JP2010526638A - Compositions, methods, devices and systems for oral care - Google Patents

Abstract

  An oral care treatment comprising a multi-component oral care composition and a method for delivering the composition to the oral cavity is provided. Oral care devices and systems for performing such oral care procedures are also provided.

Description

  The present invention relates to compositions, methods, devices, and systems for oral care.

  While it is known to use more than one oral care composition, there is a need to provide improved products and methods for delivering one or more compositions to the oral cavity.

  In general, the present invention includes multi-component oral care compositions, oral care methods (such as procedures for delivering multiple components to the oral cavity), and oral care devices, oral care kits, and oral care systems. Characterized by treatment.

1 is a side perspective view of one embodiment of an oral care system. The front perspective view of one embodiment of an oral care tool. FIG. 2B is a rear perspective view of the oral care device of FIG. 2A. FIG. 2B is a perspective front view of the oral care device of FIG. 2A. FIG. 2B is a perspective rear view of the oral care device of FIG. 2A. FIG. 6 is a rear view and a front view of the head and neck of another embodiment of the oral care device, each with the neck shown in perspective. FIG. 6 is a rear view and a front view of the head and neck of another embodiment of the oral care device, each with the neck shown in perspective. FIG. 6 is a rear view of the head and neck of another embodiment of an oral care device with the neck shown in perspective. FIG. 3 is a front perspective view of two embodiments of a brush. FIG. 3 is a front perspective view of two embodiments of a brush. FIG. 3 is a side perspective view of one embodiment of a docking station. FIG. 8B is a perspective side perspective view of the docking station of FIG. 8A. One embodiment of a docking station. Another embodiment of a docking station. 1 is a perspective view of an embodiment of an oral care system. The perspective view of the base part B of the docking station shown by FIG. 1 is a cross-sectional view of a two-compartment dispenser suitable for use with the present invention. 2 is a cross-sectional view of two dispensers suitable for use with the present invention. FIG. 1 is a front view of a dispensing toothbrush suitable for use with the present invention. FIG. 1 is a schematic view of an oral care system according to the present invention. 1 is a schematic diagram of electrical components suitable for use with the present invention.

  The following text provides a general description of many different embodiments of the present invention. This description is to be construed as merely illustrative, and it is impractical, if not impossible, to describe every possible embodiment, so the following description does not describe every possible embodiment Any of the mechanisms, features, components, compositions, ingredients, doses, products, processes, or methodologies described herein may be deleted or any of the other described herein. It will be appreciated that features, features, components, compositions, ingredients, products, processes, or methodologies may be combined or replaced in whole or in part. Numerous alternative embodiments may be implemented using either the latest technology or technology developed after the filing date of this patent, but such embodiments are also claimed in the claims. It will be included in the range. All publications and patents cited herein are hereby incorporated by reference.

  Also, within this patent, “as used herein, the term“ ______ ”is used herein. . . Using the sentence `` defined as meaning '' or a similar sentence, whether or not the term is expressly or implicitly, whether explicitly or implicitly, unless the term is explicitly defined It should be understood that the terms are not meant to be limited in any way beyond the general meaning, and such terms may include any description ( Should not be construed as limited in scope based on (except in the language of the claims). None of the terms are essential to the present invention unless they are described as essential to the present invention. To the extent that any term set forth in a claim at the end of this patent is referred to in this patent in a manner consistent with a single meaning, it is simply and clearly not to confuse the reader. And is not intended to limit the terms of the claims to their single meaning by implication or otherwise. Finally, unless the term “means” and a function is defined by describing a function without any structural details, the scope of any claim element shall be set forth in 35 USC 112. It shall not be interpreted based on the application of paragraph 6.

  In general, for oral care procedures that involve delivering two or more oral care compositions, portions of compositions, substances, formulations, or ingredients (hereinafter collectively referred to as “components”) to the oral cavity. I will discuss it. In particular, two components that are mechanically separated from each other prior to delivery will be discussed below. The components can be delivered from various oral care devices such as manual toothbrushes, power toothbrushes, packages, or dispensers. The components can be delivered simultaneously or sequentially. In some cases, the two components, when mixed together, react during delivery or in the oral cavity or otherwise interact to form an oral care composition, such as US Pat. No. 375,933 and the “Oral Care Compositions and Components” section below to form a two-component dentifrice. In another case, the component itself is a complete oral care composition, for example, the component can be a dentifrice or a mouthwash. This document first discusses various oral care procedures that can be performed. Next, examples of devices suitable for delivering components will be discussed. Finally, examples of various components that can be delivered are discussed. The component can be any shape that can be delivered by the desired delivery device, such as Newtonian fluids, non-Newtonian fluids, liquids, pastes, or gels.

Method of Use The following discussion will refer to the delivery of two components that are mechanically separated. However, it will be apparent that the method discussed can be extended to more than two components. The method described below may be performed, for example, using a dispensing device having a microprocessor controller. In the toothbrush, a stationary or movable head (or a movable part of the head) may be used. For example, U.S. Patent Application Nos. 09 / 993,167, 10 / 036,613, 10 / 114,870, 10 / 128,018, 10 / 208,213, No. 10 / 830,693, U.S. Pat. No. 5,378,153, a head (or brush or oscillating, rotating, reciprocating, translational, vibrating, etc.) A suitable toothbrush having a part of the head containing the element. U.S. Patent Application Nos. 10 / 832,168, 10 / 847,429, 10 / 842,302, 10 / 887,644, 10 / 887,667, 10 Additional toothbrushes with light emitting diodes may be used, including toothbrushes that emit light (including blue light) as described in US / 888,206. Suitable toothbrushes may or may not include a brush or cleaning element. In another embodiment, as discussed further below, a dispenser such as a multi-compartment package can be used with the present invention. Examples of suitable devices are discussed in detail in the “Oral Care Device” section below.

  The components can be delivered to the oral cavity simultaneously or sequentially. In the case of sequential delivery, both components can be separated by a particular user during a single oral care process, for example, during a single brushing process or other single treatment process (from start to finish). During one use, typically about 0.1 to 5 minutes), or alternatively, the components may be delivered individually over multiple oral care steps. For example, many combinations are possible where both components are delivered during the first oral care process and only one of the components is delivered during the second oral care process. In the following, examples of possible delivery sequences and regimens are discussed.

Simultaneous delivery The simplest case is to deliver the same amount of two components simultaneously or in a constant ratio during a single oral care process simultaneously and sequentially. In some cases, for example, when one of the components is a liquid such as a cleaning agent (rinsing agent), the ratio can be from about 1:20 to about 20: 1. The regimen of the present invention may be suitable, for example, when it is desirable to deliver two components that do not react with each other but are pharmaceutically incompatible. For example, it may be desirable to deliver two components that require different pH levels to be active, such as stannous pyrophosphate (active at low pH) and sodium fluoride (active at high pH). . The two components may be provided separately with binder systems at different pH levels and then delivered simultaneously to the oral cavity. The brushing duration is sufficiently short so that the components are not inactivated. Another application for simultaneous and continuous delivery is a system containing two components that reacts relatively slowly and remains in the oral cavity after brushing and is absorbed by the teeth and / or gums.

  Alternatively, delivery can be simultaneous and sequential, but the ratio of the two components can be varied during brushing. In some cases, first a relatively large mass of the first component is delivered with a smaller amount of the second component (e.g., a ratio of 80:20, or about 1:20 to about 20: 1). ) Then, during brushing, it is desirable to decrease the amount of the first component and increase the amount of the second component, for example, until the ratio is reversed (eg, a ratio of 20:80). is there. The change in relative amount can be linear or non-linear, e.g. a large amount of toothpaste sufficient to initiate brushing with a small amount of mouthwash followed by almost immediately thereafter. Has a greatly reduced amount of paste and an increased amount of mouthwash. Components and their proportions can also be selected to provide the user with a brushing experience that is initially smooth and transitions to an extremely clean / invigorating mouthfeel.

  In addition, the two components may be delivered simultaneously during different periods of a single oral care process (eg, between 1-5 seconds and 60-65 seconds of a 120 second oral care process), or Two components may be delivered simultaneously during different steps (eg every other step).

Sequential delivery during a single oral care process Sequential delivery during a single oral care process can take a variety of forms. In one case, the two components alternate in either a relatively long duration cycle during brushing (ABAB) or in alternating multiple times (ABABABABAB ... AB). Sent out. An example of a treatment that adapts well to this type of delivery is remineralization, a treatment that uses peroxide and peroxide activators. The preferred cycle time depends on the chemical used and may be optimized for a given chemical reaction. For example, in the case of peroxide and activator, the cycle time may be relatively long, for example 15 seconds, so that the peroxide and activator can react. Other chemicals such as remineralization systems such as those discussed herein (see “Compositions” below) may be used with shorter cycle times, eg, 5 seconds or less. Good.

  In another case, two or more components are delivered in sequence during a single oral care process, with no subsequent alternating delivery (A followed by B). For example, first a dentifrice is delivered to initiate brushing and cleaning, followed by a mouth rinse, a fluoride treatment, or a temporary sealant. Other options include peroxide followed by active agent or dentifrice to increase fluorination, copper dentifrice followed by chlorite, anti-gingivitis treatment followed by anti-inflammatory Those that follow treatment or those that provide perceptual cues to the user with a pair of components with different flavors. A change in flavor, for example, should the user brush for a longer time, finish brushing, or does the user need to change the brushing mode to a mode where the brushing speed is faster or slower, for example? Can be shown.

Sequential delivery during multiple oral care steps Another sequential treatment regimen involves multiple oral care steps. In some embodiments, the delivery device includes a clock function and is programmed to perform a predetermined procedure at a predetermined time or series of times. Depending on the time, different components may be delivered at different ratios or in different component orders. For example, one component may be delivered in the morning and a second different component may be delivered in the evening (eg, two different dentifrices, or mouthwash and dentifrice). As another example, two components may be delivered in the morning, such as a dentifrice and a mouthwash, and only a dentifrice at night. With this watch-based approach, the user has two different sensory experiences, gets two different active ingredients, or brushes twice a day (once in the morning or at night) only once a day The active ingredient can be obtained.

  Similarly, some treatment regimens are specialized according to the prescribed treatment procedure, eg only in the morning or at night, every other day (morning and / or night), or once a week (morning and / or night). May involve the delivery of a typical treatment, such as a prescription drug. The delivery device can be programmed to deliver the correct dose at the desired time during brushing. The toothpaste may be delivered at a different time and, if desired, at the same time as a specialized treatment. The professional treatment may be a prescribed toothpaste, and a standard over-the-counter toothpaste may be dispensed between use of the prescribed toothpaste as prescribed.

  Another approach that is useful across multiple oral care processes is the “count” function, which allows the delivery device to be programmed so that one of the components is delivered every x oral care processes. Is done. For example, if multiple users utilize the same toothbrush handle, the delivery device may be programmed to recognize a particular user's replaceable toothbrush head, eg, by RFID, and count only that user's processes.

  In some cases, including both a clock function and a volume monitoring function that accumulates data across multiple oral care processes, only a predetermined volume of one or both of the components within a given time period (eg, 24 It may be desirable to program the delivery device such that less than x grams of component A) is delivered over a period of time. The volume monitoring function may also be used to meter accurate dose components over a single oral care process. For example, volume monitoring is desirable when toxicity or other safety issues occur when a component exceeds the normal dose. For example, in the case of fluoride treatment for children, it is important to prevent children from receiving excessive fluoride because of the risk of fluorine poisoning. The delivered dose can be measured by any suitable method, for example, by accurately calibrating the instrument and then indirectly calculating the dose based on the number of pumping cycles. In some cases, a delivery device may be used to precisely control the dose of a particular active agent while delivering a second composition, such as a standard dentifrice, as needed.

  The delivery device accumulates data regarding the brushing time and / or the amount of each component dispensed, for example, whether the user is complying with a prescribed procedure, and / or the user's dentist or other May be programmed so that other clinicians can follow-up. This information can be displayed on the LCD display of the delivery device.

  When a delivery device (e.g., an electric toothbrush) is used by multiple users, the device can be programmed so that each user can select the components they want to use during their oral care process. For example, some users may prefer toothpastes with different flavors, or may seek toothpastes with unique performance attributes, such as reduced sensitivity to whitening.

  The toothbrush case may be configured so that the two components are delivered to different toothbrush heads. When a first head (eg, a standard electric toothbrush head) is in place, a first component, eg, dentifrice, is delivered and a second head (eg, pick, tongue scrape, or When a gingival brush or the like is in place, another component, such as a mouth rinse, is delivered. The toothbrush may be configured to automatically recognize different heads, for example, by RFID identification or by mechanical means such as pin setting. An oral care device with various head RFID identification features is described in published US Patent Application No. 2002/0129454, the entire disclosure of which is incorporated herein by reference.

