CN103251611A - Application of Aspeverin in preparation of anti-bacteria medicines - Google Patents
Application of Aspeverin in preparation of anti-bacteria medicines Download PDFInfo
- Publication number
- CN103251611A CN103251611A CN2013102173104A CN201310217310A CN103251611A CN 103251611 A CN103251611 A CN 103251611A CN 2013102173104 A CN2013102173104 A CN 2013102173104A CN 201310217310 A CN201310217310 A CN 201310217310A CN 103251611 A CN103251611 A CN 103251611A
- Authority
- CN
- China
- Prior art keywords
- aspeverin
- application
- medicines
- preparation
- bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to an application of Aspeverin in preparation of anti-bacteria medicines, and belongs to the field of medicines. The Aspeverin has a strong function of inhibiting escherichia coli, pseudomonas fluorescens, staphyloccocus aureus, proteusbacillus vulgaris and crypococcus neoformans, thus the Aspeverin can be served as an anti-bacteria compound and hopefully applied to prepare relevant medicines. The application of Aspeverin in preparation of anti-bacteria medicines is disclosed for the first time, a framework type belongs to a brand-new framework type, the Aspeverin has an unexpected strong effect of inhibiting the bacteria activity, and the revelation possibility of other compounds cannot be generated, so that the application has obvious substantive features; and moreover, the application has an obvious improved effect of preventing bacterial infection.
Description
Technical field
The present invention relates to the new purposes of compd A speverin, relate in particular to the application of Aspeverin in the preparation anti-bacterial drug.
Background technology
Human beings'health and life in the diffusion of pathogenic bacterium and chemical sproof enhancing serious threat thereof, antibacterials are widely used in acquired immune deficiency syndrome (AIDS) as routine administration, organ transplantation and Chronic consumptions are (as cancer, diabetes, uremia etc.) treatment, though the antimicrobial agent of using clinically is (as ketoconazole at present, amikacin, gentamycin, the vivocon azoles, itraconazole, terbinafine, amphotericin, fluconazol etc.) better to the curative effect of skin and superficial place infection, but the cumulative toxicity of these antibacterials is stronger, usually cause lesions of liver and kidney, digestive tract stimulates, dizzy, allergy etc. become one of focus of current medicament research and development so seek the novel antibacterial medicine of mechanism of action uniqueness.
The compd A speverin that the present invention relates to is one and delivered (Nai-Yun Ji in 2013, et al., 2013.Aspeverin, a New Alkaloid from an Algicolous Strain of Aspergillus versicolor.Organic Letters 10 (15), 2327 – 2329.) noval chemical compound, this chemical compound has brand-new framework types, present purposes only relates to and suppresses to swim vegeto-animal growth (Nai-Yun Ji, et al., 2013.Aspeverin, a New Alkaloid from an Algicolous Strain of Aspergillus versicolor.Organic Letters 10 (15), 2327 – 2329.), belong to open first for the purposes of the Aspeverin that the present invention relates in the preparation anti-bacterial drug, owing to belong to brand-new structure type, and its antibacterial activity is unexpectedly strong, there is not the possibility that is provided any enlightenment by other chemical compounds, possess outstanding substantive distinguishing features, anti-bacterial effect obviously has obvious improvement simultaneously.
Summary of the invention
The objective of the invention is to provides the application of Aspeverin in the preparation anti-bacterial drug according to not finding that it has the present situation of the report of antibacterial activity in the existing Aspeverin research.
Described compd A speverin structure is shown in formula I:
Formula I
Aspeverin has the effect of very strong inhibition escherichia coli, fluorescent pseudomonas, golden yellow Fructus Vitis viniferae ball, Bacillus proteus, neogenesis cryptococcus, so Aspeverin can be used as the chemical compound with antibacterial action, and be expected in the preparation antibacterials, be applied.
The purposes of Aspeverin in the preparation anti-bacterial drug belongs to open first, because framework types belongs to brand-new framework types, and it is active unexpectedly strong for bacteriostatic, there is not the possibility that is provided any enlightenment by other chemical compounds, possess outstanding substantive distinguishing features, the control that is used for bacterial infection simultaneously obviously has obvious improvement.
The specific embodiment
The preparation method of compd A speverin involved in the present invention is referring to document (Nai-Yun Ji, et al., 2013.Aspeverin, a New Alkaloid from an Algicolous Strain of Aspergillus versicolor.Organic Letters 10 (15), 2327 – 2329.)
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not subjected to any restriction of specific embodiment, but limited by claim.
Embodiment 1: the preparation of compd A speverin tablet involved in the present invention:
Get 20 and digest compound Aspeverin, add conventional adjuvant 180 grams of preparation tablet, mixing, conventional tablet machine are made 1000.
Embodiment 2: the preparation of compd A speverin capsule involved in the present invention:
Get 20 and digest compound Aspeverin, add conventional adjuvant such as starch 180 grams of preparation capsule, mixing is encapsulatedly made 1000.
Further specify its pharmaceutically active below by pharmacodynamic experiment.
