, or about 200,000 to about molecular weight of 7,000,000.

In some embodiments, bi-component dentifrice comprises the first dentifrice component and the second dentifrice component, and the described first dentifrice component has about 1,000 μ mho is to the ionic strength of about 50,000 μ mho, and to comprise about 0.1% to about 8% molecular weight be about 100,000 to about 10,000,000, or about 200,000 to about 7,000,000 polyoxyethylene, and one or more aqueous carriers of about 92% to about 99.5%.In alternative embodiment, described dentifrice comprises the first dentifrice component and the second dentifrice component.The described first dentifrice component has the ionic strength of about 1,000 μ mho to about 50,000 μ mho; It is about 100,000 to about 10,000,000 that the described second dentifrice component comprises about 0.1% to about 8% molecular weight, or about 200,000 to about polyoxyethylene of 7,000,000, and one or more aqueous carriers of about 92% to about 99.5%.

Suitable polyoxyethylated example comprises that molecular weight is about 100,000 to about 10,000,000, or about 200,000 to about 7,000, those of 000.Described molecular weight is preferably about 600,000 to about 2,000,000, and more preferably from about 800,000 to about 1,000,000." Polyox " is the trade name of the high molecular weight peo that made by Union Carbide.Described polyoxyethylated content is generally about 0.1% to about 8%, preferred about 0.2% to about 5% by the weight of described dentifrice component, and more preferably from about 0.3% to about 2%.

When dentifrice comprises the composition with ion characteristic, in the dentifrice high ionic strength will appear.The general composition with ion characteristic that uses comprises the material such as salt and surfactant.Dentifrice with high-load salt and/or high level of surfactant will have high ionic strength.Measure the ionic strength of dentifrice by the conductivity of dilution serosity.Described serosity is that ratio is 3: 1 the water and the serosity of dentifrice.Described dentifrice will preferably have about 5,000 μ mho to about 40,000 μ mho, and more preferably from about 10,000 μ mho to the ionic strength of about 25,000 μ mho.Total content with salt in the dentifrice of high ionic strength is generally about 4% to about 70%, preferred about 6% to about 60%, and more preferably from about 8% to about 50%.

Remineralization

The case description of two component oral care compositions with remineralization feature is in for example U.S. Patent Publication No.4, and in 083,955, described document is incorporated this paper into way of reference in full.

Use some soluble-salt by continuous mutually, generation can be reacted to form the sedimentary ion of desired remineralization, makes subsurface enamel remineralization.Can be administered on the enamel saline solution such as calcium and phosphate solution are continuous mutually, to realize remineralization.

Make dentium nitor subsurface remineralization with desired precipitation, can realize by the method for using first component and second component, described first component comprises can be as the water soluble compound of desired precipitation cationic source, and described second component comprises can be as the water soluble compound of desired precipitation negative ion source.Described method comprises the following steps: that (1) is with a kind of being administered on the dental surface in the said components, subsequently (2) with another kind of component applied to dental surface, desired ion in the another kind of thus component is diffused on the demineraliting subsurface, and form desired precipitation with the ion in first component, thereby reach the purpose that makes demineraliting subsurface remineralization.Can select the persistent period of step (1), so that desired ion can be diffused on the demineraliting subsurface.

For example, in the first step, place the component comprise the soluble-salt reactant solution, to contact with dental surface near the demineraliting subsurface.In this first reactant solution, selected cation can diffuse through dental surface, arrives its demineraliting subsurface.In second step, place and to comprise second component that contains selected anionic reactant solution, to contact with dental surface near the demineraliting subsurface.Described anion diffuses through dental surface, arrives the demineraliting subsurface, and this moment, they contacted with previous sedimentary cation, and formed attached to the precipitation on the tooth structure.Therefore, the tooth subsurface is by remineralization.

The concentration of cation and anion solutions can be 0.005% to 10%, or the solubility limit value of salt, and preferred about 0.05% to about 5%.If desired, can there be excessive salt.In cationic solution, can use more than one cation.Owing in each step, need excessive reactant with the diffusion of promotion, so the concentration of cation and anion solutions need not to equate to tooth demineraliting subsurface.Similarly, can in anion solutions, use more than one anion.After reaching eight continuous administration less, visible " white point " effect occurs, and after the expection enforcement several times continuous administration, can obtain best beneficial effect.

In order to implement adamantine remineralization, the required cationic and the anion of therapeutic dose can be administered in the oral cavity.The solution amount of putting in the oral cavity generally should comprise at least about 0.001g required cationic and the required anion of about 0.001g, and preferably comprise greater than about 0.1g required cationic and the required anion of about 0.1g, and/or less than about 10g required cationic/anion, and/or less than about 5g required cationic/anion, or less than about 2g required cationic/anion.

Though length time of contact of saline solution and dental surface is unimportant, necessary long enough of time is so that ion can be diffused on the demineraliting subsurface by dental surface.It is believed that for this diffusion, need at least ten seconds.

Every kind of solution is before precipitation and all should have about 3 to about 10 pH afterwards, and should be compatible in the oral environment.Described ion in the solution necessarily can not still must be diffused on the demineraliting subsurface zone by dental surface too early in conjunction with to form precipitation, and can form insoluble salt with the ion in the another kind of solution.Described solution and infusible precipitate are preferably colourless, and will have the toxicity (that is must be nontoxic under the concrete consumption of ion in the remineralization process) of acceptable degree certainly.

Be used for remineralization though there are many precipitate to be lower than original adamantine precipitation, can make the remineralization subsurface that demineraliting is had the resistance bigger than original enamel by the deposition dissolubility.If implement remineralization in the presence of heavy metal ion or fluorion, then the enamel of remineralization has the resistance bigger than original enamel to demineraliting.If two kinds of ions all exist, then the enamel of remineralization has demineraliting even bigger resistance.The salt that comprises heavy metal ion and fluorion they separately the concentration in the solution can be about 0.005% to about 10%, for example about 0.005% to about 0.1%.

The example of suitable heavy metal ion is aluminum, manganese, stannum, zinc, indium and rare earth metal such as lanthanum and cerium.

In some concrete enforcement, the remineralization cationic solution comprises about 0.005% to about 10%, and the soluble calcium salt of preferred about produced calcium ion of 1% and about 0.005% is to about 10%, the solubility indium salt of preferred about produced indium ion of 0.005% to 0.1%.The remineralization anion solutions comprises about 0.005% to about 10%, and the soluble phosphate of preferred about produced phosphate anion of 1% and about 0.005% is to about 10%, the preferred about 0.005% solubility villiaumite to about produced fluorion of 0.1%.Gained is precipitated as has the indium that mixes and the calcium phosphate or the hydroxyapatite of fluorion, and it is the natural constituents of dentium nitor.The method not only causes the enamel remineralization, and the enamel of remineralization has the resistance bigger than original enamel to demineraliting afterwards.

