CN101664399B - Application of perillene in preparing antibacterial drugs - Google Patents
Application of perillene in preparing antibacterial drugs Download PDFInfo
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- CN101664399B CN101664399B CN2009101046035A CN200910104603A CN101664399B CN 101664399 B CN101664399 B CN 101664399B CN 2009101046035 A CN2009101046035 A CN 2009101046035A CN 200910104603 A CN200910104603 A CN 200910104603A CN 101664399 B CN101664399 B CN 101664399B
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- Prior art keywords
- perillene
- antibacterial drugs
- application
- preparing antibacterial
- staphylococcus aureus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses application of perillene in preparing antibacterial drugs, which is characterized by using the perillene as an active ingredient of the antibacterial drugs. The antibacterial drugs have particular effects on staphylococcus aureus and colibacillus.
Description
Technical field
The present invention relates to the new drug purposes of perillene, specifically, is the purposes of perillene in the preparation antibacterials.
Technical background
The perillene chemical structural formula is:
It is present in the volatile oil of dried leaves (or band tender leaf) by the vapor distillation extraction of labiate Folium Perillae Perilla frutescens (L) Britt..But document is not reported its medical active so far.
Goal of the invention
Purpose of the present invention provides the pharmaceutic usage of perillene, specifically, provides the purposes of perillene in the preparation antibacterials.
The present invention is based on and discovers that perillene has the experimental result of antibacterial action.Especially at staphylococcus aureus and escherichia coli.Adopt conventional preparation method to make various pharmaceutical dosage forms as active component and pharmaceutically acceptable excipient perillene.
Experimental example
(1), trial drug
1. perillene test sample (it is rare 90% to contain Folium Perillae, is provided by Tai Ji group Chongqing Fuling Pharmaceutical Factory).Perillene content in HUOXIANG ZHENGQI YE is about 0.01%.
Staphylococcus aureus (Staphylococcus aureus), escherichia coli (Escherichia coli), solid LB culture medium is microbial room provides.
(2), experimental procedure and result
Get the perillene crude product,, be made into 10 μ l/mL (be equivalent in the HUOXIANG ZHENGQI YE perillene 125 times) solution with petroleum ether (30～60 ℃) dilution.To test with staphylococcus aureus and escherichia coli and be inoculated in respectively on the solid LB culture medium, on culture medium, punch, respectively add 1 above-mentioned solution in the hole, cultivate 24h in 37 ℃, survey antibacterial circle diameter (mm), compare, the results are shown in Table 1 with undiluted HUOXIANG ZHENGQI YE.
Table 1. perillene bacteriostatic activity is investigated (n=3)
Claims (1)
1. perillene has purposes in the antibacterial action medicine as unique active component in preparation, and wherein antibiotic is that staphylococcus aureus and escherichia coli are had resistant function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101046035A CN101664399B (en) | 2009-08-11 | 2009-08-11 | Application of perillene in preparing antibacterial drugs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101046035A CN101664399B (en) | 2009-08-11 | 2009-08-11 | Application of perillene in preparing antibacterial drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101664399A CN101664399A (en) | 2010-03-10 |
| CN101664399B true CN101664399B (en) | 2011-09-28 |
Family
ID=41801284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101046035A Active CN101664399B (en) | 2009-08-11 | 2009-08-11 | Application of perillene in preparing antibacterial drugs |
Country Status (1)
| Country | Link |
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| CN (1) | CN101664399B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108440460B (en) * | 2018-04-16 | 2021-09-07 | 重庆大学 | Preparation method of perillene and analogues thereof |
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2009
- 2009-08-11 CN CN2009101046035A patent/CN101664399B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 伍永富 等.紫苏叶油的研究进展.《时珍国医国药》.2007,第18卷(第8期),2019-2020. * |
| 刘建辉 等.紫苏油中主要化学成分的分离和鉴定.《香料香精化妆品》.1998,(第1期),第19-21页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101664399A (en) | 2010-03-10 |
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| C14 | Grant of patent or utility model | ||
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