CN102861087B - Application of Houttuynoid D in anti-human fungi medicine - Google Patents
Application of Houttuynoid D in anti-human fungi medicine Download PDFInfo
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- CN102861087B CN102861087B CN 201210418718 CN201210418718A CN102861087B CN 102861087 B CN102861087 B CN 102861087B CN 201210418718 CN201210418718 CN 201210418718 CN 201210418718 A CN201210418718 A CN 201210418718A CN 102861087 B CN102861087 B CN 102861087B
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Abstract
The invention relates to application of Houttuynoid D in preparation of an anti-human fungi medicine, belonging to the technical field of new application of medicine. Houttuynoid D has very strong effect on inhibiting epidrmophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that Houttuynoid D is taken as an anti-human fungi compound and is expected to be applied to preparation of the relative medicines. The application of Houttuynoid D in the anti-human fungi medicine is disclosed firstly. The skeleton type belongs to new skeleton type, and the activity of Houttuynoid D on inhibition of human fungi is unexpectedly strong; and the probability that any revelation is provided by other compounds does not exist, Houttuynoid D has the excellent substantive features, and Houttuynoid D obviously has a remarkable progress when being used for preventing and treating human fungi infection.
Description
Technical field
The present invention relates to the purposes of Houttuynoid D, relate in particular to the application of Houttuynoid D in the anti-human body fungi-medicine of preparation.
Background technology
The mankind's health and lives in the enhancing serious threat of the diffusion of pathogenic bacterium and drug resistance thereof, antibacterials are widely used in acquired immune deficiency syndrome (AIDS) as routine administration, organ transplantation and Chronic consumptions are (as cancer, diabetes, uremia etc.) treatment, although the antimicrobial agent of using clinically at present is (as ketoconazole, amikacin, gentamycin, voriconazole, itraconazole, terbinafine, amphotericin, fluconazol etc.) better to the curative effect of skin and superficial place infection, but the cumulative toxicity of these antibacterials is stronger, usually cause lesions of liver and kidney, digestive tract stimulates, dizzy, irritated etc., become one of focus of current medicament research and development so find the novel antibacterial medicine of mechanism of action uniqueness.
The compound H outtuynoid D the present invention relates to is one and within 2012, delivers (Chen, S. D. et al., 2012. Houttuynoid D_E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata. Organic Letters 14 (7), 1772 – 1775.) New skeleton compound, this compound has brand-new framework types, current purposes only relates to anti-herpes simplex virus activity (Chen, S. D. et al., 2012. Houttuynoid D_E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata. Organic Letters 14 (7), 1772 – 1775.), purposes for the Houttuynoid D the present invention relates in the anti-human body fungi-medicine of preparation treatment belongs to open first, because framework types belongs to brand-new framework types, and it suppresses active unexpectedly strong for Human Fungi, there do not is the possibility that is provided any enlightenment by other compounds, possesses outstanding substantive distinguishing features, the control of simultaneously infecting for Human Fungi obviously has significant progress.
Summary of the invention
The object of the invention is to:
The application of a kind of Houttuynoid D of the present invention in the anti-human body fungi-medicine of preparation is provided.
Described compound H outtuynoid D structure is as shown in formula I:
Houttuynoid D has the red hair of very strong inhibition moss bacterium, microsporum canis or the disconnected effect of sending out the moss bacterium, so Houttuynoid D can be used as the compound with the effect of anti-human body fungus, and is expected to be applied in the anti-human body fungi-medicine of preparation.
The purposes of the Houttuynoid D the present invention relates in the anti-human body fungi-medicine of preparation treatment belongs to open first, because framework types belongs to brand-new framework types, and it suppresses active unexpectedly strong for Human Fungi, there do not is the possibility that is provided any enlightenment by other compounds, possess outstanding substantive distinguishing features, the control of simultaneously infecting for Human Fungi obviously has significant progress.
The specific embodiment
The preparation method of compound H outtuynoid D involved in the present invention is referring to document (Chen, S. D. et al., 2012. Houttuynoid D_E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata. Organic Letters 14 (7), 1772 – 1775.).
The present invention is further detailed explanation by the following examples, but protection scope of the present invention is not subject to any restriction of specific embodiment, but be limited by claim.
Embodiment 1: the preparation of compound H outtuynoid D tablet involved in the present invention:
Get 20 and digest compound Houttuynoid D, add conventional adjuvant 180 grams that prepare tablet, mix, conventional tablet machine is made 1000.
Embodiment 2: the preparation of compound H outtuynoid D capsule involved in the present invention:
Get 20 and digest compound Houttuynoid D, add the conventional adjuvant for preparing capsule as starch 180 grams, mix, encapsulatedly make 1000.
Further illustrate its pharmaceutically active below by pharmacodynamic experiment.
Experimental example: the anti-human body fungi activity of Houttuynoid D
Anti-human body fungi activity experiment is the method for employing concentration dilution, measures triplicate at every turn, and the test pathogen has red hair moss bacterium, microsporum canis and a disconnected moss bacterium, and bacterial concentration is 10
5individual/mL.Houttuynoid D initial concentration is 50.0 μ g/mL(5% dimethyl sulfoxide DMSO), gradient dilution to 0.098 μ g/mL, the bacterium liquid of equivalent volumes and specimen Mixed culture are in 96 orifice plates, the Human Fungi cultivation temperature is respectively 28 ℃, after incubation time 24h, observe, while if find, not having bacterium colony to form, be the minimum anti-human body fungi concentration of sample, i.e. MIC value.This experiment positive control is ketoconazole, and the anti-human body fungus of Houttuynoid D the results are shown in Table 1.
The anti-human body fungus of table 1 Houttuynoid D MIC value (μ g/mL)
Conclusion: Houttuynoid D has very strong anti-human body fungi activity, and therefore Houttuynoid D of the present invention is expected to be used to prepare novel anti-human body fungi-medicine.
Claims (1)
1.Houttuynoid D is the application in anti-human body fungi-medicine in preparation, described Human Fungi is: red hair moss bacterium, microsporum canis and disconnectedly send out a moss bacterium, described compound H outtuynoid D structure as
formula Ishown in:
formula I.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210418718 CN102861087B (en) | 2012-10-27 | 2012-10-27 | Application of Houttuynoid D in anti-human fungi medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210418718 CN102861087B (en) | 2012-10-27 | 2012-10-27 | Application of Houttuynoid D in anti-human fungi medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102861087A CN102861087A (en) | 2013-01-09 |
| CN102861087B true CN102861087B (en) | 2013-12-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN 201210418718 Expired - Fee Related CN102861087B (en) | 2012-10-27 | 2012-10-27 | Application of Houttuynoid D in anti-human fungi medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102861087B (en) |
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2012
- 2012-10-27 CN CN 201210418718 patent/CN102861087B/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| Houttuynoids A_E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata;Shao-Dan Chen 等;《Organic Letters》;20120313;第14卷(第07期);第1772–1775页 * |
| Shao-DanChen等.HouttuynoidsA_E Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata.《Organic Letters》.2012 |
| 中药鱼腥草乙醚提取物抗角膜真菌作用研究;王锦 等;《时珍国医国药》;20061231;第17卷(第06期);第992页 * |
| 王锦 等.中药鱼腥草乙醚提取物抗角膜真菌作用研究.《时珍国医国药》.2006,第17卷(第06期),第992页. |
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| CN102861087A (en) | 2013-01-09 |
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Granted publication date: 20131218 Termination date: 20191027 |