Suitable solubility villiaumite and indium salt includes but not limited to sodium fluoride, zinc fluoride, fluoridizes betanin, alanine stannous fluoride, hexylamine fluoride, indium chloride, indium sulfate and indium nitrate.

Provide the anion of desired infusible precipitate to comprise phosphate radical, have fatty acid radical, fluorion, fluorophosphoric acid root, hexafluosilicic acid root, sulfate radical, tartrate anion, Pyrusussuriensis acid group, alkyl azochlorosulfonate, carbonate of 8 to 18 carbon atoms etc. with 6 to 18 carbon atoms.These anionic mixture are desired.

Provide the cation of desired infusible precipitate to comprise heavy metal ion mentioned above, and calcium and magnesium.These cationic mixture are desired.

Form the solution that sedimentary these cationes of insoluble remineralization and anion can derive from corresponding soluble-salt.The cationic suitable soluble-salt that is used for the present invention comprises halogenide, for example the chloride of required cationic, nitrate, sulfate, acetate and gluconate.Similarly, the anionic suitable soluble-salt of the present invention comprises alkali metal (for example sodium and potassium) salt, ammonium salt and low-molecular-weight substituted ammonium salt.The example of low-molecular-weight substituted ammonium salt be wherein the one or more hydrogen on the ammonium ion had the alkyl of 1 to 3 carbon atom or hydroxyalkyl such as methyl, ethyl, propyl group, hydroxyethyl, 2-hydroxypropyl or 3-hydroxypropyl replace those, for example an alcohol salt, diethanol ammonium salt or tri ethanol ammonium salt, or an ethyl ammonium salt, diethyl ammonium salt or triethyl ammonium salt.

With many different cationes and anion combinations that make the enamel remineralization, to form many different precipitations.Most preferred precipitation is the calcium phosphate compound that wherein is mixed with small amount of indium and fluorine.Following precipitation not only discloses desired remineralization precipitation, and also discloses required cation and the anion of formation precipitation naturally.It will be recognized by those skilled in the art that some in these precipitations can be by at first forming initial precipitation, it further precipitates shown in the reaction formation and forms then.For example, can at first form hydroxide, further reaction forms corresponding oxide then.

Preferred precipitation is: calcium phosphate; ZnNH ₄PO ₄InPO ₄The phosphate of rare earth element is such as lanthanum orthophosphate, Cerium monophosphate and samaric orthophosphate; Rare earth fluoride is such as lanthanum fluoride, cerium fluoride, praseodymium fluoride, neodymium fluoride and samaric fluoride; Alkyl sulfonic acid magnesium, wherein said alkyl have 10 to 22 carbon atoms; Magnesium stearate; Calcium stearate; Zinc stearate; And aluminum phosphate.

Deposited components can be subsequently via two kinds independently delivery vector be delivered on the dental surface, every kind of carrier comprises a kind of component, for example collutory and toothpaste.For example, can use oral care appliance described herein to send deposited components.

Alleviate hemodia

The case description of two component oral care compositions that can alleviate hemodia is in U.S. Patent Publication 6,953,817 for example, and described document is incorporated this paper into way of reference in full.

Preparation desensitizing dentifrice compositions, with eliminate or alleviate dentine super quick bring do not accommodate pain.This based composition comprises the two components desensitization tooth composite that contains the potassium salt desensitizer.

Described tooth composite can comprise two kinds of semi-solid aqueous components: keeping at least about 9.0, and preferred about 9.0 remain on pH to first component of about 12.0 alkaline pHs with the phosphate-buffered composition 6.5 to 7.5 second component through buffering.But at least a component comprises the salt compound of releasing fluoride ion and can discharge the salt compound of potassium in the acceptable carrier of oral cavity, the concentration content of described fluoride is enough to discharge the fluorine of about 2500 to 8800 parts each 1,000,000 parts (ppm) from described chemical compound.After component was mixed and made up, formation had about compositions of 6.5 to about 7.0pH.After being administered to described mixture on the tooth repeatedly, user feels that the super quick misery of dentine is more and more lighter.

Preferably make two combination of components with about part by weight that waits, with convenient combination of components and by as brush teeth when being administered on the tooth, in arbitrary component, will have any concrete composition of about 1/2nd concentration.Two kinds of components of preferred preparation are to have similar physical characteristic, so that two components can be sent by required scheduled volume simultaneously.

For preparation has the dentifrice component of neutral pH basically, mix buffer agent, use the carrier that comprises water, wetting agent, surfactant and grinding agent to prepare described buffer agent usually.Described buffer agent is preferably the mixture of sodium dihydrogen phosphate and perlate salt and is incorporated in the dentifrice component with about 5% to about 10% and preferred by weight about 6% to about 10% concentration by weight in described component.

Use to form and form similar carrier, prepare dentifrice component with alkaline pH with buffered neutral pH component.In basic component, mix alkaline reagent such as alkali metal compound, comprise that (weight rate is 3.22 sodium silicate in 34.6% water for sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium carbonate, N-sodium silicate, derive from PQ Corporation), the amount of described alkaline reagent is by the weight of described component about 0.5% to about 15%, by the weight of described component preferred about 1.0% to about 8%, and by the weight of described component most preferably from about 1.0% to about 5.0% scope.Also can use the mixture of above-mentioned alkali metal compound.

But the salt of releasing fluoride ion is characterised in that, the ability of their releasing fluoride ion in water.The preferred soluble fluoride salt that uses, it provides about fluorion of 1000 to about 9000ppm, and about fluorion of 2500 to about 8800ppm preferably is provided.But the suitable example of the salt of releasing fluoride ion comprises the water-soluble inorganic slaine, for example sodium fluoride, potassium fluoride, sodium monofluorophosphate, stannous fluoride and prodan.But sodium fluoride, sodium monofluorophosphate and stannous fluoride are the salt of preferred releasing fluoride ion.

The desensitization potassium ion source is generally water solublity potassium salt, comprises potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate and potassium oxalate, preferred potassium nitrate.Described potassium salt generally with by weight about 1% to about 20%, and preferred about 3% to about 10% concentration by weight is incorporated in one or more dentifrice components.

The prevention gum disease

Two component oral care composition case descriptions of prevention gum disease are in for example U.S. Patent Publication 5,281,410, U.S. Patent Publication 5,145,666, U.S. Patent Publication 4,849,213, U.S. Patent Publication 4,528,180 and U.S. Patent Publication 5, in 632,972, incorporate described document into this paper with way of reference in full.