Delivery Parameters Delivery by any of the treatment regimens discussed herein may be intermittent, i.e., with an interruption period during which no delivery occurs. Note that even “continuous” delivery may be intermittent in the sense that the pumping mechanism of the delivery instrument may operate in a pulsating manner. However, the treatment regimen may include additional interruption periods and / or longer interruption periods by appropriately programming the delivery device.

  From any delivery device, about 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.5, 1.8, 2, 4, 6, 8, 10, 15, Over a period of 30, 60, 90, or 120 seconds, the first component is about 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1.4, 1.5, 1.6, 1.8, or 2 grams (or about 0.05, 0.00). 1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1. 4, 1.5, 1.6, 1.8, 2, 5, 7, 10, 12, 15, 20, 25, or 30 mL), and about 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.5, 1.8, 2, 4, 6, 8, 10, 15 Over a period of 30, 60, 90, 120, 180, 240, or 300 seconds, the second component is about 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0,. 4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1.4, 1.5, 1.6, 1.8, or 2 grams (or about 0.05, 0.1, 0.15, 0.2, 0.25, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.2, 1.4, 1.5, 1.6, 1.8, 2, 5, 7, 10, 12, 15, 20, 25, or 30 mL). In the case of a manually pumped delivery device (eg, a two-compartment dispenser as shown in FIG. 13), the first and / or second component is about 1, 2, 3, 4, or 10 times or more of the pump. May be dispensed by actuation of Also, about 90/10, 80/20, 70/30, 60/40, 50/50, 40/60, 30/70, 20/80, or 10/90 (first component / second configuration The first and second components may be distributed in a ratio of (component). Other ratios can be from about 1:20 to about 20: 1.

  As discussed above, the first and second components may be delivered simultaneously or sequentially (so that the second component is about 0.2, 0.4 of the first component). , 0.6, 0.8, 1, 1.2, 1.5, 1.8, 2, 4, 6, 8, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55 , 60, 75, 90, 105, or 120 seconds). In addition, the second component may be distributed during the second brushing process following the first brushing process, in which case the second brushing process starts from the end of the first brushing process. Leave at least about 4, 6, 8, 10, or 12 hours until time. Also, the second component can be dispensed during the same oral care regimen, but after the time interval between the use of the first component and the use of the second component has elapsed. For example, the dentifrice (first component) may be used for 2 minutes, and after the use of the dentifrice is completed, the cleaning agent (second component) may be applied for a few seconds or minutes.

  There may be multiple orders during the brushing process, including combinations such as weight, volume, and time described above. This order may be simultaneous or sequential and may include the interruption periods described above. For example, within a two minute brushing process, the first order may include simultaneous distribution of a volume of the first component and a volume of the second component, followed by the second order being A period of time including a distribution of a volume of a first component and then no distribution may occur, followed by a third sequence including a distribution of a volume of a second component and the following: A period of no distribution may occur, followed by a fourth order that may include a distribution of a volume of the first component.

Delivery Devices A wide variety of oral care devices can be used to dispense the components of the present invention, such as manual toothbrushes, electric toothbrushes, and various other packages (eg, hand pumps) and devices. First, an oral care device that can deliver two components simultaneously will be discussed.

  Referring to FIG. 1, one embodiment of an oral care system 10 is shown that includes an oral care device 12, in this case a toothbrush, and a docking that holds the oral care device 12 in an upright position within a receiving portion of a docking station. Station 14. The oral care device 12 is an electric toothbrush having a motorized head and is designed to release two components (such as a dentifrice and a mouthwash) during a brushing cycle. The docking station 14 is designed to recharge the battery in the oral care device and refill the oral care device with the components.

  With reference to FIGS. 2A and 2B, the oral care device 12 includes a separable housing 16 comprised of three interconnected compartments 152, 154 and 156. When assembled, the oral care device 12 includes a distal portion 18 in which the head 20 is disposed and a proximal portion 22 in which a handle 24 is disposed. The neck portion 26 connects the handle 24 and the head 20. The head 20 is sized to fit in the user's mouth for brushing and the handle 24 is grippable by the user to facilitate operation of the head 20 during use.

  Referring to FIG. 2B, which shows a rear view of the oral care device 12, an inlet 28 is positioned near the distal surface 30 at the proximal portion 22 of the oral care device. The inlet 28 can mesh with a corresponding outlet 280 (FIG. 8A) located at the docking station 14 for refilling the oral care device.

  3A and 3B, the internal components of the oral care device 12 are shown. Oral care device 12 includes motors 34 and 36. The motor 34 moves the pair of components toward the distal portion 18 of the oral care device 12 along respective passages (only one passage 40 is shown in FIGS. 3A and 3B). Drive. Pumping assembly 38 uses a compression element to assemble portions of tubes 514 and 516 (FIG. 4A) as described in US patent application Ser. No. 10 / 861,253, the entire disclosure of which is incorporated herein by reference. By compressing, each component may be moved through the respective passage. Similar to the pump assembly described in US patent application Ser. No. 10 / 861,253, when a tube is gradually compressed using a series of fingers, the fingers extend in the width direction of the two tubes to It is dimensioned so that it can be compressed simultaneously.

  The motor 36 drives the drive shaft 42, which in turn moves (eg, rotates) the head 20. A rechargeable battery 44 is electrically connected to the motor to supply power to the motors 34, 36 and 37. A suitable rechargeable battery is lithium ion UR 14500P available from Sanyo.

  Referring to FIGS. 4A and 4B, the oral care device includes a pair of tubes 514 and 516 that direct two fluid streams within the oral care device. As shown, each of the tubes 514 and 516 is connected to the head at a position offset from a longitudinal axis 531 perpendicular to the rotational axis 518 of the movable head 20. In some embodiments, one of the tubes may be connected to the head at a rotational axis and the other connected at a position offset from the rotational axis. Referring to FIG. 5, a variation is shown in which tubes 550 and 552 are fluidly connected to each other downstream of the pumping assembly and upstream of the fluid outlet in the head. This embodiment may be advantageous when it is desirable to mix the components in the passage just before delivery to the brushing surface.

  In FIGS. 3A-3B, it should be pointed out that only one passage 40 is shown in order to clarify the scale of these figures. In general, oral care device 12 includes two passages (eg, tubes 514 and 516 in FIGS. 4A and 4B) as described above. However, in some cases, for example, where two components can be mixed upstream of the head near a separate chamber where the two components are stored, a single passage may be used.

  Referring again to FIG. 3A, the oral care device 12 includes a control circuit or controller 400 that is electrically connected to the motors 34 and 36 and generally manages the operation of these motors. User interface 402 provides external interaction with controller 400. User interface 402 includes on / off buttons 404 and 406 and fluid level switch 408, all of which are accessible from the exterior of housing 16 (see FIG. 2A).

  While the controller can be programmed as desired, by way of example, the controller can cause only one of the motors, such as motor 36, to start by depressing button 404 to start motors 34 and 36 and depress button 406. Designed to start up. By depressing button 404 or 405, both head movement and fluid flow can be initiated, with button 404 activating one flow and button 405 activating the other flow. By depressing button 406, only one of fluid flow and head movement can be triggered. By depressing button 404 or 406, the associated motor (s) can also be stopped following startup. In the case where only the motor 36 is started and stopped by the button 406, the user can, for example, perform brushing without delivering either component, and can rinse the oral care device 12 while rotating the head. Fluid level switches 408, 409 allow the user to select from preselected fluid delivery speeds (such as high speed, medium speed, and low speed). The three LEDs 410 can be selectively lit to indicate the selected fluid delivery level. Alternatively or additionally, an LCD display can be included to communicate fluid delivery levels and / or to display other information such as fluid levels in the oral care device 12 and / or battery charge status. Can be used.

  Controller 400 may also be programmed to adjust the paste delivery level following motor 34 startup. In some embodiments, the controller has a relatively large amount of two components delivered immediately after the motor 34 is started, for example, having a sufficient amount of paste to initiate brushing, For example, the delivery level is programmed to be reduced to a lower delivery level throughout the remainder of the brushing cycle. Paste delivery levels may be reduced, for example, by intermittent bursts of fluid and / or by slower fluid delivery. As an example, the controller may be programmed to provide three delivery settings: low, medium and high. In one embodiment, in the low delivery setting, the controller is programmed to deliver the mass by activating the motor 34 for about 7 seconds. After about 7 seconds, the controller intermittently activates the motor 34 for about 0.75 seconds and deactivates the motor 34 for about 2.4 seconds (ie, runs the motor in an on / off cycle at these intervals). . In the same embodiment, in the medium delivery setting, the controller releases the mass by activating the motor 34 for about 7 seconds, and then operates the motor on a cycle of about 0.75 seconds on and about 1.63 seconds off. Programmed to let In the high delivery setting, the controller sends a chunk by activating the motor 34 for about 7 seconds and then runs the motor in a cycle of about 0.75 seconds on and about 1.2 seconds off. Is done. Depending on the desired programming of the controller 400, more or fewer user interface controls can be used to initiate various functions.

  Referring again to FIG. 3A, the motor 36 moves the pivot drive shaft 42 (eg, translates linearly), which in turn moves the rotary head 20 (eg, pivots rotationally). The drive shaft 42 is a fluid outlet in the head 20 and tube 82 (or a pair of tubes if the two flows of material are kept separate) that forms a portion of the fluid passage in the neck 26 of the housing 16. It is connected to the rotary head 20 using an offset design that facilitates placement. This offset design is described in further detail in US patent application Ser. No. 10 / 861,253. The movement of the rotary head 20 is achieved, in part, by using a cam and follower system that converts the rotational output of the motor 36 into a linear motion used to drive the drive shaft 42 back and forth. May be. Such an arrangement is described in US patent application Ser. No. 10 / 861,253, incorporated above by reference.

  6 and 7, head 20 includes a base 136 having an opening 124 through which valve 122 extends, for example, a duckbill valve as shown. . In some embodiments, the distal end of tube 82 forms a fluid outlet without using a valve attached thereto. If it is desired to keep the two streams separate until the two streams exit the head, then two valves, or US patent application Ser. No. 11/114 filed Apr. 26, 2005, the entire disclosure of which is incorporated herein by reference. , 987, a dual duckbill valve may be used. Extending from the base 136 is an array of brush tufts 138. Each tuft 138 is shown as a tight mass in the figure, but each tuft is actually made up of a large collection of individual plastic hairs. For a more detailed description of the brush head, Applicants cite pending US patent application Ser. No. 10 / 666,497, filed Sep. 9, 2003, the entire disclosure of which is hereby incorporated herein by reference. Include in the book.

  The oral care device 12 can be coupled to the docking station 14 when not in use. The docking station 14 can be connected to an electrical outlet (not shown) or other suitable power source. With reference to FIGS. 8A and 8B, the docking station 14 is configured to hold the oral care device 12 in an upright position within the receiving portion 273. The receiving portion 273 includes a floor 275 that extends between a vertical recess 295 formed in the housing 291 and the housing extension 297. The recess 295 is contoured to receive a portion of the oral care device 12. The docking station 14 includes a reactive device, such as a sensor (not shown), that detects an input when an oral care device is received by the docking station and sends a signal to the controller in response to the input. The details are described in more detail below.

  Referring now to FIGS. 8B and 9, the docking station 14 includes a multi-chamber fluid reservoir 274, two of which are connected to the outlet 280 using a tube 276. In some embodiments, for example, as shown in FIG. 9, the fluid reservoir 274 is formed as an integral part of the separable and replaceable portion 301 of the docking station 14. In another embodiment, two replaceable pouches 303 (only one of which is shown in FIG. 10) from the fluid reservoir are shown by FIG. In this case, the top 301 of the docking station is removable and the consumer can easily remove the sachet 303 and replace the sachet when the consumer runs out of the contents of the sachet 303 or the user wants to use a different product. Can be inserted. Referring to FIG. 8B, the docking station includes a pump assembly 282 to move components from the fluid reservoir to the oral care device. Details of the refill mechanism within the docking station are provided in US patent application Ser. No. 10 / 861,253.

  Referring again to FIG. 8B, a pair of conductors 336, 338 are exposed in the receiving portion 273 of the docking station 14. The leads 336, 338 are positioned to contact a pair of contacts 340, 342 (FIG. 2A) on the oral care device 12 when the oral care device 12 is placed in the receiving portion 173. This contact electrically connects the oral care device 12 and the docking station 14 so that a power source connected to the docking station can charge the rechargeable battery in the oral care device. The contacts 340, 342 are electrically connected to the rechargeable battery and allow power to flow from the docking station to the battery.