Experimental example: Aspeverin antibacterial activity
Antibacterial activity test is to adopt the method for concentration dilution, measures triplicate at every turn, and the test pathogen has escherichia coli, fluorescent pseudomonas, golden yellow Fructus Vitis viniferae ball, Bacillus proteus, neogenesis cryptococcus, and bacterial concentration is 105/mL.The Aspeverin initial concentration is 50.0 μ g/mL(5% dimethyl sulfoxide DMSO), gradient dilution to 0.098 μ g/mL, the bacterium liquid of equivalent volumes and specimen Mixed culture are in 96 orifice plates, the antibacterial culturing temperature is respectively 37 ℃, observe behind the incubation time 24h, if discovery is the sample lowest concentration of antimicrobial when not having bacterium colony to form, i.e. the MIC value.This experiment positive control is amikacin sulfate, and the Aspeverin The anti-bacterial result sees Table 1.
The table antibiotic MIC value of 1Aspeverin (μ g/mL)
Conclusion: Aspeverin has very strong antibacterial activity, and therefore Aspeverin of the present invention is expected to be used to prepare the novel antibacterial medicine.
Claims (1)
1.Aspeverin the application in the preparation anti-bacterial drug, described compd A speverin structure is shown in formula I:
Formula I.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102173104A CN103251611A (en) | 2013-06-03 | 2013-06-03 | Application of Aspeverin in preparation of anti-bacteria medicines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102173104A CN103251611A (en) | 2013-06-03 | 2013-06-03 | Application of Aspeverin in preparation of anti-bacteria medicines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103251611A true CN103251611A (en) | 2013-08-21 |
Family
ID=48956046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013102173104A Pending CN103251611A (en) | 2013-06-03 | 2013-06-03 | Application of Aspeverin in preparation of anti-bacteria medicines |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103251611A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107459527A (en) * | 2017-09-22 | 2017-12-12 | 中国科学院烟台海岸带研究所 | A kind of six ring alkaloid compounds and its preparation and application |
| CN107629070A (en) * | 2017-09-22 | 2018-01-26 | 中国科学院烟台海岸带研究所 | A kind of carbamate compound and its preparation and application |
| CN107652305A (en) * | 2017-09-22 | 2018-02-02 | 中国科学院烟台海岸带研究所 | A kind of indoles cyanoalkaloids compound and its preparation and application |
-
2013
- 2013-06-03 CN CN2013102173104A patent/CN103251611A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107459527A (en) * | 2017-09-22 | 2017-12-12 | 中国科学院烟台海岸带研究所 | A kind of six ring alkaloid compounds and its preparation and application |
| CN107629070A (en) * | 2017-09-22 | 2018-01-26 | 中国科学院烟台海岸带研究所 | A kind of carbamate compound and its preparation and application |
| CN107652305A (en) * | 2017-09-22 | 2018-02-02 | 中国科学院烟台海岸带研究所 | A kind of indoles cyanoalkaloids compound and its preparation and application |
| CN107459527B (en) * | 2017-09-22 | 2019-07-05 | 中国科学院烟台海岸带研究所 | Six ring alkaloid compounds of one kind and its preparation and application |
| CN107629070B (en) * | 2017-09-22 | 2019-07-19 | 中国科学院烟台海岸带研究所 | A kind of carbamate compound and its preparation and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103251611A (en) | Application of Aspeverin in preparation of anti-bacteria medicines | |
| CN102861076B (en) | Application of Houttuynoid A in antibacterial medicine | |
| CN102872090B (en) | Application of Houttuynoid D in anti-bacterial agents | |
| CN102872105B (en) | Application of Houttuynoid C in antibacterial medicine | |
| CN103462968B (en) | Incarviatone A is preparing the application in anti-bacterial drug | |
| CN103446125B (en) | Lycojaponicumin B is preparing the application in anti-bacterial drug | |
| CN102872030B (en) | Application of Gypensapogenin B in antibacterial drugs | |
| CN102895238B (en) | Application of Gypensapogenin A in antibacterial medicament | |
| CN103446114A (en) | Applications of Sarcaboside A in antibacterial medicament | |
| CN103027907A (en) | Application of Aphanamixoid A in preparation of antibacterial drugs | |
| CN102895251A (en) | Application of Houttuynoid E in antibacterial drugs | |
| CN102872146A (en) | Application of Houttuynoid D in antibacterial drugs | |
| CN103381153B (en) | Chukrasone B is preparing the application in anti-bacterial drug | |
| CN103381164B (en) | Chukrasone A is preparing the application in anti-bacterial drug | |
| CN103638010B (en) | Application of Artoxanthochromane in antibacterial drugs | |
| CN103356517B (en) | Application of Scopariusins in preparation of antibacterial medicines | |
| CN103127067A (en) | Application of Eryngiolide A in antibacterial medicines | |
| CN103463037B (en) | Lycojaponicumin A is preparing the application in anti-bacterial drug | |
| CN103463075B (en) | Lycojaponicumin C is preparing the application in anti-bacterial drug | |
| CN102861087B (en) | Application of Houttuynoid D in anti-human fungi medicine | |
| CN103462982B (en) | Spirooliganones B is preparing the application in anti-bacterial drug | |
| CN103446106A (en) | Applications of Sarcaboside B in antibacterial medicament | |
| CN105412091A (en) | Application of Daphnilongeranine C in preparing antibacterial drugs | |
| CN103463099A (en) | Application of Kadcoccitones A in preparing antibacterial medicines | |
| CN105902532A (en) | Anti-bacterial medicine, preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130821 |