Some oral care composition can be extenuated dental plaque and gingivitis, does not cause significant tooth discoloration simultaneously.By using two-component composition, can reduce tooth discoloration, described compositions comprises pyrophosphate ion and stannous compound, for example comprises stannous fluoride and another kind of stannous compound in a component, and comprise pyrophosphate ion in another component.Two kinds of components generally comprise pharmaceutically useful carrier.

Stannous fluoride is first solvent in the inferior stannum component.The content of this material in inferior stannum compositions is about 0.05% to about 1.1%, preferred about 0.4% to about 0.95%.Will be appreciated that, can use independent solubility tin salt and fluoride salt to form stannous fluoride on the spot, and directly add this salt.Be applicable to that the salt that forms stannous fluoride on the spot comprises stannous chloride and sodium fluoride or the like.

In inferior stannum component, generally comprise second stannous compound.Described second stannous compound is the tin salt of 'alpha '-hydroxy acids, phytic acid, ethylenediaminetetraacetic acid, glycine, and their mixture.In some embodiments, second stannous compound is the inferior stannum of gluconic acid.These materials are known inferior stannum chelates, and can be used as chelate or as independent solubility tin salt and with the chelate that forms on the spot such as stannous fluoride, be provided in the compositions of the present invention.Suitable 'alpha '-hydroxy acids comprises gluconic acid, citric acid, malic acid, tartaric acid and lactic acid.This type of salt comprises stannous chloride and stannous fluoride.Content in the component of the present invention of second stannous compound is generally about 0.1% to about 11%, preferred about 2% to about 4%.

Second component is for comprising the component that the effective dose pyrophosphate ion maybe can be provided.Pyrophosphate ion can be a pyrophosphoric acid or anyly be easy to water-soluble pyrophosphate for example.This type of salt comprises any alkali metal salt, such as sodium, potassium and lithium salts, and comprises ammonium salt.

The amount of pyrophosphate ion is any effective dose, is generally about 1% to about 15%, and preferred about 1% to about 10%, most preferably from about 3% to about 7%.

In some embodiments, can be in the oral cavity with the described component applied of safety and effective dose.If toothpaste or collutory then make this tittle (for example about 0.3g is to about 15g) keep about 15 to about 60 seconds in the oral cavity.The described component that can anyly use in order, but inferior stannum component preferably at first used.

In some embodiments, hydrogen peroxide or urea peroxide are dissolved in the nontoxic gel, be used in combination with the paste that with independent storage but basically distributes simultaneously, described paste comprises sodium bicarbonate, food (or other suitable) salt, and preferably comprises the flavor substance of additional cleaning agent, caries preventive agent and polishing agent and valid density.

The gel of controlled quentity controlled variable and paste can be discharged on the toothbrush simultaneously, and are administered to immediately on tooth and the gums.Therefore, peroxide, salt and NaHCO ₃The control of delivering amount is subjected to the influence of activity component concentration in hole opening specification and each pipe (or pump chamber).When tooth and gums are implemented to scrub, the instant mixing takes place in product, generates active oxygen and carbon dioxide then fast.Simultaneously, discharge the effervescent that together takes place with active oxygen and make the flavoring agent activation that is included in the bicarbonate paste, and produce the pure and fresh taste of persistent height in the oral cavity, this is different from any other local flavor that existing toothpaste or gel are provided.

Peroxyl Gel can following amount comprise following ingredients--H ₂O ₂: about 1.0% to 10.0%, and preferred about 3.0% to 6.5%; Acrylic copolymer: about 0.05% to 1.20%, and preferred about 0.3% to 0.8%; Non-ionic cellulose glue: about 0.1% to 1.5%, and preferred about 0.3% to 0.8%; Nertralizer (triethanolamine, diisopropanolamine (DIPA), NaOH, KOH): be enough to make pH of latex gel to rise to about amount of 3.0 to 6.0.Surplus is purification (distillation or deionization) water.

Described sodium bicarbonate paste comprises sodium bicarbonate, sodium chloride, purification (distillation or deionization) water and thickeners/stabilizers such as cellulose gum and aluminium-magnesium silicate, as neccessary composition.For most of " Chalk " flavor of being given by bicarbonate is scattered, add taste agent, such as sorbitol, glycerol or ethylene glycol.In addition,, then can add cleaning agent such as calcium sulfate, calcium phosphate and hydrated alumina if paste and gel combination substitute toothpaste fully, and foaming agent such as sodium lauryl sulfate (it also can strengthen the effect between peroxide-bicarbonate).

The component of bicarbonate paste and amount are as follows: sodium bicarbonate: about 10% to 50%, and preferred 20% to 40%; Polyol: about 5% to 30%, and preferred 15% to 25%; Cellulose gum: about 1% to 3%, and preferred 1.2% to 1.8%; Sodium chloride: about 1% to 6%, and preferred about 2% to 4%; Polishing agent/cleaning agent: about 1% to 40%, and preferred about 1.5% to 30%; Foaming agent: about 0.1% to 2.5%, and preferred about 0.2% to 0.5%; Flavoring agent: to flavoursome, less than about 1%; Antiseptic: about 0.1% to 0.5%.Surplus is a purified water.Paste and gel are preferably with equal-volume ratio use basically.

In some embodiments, by to oral delivery first component and second component, and in the oral cavity, stir the combination of first and second compositionss, fiercely contact with periodontal tissue with gums, perhaps scrub gums simultaneously and around the periodontal surface of tooth with the combination of first and second components, can suppress gingiva bleeding gingival hemorrhage, and can improve the texture and the continuity of gums and periodontal tissue, described first component comprises about by weight 0.1% to about 10% zinc salt in pharmaceutically suitable carrier, described second component comprises about by weight 1% to about 80% bicarbonate in pharmaceutically suitable carrier.

In a preferred embodiment, described first component also comprises peroxide.Another embodiment uses ascorbic acid or citric acid to replace peroxide.

This combination of zinc salt and bicarbonate can be sent the effect that extremely effectively suppresses gums and periodontal tissue's damage.This effect needs zinc salt and bicarbonate separately to pack before joining them in the oral cavity.For example, be packaged in the oral care appliance as herein described.