  An oral care system 600 suitable for delivering two components sequentially is shown in FIG. The oral care system 600 includes an oral care device 602 in the form of a toothbrush and a docking station 604. Oral care device 602 is connected to docking station 604 by a very short portion of tubing 605 shown in FIG. Tubing material 605 is flexible and is long enough to allow the user to easily operate the oral care device, for example about 2.5 to 3.5 feet long. Tubing material 605 may be connected to the oral care device at any desired location, such as a head or handle, as discussed below.

  Oral care device 602 includes a handle 606 and a removable head / neck portion 608. Since the pumping mechanism or pump motor is provided in the docking station as discussed below, the handle 606 does not include those components. The handle 606 contains a motor and other components necessary to drive the head, and may contain two fluid passages.

  Docking station 604 includes a tower portion T and a base portion B. The tower portion contains two reservoirs (not shown) and is removable from the base portion so that the user can refill or replace the reservoir. The base portion B supports two pumps 610, 612, as shown in detail in FIG. 12, which receive two components from the reservoir through tubes 614, 616, downstream of the tube. 618 and 620. After exiting the docking station, the tube may be wrapped in a single sheath that forms tube material 605 as shown in FIG. 11 or otherwise accommodated. Pumps 610 and 612 are independently driven by motors 622 and 624. The activation of the motor is driven by a controller, such as one or more microprocessors, which may be mounted on the printed circuit boards 626, 628.

  When tubing 605 enters the oral care device at the base location or within the handle, the handle contains tubing that defines two fluid pathways. If the tubing 605 enters the oral care device at the head location, a standard handle containing only the head drive components may be used.

  Any desired type of reservoir may be used to house the two components within the oral care device described above. A suitable reservoir is described in US patent application Ser. No. 10 / 861,253, incorporated by reference above.

  In another embodiment, the delivery device can be provided in the form of a two-compartment dispenser that can be used alone or in combination with the aforementioned electric toothbrush. Referring to FIG. 13, a two compartment dispenser 700 having a first outlet 705 and a second outlet 710 is shown. The dispenser 700 has a first compartment 715 that stores a first component and a second compartment 720 that stores a second component. The first compartment 715 is in fluid communication with the first outlet 705 via the tube 722, and the second compartment 720 is in fluid communication with the second outlet 710 via the tube 724. In this embodiment, the first and second compartments 715 and 720 are not in fluid communication with each other downstream so that the first and second components are not mixed, substantially not mixed, not mixed, or In other ways, they are not distributed together. A piston-type pump 726 can be used to pump the first component from the first compartment 715, while a separate piston-type pump 728 can be used to send the second component to the second compartment. 720 can be pumped. Pumps 726 and 728 can be biased by springs 730 and 732. One or more valves 736 can be provided to facilitate operation of the piston pump. The valve 736 can be provided as a check valve that moves the fluid in only one direction. The volume of the first and second compartments can be the same or approximately the same. In another embodiment, the volumes of the first and second compartments are different, which is useful when the amounts of the first and second components dispensed during the oral care regimen are different. there is a possibility. An orifice 734 may be provided for the purpose of metering the dose of the first or second component for each piston pump stroke. The dose can also be controlled by the size (eg, inner diameter) and / or stroke of the piston pump.

  The first and second compartments 715 and 720 can be provided as replaceable cartridges that releasably engage the housing 734 of the dispenser 700. For example, compartments 715 and 720 may engage housing 734 by screwing. The compartments 715 and 720 have different threads (pitch) so that if the dose or metering is different between the first component and the second component, each compartment is properly paired with a piston pump or orifice. Or size). Although a first outlet and a second outlet are shown, a single piston pump and outlet can also be provided, in which case the single piston pump and outlet are It can be placed in selective fluid communication with either one of the compartments or the second compartment. Any component, dose, or regimen described herein in whole or in part can be used with the dispenser 700. The dispenser 700 is one dispensing device suitable for use with the present invention, although it will be appreciated that other dispensing devices can be used.

  In one method of the invention, as part of a brushing regimen, the user dispenses a first component onto the toothbrush and subsequently applies the first component to the oral cavity. After using the first component, as part of the brushing regimen, the user sequentially dispenses the second component onto the toothbrush and applies the second component to the oral cavity. Optionally, the user may rinse the brush and / or his oral cavity before applying the second component to the toothbrush. The toothbrush is activated when a predetermined period of time elapses for the purpose of notifying the user when to switch between the first component and the second component or when the second component has been used. A timer may be included. In one embodiment, the second component is about 15, 30, 45, 60, 120, 180, 240, 300, 360, 420 seconds, or 10 after applying the first component to the toothbrush or oral cavity. Within 15 or 20 minutes, applied to toothbrush or oral cavity.

  Although the dispenser 700 has been described as comprising first and second compartments, it will be appreciated that more than two compartments may be provided. The dispenser 700 can be provided in a wide variety of shapes, sizes, and configurations.

  Referring to FIG. 14, in another embodiment, the first compartment and the second compartment may be provided in the form of completely separate packages, which may be packaged as a kit. For example, a first component provided as a dentifrice can be provided in the first dentifrice dispenser 800 and a second component provided as a dentifrice is a second separate dentifrice. It can be provided in the dispenser 805. The first and second dispensers may be the same or different and are shown with the same structure as dispenser 700 (FIG. 13) for simplicity. The user dispenses a first amount from the first dentifrice package onto the toothbrush, brushes with the first component for a period of time, and then an amount from the second dentifrice package onto the same toothbrush. The second component can be dispensed to complete the brushing regimen with the second component. The first and second dentifrice packages can be provided in visually distinct shape, size, or color (s) so that the user can easily distinguish the two. In addition, the first and second dentifrice packages may have a figure, a character string, an icon, or a number for distinguishing the two. In some embodiments, the first and second dentifrice packages provide the first dose so that a specific dose is delivered, so that a controlled ratio between the first and second components is applied. And the second component can be weighed.

  In yet another embodiment, the delivery device can be provided in the form of an oral care device capable of dispensing a liquid such as a mouth rinse. The oral care device can be provided in the form of a toothbrush, some examples of which are described in U.S. Pat. Nos. 6,331,088, 6,047,429, 6,689,078, And US Pat. No. 6,739,782. The toothbrush may comprise a movable bristle holder and / or a stationary or non-movable bristle holder. The toothbrush head may be releasably attached to the toothbrush handle. With reference to FIG. 15, an example of a fluid dispensing toothbrush suitable for use with the present invention is described below. The toothbrush 900 has a handle 905, a head 910, and a liquid reservoir 915 disposed within the handle. The liquid reservoir 915 can be a replaceable single use reservoir or a toothbrush user that can be refilled. The liquid reservoir 915 is in fluid communication with one or more outlets 920 disposed in the head 910. The outlet 920 is connected to the liquid reservoir 915 by a conduit 925. A pump 930 is provided to pump and pressurize the liquid 913 in the liquid reservoir 915. The pump 930 can be provided in a wide variety of forms known in the art. For example, a piston pump such as that described in US Pat. No. 6,689,078 can be used. In one embodiment, the pump 930 can be an air pump used to pressurize the liquid in the reservoir 915. When pressurized, the liquid may exit the reservoir when the valve 935 is opened. Valve 935 may be opened or actuated by depressing a button (not shown) on handle 905.

  The first component or composition is preferably in the form of a dentifrice, although other forms may be used and may be used by the user by the tuft 945 (or other tooth cleaning element) of the head 910 of the toothbrush 900. ) Can be applied. The first component can include any of the components described herein (and combinations thereof) and / or other components known in the art. As a result, the first component is applied to the hard and / or soft tissue of the oral cavity when a toothbrush is used. The second component or composition is preferably in the form of a liquid or mouthwash, but then the user activates or opens valve 935 at the beginning, during or at the end of the brushing regimen. Thus, the toothbrush 900 can be selectively applied to the whole or part of the oral cavity. The second component can include any of the components described herein (and combinations thereof) and / or other components known in the art.

  Referring to FIG. 16, one or more of the instruments described herein can be used with a display device 950 having a screen 952. In addition, various devices are disclosed in US Patent Application No. 60 / 859,226 filed on Nov. 15, 2006, No. 60 / 920,698 filed on Mar. 29, 2007, filed Apr. 16, 2007. No. 60 / 912,111. A system 955 that includes one or more oral care products such as a dispensing toothbrush 900, a manual or electric toothbrush 958, a packaged dentifrice 960, a packaged mouth rinse 965, and a two-compartment dispenser 700. It is shown. Some examples of manual or electric toothbrushes 955 suitable for use with the present invention are US Pat. Nos. 5,974,615, 5,930,858, 6,006,394, 6,108,869, 5,943,723, 6,308,367, 2003 / 0101,526, 2003 / 0154,567, 6,536 No. 068, No. 2002/0129454, and No. 5,987,688. For simplicity, specific devices and products are shown in FIG. 16, but various oral care devices may be used with system 955, including other oral care devices and products described in this application. It will be understood. The oral care product can communicate with display device 950 or an intermediate device using data links 970, 972, 974, 976, and 978, which in turn communicates data with display device 950. One or more oral care products, display devices, and / or system components described herein can be combined for distribution or sale as a kit to a user. System 955 may also be connected to network 982 via data link 984. The network 982 can comprise one or more computers, servers and clients, or electronic devices 985.

  The oral care products and devices of system 955 can use various methods and devices for storing, transmitting, and / or communicating data between the device / product and display device 950. The term “data” is intended to refer to any form of digital or analog information transmitted or communicated. Data may include any data actively transmitted by a data transmitter and / or data detected passively by a data reader. If the data to be communicated is digital, the data may include 1 and 0. In another embodiment, the data can be a series of digits, such as “12345678”, where each digit can represent information regarding the characteristics of the oral care device (eg, for a manual toothbrush). The first digit can represent the brushing time in minutes, the second digit can represent the number of months until the brush should be replaced, and the third and fourth digits are type-specific rewards Etc.) The data may include an arrangement of optical elements (eg, barcodes) that represent the information. The data may include cases where electromagnetic energy (eg, magnetic field) or the like is present or absent. Data may be stored, interpreted, decoded, or analyzed by the processor 986 shown in FIG. For example, if the data is a series of digits such as “12345678”, the processor 986 and / or associated memory 987 decodes or interprets the data to determine what the information represented by the data is. A set of instructions can be included.

  A data transmitter is a device or component that actively transmits data to a data reader. A high-frequency identification tag (IC tag, wireless tag, electronic tag), that is, an RFID tag is an example of a data transmitter. A data communicator is a device or component that has data that may or may not be actively transmitted but may be detected. A data transmitter such as an RFID tag is a kind of data communication device, but the data communication device does not necessarily need to actively transmit data. Examples of data communicators that contain data that can be detected or read by a data reader but that do not actively transmit data are bar codes (if the bar code reader is a data reader), spot codes, or halls An effect magnet (when the Hall effect sensor is a data reader). Thus, as will be appreciated, the terms “data communicator”, “data transmitter”, and “data reader” include a variety of analog or digital, including simply detecting the presence of a data communicator. It is intended to encompass a wide variety of devices and configurations for data transmission, communication, and / or detection. The term “data communication” means that data is transmitted by the device of the present invention, including data communication between two components, such as a data reader, a data transmitter, a data communicator, and either a display device and an oral care product. It is intended to encompass all methods and forms that may be transmitted, communicated, and / or detected.

  The data stored and / or transmitted or communicated by RFID tags or other data transmitters / communication devices can be very diverse. As part of the classification of data, product identification data (eg, trade name or product name), product usage or regimen data (eg, usage time of 1 minute regimen for cleaning agents, product usage, etc. String or graphic instructions, information about order of use, etc., one or more rewards, and component or product exchange data (eg, number of times or time that can be used before the component or product should be replaced) ). Instructional images, text strings, or data may be particularly useful when a child establishes an appropriate brushing regimen. The data can be displayed directly on the display device 950 or can be used as input to the processor 986 regarding the functions or features of the display device 950. For example, each of the oral care products can include an RFID tag 988 that can transmit usage or regimen data to a reader 990 associated with the display device 950. In one embodiment, the usage data can be used as input to a count up or count down timer displayed on display device 950. To initiate data transmission from the RFID tag to the data reader 990 associated with the display device 950, simply place the oral care product containing the RFID tag into the reader 990 sufficient to increase the output of the RFID tag. Just place them close together.

