CN101664529A - Zedoary turmeric oil-containing medicament for treating onychomycosis - Google Patents
Zedoary turmeric oil-containing medicament for treating onychomycosis Download PDFInfo
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- CN101664529A CN101664529A CN200810120652A CN200810120652A CN101664529A CN 101664529 A CN101664529 A CN 101664529A CN 200810120652 A CN200810120652 A CN 200810120652A CN 200810120652 A CN200810120652 A CN 200810120652A CN 101664529 A CN101664529 A CN 101664529A
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- zedoary turmeric
- turmeric oil
- tinea unguium
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Abstract
The invention relates to a zedoary turmeric oil-containing medicament for treating onychomycosis. The medicament is solution prepared by 0.1 to 5.0 percent of zedoary turmeric oil, 10.0 to 20.0 percent of emulsifier 80, 0.1 to 1.0 percent of benzoic acid, 20.0 to 40.0 percent of glacial acetic acid, 5.0 to 20.0 percent of ethanol, and water.
Description
Invention field
The present invention relates to a kind of treatment tinea unguium medicine that comprises Zedoary turmeric oil and preparation method thereof.Particularly, the present invention relates to a kind of liquid preparation, this preparation contains Oleum Curcumae and glacialacetic acid composition, can effectively treat the tinea unguium that fungal infection causes, and relates to the method for preparing preparation.
Background of invention
Tinea unguium (also claiming tinea unguium, first skin ulcer, tinea unguium) mainly is to be caused by dermatophytosis, yeast and mycete three big fungal infection, and has the mixed infection of significant proportion.Fungus can produce about 150 kinds of different toxin, and wherein many toxin can be carcinogenic and toxicity is extremely strong, than huge drugs potassium cyanide tens times of poison also, is strong carcinogen as the toxicity of aflatoxin B1 in the mycete.Tinea unguium not only influences people's overall appearance, and health risk, because the tinea unguium easy infection is given the family and friends, can bring very big inconvenience to the patient's that suffers from tinea unguium work and life, has a strong impact on mood, causes the abnormal mind obstacle.Tinea unguium not only infects, endangers skin histology, invades human internal organs too, even causes death.
Oleum Curcumae is the volatile oil that extracts from the dry rhizome of zingiberaceous plant Rhizoma Curcumae, contains volatile oil 1～1.5%.Main constituent is the sesquiterpene class in the oil.A sesquialter times terpene of getting from rhizome has fluffy art epoxy ketone, zedoarone, Furanodiene., curzerene, furanodienone, isofuranodienone, paulin Rhizoma Curcumae ketenes, table furanodienone, curdiono, curcolone, Rhizoma Curcumae Longae epoxy enol difficult to understand, procurcumenol, different Rhizoma Curcumae Longae epoxy enol difficult to understand, Curcumol, curcumadiol.Also contain curcumin, dehydrocurdione.Number of chemical compositions such as the sesquiterpene alcohols that Oleum Curcumae contains, curcumenol, α-zingiberene, eucalyptol, α-camphene have the effect (antifungal, antibacterium, antiviral, anti-mycoplasma etc.) of broad-spectrum resisting pathogenic microbes.Zedoary oil injecting agent and suppository are clinical commonly used drug, and determined curative effect is welcome by the patient deeply.
Detailed Description Of The Invention
The external used medicine of treatment tinea unguium mostly is water solublity, such as acetic acid or other Chinese medicine extraction composition, because fingernail is the collenchyme of one deck densification, so being difficult to go deep into fingernail inside, these medicines reach bactericidal effect, and Oleum Curcumae is the oil-soluble antibacterials, has better fat-solublely, is more conducive to infiltrate through fingernail, the performance pharmacologically active, cure diseases.Therefore, we design and develop and contain Zedoary turmeric oil treatment tinea unguium medicine.
Oleum Curcumae is as main medicine in the said preparation; Glacial acetic acid and benzoic acid are as auxiliary antipathogenic composition; Tween 80 makes Oleum Curcumae soluble in water as surfactant, keeps solution-stabilized, has bacteriostasis concurrently; Ethanol is cosolvent, has bacteriostasis concurrently.It is reasonable in design to write out a prescription, and technology is simple, uses multiple medicine combined effect kill harmful fungus, obtains good result.
The medicinal liquid of this treatment tinea unguium is made of following composition, comprising: Oleum Curcumae (0.1%-5.0%), Tween 80 (10.0%-20.0%), benzoic acid (0.1%-1.0%), glacial acetic acid (20.0%-40.0%), ethanol (5.0%-20.0%) adds water to capacity.
Method for making: get Oleum Curcumae, benzoic acid, Tween 80 mixing, pour in the mixed liquor of glacial acetic acid, second alcohol and water, stirring and evenly mixing, promptly.These product are light yellow transparent liquid.
Embodiment 1: get Oleum Curcumae 1g, add benzoic acid 0.5g, tween 10g mixing gets solution A.
Get glacial acetic acid 35g, add ethanol 10g, water 20g mixing gets solution B.
Solution A is poured in the solution B, and mixing adds water to capacity.
Using method: this preparation is a medicine for external use, directly is applied to diseased nails during use or fingernail is soaked in the medicinal liquid to get final product, and is easy to use.
Claims (4)
1. a treatment tinea unguium solution that contains Zedoary turmeric oil is characterized in that, the Oleum Curcumae that contains percentage by weight and be 0.1%-5.0% is a primary raw material, be equipped with auxiliary material such as benzoic acid, glacial acetic acid, ethanol, a kind of technology that makes is simple, easy to use, the pharmaceutical preparation of determined curative effect.
2. the treatment tinea unguium solution that contains Zedoary turmeric oil as claimed in claim 1, it is characterized in that, described solution is made by the component of following weight portion: Oleum Curcumae (0.1%-5.0%), Tween 80 (10.0%-20.0%), benzoic acid (0.1%-1.0%), glacial acetic acid (20.0%-40.0%), ethanol (5.0%-20.0%) adds water to capacity.
3. the treatment tinea unguium solution that contains Zedoary turmeric oil as claimed in claim 2 is characterized in that Oleum Curcumae is as main medicine; Glacial acetic acid and benzoic acid are as auxiliary antipathogenic composition; Tween 80 makes Oleum Curcumae better soluble in water as surfactant, keeps solution-stabilized, has bacteriostasis concurrently; Ethanol is cosolvent, has bacteriostasis concurrently.
4. the treatment tinea unguium solution that contains Zedoary turmeric oil as claimed in claim 2, its preparation principle are with ethanol and the water mixed solvent oil-in-water emulsion solution as continuous phase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810120652A CN101664529A (en) | 2008-09-04 | 2008-09-04 | Zedoary turmeric oil-containing medicament for treating onychomycosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810120652A CN101664529A (en) | 2008-09-04 | 2008-09-04 | Zedoary turmeric oil-containing medicament for treating onychomycosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101664529A true CN101664529A (en) | 2010-03-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810120652A Pending CN101664529A (en) | 2008-09-04 | 2008-09-04 | Zedoary turmeric oil-containing medicament for treating onychomycosis |
Country Status (1)
| Country | Link |
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| CN (1) | CN101664529A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058633A (en) * | 2010-12-23 | 2011-05-18 | 王运生 | External medicine for treating tinea unguium |
-
2008
- 2008-09-04 CN CN200810120652A patent/CN101664529A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102058633A (en) * | 2010-12-23 | 2011-05-18 | 王运生 | External medicine for treating tinea unguium |
| CN102058633B (en) * | 2010-12-23 | 2012-02-08 | 王运生 | External medicine for treating tinea unguium |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20100310 |