Described first component comprises the salt that can send zinc ion.Term " zinc ion " is meant, solid or not the zinc atom part in the dissociative state zinc compound molecule can be separated into the zinc ion of simple or complexation, in the time of especially in being distributed to water-bearing media.Spendable described examples for compounds is the zinc salt of following inorganic ions: borate, bromide ion, carbonate, hexafluorosilicic acid root, pyrophosphate, silicate, sulfate radical and titanate radical.Organic anion be have 2 to 22 carbon atoms have those of charged group, described charged group is selected from carboxylate radical, sulfonate radical, sulfate radical and phosphate radical.Instantiation includes but not limited to acetate, benzoate anion, citrate, glycine root, lactate, hydroxy benzenesulfonic acid root, salicylate, tartrate anion, acetylacetone,2,4-pentanedione acid group, maleate, amber acid radical, ascorbic acid root and glucose acid group.

The content of zinc salt in oral care composition is generally about 0.05% by weight to about 10%, and is preferably between about 0.2% to 5%, the most desirable between about 0.8% to 3%.

Described first component can be a gel, and described second compositions can be opaque paste form.Described gel comprises peroxide, such as hydrogen peroxide, urea peroxide, calper calcium peroxide, and perborate, persilicate, perphosphate and percarbonate.The amount of peroxide by weight about 0.1% to about 10% scope.With regard to hydrogen peroxide active substance weight, described amount is by weight about 0.5% to about 5%, and preferred about 0.8% to about 4%, in the most desirable about scope of 1% to 3%.

Described first component can comprise C ₂-C ₂₀Carboxylic acid substitutes peroxide.Illustrative acid comprises citric acid, malic acid, lactic acid and ascorbic acid.The content and the amount of peroxide of acid are similar, promptly by weight about 0.1% to about 10% scope.Citric acid most preferably.If present, these acid can be in liquid, gel or paste type compositions.

Advantageously, the pH of described first component will remain between about 3.2 to 5.0, and preferred 4.0 to 4.5.

Comprise bicarbonate second component can also with above comprise the preventing decayed tooth fluoride in those the substantially the same amounts described in first compositions, described fluoride be selected from above at those the identical fluorides described in first compositions.Especially preferred fluorinated sodium.Bicarbonate exists with alkali metal salt, and the example is sodium bicarbonate and potassium bicarbonate.Usually, the concentration of bicarbonate is by weight about 0.5% to about 80%, and preferred about 5% to about 50%, the most desirable between about 8% to about 20% scope.The pH of bicarbonate compositions can be about 7.0 to about 9.5, most preferably from about in 8.0 to 9.0 the scope.When the bicarbonate compositions was toothpaste or gel form, usually with about 0.1% to 10% by weight, preferred about amount of 0.5% to 5% comprised natural or synthetic thickening agent.

The relative weight ratio of first compositions and second compositions is preferably about 1: 1 in about 1: 2 to 2: 1 scope.

Dentifrice composition and component

The oral care composition and the component that are mixed with dentifrice generally comprise binding agent, carrier and active component.In some cases, dentifrice also can comprise one or more following materials: surfactant and/or detergent, thickening agent, polishing agent, carrier, wetting agent, salt etc.The case description of suitable dentifrice composition is in hereinafter.

Binding agent

Described adhesive composition normally determines the principal element of described oral care composition rheological properties.Described binding agent also is used for making any solid phase in the mouth care component to keep suspending, and prevents that therefore the solid phase part in the described mouth care component from separating from liquid phase part.In addition, described binding agent also can be described oral care composition denseness or concentration is provided.Therefore, in some cases, binding agent also can be oral care composition thickening function is provided.

The example of binding agent comprises that sodium carboxymethyl cellulose, cellulose ether, xanthan gum, carrageenin, sodium alginate, acrylate copolymer or silicate are such as silicate hydrate lithium magnesium sodium.Other embodiment of suitable binders comprises polymer such as hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, guar gum, Tragacanth, karaya, Radix Acaciae senegalis, Irish moss, starch and alginate.Alternatively, described binding agent can comprise clay, for example, and synthesis of clay such as Strese Hofmann's hectorite., or natural clay.Every kind of binding agent can use separately or use with other binder combination.

Surfactants/detergents

In some cases, dentifrice can comprise one or more surfactants or detergent, so that desired frothing capacity to be provided.

Surfactant generally includes anion, nonionic, cation and amphion or amphoteric composition.The embodiment of surfactant comprise soap, sulfate (as, sodium lauryl sulfate and dodecylbenzene sodium sulfonate), the sorbitan ester of sodium lauryl sarcosinate, fatty acid, sulfobetaines (as, cocamido propyl betaine) and D-glycopyranoside C _10-16The alkyl oligomer.In some embodiments, described surfactant comprises sodium lauryl sulfate, cocamido propyl betaine and C ₁₀-C ₁₆Alkyl D-pyranglucoside oligomer.Generally speaking, the amount of surfactant for by weight about 0.2 to about 8% (as, about 1 to about 5% or about 1.5 to about 3.5%).

Thickening agent

The example of thickening agent comprises thickening silica, polymer, clay and their combination.Content is between about 4% thickening silica to about 8% (for example about 6%) by weight, and for example SILODENT 15 hydrated SiO 2s provide desired oral cavity characteristic.Phrase described herein " oral cavity characteristic " is meant, when dentifrice bubbles in the user oral cavity, and its denseness and concentration.

Polishing agent

The example of polishing agent comprises grinding agent such as carbonate (for example sodium bicarbonate, calcium carbonate), water-colloidal silica, precipitated silica (for example Shionox), sodium aluminosilicate, comprise aluminium oxide each etc. grade silicon dioxide, hydrated alumina, dicalcium phosphate, insoluble Polymeric sodium metaphosphate. and magnesium (for example tricresyl phosphate magnesium).The Sq of polishing agent is that excellent polishing and spatter property can be provided safely, and when mixing with other composition, can provide smooth, can flow and the amount of many sand grains of no mistake in treatment matter compositions.Generally speaking, when comprising polishing agent, their content is about 5% to about 50% (for example about 5% to about 35%, or about 7% to about 25%) by weight.

Carrier

The example of carrier comprise water, Polyethylene Glycol, glycerol, polypropylene glycol, starch, sucrose, alcohol (as, methanol, ethanol, isopropyl alcohol etc.) or their combination.The example of combination comprises various water and alcohol combination and various Polyethylene Glycol and polypropylene glycol combination.Generally speaking, vector contg is according to the concentration of described adhesive composition, and the amount of dissolved salt, surfactant and decentralized photo is determined.

Wetting agent

Usually, wetting agent is a polyhydric alcohol.The example of wetting agent comprises glycerol, sorbitol, propylene glycol, xylitol, lactose, polypropylene glycol, Polyethylene Glycol, hydrogenated corn syrup and their mixture.In general, when comprising wetting agent, their content is about 10% to about 60% by weight.