  In one embodiment, the oral care regimen includes a dentifrice package 960 (containing a dentifrice) to communicate data about the dentifrice (eg, the amount of time the dentifrice is applied to the oral cavity) and data about the cleaning agent to the display 950. And a cleaning agent package 965 are placed in data communication with the display device 950 (or an intermediate component in data communication with the display device 950). Can be included. The dentifrice is applied to the head 910 of the toothbrush 900 and the liquid cleaning agent is loaded into the liquid reservoir 913. The toothbrush 900 is then placed in data communication with the display device 950 so that a timer is started and the time interval is displayed on the display device 950 and communicated by the RFID tag associated with the dentifrice package 960. It is set according to the data. The display device 950 allows the user of the toothbrush 900 to use the cleaning agent 965 based on data communicated to the reader 990 by the packaged cleaning agent 965 data communicator at the beginning, middle, or end of the time interval. One or more audible and / or visible signals can be displayed or sent indicating that the should be distributed. In one embodiment, the timer is any of the time intervals for dispensing the cleaning agent into the oral cavity in order to approximate the time interval for the use of the cleaning agent in the oral cavity, which approximates the dose and / or duration of application of the cleaning agent. A second time interval displayed on the display device 950 can be initiated. The second time interval can be set according to data communicated by an RFID tag (or other data communicator) associated with the cleaning agent package 965. The dentifrice or first time interval can be about 30 seconds to 3 minutes, and the liquid cleanser or second time interval can be about 30 seconds to 3 minutes. The length of the time interval can vary depending on the intended interaction between the dentifrice and the liquid detergent. It will be appreciated that the steps described herein can be performed in various orders and that some steps may not necessarily be performed in each oral care or toothpaste cycle. For example, the liquid reservoir 913 may not necessarily be refilled each time, and the dentifrice and cleaner package is in data communication with the display 950 only once, such as when the dentifrice and cleaner are first used. Should be arranged. The data communicated by the RFID tag can then be stored in memory 987 until the data is erased or replaced, such as when a new dentifrice and cleaning product package is purchased and first used. Furthermore, while the application of dentifrices and cleaning agents to the oral cavity has been described as sequential, the application can occur as such, simultaneously or entirely (eg, a dentifrice is applied to the oral cavity, Immediately thereafter, the cleaning agent is expected to be applied). Display device 950 can also display other information, such as a visual guide that helps to apply a dentifrice or cleaning agent to all quadrants of the oral cavity. For example, displaying a representation of each quadrant of the oral cavity on the display 950 to indicate when or how long a dentifrice, cleaning agent, or brushing operation should be applied to that quadrant of the oral cavity Can do.

  In another embodiment, a two-compartment dispenser 700 and / or a toothbrush 958 can be placed in data communication with the display device 950. The two-compartment dispenser 700 can include one or more data communicators. In some embodiments, one data communicator may be associated with each partition. A timer can be started by data communication with display device 950. The display device 950 can then display a count up or count down time interval based on data transmitted by the toothbrush 958 and / or the data communicator of the compartmental dispenser 700. For example, a data communicator such as RFID tag 988 may communicate data representing the amount of time that the oral care composition of the first compartment 715 should be used. The RFID tag 988, or a second RFID tag associated with the second compartment 720, may also communicate data representing the amount of time that the oral care composition of the second compartment should be used. For example, the RFID tag 988 communicates such that the oral care composition of the first compartment 715 is applied to the oral cavity for 1 minute and the oral care composition of the second compartment 720 is applied to the oral cavity for 2 minutes. When this data is communicated (or any other data is communicated, such as the placement of a toothbrush 958 that is in data communication with the display 950, or even by actuating a button or touch screen element 953). When the display device timer is manually started), the display device 950 can display a first time interval or a one minute timer. At the end of the first time interval, display device 950 applies the second oral care composition from second compartment 720 to the head of toothbrush 958 (and / or applies the second oral care composition). Additional action, such as rinsing the toothbrush and / or the oral cavity before), and then applying the second oral care composition from the second compartment 720 to the oral cavity. Display device 950 can display a second time interval or period, such as the two minutes above, where the second oral care composition is applied to the oral cavity. The second time interval is determined by placing the toothbrush 958 in data communication with the display device 950, thereby causing the user to activate a switch, button, or other control on or associated with the display device 950, Or it can start automatically after a predetermined period. When the second time interval ends, the display device 950 detects that the second time interval has elapsed, such as an auditory signal (a signal that is grasped through hearing, a signal that works on hearing, a voice signal) and / or a visual signal (ascertained through vision). Signal, visual signal, video signal) can be provided. After the second time interval has elapsed, the use of the second oral care composition may be stopped. As will be appreciated, other information (eg, instructional information, regimen or usage information (eg, user information history, etc.) associated with the compartmentalized package 700 and / or the oral care composition stored therein. ), Rewards, educational information, coupons, etc.) can be displayed by the display device 950. Furthermore, although for simplicity the system 955 has been described herein in connection with a two-compartment dispenser 700, the method of the present invention can be used in any package that includes one or more compartments and / or oral care compositions. It will be appreciated that, or alternatively, it can be used with a plurality of individual packages each containing one or more oral care compositions.

Oral Care Composition and Components In the following, a two-component oral care composition will be described. In some cases, the two components are delivered separately into the user's mouth, or the two components of the oral care composition are kept separate until use to mix the components during delivery or in the oral cavity. Is beneficial or necessary. For example, as described above in the “Methods” section, when stored together, the two components react and / or neutralize with each other, or the components within the two components are active at different pH levels. This may be the case. Subsequently, various two-component compositions and examples of their use are described. As shown below, in some cases, some of the described compositions are delivered sequentially or simultaneously with any other desired component (such as a standard dentifrice or mouthwash) according to the method described above. It may be provided as a single component that may be

  The following discussion will focus on two-component compositions that can be advantageously delivered in whole or in part using the methods and apparatus described above. However, the methods and devices described above are useful for delivering two unrelated components, such as, for example, dentifrices and mouthwashes, two flavoring dentifrices, and other two-component compositions not mentioned below. Note that is equally suitable.

Malodor treatment The hard and soft tissues of the mouth are covered with microbial populations containing bacteria with different metabolic capacities. Gram-positive bacteria within these microbial populations easily catabolize carbohydrates to produce acids that attack the oral hard tissue, resulting in the formation of caries (cavities). In contrast, gram-negative bacteria, especially anaerobic bacteria, easily metabolize various amino acids contained in saliva and peptides and proteins in the oral cavity (not as much as amino acids) to produce bad breath and teeth. Forms a final product that promotes the development of peritonitis.

  Bad breath (clinically called halitosis) is a plaque, residue attached to the mucous membrane, and salivary cells that produce volatile sulfur compounds, mainly hydrogen sulfide, methyl mercaptan, and trace amounts of methyl sulfide. It may be due to the spoilage of these microorganisms on the element.

  Some two-component oral care compositions can reduce bad breath, improve breath freshness, and / or prevent plaque accumulation. The first component of the oral care composition includes a metal salt, such as a copper salt such as Cu (II), and the second component of the oral care composition includes an oxidant, such as a chlorite. Is mentioned. The two components are held separately in the two compartments of the delivery device, for example as described above, until use or just before use. This component is not a single-step process by the user, for example using the appliances described herein, rather than by a two-step process of first brushing teeth with a dentifrice and then using an oral care mouthwash. It can be applied in the process.

  Without being bound by theory, such compositions can reduce malodor by a dual approach. First, the concentration of VSC can be reduced by causing the metal salt to precipitate volatile sulfur compounds (VSC) as metal sulfides. Using a separate chemical pathway, the oxidant oxidizes malodorous compounds (such as amines and sulfides) into a non-volatile, or odorless form. In addition, oxidants and metal salts, especially Cu (II) salts, have antibacterial action, which can also provide an anti-carries effect to the user.

  In some embodiments, the two-component composition has a mouthwash as compared to the use of a single-component oral care product (eg, a dentifrice or mouthwash only), or even in some cases after a dentifrice. Compared with subsequent use of oral care regimens, it can lead to increased efficacy. Thus, in some embodiments, a smaller amount of active ingredient is applied in a two-component composition compared to the amount that would be applied in a single component system to achieve approximately equivalent efficacy, Or, conversely, the same amount of active ingredient will provide greater efficacy.

  Examples of suitable metal salts include Cu salts, Zn salts, Ag salts, Sn salts, Mg salts, Fe salts, and Mn salts. In some of the preferred embodiments, the first component includes a copper salt capable of releasing Cu (II) ions into the solution. Examples of suitable copper salts include copper gluconate, copper chlorate, copper chloride, copper fluoride, and copper nitrate. Generally, the copper salt is present in the first component at a concentration of about 50 to 10,000 ppm, or about 200 to about 2000 ppm, such as 500 to about 1000 ppm.

  Examples of suitable oxidizing agents include chlorite, hydrogen peroxide, and perborate, perchlorate, peroxyacid and hyperchlorates. In some preferred embodiments, the second component includes chlorite capable of releasing chlorite ions into the solution. An example of a suitable chlorite is sodium chlorite. Generally, chlorite is present in the second component at a concentration of about 100 to 10,000 ppm, or about 1000 to about 4000 ppm, such as about 1600 to about 2400 ppm.

  Each of the two components of the oral care composition can be formulated independently as a dentifrice or as a mouth rinse. Generally, if each component of the oral care composition is formulated as a dentifrice, the components may be delivered simultaneously or sequentially into the user's mouth. The first and second components can be delivered using a delivery device such as those described above. Each component of the oral care composition can be delivered in a single mass, or, for example, from about 0.01 mL / min to about 20 mL / min, or about 0.15 mL / min over a 2 minute brushing period. It can be delivered continuously during a user brushing period at a rate of about 1 mL / min, or about 0.15 mL / min to about 0.5 mL / min.

  In another embodiment, both components of the oral care composition are delivered as a mouth rinse. Each component can be administered alone, or the two components can be mixed immediately prior to use. Generally, about 15 mL to about 30 mL of the total mouth rinse is used for about 30 seconds, for example at a component ratio of 1: 1.

  In another embodiment, one component can be administered as a dentifrice and the other as a mouth rinse. The components can be administered simultaneously or sequentially. In one embodiment, when the first and second components are administered simultaneously, the ratio of the first component to the second component can be varied during administration of the oral care composition. For example, an oral care composition is administered using the oral care device described herein, and the oral care composition is initially administered in a ratio of first and second components of about 80:20. And the ratio of the first component to the second component can vary up to about 20:80 throughout the administration period.

  Another example of an oral care composition that can improve bad breath is the two-component dentifrice described in US Pat. No. 6,375,933, which is incorporated herein by reference in its entirety. These dentifrices contain zinc and chlorite ion releasable compounds contained within a separate semi-solid aqueous component. In some embodiments, the first component comprises a zinc salt as a zinc ion source and a chlorite as a chlorite ion source of about 6.0 to 7.5, such as about 6.8. In the form of an orally acceptable excipient having a near neutral pH. The second component has an acidic pH of about 2.0 to about 6.0, preferably about 4.0 to about 5.5. By mixing and combining the two components of the oral care composition, the pH of the final product is 6.5 or less, preferably from about 5.8 to about 6.4, thereby producing chlorine dioxide. . The two components are preferably formulated with water, humectant, surfactant, and abrasive to give similar physical properties, and for acidic components the pH is adjusted to the desired acidity For this purpose, an acid compound is added.

  Suitable zinc ion releasable compounds are generally water-soluble zinc salts (such as zinc nitrate, zinc citrate, zinc chloride, zinc sulfate, zinc bicarbonate, and zinc oxalate), preferably zinc nitrate . Zinc salts are generally incorporated in neutral dentifrice ingredients at a concentration of about 0.25 to about 10% by weight, preferably about 0.5 to about 2.0% by weight. Chlorite ion releasable compounds include alkali metal chlorite, alkaline earth metal chlorite, and any other transition metal, chlorite and / or polymer salt of an internal transition metal. Water-soluble chlorite is preferred. Examples of suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. A mixture of two or more chlorite sources may also be used. The chlorite ion releasable salt is generally incorporated in the neutral pH dentifrice component at a concentration of about 0.5 to about 5% by weight, preferably about 0.1 to about 1% by weight.

  The acidic dentifrice component of the dentifrice composition includes an acid or a mixture of acids to acidify, thereby activating the chlorite compound present in the neutral dentifrice component. Releases chlorine dioxide when the two components are combined prior to use.

Acidic compounds that can be present in the acidic dentifrice ingredients of the present invention include both mineral and organic acids (eg, sulfuric acid, hydrochloric acid, malic acid, alginic acid, citric acid, succinic acid, lactic acid, tartaric acid, Potassium bitartrate, acid sodium citrate, phosphoric acid, and sodium phosphate). Acid phosphates (such as phosphoric acid or salts of phosphoric acid containing PO ₄ ions) are preferred, and such acids and their acid salts (such as monosodium phosphate) should only provide the required acidity. It also provides phosphate ions and suppresses the demineralization of tooth enamel that can occur by applying a two-component dentifrice to the teeth. The preferred acid, phosphoric acid, is commercially available as a liquid at a concentration of 85%. When the neutral dentifrice component and acidic dentifrice component of the present invention are combined, the acid has a pH of the dentifrice of from about 2.0 to about 6.0, preferably from about 4.0 to about 5.5. Added to the dentifrice component in an amount to maintain the pH, the combined composition has a pH of about 5.8 to about 6.4.