Buffer agent and/or salt

The example of buffer agent and salt comprises primary, the second month in a season or tertiary base metal phosphate, citric acid, sodium citrate, saccharin sodium, tetrasodium pyrophosphate, sodium hydroxide etc.

Active component

Dentifrice can comprise active component, and for example to prevent cavity, tooth-whitening makes breath freshening, sends mouth cavity medicine, and provide other treatment and the beauty treatment beneficial effect, such as above-mentioned those.The example of active component comprises following: caries preventive agent (for example soluble fluoride salt, fluosilicate, fluozirconate, fluostannous acid salt, borofluoride, fluotitanate, fluogermanate, blended halogenide and casein); Anticalculus agent; Anti-calculus agent (for example alkali metal pyrophosphate, the polymer that comprises the hypophosphorous acid root, organic phosphoric acid citrate, phosphoric acid citrate, polyphosphate); Antibacterial (for example bacteriocin, antibody, enzyme); Antimicrobial enhancing agent; Antimicrobial (triclosan for example, chlorhexidine, mantoquita, zinc salt and tin salt such as zinc citrate, zinc sulfate, zinc glycinate, Sanguinarine extract, metronidazole, quaternary ammonium compound are such as cetylpyridinium chloride; Biguanide such as chlorhexidine gluconate, hexatidine, Octenidine, alexidine; And the halogenation bisphenol compound, such as 2,2 '-methylene two-(4-chloro-6-bromine phenol)); Desensitizer (for example potassium citrate, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt); Whitening agent (bleach for example, such as per-compound, peroxide diphosphonic acid potassium for example); Antiplaque agent; The gums protective agent (vegetable oil for example, such as Oleum helianthi, rapeseed oil, soybean oil and Flos Carthami oil, and other oil, such as silicone oil and hydrocarbon ils).Described gums protective agent can be the material that can improve the permeability barrier of gums.Other active component comprises wound rehabilitation agent (for example urea, allantoin, pantothenylol, alkali metal thiocyanate, based on the active substance of Chamomile and acetyl-salicylic derivate, ibuprofen, flurbiprofen, aspirin, indomethacin etc.); The tooth buffer agent; Remineralizing agent; Antiinflammatory; Remove malodorant; Flavorants; And the reagent that is used for the treatment of oral condition such as gingivitis or periodontitis.

Other composition

In some cases, dentifrice can comprise effervescent system such as sodium bicarbonate citric acid system, or the variable color system.

Dentifrice also can comprise one or more following materials: phenolic compounds (as, phenol and homologue thereof comprise 2-methylphenol, 3-methylphenol, 4-methylphenol, 4-ethyl-phenol, 2,4-hydroxymethyl-phenol and 3,4-hydroxymethyl-phenol); Sweeting agent (for example saccharin sodium, Sodium Cyclamate, sucrose, lactose, maltose and fructose); Flavoring agent (for example Oleum menthae, Oleum Menthae Rotundifoliae, Eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and other natural or natural equivalent quintessence oil or synthetic flavoring agent); Antiseptic (for example methyl parahydroxybenzoate, ethylparaben or propyl p-hydroxybenzoate, sodium sorbate, sodium benzoate, bromine chlorine sweet smell, triclosan, hexatidine, phenyl salicytate, biguanide and peroxide); Opacifier and coloring agent are such as titanium dioxide or F D﹠amp; The C dyestuff; And vitamin, such as retinol, tocopherol or ascorbic acid.

Collutory compositions and component

Compositions as herein described and component can collutory or the mouthwass form provide.

Composition in this type of mouthwass and the collutory generally includes one or more in water (about 45% to about 95%), ethanol (about 0% to about 25%), wetting agent (about 0% to about 50%), surfactant (about 0.01% to about 7%), flavoring agent (about 0.04% to about 2%), sweeting agent (about 0.1% to about 3%) and the coloring agent (about 0.001% to about 0.5%).This type of mouthwass and collutory also can comprise one or more caries preventive agents (about 0.05% to about 0.3%, presses fluorine ionometer) and anti-calculus agent (about 0.1% to about 3%).

Compositions as herein described and component also can be dental solution and flush fluid form.Component in this type of dental solution generally includes one or more in water (about 90% to about 99%), antiseptic (about 0.01% to about 0.5%), thickening agent (0% to about 5%), flavoring agent (about 0.04% to about 2%), sweeting agent (about 0.1% to about 3%) and the surfactant (0% to about 5%).Some case description of the collutory that can use with the present invention is in the U.S.6 that authorizes Libin, 440,395; Authorize the U.S.6 of Adamy, 355,229; Authorize the U.S.6 of Rolla, 344,184; Authorize people's such as Wi cks U.S.6,117,417; Authorize people's such as Jampani U.S.5,980,925; Authorize people's such as Nelson U.S.5,948,390; All authorize people's such as McLaughlin U.S.5,686,063 and U.S.5,681,549; Authorize people's such as Shimada U.S.5,626,837; Authorize people's such as Scodari U.S.5,560,906; All authorize the U.S.5 of Konopa, 407,664 and U.S.5,292,527; Authorize the US5 of Hall, 405,604; All authorize people's such as Yamagishi U.S.5,374,418 and U.S.5,370,865; Authorize people's such as Garlich U.S.5,286,479; U.S.No.5,525,330,5,256,396,5,158,763,4,370,314,4,339,430,4,273,759,4,224,309,4,188,372,4,137,303,4,123,512,4,118,476,4,118,475,4,118,474,4,118,473,4,118,472,4,110,429,4,102,993,4,100,270,4,089,880,4,080,441,4,042,679 and 3,864,472 and WO 03/075865 (all transferring ColgatePalmolive); Authorize people's such as Charbonneau U.S.4,994,262; All authorize the U.S.No.4 of Ryan, 959,204,4,663,154 and 4,472,373; Authorize the U.S.44 of Shah, 325,939; Authorize Parran, the U.S.4 of Jr., 323,551; WO 96/15770, WO94/27566 and WO 94/18939; WO 00/44338; U.S.2006/0171907A1; U.S.7,195,753; U.S.7,192,573; U.S.7,153,493; U.S.6,696,047; U.S.6,361,762; U.S.6,350,438; US 6,348, and 187; US 6,261, and 540; US6,251,372; US 5,707, and 610; U.S.5,681,548; U.S.5,945,088; U.S.5,945,087; U.S.5,723,106; U.S.5,338,538; U.S.5,330,749; US5,310,546; US 5,302, and 373; U.S.5,236,699; US 5,229, and 103; US5,256,401; U.S.5,174,990; U.S.5,104,644; U.S.5,087,444; U.S.5,043,183; U.S.4,894,220; U.S.4,684,517; And U.S.4,537,778.

Can continue (i.e. second component after the elder generation's first component) first component/compositions of sending and some limiting examples of second component/compositions via multiple device and/or packing (some of them have been described in herein) simultaneously or mutually is shown in the following table 1.Can use any scheme as herein described, dosage, step or method, send first and second components in the table 1 in whole or in part, and described first and second components can provide in a variety of forms, include but not limited to dentifrice, collutory, gel, liquid or paste.

Table 1

	First component	Second component
			1	Tin salt is such as stannous chloride, stannous fluoride, the inferior stannum of lactic acid, the inferior stannum of gluconic acid and their combination.	Peroxide source is such as hydrogen peroxide or its precursor and their combination.
2	Tin salt is such as stannous chloride, stannous fluoride, the inferior stannum of lactic acid, the inferior stannum of gluconic acid and their combination.	The chlorous acid Yanyuan, such as sodium chlorite, calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite, and their combination.
			3	Calcium salt is such as calcium fluoride, calcium chloride, lime nitrate, calcium sulfate, calcium acetate, calcium gluconate and their combination.	Phosphate is such as phosphoric acid or comprise PO 4Ionic phosphate, such as acid or its salt, such as sodium dihydrogen phosphate, sodium hydrogen phosphate, tertiary sodium phosphate, and their combination.
4	Tin salt is such as stannous chloride, stannous fluoride, the inferior stannum of lactic acid and the inferior stannum of gluconic acid; And/or/optional quaternary ammonium compound, such as cetylpyridinium chloride; Biguanide such as chlorhexidine gluconate, hexatidine, Octenidine, alexidine; And the halogenation bisphenol compound, such as 2,2 '-methylene two-(4-chloro-6-bromine phenol); And/or/combination of optional and flavoring agent, such as Oleum menthae, Oleum Menthae Rotundifoliae, Eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and other natural or natural equivalent quintessence oil or synthetic flavoring agent; And above-mentioned combination.	Grinding agent, such as carbonate (for example sodium bicarbonate, calcium carbonate), water-colloidal silica, precipitated silica (for example Shionox), sodium aluminosilicate, comprise aluminium oxide each etc. grade silicon dioxide, hydrated alumina, dicalcium phosphate, insoluble Polymeric sodium metaphosphate. and magnesium (for example tricresyl phosphate magnesium); And/or/combination of optional and surfactant (for example anion, nonionic, cation and amphion or amphoteric composition), such as soap, sulfate (for example sodium lauryl sulfate and dodecylbenzene sodium sulfonate), sodium lauryl sarcosinate, sorbitan fatty esters, sulfobetaines (for example cocamido propyl betaine) and D-glycopyranoside C 10- 16The alkyl oligomer; And above-mentioned combination.
			5	Phosphate is such as phosphoric acid or comprise PO 4Ionic phosphate, such as acid or its salt, such as sodium dihydrogen phosphate, sodium hydrogen phosphate, tertiary sodium phosphate, and their combination.	Calcium salt is such as calcium fluoride, calcium chloride, lime nitrate, calcium sulfate, calcium acetate, calcium gluconate and their combination.

6	At the fluoride source under about 2 to about 6pH, such as sodium fluoride, zinc fluoride, fluoridize betanin, alanine stannous fluoride, hexylamine fluoride, and their combination.	PH is greater than any compositions of about 7.
			7	First flavoring agent, such as Oleum menthae, Oleum Menthae Rotundifoliae, Eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and other natural or natural equivalent quintessence oil or synthetic flavoring agent, and their combination.	Second flavoring agent, such as Oleum menthae, Oleum Menthae Rotundifoliae, Eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and other natural or natural equivalent quintessence oil or synthetic flavoring agent, and their combination.
8	Quaternary ammonium compound is such as cetylpyridinium chloride; Biguanide such as chlorhexidine gluconate, hexatidine, Octenidine, alexidine; And the halogenation bisphenol compound, such as 2,2 '-methylene two-(4-chloro-6-bromine phenol); And their combination.	Peroxide source is such as hydrogen peroxide or its precursor and their combination.
			9	Flavoring agent, such as Oleum menthae, Oleum Menthae Rotundifoliae, Eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and other natural or natural equivalent quintessence oil or synthetic flavoring agent, and their combination.	Peroxide source is such as hydrogen peroxide or its precursor and their combination.
10	Quaternary ammonium compound is such as cetylpyridinium chloride; Biguanide such as chlorhexidine gluconate, hexatidine, Octenidine, alexidine; And the halogenation bisphenol compound, such as 2,2 '-methylene two-(4-chloro-6-bromine phenol)); And their combination.	The chlorous acid Yanyuan is such as sodium chlorite, calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite and their combination.

11	Flavoring agent is such as Oleum menthae, Oleum Menthae Rotundifoliae, Eucalyptus oil, aniseed oil, fennel oil, caraway oil, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and other natural or natural equivalent quintessence oil or synthetic flavoring agent and their combination.	The chlorous acid Yanyuan is such as sodium chlorite, calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite and their combination.
			12	Calcium salt is such as calcium fluoride, calcium chloride, lime nitrate, calcium sulfate, calcium acetate, calcium gluconate and their combination.	Fluoride source is such as sodium fluoride, zinc fluoride, fluoridize betanin, alanine stannous fluoride, hexylamine fluoride and their combination.
13	Fluoride source is such as sodium fluoride, zinc fluoride, fluoridize betanin, alanine stannous fluoride, hexylamine fluoride and their combination.	Calcium salt is such as calcium fluoride, calcium chloride, lime nitrate, calcium sulfate, calcium acetate, calcium gluconate and their combination.
			14	Developer is such as fluorescein, dibromofluorescein, tribromo fluorescein, eosin, other fluorescein derivative (salt that comprises them), xanthene, pyrene (for example pyrans element), D﹠amp; C blue No. 1, D﹠amp; C blue No. 2, D﹠amp; C green No. 3, D﹠amp; C red No. 3, D﹠amp; C red No. 6, D﹠amp; C red No. 7, D﹠amp; C red No. 21, D﹠amp; C red No. 22, D﹠amp; C red No. 27, D﹠amp; C red No. 28, D﹠amp; C red No. 33, D﹠amp; C red No. 40, D﹠amp; C yellow No. 5, D﹠amp; C yellow No. 6, D﹠amp; Yellow No. 10 of C, they combination or be used for any other dyestuff and their combination of medicine and cosmetics by regulator's approval.	Grinding agent, such as carbonate (for example sodium bicarbonate, calcium carbonate), water-colloidal silica, precipitated silica (for example Shionox), sodium aluminosilicate, comprise aluminium oxide each etc. grade silicon dioxide, hydrated alumina, dicalcium phosphate, insoluble Polymeric sodium metaphosphate. and magnesium (for example tricresyl phosphate magnesium); And/or/combination of optional and surfactant (for example anion, nonionic, cation and amphion or amphoteric composition), such as soap, sulfate (for example sodium lauryl sulfate and dodecylbenzene sodium sulfonate), sodium lauryl sarcosinate, sorbitan fatty esters, sulfobetaines (for example cocamido propyl betaine) and D-glycopyranoside C 10-16The alkyl oligomer; And above-mentioned any combination.