This composition is an anticalculus pyrophosphate such as dialkali or tetraalkali metal pyrophosphate (Na ₄ P ₂ O ₇ (TSPP), K ₄ P ₂ O ₇ , Na ₂ K ₂ P ₂ O ₇ , Na ₂ H ₂ P ₂ O ₇ , and K ₂ H ₂ P ₂ O ₇ ). Examples of the polyphosphate include water-soluble alkali metal tripolyphosphate (such as sodium tripolyphosphate and potassium tripolyphosphate). The pyrophosphate may be incorporated at a concentration of about 0.05 to about 2.0% by weight, preferably about 0.5 to about 2% by weight, while the polyphosphate is about 1.0%. May be incorporated at a concentration of about 7.0% by weight.

Tooth whitening compositions Examples of two-component oral care compositions that can be used for tooth whitening are described, for example, in US Pat. No. 6,174,516, which is incorporated herein by reference in its entirety.

  The tooth whitening efficacy of the peroxide-containing dentifrice component can be substantially enhanced by first applying an aqueous alkaline detergent component having an alkaline pH to the tooth and then applying the peroxide dentifrice to the tooth. Alkaline cleaners tend to initiate and accelerate the rapid release of oxygen from the peroxide contained in the dentifrice. Such sequential administration can be performed using the methods and devices described above. For example, alkaline detergents and peroxidation can be given either once after cleaning, then once as dentifrice, or alternately (cleaning, dentifrice, cleaning, dentifrice, etc.) The delivery device can be programmed to deliver the dentifrice sequentially.

  In some embodiments, the aqueous detergent component includes about 70% to about 95%, preferably about 65% to 95% water, and about 0% to 35% water or a mixture of water and ethanol. Contains ethanol.

  The peroxide compound is included in an amount sufficient to release sufficient oxygen during brushing the teeth to exert its whitening effect. The peroxide compound is preferably included at about 5 to about 15% by weight of the constituent components. Examples of peroxide compounds suitable for use in preparing a dentifrice component used in the practice of the present invention include calcium peroxide, hydrogen peroxide, urea peroxide, glyceryl peroxide, benzoyl peroxide, and the like. Of the peroxide. A preferred peroxide compound is urea peroxide.

  When a metal ion chelating agent is included in the peroxide dentifrice component, the metal ion chelating agent can be used to form a peroxide compound when an abrasive (such as calcined alumina or calcium pyrophosphate) is also present in the dentifrice. Can contribute to chemical stability. Examples of suitable metal ion chelators include alkali metal stannates (such as sodium stannate and potassium stannate), ethylenediaminetetraacetic acid (EDTA), and salts thereof. The metal ion chelator is incorporated into the dentifrice component at a concentration of about 0.01 to about 1% by weight.

  In preparing the peroxide dentifrice component, the pH is adjusted to a range of about 3.0 to about 8, preferably about 5 to about 7, with an acid such as phosphoric acid.

Flavor Examples of oral care compositions that can enhance flavor improvement include those described in US Pat. No. 6,696,047, which is incorporated herein by reference in its entirety. Can be mentioned. Some of the two-component oral compositions containing chlorite are against the loss of chlorite by conversion to chlorine dioxide and the degradation of other composition components (flavor and sweetener) stable. In oral care compositions, in addition to maintaining a certain concentration of chlorite ions for efficacy, the consumer acceptability of the product is greatly influenced by the flavor and taste of the product, It is especially important that the does not decompose.

  In some embodiments, the aqueous component is formulated at a basic pH so that the pH does not change significantly during storage. In some embodiments, when the two components are mixed, the resulting composition does not have an unpleasant pungent odor of chlorine dioxide that can alter the flavor characteristics of the product.

  The first component may include chlorite ions and the second component may include a pharmaceutically acceptable topical oral carrier but does not include chlorite. The first component can also include a pharmaceutically acceptable topical oral carrier that is compatible with chlorite ions. Preferably, the first component further comprises one (or one or more) compatible binders, buffers, and / or preservatives. Preferably, the second component free of chlorite comprises a flavoring agent, surfactant, fluoride ion, humectant, and / or abrasive.

  The two components can be delivered simultaneously and can be combined during dispensing to form a composition, for example in a 1: 1 volume ratio.

  The concentration of chlorite ions in the composition is determined by the amount of chlorite in the gingiva / mucosal tissue and / or teeth due to the difference in the effect of the composition in contact with the gingiva / mucosal tissue or teeth and the amount of the composition used in general. It can be determined depending on the type of composition (eg toothpaste or mouth rinse) used in applying the acid ions. This concentration is also determined depending on the disease or condition being treated.

  In general, for mouth rinses to be taken into the mouth, the concentration of chlorite ions is preferably in the range of about 0.02% to about 0.5% by weight of the composition, about 0.10%. % To about 0.30% by weight is more preferred. Preferably, the mouth rinse composition of the present invention delivers about 3.75 to about 30.0 mg of chlorite ions to the oral cavity when about 15 mL of the cleaner is used. For dentifrices (such as toothpastes and dentifrice gels) and non-abrasive gels, the concentration of chlorite ions is preferably in the range of about 0.5% to about 3.0% by weight of the composition. The above concentration of chlorite ion represents the concentration of chlorite ion after the components are mixed together to form the composition. Accordingly, the concentration of chlorite ions in the chlorite-containing component varies depending on the amount of the second component or additional component that is mixed with the chlorite-containing component in order to obtain the final composition.

Systemic Health In some embodiments, use a one or two component topical oral composition that includes a safe and effective amount of chlorite ions in a mixture with a pharmaceutically acceptable carrier. Can promote the general health of humans and animals, and the composition can control bacterial-mediated diseases and conditions that exist in the oral cavity, and can prevent oral pathogens and associated bacterial toxins in the bloodstream. It is effective in suppressing the spread and the accompanying inflammatory cytokines and mediators. These compositions can be topically applied to the oral cavity using a safe and effective amount of chlorite ions for the purpose of promoting and / or improving the general health of humans and other animals. .

  Examples of oral care compositions that are effective for use on general health can be found, for example, in US Pat. No. 6,846,478, which is incorporated herein by reference in its entirety. In some embodiments, a topical oral composition can be used to promote the general health of humans and animals, and the composition is safe and effective in admixture with a pharmaceutically acceptable carrier. Effective amount of bacterial mediated diseases and conditions present in the oral cavity, and the spread of pathogenic bacteria in the bloodstream, the accompanying bacterial toxins, and associated inflammatory cytokines And suppress mediators.

  Some embodiments include methods of using these compositions by topical application to the oral cavity for the purpose of promoting and / or improving the general health of humans and other animals. More specifically, the composition is used to treat cardiovascular disease, stroke, atherosclerosis, diabetes, severe respiratory infections, preterm birth, and low birth weight (and postpartum nerve and developmental dysfunction). Can be reduced, as well as the risk of death associated therewith. In a preferred method, the composition is used to treat and prevent oral diseases and conditions, such as periodontal disease, thereby strengthening the individual being treated as evidenced by the following health indicators or biomarkers: Promote and / or improve general health.

1) Reduced risk of heart failure, stroke, diabetes, respiratory infection, low birth weight at birth, postpartum neuro / developmental dysfunction, and associated death risk 2) Arterial fatty streak, atheroma plaque , Progression of plaque formation, thinning of the fibrous capsule on the atheromatous plaque, rupture of the atheromatous plaque, and the resulting reduction of blood clotting symptoms 3) Carotid (intimal) wall thickness (eg, chlorite ion) 4) Reduction of blood chlorite ion concentration and / or reduction of chlorite ion concentration (specifically, oral bacteria, lipopolysaccharide (LPS) in the blood) Resulting in reduced concentrations and / or incidence of arterial plaques, arterial structures, and / or oral pathogens and / or components thereof found in distant organs (eg heart, liver, pancreas, kidney))
5) Lower respiratory exposure to pathogen inhalation and associated reduction of pneumonia and / or worsening of chronic obstructive pulmonary disease 6) Reduction of changes in circulating hematocrit, hemoglobin, white blood cell count, and / or platelet count 7 ) Reduced incidence of dysregulation of blood / serum concentrations of inflammatory mediators / cytokines (TNF-α, IL-6, CD-14, IL-1, etc.) 8) Acute phase reactants (C-reactive protein, Reduced incidence of dysregulation of blood / serum concentrations such as fibrinogen and haptoglobin) 9) Blood / serum markers of metabolic dysregulation (homocysteine, glycosylated hemoglobin, 8-iso-PGF-2α, uric acid, etc.) ) Reduced incidence of dysregulation 10) Dysregulation of glucose metabolism (typically assessed by impaired glucose tolerance test), increased fasting blood glucose levels, Reduction in incidence of abnormal abdominal insulin concentration 11) Blood lipid concentration (specifically, blood or serum cholesterol, triglyceride, LDL, HDL, VLDL, apolipoprotein B, and / or apolipoprotein A-1) Alleviation of dysregulation.

  Without being bound by theory, the composition promotes general health by controlling bacterial-mediated diseases and conditions that are present in the oral cavity, and thus blood flow and other body parts. It is thought to prevent the spread of bacteria, bacterial toxins and endotoxins, and inflammatory mediators / cytokines.

In some embodiments, the oral care composition includes a therapeutic cleanser, especially a mouth rinse, as well as a toothpaste, toothpaste gel, toothpaste, non-abrasive gel (including subgingival gel). And these are
(A) a safe and effective amount, preferably a minimum effective amount of a chlorite ion agent;
(B) a pharmaceutically acceptable topical oral carrier, in which case the final composition is essentially free of chlorine dioxide or zinc acid, and the composition comprises hypochlorite ions or hypochlorous acid. Essentially free of salt, the final pH is greater than 7, preferably greater than 7.5, more preferably about 8-12. The chlorite ion agent is preferably incorporated into the composition in an amount comprising from about 0.02% to about 6.0% by weight of the chlorite ion.

  “Essentially free of zinc diacid or chlorine dioxide” as used herein refers to known analytical techniques (very specific electron spin resonance (ESR) for measuring chlorine dioxide or zinc diacid. ) Means a composition containing very low levels, eg less than about 2 ppm, preferably less than about 1 ppm chlorine dioxide or zinc acid.

  The composition comprises antibacterial / anticalculus agents, biofilm inhibitors, anti-inflammatory agents (such as cyclooxygenase inhibitors and lipoxygenase inhibitors), H2-antagonists, metalloproteinase inhibitors, cytokine receptor antagonists, lipopolysaccharide complex Further comprising one or more additional therapeutic agents selected from the group consisting of agents, tissue growth factors, immunostimulants, cellular redox regulators (antioxidants), analgesics, hormones, vitamins, and minerals Is preferred.

  In some embodiments, for example, if the composition includes an additional therapeutic agent, the composition includes a first component that includes chlorite ions and an additional therapeutic agent. A second component may be included.

Chlorite ion source In some embodiments, chlorite ions are an essential ingredient in the described compositions and methods. The chlorite ion can be derived from any type of chlorite. Examples include alkali metal chlorites, alkaline earth metal chlorites, and any other transition metals, chlorites and / or polymer salts of internal transition metals. Water-soluble chlorite is preferred. Examples of suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. Preference is given to sodium chlorite and potassium chlorite. Sodium chlorite is particularly preferred. A mixture of two or more chlorite sources may be used.

  In dentifrice compositions, the concentration of chlorite ions is greater than about 0.005%, greater than 0.01%, greater than 0.02%, and 0.4% by weight of the composition. Greater than, greater than 0.6 wt%, greater than 0.75 wt%, and / or less than about 2 wt%, less than 1.5 wt%, or less than 1 wt%.

  In the mouthwash composition, the concentration of chlorite ions is greater than about 0.02%, preferably greater than about 0.075%, more preferably greater than about 0.15% by weight of the composition. Is also big.

  For methods of treating or preventing gingivitis, the composition preferably comprises about 0.1% to about 6% by weight of the composition of chlorite ions.

  Chlorite is available from various suppliers as sodium chlorite. Sodium chlorite is commercially available as industrial powder or flakes and as aqueous concentrates of various concentrations. Sodium chlorite reduction includes sodium chlorite available from Aragonesas and from Vulcan. These sources generally also have up to 4% sodium chlorate.