15	Grinding agent, such as carbonate (for example sodium bicarbonate, calcium carbonate), water-colloidal silica, precipitated silica (for example Shionox), sodium aluminosilicate, comprise aluminium oxide each etc. grade silicon dioxide, hydrated alumina, dicalcium phosphate, insoluble Polymeric sodium metaphosphate. and magnesium (for example tricresyl phosphate magnesium); And/or/combination of optional and surfactant (for example anion, nonionic, cation and amphion or amphoteric composition), such as soap, sulfate (for example sodium lauryl sulfate and dodecylbenzene sodium sulfonate), sodium lauryl sarcosinate, sorbitan fatty esters, sulfobetaines (for example cocamido propyl betaine) and D-glycopyranoside C 10-16The alkyl oligomer; And above-mentioned combination.	Developer is such as fluorescein, dibromofluorescein, tribromo fluorescein, eosin, other fluorescein derivative (salt that comprises them), xanthene, pyrene (for example pyrans element), D﹠amp; C blue No. 1, D﹠amp; C blue No. 2, D﹠amp; Green No. 3 of C, D﹠amp; Red No. 3 of C, D﹠amp; Red No. 6 of C, D﹠amp; Red No. 7 of C, D﹠amp; Red No. 21 of C, D﹠amp; Red No. 22 of C, D﹠amp; Red No. 27 of C, D﹠amp; Red No. 28 of C, D﹠amp; Red No. 33 of C, D﹠amp; Red No. 40 of C, D﹠amp; C yellow No. 5, D﹠amp; C yellow No. 6, D﹠amp; Yellow No. 10 of C, they combination or be used for any other dyestuff and their combination of medicine and cosmetics by regulator's approval.
			16	Calcium salt is such as calcium fluoride, calcium chloride, lime nitrate, calcium sulfate, calcium acetate, calcium gluconate and their combination.	Phosphate is such as phosphoric acid or comprise PO 4Ionic phosphate is such as acid or its salt, such as sodium dihydrogen phosphate, sodium hydrogen phosphate and tertiary sodium phosphate; With the combination of fluoride source, such as sodium fluoride, zinc fluoride, fluoridize betanin, alanine stannous fluoride, hexylamine fluoride; And above-mentioned combination.
17	Zinc salt is such as zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, bicarbonate zinc, zinc oxalate, zinc fluoride, zinc lactate, zinc gluconate and their combination.	Peroxide source is such as hydrogen peroxide or its precursor and their combination.
			18	Zinc salt, such as zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, bicarbonate zinc, zinc oxalate, zinc fluoride, zinc lactate, zinc gluconate, and above-mentioned combination.	The chlorous acid Yanyuan, such as sodium chlorite, calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite, and above-mentioned combination.

19	Mantoquita is such as copper gluconate, copper chlorate, copper chloride, copper fluoride, copper nitrate and their combination.	The chlorous acid Yanyuan is such as sodium chlorite, calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite and their combination.
			20	Mantoquita is such as copper gluconate, copper chlorate, copper chloride, copper fluoride, copper nitrate and their combination.	Peroxide source is such as hydrogen peroxide or its precursor and their combination.
21	Peroxide source is such as hydrogen peroxide and precursor and their combination.	Metallic catalyst is such as ferrum, copper, manganese and molybdate and their combination.
			22	Metallic catalyst is such as ferrum, copper, manganese and molybdate and their combination.	Peroxide source is such as hydrogen peroxide or its precursor and their combination.
23	Tin salt is such as stannous chloride, stannous fluoride, the inferior stannum of lactic acid, the inferior stannum of gluconic acid and their combination.	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7, and wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.
			24	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7And wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.	Tin salt is such as stannous chloride, stannous fluoride, the inferior stannum of lactic acid, the inferior stannum of gluconic acid and their combination.

25	Zinc salt is such as zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, bicarbonate zinc, zinc oxalate, zinc fluoride, zinc lactate, zinc gluconate and their combination.	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7And wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.
			26	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7And wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.	Zinc salt is such as zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, bicarbonate zinc, zinc oxalate, zinc fluoride, zinc lactate, zinc gluconate and their combination.
27	Mantoquita is such as copper gluconate, copper chlorate, copper chloride, copper fluoride, copper nitrate and their combination.	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7, and wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.

28	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7And wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.	Mantoquita is such as copper gluconate, copper chlorate, copper chloride, copper fluoride, copper nitrate and their combination.
			29	Slaine is such as inferior stannum, copper, zinc, silver, stannum, manganese, ferrum, magnesium and their combination.	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7, and wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.
30	Pyrophosphate is such as two alkali metal or four alkali metal pyrophosphates, such as Na 4P 2O 7(TSPP), K 4P 2O 7, Na 2K 2P 2O 7, Na 2H 2P 2O 7And K 2H 2P 2O 7And wherein said polyphosphate can comprise the water-soluble alkali tripolyphosphate, such as sodium tripolyphosphate and PTPP (potassium tripolyphosphate); And/or/combination of optional and polyphosphate, such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And above-mentioned combination.	Slaine is such as inferior stannum, copper, zinc, silver, stannum, manganese, ferrum, magnesium and their combination.
			31	Slaine is such as inferior stannum, copper, zinc, silver, stannum, manganese, ferrum, magnesium and their combination.	Oxidant is such as chlorite, hydrogen peroxide (or peroxide source), perborate, perchlorate, perchlorate and their combination.