  The chlorite ion source is preferably highly pure, for example 70% or higher. Furthermore, it is preferred that the compositions of the present invention are essentially free of hypochlorite or hypochlorite ions, dichloroisocyanurate, or salts thereof.

  The concentration of chlorite ions is preferably measured by gradient separation of inorganic and organic acid anions using an exchange column Ion Pac ASII available from Dionex Corporation of Sunnyvale, California. .

  The final composition of the present invention contains only a low concentration of chlorine dioxide or chlorous acid, or is essentially free of chlorine dioxide or chlorous acid (ie, about chlorine dioxide or chlorous acid. Less than 2 ppm, preferably less than about 1 ppm).

  In a two-component composition, the concentration of chlorine dioxide or chlorous acid is measured within about 2-3 minutes after the two components are mixed.

  The pH of the final composition is generally greater than 7, preferably greater than 7.5, more preferably 8-12, and even more preferably 9-10.

Improved Sensory Properties Examples of dentifrices with improved sensory properties are described, for example, in US Pat. No. 5,820,854, which is hereby incorporated by reference in its entirety. These dentifrices may be provided and delivered as a single component or as a two-component composition.

  For example, the sensitive properties of dentifrices having a high ionic strength of about 1,000 μmho to about 50,000 μmho can be improved in sensitivity by adding polyoxyethylene. This dentifrice provides increased foam volume, increased foam viscosity, and a smooth tooth feel. In a two-component dentifrice, the polyoxyethylene may be present in a second dentifrice component that is distributed alongside the high ionic strength dentifrice component. Alternatively, the second stream comprising polyoxyethylene in a high ionic strength dentifrice component and dispensed by the delivery device may be a different component, such as a mouth rinse or another type of dentifrice. The molecular weight of the polyoxyethylene may be from about 100,000 to about 10,000,000, or from about 200,000 to about 7,000,000.

  In some embodiments, the two-component dentifrice has an ionic strength of about 1,000 μmho to about 50,000 μmho and a molecular weight of about 100,000 to about 10,000,000, or about 200,000 to about A first dentifrice component comprising about 0.1% to about 8% polyoxyethylene, which is 7,000,000, and about 92% to about 99.5% of one or more aqueous carriers; And a second dentifrice component. In an alternative embodiment, the dentifrice includes a first dentifrice component having an ionic strength of about 1,000 μmho to about 50,000 μmho, and a molecular weight of about 100,000 to about 10,000,000, or about 200, A second dentifrice comprising from about 0.1% to about 8% polyoxyethylene from about 000 to about 7,000,000 and from about 92% to about 99.9% of one or more aqueous carriers Contains ingredients.

  Examples of suitable polyoxyethylenes include those having a molecular weight of about 100,000 to about 10,000,000, or about 200,000 to about 7,000,000. Preferably, the molecular weight will be about 600,000 to about 2,000,000, more preferably about 800,000 to 1,000,000. “Polyox” is a trade name for high molecular weight polyoxyethylene manufactured by Union Carbide. The polyoxyethylene is generally from about 0.1% to about 8%, preferably from about 0.2% to about 5%, more preferably from about 0.3% to about 2% of the dentifrice component. Present in an amount of% by weight.

  The high ionic strength of the dentifrice occurs when the dentifrice contains a component having ionic properties. Among the components having ionic characteristics, substances widely used include substances such as salts and surfactants. Dentifrices with high salinity and / or high surfactant concentrations have high ionic strength. The ionic strength of the dentifrice is measured by the conductivity of the diluted slurry. The slurry is a 3: 1 slurry of water and dentifrice. Preferably, the dentifrice has an ionic strength of from about 5,000 μmho to about 40,000 μmho, more preferably from about 10,000 μmho to about 25,000 μmho. The total salinity of dentifrices with high ionic strength is generally about 4% to about 70%, preferably about 6% to about 60%, more preferably about 8% to about 50%.

Remineralization Examples of two-component oral care compositions with remineralization properties are described, for example, in US Pat. No. 4,083,955, which is hereby incorporated by reference in its entirety. .

  The subsurface enamel can be remineralized by sequentially applying specific soluble salts that generate ions that react to form the desired remineralized precipitate. Saline (such as calcium and phosphate solutions) can be sequentially applied to the enamel to effect remineralization.

  Remineralizing the subsurface of the tooth enamel with the desired precipitate includes a first component that includes a water-soluble compound that can act as a cation source for the desired precipitate, and a desired It can be realized by a process using a second component containing a water-soluble compound that can act as an anion source for the precipitate. The process includes (1) applying one of the above components to the tooth surface, and (2) applying the other component to the tooth surface, whereby the other component The desired ions diffuse down to the demineralized subsurface, forming a desired precipitate with the first constituent ions, resulting in demineralized subsurface remineralization. The duration of step (1) may be selected so that the desired ions can diffuse down to the demineralized surface.

  For example, in the first step, a component containing a soluble salt reaction solution is placed in contact with the tooth surface closest to the demineralized surface layer. In this first reaction solution, there are certain cations that diffuse through the tooth surface down to its demineralized surface. In the second step, the second component (including the reaction solution containing a specific anion) is placed in contact with the tooth surface closest to the demineralized surface layer. This anion diffuses through the tooth surface down to the demineralized surface, where it contacts the pre-deposited cations and forms a precipitate that is bound to the tooth structure. As a result, the subsurface layer of the tooth is recalcified.

  The concentration of the cation solution and the anion solution may be 0.005 to 10%, that is, the salt solubility limit, and preferably about 0.05 to about 5%. If desired, an excess of salt can be present. One or more cations may be used in the cation solution. In each step, excess reactants are required to promote diffusion of the teeth into the demineralized subsurface, so the concentrations of the cation solution and the anion solution need not be equal. Similarly, two or more anions may be used in the anion solution. After only 8 sequential applications, a visible effect appears on the “white spot”, and adopting several sequential applications is considered to yield the most beneficial results.

  Therapeutic amounts of desired cations and anions may be used in the oral cavity to effect enamel remineralization. The amount of solution placed in the mouth should generally contain at least about 0.001 g of the desired cation and about 0.001 g of the desired anion, and preferably more than about 0.1 g of the desired cation. More than about 0.1 g of desired anion, and / or less than about 10 g of desired cation / anion, and / or less than about 5 g of desired cation / anion, or less than about 2 g of desired cation / anion.

  The length of contact time between the saline solution and the tooth surface is not critical, but this length of time must be long enough to allow ions to diffuse through the tooth surface to the demineralized subsurface. is there. This diffusion is believed to require at least 10 seconds.

  The pH of each solution must be about 3 to about 10 before and after the precipitation reaction, otherwise each solution must be compatible in the oral environment. The ions must not be combined early in the solution to form a precipitate, but can diffuse through the tooth surface to the demineralized subsurface area, and the other solution ions and insoluble salts can be Must be formable. Solutions and insoluble precipitates are colorless and, of course, preferably have an acceptable level of toxicity (ie, certain ions should be harmless in the amounts used in the remineralization process). Must not).

  A variety of precipitates may be used for remineralization, but by depositing precipitates that are less soluble than the original enamel, a remineralized surface layer that is more resistant to demineralization than the original enamel is produced. can do. When remineralization is performed in the presence of either heavy metal ions or fluoride ions, the remineralized enamel is more resistant to decalcification than the original enamel. If both ions are present, the remineralized enamel is even more resistant to decalcification. The concentration of the salt each containing heavy metal ions and fluoride ions in the solution may be from about 0.005 to about 10%, such as from about 0.005 to about 0.1%.

  Examples of suitable heavy metal ions are aluminum, manganese, tin, zinc, indium, and rare earth metals such as lanthanum and cerium.

  In certain embodiments, the remineralized cation solution has about 0.005 to about 10%, preferably about 1%, soluble calcium salt that produces calcium ions, and about 0% soluble indium salt that produces indium ions. 0.005 to about 10%, preferably about 0.005 to 0.1%. The remineralized anion solution contains about 0.005 to about 10%, preferably about 1%, of soluble phosphate that produces phosphate ions, and about 0.005 of soluble fluoride salt that produces fluoride ions. To about 10%, preferably about 0.005 to about 0.1%. The resulting precipitate is calcium phosphate or hydroxyapatite (a natural component of tooth enamel) that incorporates indium and fluoride ions. This process not only results in remineralized enamel, but the remineralized enamel is more resistant to subsequent demineralization than the original enamel.

  Suitable soluble fluoride and indium salts include sodium fluoride, zinc fluoride, betaine fluoride, stannous fluoride, hexylamine, indium chloride, indium sulfate, and indium nitrate. It is not limited to.

  Anions that lead to desirable insoluble precipitates include phosphates, fatty acid groups having 8 to 18 carbon atoms, fluorides, fluorophosphates, fluorinated silicas, sulfates, tartrate salts, sorbates, 6 to Examples include alkyl sulfonates having 18 carbon atoms, carbonates, and the like. Mixtures of these anions are desirable.

  Cations that yield the desired insoluble precipitate include the heavy metal ions described above, as well as calcium and magnesium. A mixture of these cations is desirable.

  These cations and anions that form insoluble remineralized precipitates can be obtained from solutions of the corresponding soluble salts. Suitable soluble salts of cations used in the present invention include halides such as chlorides, nitrates, sulfates, acetates, and gluconates of the desired cation. Similarly, suitable soluble salts of the anions of the present invention include alkali metal salts (eg, sodium and potassium), ammonium salts, and low molecular weight substituted ammonium salts. Examples of low molecular weight substituted ammonium salts are those in which one or more of the hydrogen atoms on the ammonium ion is 1-3 carbon atoms, alkyl or hydroxyalkyl groups (eg methyl, ethyl, propyl, hydroxyethyl, 2-hydroxypropyl, or Substituted with 3-hydroxypropyl), for example mono-, di-, or triethanolammonium salts, or mono-, di-, or triethylammonium salts.

  The combination of a wide variety of cations and anions capable of remineralizing tooth enamel forms a wide variety of precipitates. The most preferred precipitate is a calcium phosphate compound in which small amounts of indium and fluoride are incorporated. The following precipitates reveal not only the desired remineralized precipitate, but, of course, the cations and anions necessary to form the precipitate. One skilled in the art will recognize that some of these precipitates can be formed by first forming a raw material precipitate and then further reacting to form the precipitate. For example, a hydroxide can first be formed and then further reacted to form the corresponding oxide.

Preferred precipitates include calcium phosphate, ZnNH ₄ PO ₄ , InPO ₄ , rare earth phosphates (such as lanthanum acid, cerium phosphate, and samarium phosphate), rare earth fluorides (lanthanum fluoride, cerium fluoride, praseodymium fluoride, Neodymium fluoride, samarium fluoride, etc.), magnesium alkyl sulfonate (alkyl group having 10 to 22 carbon atoms), magnesium stearate, calcium stearate, zinc stearate, and aluminum phosphate.

  The components of the precipitate can be delivered substantially to the surface of the tooth using two separate delivery excipients, each containing one component, for example mouthwash and toothpaste. For example, the constituents of the precipitate can be delivered using the oral care device described herein.

Tooth Sensitivity Reduction Examples of two-component oral care compositions that can reduce tooth sensitivity are described, for example, in US Pat. No. 6,953,817, incorporated herein by reference in its entirety.

  Formulate a desensitizing dentifrice composition to eliminate or reduce discomfort and pain associated with dentin hypersensitivity. Examples of such a composition include a desensitized dental two-component composition containing a potassium salt desensitizer.

  The dental composition has a first component buffered to maintain an alkaline pH of at least about 9.0, preferably about 9.0 to 12.0, and 6.5 with a phosphate buffering component. Two semi-solid aqueous components can be included with a second component maintained at a pH of ˜7.5. At least one of the components comprises a fluoride ion-releasing salt and a potassium-releasing salt compound in the form of an orally acceptable excipient, and contains about 2500-8800 parts per million (ppm) of the compound from the compound. The fluoride compound is present at a concentration sufficient to release the fluoride. Mixing and combining the components forms a composition having a pH of about 6.5 to about 7.0. When this mixture is repeatedly applied to the tooth, the user experiences an increased reduction in dentine hypersensitivity.

  The two components are preferably combined in an approximately equal weight ratio so that when the components are combined and applied to the tooth, such as by brushing, any particular component in either component is about 2 minutes. 1 concentration. Both components are preferably formulated to have similar physical properties so that the two components can be delivered in the desired predetermined amount simultaneously.

  To prepare a dentifrice component that is substantially neutral in pH, a buffer is incorporated, which is usually an excipient containing water, a humectant, a surfactant, and an abrasive. It is prepared using. The buffering agent is preferably a mixture of primary and dibasic sodium phosphate salts and has a concentration in the dentifrice component of about 5 to about 10%, preferably about 6 to about 10% by weight of the component. Incorporated.