32	Antibacterial, such as triclosan (2,4,4-three chloro-2 '-dihydroxy diphenyl ether), chlorhexidine, mantoquita, zinc salt and tin salt (such as zinc citrate, zinc sulfate, zinc glycinate), Sanguinarine extract, metronidazole, quaternary ammonium compound be such as cetylpyridinium chloride; Biguanide such as chlorhexidine gluconate, hexatidine, Octenidine, alexidine; And the halogenation bisphenol compound, such as 2,2 '-methylene two-(4-chloro-6-bromine phenol); And their combination.	Polyphosphate is such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And/or/optional oxidizing agent, such as chlorite, hydrogen peroxide, perborate, perchlorate and perchlorate; And/or/optional chelating agen, such as alkali metal stannate such as sodium stannate and potassium stannate, ethylenediaminetetraacetic acid (EDTA) and salt thereof, citrate plus malate salt, and their salt and acid; And above-mentioned combination.
			33	Developer is such as fluorescein, dibromofluorescein, tribromo fluorescein, eosin, other fluorescein derivative (salt that comprises them), xanthene, pyrene (for example pyrans element), D﹠amp; C blue No. 1, D﹠amp; C blue No. 2, D﹠amp; C green No. 3, D﹠amp; C red No. 3, D﹠amp; C red No. 6, D﹠amp; C red No. 7, D﹠amp; C red No. 21, D﹠amp; C red No. 22, D﹠amp; C red No. 27, D﹠amp; C red No. 28, D﹠amp; C red No. 33, D﹠amp; C red No. 40, D﹠amp; C yellow No. 5, D﹠amp; C yellow No. 6, D﹠amp; Yellow No. 10 of C, they combination or be used for any other dyestuff and their combination of medicine and cosmetics by regulator's approval.	Polyphosphate is such as sodium hexameta phosphate or any polyphosphate (PO 4) n, wherein n is 2 to 40; And/or/optional oxidizing agent, such as chlorite, hydrogen peroxide, perborate, perchlorate and perchlorate; And/or/optional chelating agen, such as alkali metal stannate such as sodium stannate and potassium stannate, ethylenediaminetetraacetic acid (EDTA) and salt thereof, citrate plus malate salt, and their salt and acid; And above-mentioned combination.
34	Tin salt is such as stannous chloride, stannous fluoride, the inferior stannum of lactic acid, the inferior stannum of gluconic acid and their combination.	Quaternary ammonium compound is such as cetylpyridinium chloride; Biguanide such as chlorhexidine gluconate, hexatidine, Octenidine, alexidine; And the halogenation bisphenol compound, such as 2,2 '-methylene two-(4-chloro-6-bromine phenol)); And their combination; With the combination of peroxide source, such as hydrogen peroxide or its precursor and their combination.

Other embodiment

Though many embodiments of the present invention are described, should be appreciated that under the condition that does not deviate from spirit and scope of the invention and can carry out various modifications.Therefore, other embodiment is also within the scope of following claim.

All documents of quoting in the detailed Description Of The Invention are incorporated this paper into way of reference.Quoting of any document be may not be interpreted as all admitting that it is a prior art of the present invention.When any implication of term in any implication of term among the present invention or definition and the file of introducing for your guidance or when defining contradiction, should obey the implication or the definition of giving this term in the present invention.

Claims (28)

1. oral care method, described method is used display and toothbrush, described toothbrush have shank, head, with export liquid storage device and the pump that fluid is communicated with, described method comprises:

Be assigned to oral care composition on the head of described toothbrush from packing;

Use described toothbrush that described oral care composition is administered in the oral cavity; And

Wherein said display provides signal to distribute the liquid from the described liquid storage device of described toothbrush by described outlet to user.

2. the method for claim 1, wherein said signal is audible signal, visual signal or their combination.

3. the method for claim 1, wherein said toothbrush also comprise the data-phone that keeps data communication with described display.

4. method as claimed in claim 3, wherein said data-phone are radio-frequency (RF) tag.

5. method as claimed in claim 4, wherein said oral care composition are the dentifrice that is stored in the dentifrice packing.

6. method as claimed in claim 5, described method also comprise described liquid are assigned to the described liquid storage device from flexible package punch.

7. method as claimed in claim 6, wherein said dentifrice packing and described flexible package punch also comprise data-phone separately.

8. method as claimed in claim 7, the data-phone of wherein said dentifrice packing and described flexible package punch is a radio-frequency (RF) tag.

9. method as claimed in claim 8, described method also comprise places described toothbrush, dentifrice packing and collutory packing so that described data-phone can be communicated by letter with described display near described display.

10. the method for claim 1, wherein said pump makes described liquid storage device supercharging.

11. the method for claim 1, wherein said pump is pumped to described outlet with described liquid from described liquid storage device.

12. the method for claim 1, wherein said display are presented at the interval that uses described dentifrice in the oral cavity.

13. method as claimed in claim 12 wherein uses the interval of described dentifrice in the oral cavity between about 1 minute and about 3 minutes.

14. method as claimed in claim 13, wherein said display are presented at the interval that uses described liquid in the oral cavity.

15. method as claimed in claim 14 wherein uses the interval of described liquid in the oral cavity between about 20 seconds and about 2 minutes.

16. an oral care method, described method is used display, toothbrush and is comprised first compartment and the packing of second compartment, and described first compartment has first compositions, and described second compartment has second compositions, and described method comprises:

Be assigned to described first compositions on the head of described toothbrush from described packing;

Use described toothbrush that described first compositions is administered to the oral cavity;

Wherein said display provides signal to be assigned to described second compositions on the head of described toothbrush from described packing to user; And

Use described toothbrush that described second compositions is administered to the oral cavity.

17. method as claimed in claim 16, wherein said signal are audible signal, visual signal or their combination.

18. method as claimed in claim 16, wherein said toothbrush also comprise the data-phone that keeps data communication with described display.

19. method as claimed in claim 18, wherein said data-phone are radio-frequency (RF) tag.

20. method as claimed in claim 19, wherein said packing comprises data-phone.

21. method as claimed in claim 20, the data-phone of wherein said packing are radio-frequency (RF) tag.

22. method as claimed in claim 21, described method also comprise described toothbrush is placed so that described data-phone can be communicated by letter with described display near described display with described packing.

23. method as claimed in claim 16, wherein said display are presented at the interval that uses described first compositions in the oral cavity.

24. method as claimed in claim 23 wherein uses the interval of described first compositions in the oral cavity between about 30 seconds and about 3 minutes.

25. method as claimed in claim 23, wherein said display are presented at the interval that uses described second compositions in the oral cavity.

26. method as claimed in claim 25 wherein uses the interval of described second compositions in the oral cavity between about 30 seconds and about 2 minutes.

27. method as claimed in claim 25 wherein uses the interval of described second compositions to show after the interval that uses described first compositions.

28. an external member, described external member comprises:

Dentifrice packing with data-phone;

Flexible package punch with data-phone;

Toothbrush with liquid storage device and data-phone; With

Can carry out the display of data communication with described data-phone.

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