  A dentifrice component having an alkaline pH is prepared using an excipient having a composition similar to that of a neutral pH buffer component. Alkalizing agents such as sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium carbonate, N-sodium silicate (3.22 by weight sodium silicate available from PQ Corporation (moisture 34. 6%)) in the alkaline component is from about 0.5 to about 15%, preferably from about 1.0 to about 8%, most preferably from about 1.0 to about 15% by weight of the composition. Incorporated in an amount ranging from 5.0% by weight. Mixtures of the above alkali metal compounds can also be used.

  Fluoride ion-releasing salts are characterized by being able to release fluoride ions in water. It is preferred to use a water soluble fluoride salt that provides about 1000 to about 9000 ppm fluoride ions, preferably about 2500 to about 8800 ppm fluoride ions. Suitable examples of fluoride ion releasing salts include water-soluble inorganic metal salts such as sodium fluoride, potassium fluoride, sodium monofluorophosphate, stannous fluoride, and sodium fluorosilicate. Sodium fluoride, sodium monofluorophosphate, and stannous fluoride are preferred fluoride ion releasing salts.

  The desensitizing potassium ion source is generally a water-soluble potassium salt such as potassium nitrate, potassium citrate, potassium chloride, potassium bicarbonate, and potassium oxalate, with potassium nitrate being preferred. The potassium salt is generally incorporated in the one or more dentifrice ingredients at a concentration of about 1 to about 20% by weight, preferably about 3 to about 10% by weight.

Prevention of Gingival Disease Examples of two-component oral care compositions for preventing gingival disease are, for example, US Pat. No. 5,281,410, US Pat. No. 5,145,666, which is incorporated herein by reference in its entirety. U.S. Pat. No. 4,849,213, U.S. Pat. No. 4,528,180, and U.S. Pat. No. 5,632,972.

  Some oral care compositions can reduce plaque and gingivitis, but at the same time do not generate significant coloration. For coloring, by using a two-component composition containing a pyrophosphate ion and a stannous compound, for example, stannous fluoride and another stannous compound in one component are separated from each other. It can be reduced by using pyrophosphate ions in the constituents. In general, both components contain a pharmaceutically acceptable carrier.

  Stannous fluoride is the first essential component of the first tin component. This material is present in the form of a tin composition at a level of from about 0.05% to about 1.1%, preferably from about 0.4% to about 0.95%. Separate soluble tin fluoride and fluoride salts may be used to form tin fluoride in situ and add the salt directly. Salts suitable for forming stannous fluoride in situ include stannous chloride and sodium fluoride, among others.

  The second stannous compound is generally included in the stannous component. The second stannous compound is a stannous salt of alpha hydroxy acid, phytic acid, EDTA, glycine, and mixtures thereof. In some embodiments, the second stannous compound is stannous gluconate. These substances are known stannous chelates and are provided in the compositions of the present invention as chelates or as separate soluble stannous salts and chelates formed in situ, such as by stannous fluoride. May be. Suitable alpha hydroxy acids include gluconic acid, citric acid, malic acid, tartaric acid, and lactic acid. Such salts include stannous chloride and stannous fluoride. The second stannous compound is generally present in the components of the present invention at a concentration of about 0.1% to about 11%, preferably about 2% to 4%.

  The second component is a component that contains or can provide an effective amount of pyrophosphate ions. The pyrophosphate ion can be, for example, pyrophosphate, or any readily water-soluble pyrophosphate. Such salts include any of alkali metal salts (such as sodium, potassium, and lithium), and further include ammonium.

  The amount of pyrophosphate ion is generally any effective amount from about 1% to about 15%, preferably from about 1% to about 10%, most preferably from about 3% to about 7%.

  In some embodiments, these components can be applied to the oral cavity in a safe and effective amount. In the case of toothpaste or mouthwash, these amounts (eg, about 0.3 to about 15 g) are held in the mouth for about 15 to about 60 seconds. These components can be used in any order, but the stannous component is preferably used first.

  In some embodiments, a paste that is stored separately but dispensed substantially simultaneously, sodium bicarbonate, table salt (or another suitable salt), and preferably additional cleaning agents, anti-cariogenic agents In addition to pastes containing abrasives, hydrogen peroxide or urea peroxide is dissolved in non-toxic gels for use in combination with effective concentrations of flavoring substances.

Controlled amounts of gel and paste are simultaneously released onto the toothbrush and can be immediately applied to the teeth and gums. Thus, control of the amount of peroxide, salt, and NaHCO ₃ delivered can be achieved by specifying the orifice opening and active ingredient concentration of each tube (or pump compartment). When the brush is applied to the teeth and gums, the product mixes immediately, followed by the generation of active oxygen and carbon dioxide in a short time. At the same time, the foaming associated with the release of active oxygen activates the flavor contained in the bicarbonate paste and produces a strong refreshing taste that lasts in the mouth. Or it is different from any flavor that the gel brings.

Hydrogen peroxide gel is about 1.0 to 10.0%. Preferably about 3.0 to 6.5% _H 2 _{O 2,} about 0.05 to 1.20%, preferably about from 0.3 to 0.8% of an acrylic acid copolymer, about 0.1 to 1. 5%, preferably about 0.3-0.8% of nonionic cellulose gum, an amount of neutralizing agent (triethanolamine, sufficient to raise the pH of the gel to about 3.0-6.0 Diisopropanolamine, NaOH, KOH) may be contained. The balance is purified water (distilled water or deionized water).

  Sodium bicarbonate paste contains sodium bicarbonate, sodium chloride, purified water (distilled or deionized water), and thickener / stabilizer (cellulose gum and aluminum magnesium silicate) as essential ingredients. A viscosity-imparting agent (such as sorbitol, glycerin, or glycol) is added, mainly for the purpose of dispersing the “chalk-like” taste attributed by bicarbonate. In addition, if the paste is combined with the gel to completely replace the toothpaste, detergents (such as calcium sulfate, calcium phosphate, and hydrated aluminum oxide), and foaming agents such as sodium lauryl sulfate (peroxide- Bicarbonate-salt action) may also be added.

  Bicarbonate constituents and amounts are about 10-50%, preferably 20-40% sodium bicarbonate, about 5-30%, preferably about 15-25% polyol, about 1-3%, preferably 1.2-1.8% cellulose gum, about 1-6%, preferably about 2-4% sodium chloride, about 1-40%, preferably about 1.5-30% abrasive / cleanser About 0.1-2.5%, preferably about 0.2-0.5% blowing agent, less than about 1% flavoring agent (s), about 0.1-0 .5% preservative. The balance is purified water. The paste and gel are preferably used in a substantially equal volume ratio.

  In some embodiments, the first component includes about 0.1 to about 10% by weight zinc salt in a pharmaceutically acceptable carrier and about 1% bicarbonate in a pharmaceutically acceptable carrier. Delivering a second component to the oral cavity containing ~ 80% by weight and moving the combination of the first and second compositions vigorously in the mouth to contact the gingiva and periodontal tissue; or By combining the first and second components and brushing the gingiva and periodontal surface surrounding the teeth, gingival bleeding can be suppressed and the texture and consistency of the gingiva and periodontal tissue can be improved. .

  In a preferred embodiment, the first component can also include a peroxygen compound. In another embodiment, ascorbic acid or citric acid is used in place of the peroxygen compound.

  This combination of zinc salt and bicarbonate can provide a very powerful inhibitory effect on gingival and periodontal tissue damage. For such an effect, it is necessary to package the zinc salt and bicarbonate separately until they are introduced into the oral cavity. For example, within the oral care device described herein.

  The first component includes a salt capable of delivering zinc ions. The term “zinc ion” means that the zinc atom portion of a molecule of a zinc compound that is in a solid or non-dissociated state can dissociate into simple or complex zinc ions, especially when dispersed in an aqueous medium. To do. Examples of compounds that may be used are zinc salts of inorganic ions such as borates, bromides, carbonates, hexofluorosilicates, pyrophosphates, silicates, sulfates, and titanates. Organic anions are those having 2 to 22 carbon atoms with charged groups selected from carboxylates, sulfonates, sulfates, and phosphates. Specific examples include acetate, benzoate, citrate, glycinate, lactate, phenolsulfonate, salicylate, tartrate, acetylacetonate, maleate, succinate, ascorbate, And gluconates, but are not limited to these.

  The zinc salt is generally present in the oral care composition in an amount of about 0.05 to about 10% by weight, preferably about 0.2 to 5% by weight, optimally about 0.8 to 3% by weight.

  The first component may be a gel and the second composition may be in the form of an opaque paste. Gels include peroxygen compounds such as hydrogen peroxide, urea peroxide, calcium peroxide, and perborate, persilicate, perphosphate, and percarbonate salts. The amount of peroxygen compound may range from about 0.1 to about 10% by weight. For active weight hydrogen peroxide, the amount ranges from about 0.5 to about 5% by weight, preferably from about 0.8 to about 4% by weight, optimally from about 1 to 3% by weight.

Instead of peroxygen compound, the first component may contain a carboxylic acid of the C ₂ -C _20. Illustrative acids include citric acid, malic acid, lactic acid, and ascorbic acid. The acid concentration may be in the same amount as the peroxygen compound, i.e. in the range of about 0.1 to about 10% by weight. Citric acid is most preferred. These acids, when present, are either liquid, gel, or paste type compositions.

  Advantageously, the pH of the first component is maintained at about 3.2-5.0, preferably 4.0-4.5.

  The second component containing bicarbonate may contain an anticaries fluoride compound selected from the same fluoride compound in essentially the same amount as described above for the first composition. Good. Particularly preferred is sodium fluoride. Bicarbonate exists in the form of alkali metals, such as sodium and potassium. Typically, the bicarbonate concentration is about 0.5 to about 80% by weight, preferably about 5 to about 50% by weight, optimally about 8 to about 20% by weight. The pH of the bicarbonate composition may be about 7.0 to about 9.5, most preferably about 8.0 to 9.0. When the bicarbonate composition is in the form of a toothpaste or gel, typically the natural or synthetic thickener is about 0.1-10% by weight, preferably about 0.5-5% by weight. Included in quantity.

  The relative weight of the first composition and the second composition is about 1: 2 to 2: 1, preferably about 1: 1.

Dentifrice compositions and components Oral care compositions and components formulated as dentifrices generally include a binder, a carrier, and an active ingredient. In some cases, dentifrices may contain one or more of surfactants and / or detergents, thickeners, abrasives, carriers, humectants, salts, and the like. Examples of suitable dentifrice ingredients are given below.

Binder The binder system is generally a key factor in determining the rheological properties of an oral care composition. The binder also serves to maintain the solid phase of the oral care component in suspension and, as a result, prevent the solid phase portion of the oral care component from separating from the liquid phase portion. In addition, the binder can impart body or thickness to the oral care composition. Thus, in some cases, the binder can also provide a thickening action to the oral care composition.

  Examples of binders include silicates such as sodium carboxymethylcellulose, cellulose ether, xanthan gum, carrageenan, sodium alginate, carbopol, or hydrous sodium magnesium silicate. Other examples of suitable binders include polymers such as hydroxypropylmethylcellulose, hydroxyethylcellulose, guar gum, tragacanth gum, karaya gum, gum arabic, Irish moss, starch, and alginate. Alternatively, the binder may include clay, for example synthetic clay such as hectorite or natural clay. Each of the binders can be used alone or in combination with other binders.

Surfactants / Detergents In some cases, dentifrices can contain one or more surfactants or detergents to provide desirable foaming properties.

Surfactants generally include anionic, nonionic, cationic, zwitterionic or amphoteric compositions. Examples of surfactants include soaps, sulfates (eg, sodium lauryl sulfate and sodium dodecylbenzenesulfonate), sodium lauryl sarcosinate, sorbitan esters of fatty acids, sulfobetaines (eg, cocamidopropylbatine), And D-glucopyranoside C _10-16 alkyl oligomers. In some embodiments, as the surfactant, sodium lauryl sulfate, cocamidopropyl betaine, and C ₁₀ -C ₁₆ alkyl -D- glucopyranoside oligomer (D-glucopyranoside C10-C16 alkyl oligomeric) can be mentioned. Generally, the surfactant is present in an amount of about 0.2 to about 8% by weight (eg, about 1 to about 5% by weight or about 1.5 to about 3.5% by weight).

Thickeners Examples of thickeners include thickened silica, polymers, clays, and combinations thereof. Thickened silica, such as hydrated silica SILODENT 15, in an amount of about 4 wt% to about 8 wt% (eg, about 6 wt%) provides desirable oral properties. As used herein, the expression “oral characteristics” relates to the body or thickness of the dentifrice when the dentifrice foams in the user's mouth.

Abrasives Examples of abrasives include carbonates (eg, sodium bicarbonate, calcium carbonate), water-colloidal silica, precipitated silica (eg, hydrated silica), silica grades containing sodium aluminosilicate, alumina, Examples include abrasives such as hydrated alumina, dicalcium phosphate, insoluble sodium metaphosphate, and magnesium (eg, 3 magnesium phosphate). A suitable amount of abrasive is an amount that safely provides excellent polishing and cleaning action and an amount that, when combined with another component, results in a composition that is smooth, fluid, and not too grainy. is there. Generally, when an abrasive is included, the abrasive is in an amount of about 5% to about 50% by weight (eg, about 5% to about 35%, or about 7% to about 25% by weight). Exists.

Carriers Examples of carriers include water, polyethylene glycol, glycerin, polypropylene glycol, starch, sucrose, alcohol (eg, methanol, ethanol, isopropanol, etc.) or combinations thereof. Examples of combinations include various combinations of water and alcohol, and various combinations of polyethylene glycol and polypropylene glycol. In general, the amount of carrier included will depend on the concentration of the binder system, as well as the amount of dissolved salt, surfactant, and dispersed phase.

Humectant Generally, the humectant is a polyol. Examples of wetting agents include glycerin, sorbitol, propylene glycol, xylitol, lactitol, polypropylene glycol, polyethylene glycol, hydrogenated corn syrup and mixtures thereof. Generally, when a humectant is included, the humectant can be present in an amount from about 10% to about 60% by weight.

Buffering agents and / or salts Examples of buffering agents and salts include primary, secondary, or tertiary alkali metal phosphates, citric acid, sodium citrate, sodium saccharin, tetrasodium pyrophosphate, sodium hydroxide And the like.

Active ingredients Dentifrices are active, for example, for the purpose of preventing tooth decay, whitening teeth, cooling the breath, supplying oral medication, and other therapeutic and cosmetic effects such as those mentioned above. Ingredients may be included. Examples of active ingredients include: anti-carious agents (eg, water-soluble fluorides, fluorosilicates, fluorozirconates, fluorostannites, fluoroborates, fluorotitanates, Fluorogermanates, mixed halides and casine, anti-tarter agents, anti-calculus agents (eg, alkali metal pyrophosphates, hypophosphorous acid Salt-containing polymers, organic phosphocitrates, phosphocitrates, polyphosphates, antibacterial agents (eg bacteriocins, antibodies, enzymes), antibacterial enhancers, antimicrobial agents (eg triclosan) , Copper-, zinc- and tin salts such as chlorhexidine, zinc citrate, zinc sulfate, zinc glycinate, sanguinari Extracts, quaternary ammonium compounds such as metronidazole and cetylpyridinium chloride, bis-guanides such as chlorhexidine digluconate, hexetidine, octenidine and alexidine, and 2,2'methylenebis- (4-chloro-6-bromophenol)) Halogenated bisphenol compounds, desensitizers (eg, potassium citrate, potassium chloride, potassium tartrate, potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salts), whitening agents (eg, bleaching agents such as peroxy compounds, eg, Potassium peroxydiphosphate, anti-plaque, gingival protectors (eg, vegetable oils such as sunflower oil, rapeseed oil, soybean oil and safflower oil, and other oils such as silicone oil and hydrocarbon oil). The gingival protective agent can be an agent capable of improving the gingival permeation barrier. Other active ingredients include wound healing agents (eg urea, allantoin, panthenol, alkali metal thiocyanate, chamomile-based active substances and acetylsalicylic acid derivatives, ibuprofen, flurbiprofen, aspirin, indomethacin, etc.), tooth buffer Agents, reminieralization agents, anti-inflammatory agents, anti-odor agents, breath freashing agents, and agents for treating oral conditions such as gingivitis or periodontitis.

Other Components In some cases, the dentifrice may include a foaming system (such as a sodium bicarbonate citrate system), or a discoloration system.

  Dentifrices also contain phenolic compounds (eg 2-methylphenol, 3-methylphenol, 4-methylphenol, 4-ethylphenol, 2,4-dimethylphenol, 3,4-dimethylphenol, etc. Homologues), sweeteners (for example, saccharin sodium, sodium cyclamate, sucrose, lactose, maltose, and fructose), flavoring (for example, peppermint oil, spearmint oil, eucalyptus oil, brother seed oil, fennel oil, Japanese apricot oil) Oils, methyl acetate, cinnamic aldehyde, anethole, vanillin, thymol, and other natural or natural essential oils or synthetic flavors), preservatives (eg, methyl p-hydroxybenzoate, ethyl or propyl esters, sorbine) Sodium phosphate, sodium benzoate , Bromochlorophene, triclosan, hexetidine, phenyl silicylate, biguanides, and peroxides, opacifiers / colorants (such as titanium dioxide or FD & C dyes), and vitamins (such as retinol, tocopherol, and ascorbic acid) One or more may be included.

Mouth Wash Compositions and Components The compositions and components discussed herein may be provided in the form of mouth rinses or mouthwashes.

  Such mouthwash and mouthwash ingredients typically include water (about 45% to about 95%), ethanol (about 0% to about 25%), humectants (about 0% to about 50%). ), Surfactant (about 0.01% to about 7%), flavoring agent (about 0.04% to about 2%), sweetener (about 0.1% to about 3%), and coloring agent (about 0.001% to about 0.5%). Such mouth washes and gargles include anti-cariogenic agents (about 0.05% to about 0.3% as fluoride ions), and anticalculus agents (about 0.1% to about 3%). One or more may be included.

  The compositions and components discussed herein may be in the form of dental solutions and cleaning fluids. The components of such dental solutions are generally water (about 90% to about 99%), preservatives (about 0.01% to about 0.5%), thickeners (0% to about 5%), One or more of a flavoring agent (about 0.04% to about 2%), a sweetening agent (about 0.1% to about 3%), and a surfactant (0% to about 5%) are included. Some examples of cleaning agents that may be used with the present invention include Libin US Pat. No. 6,440,395, Adamy US Pat. No. 6,355,229, Rolla US Pat. No. 6,344,184, US Pat. No. 6,117,417 to Wicks et al., US Pat. No. 5,980,925 to Jampani et al., Nelson et al. US Pat. No. 5,948,390, McLaughlin et al., US Pat. Nos. 5,686,063 and 5,681,549, Shimada et al., US Pat. No. 5,626,837 Scodari et al., US Pat. No. 5,560,906, Conopa US Pat. Nos. 5,407,664 and 5,292,527, Hall US Pat. No. 604, Yamagi U.S. Pat. Nos. 5,374,418 and 5,370,865 to Yamagishi et al., U.S. Pat. Nos. 5,286,479 to Garlich et al., 5,525,330, 5,256,396, 5,158,763, 4,370,314, 4,339,430, 4,273,759, 4,224 309, 4,188,372, 4,137,303, 4,123,512, 4,118,476, 4,118,475, 4,118,474, 4,118,473, 4,118,472, 4,110,429, 4,102,993, 4,100, No. 270, No. 4,089,880, No. 4,080,441, No. 4,042, 679, and 3,864,472, and WO 03/075865 (all assigned to Colgate Palmolive), US Pat. No. 4,994,262 to Charbonneau et al., Ryan ), U.S. Pat. Nos. 4,959,204, 4,663,154, and 4,472,373; Shah, U.S. Pat. No. 4,325,939; (Parran Jr.), U.S. Pat. No. 4,323,551, WO 96/15770, WO 94/27566, and WO 94/18939, WO 00/44388, U.S. Patent Publication No. 2006/0171907 (A1), U.S. Pat. Patent Nos. 7,195,753, 7,192,573, 7,153,493, US Pat. No. 6,696,047, US Pat. No. 6,361,762, US Pat. 6,350,438, U.S. Patent 6,348,187, U.S. Patent 6,261,540, U.S. Patent 6,251,372, U.S. Patent 5,707,610, U.S. Patent No. 5,681,548, US Pat. No. 5,945,088, US Pat. No. 5,945,087, US Pat. No. 5,723,106, US Pat. No. 5,338,538, US Pat. No. 5,330,749, US Pat. No. 5,310,546, US Pat. No. 5,302,373, US Pat. No. 5,236,699, US Pat. No. 5,229,103, US Pat. No. 5,256,401, US Pat. No. 5,174,990, US Pat.No. 5,104,644, US Pat. No. 5,087,444, US Pat. No. 5,043,183, US Pat. No. 4,894,220, US Pat. No. 4,684,517, and US Pat. No. 4,537,778.

A first, which can be delivered by a wide variety of instruments and / or packages as described herein, either simultaneously or sequentially (ie, first component followed by second component). Some non-limiting examples of one component / composition and second component / composition are listed in Table 1 below. The first and second components of Table 1 can be delivered using any of the regimens, doses, steps, or methods described in whole or in part herein, It may be provided in a variety of forms including but not limited to cleaning agents, gels, liquids, or pastes.

Other Embodiments A number of embodiments of the invention have been described. However, it will be understood that various modifications can be made without departing from the spirit and scope of the invention. Accordingly, other embodiments are within the scope of the following claims.

  All documents cited in “DETAILED DESCRIPTION OF THE INVENTION” are incorporated herein by reference, but any citation of any document should be construed as an admission that it is prior art to the present invention. is not. To the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of a term in a document incorporated by reference, the meaning or definition given to that term in this document applies And

Claims (28)

An oral care method using a display device and a toothbrush having a liquid reservoir and a pump in fluid communication with a handle, head, outlet,
Dispensing an oral care composition from a package onto the head of the toothbrush;
Using the toothbrush to apply the oral care composition to the oral cavity,
The method, wherein the display device provides a user with a signal to dispense liquid from the liquid reservoir of the toothbrush through the outlet.   The method of claim 1, wherein the signal is an audio signal, a visual signal, or a combination thereof.   The method of claim 1, wherein the toothbrush further comprises a data communicator in data communication with the display device.   The method of claim 3, wherein the data communicator is an IC tag.   The method of claim 4, wherein the oral care composition is a dentifrice stored in a dentifrice package.   The method of claim 5, further comprising dispensing the liquid from a liquid package into the liquid reservoir.   The method of claim 6, wherein each of the dentifrice package and the liquid package further comprises a data communicator.   The method of claim 7, wherein the data communicator of the dentifrice package and the liquid package is an IC tag.   9. The method of claim 8, further comprising placing the toothbrush, the dentifrice package, and a cleaning agent package in proximity to the display device so that the data communicator can communicate with the display device.   The method of claim 1, wherein the pump pressurizes the liquid reservoir.   The method of claim 1, wherein the pump pumps the liquid from the liquid reservoir to the outlet.   The method according to claim 1, wherein the display device displays a time interval for using the dentifrice in the oral cavity.   13. The method of claim 12, wherein the time interval for using the dentifrice in the oral cavity is from about 1 minute to about 3 minutes.   The method according to claim 13, wherein the display device displays a time interval for using the liquid in the oral cavity.   15. The method of claim 14, wherein the time interval for using the liquid in the oral cavity is about 20 seconds to about 2 minutes. An oral care method using a display device, a toothbrush, and a package comprising a first compartment having a first composition and a second compartment having a second composition,
Dispensing the first composition from the package onto the head of the toothbrush;
Using the toothbrush to apply the first composition to the oral cavity;
Using the toothbrush to apply the second composition to the oral cavity,
The method, wherein the display device provides a user with a signal to dispense the second composition from the package onto the head of the toothbrush.   The method of claim 16, wherein the signal is an audio signal, a visual signal, or a combination thereof.   The method of claim 16, wherein the toothbrush further comprises a data communicator in data communication with the display device.   The method of claim 18, wherein the data communicator is an IC tag.   The method of claim 19, wherein the package comprises a data communicator.   21. The method of claim 20, wherein the data communicator of the package is an IC tag.   24. The method of claim 21, further comprising placing the toothbrush and the package in the vicinity of the display device so that the data communicator can communicate with the display device.   The method of claim 16, wherein the display device displays a time interval for using the first composition in the oral cavity.   24. The method of claim 23, wherein the time interval for using the first composition in the oral cavity is from about 30 seconds to about 3 minutes.   24. The method of claim 23, wherein the display device displays a time interval for using the second composition in the oral cavity.   26. The method of claim 25, wherein the time interval for using the second composition in the oral cavity is from about 30 seconds to about 2 minutes.   26. The method of claim 25, wherein the time interval using the second composition is displayed after the time interval using the first composition. A dentifrice package having a data communication device;
A liquid package having a data communication device;
A toothbrush having a liquid reservoir and a data communicator;
A display device capable of data communication with the data communication device.

Images