CN101654407A - Lithium gluconate and production method thereof - Google Patents
Lithium gluconate and production method thereof Download PDFInfo
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- CN101654407A CN101654407A CN200810012866A CN200810012866A CN101654407A CN 101654407 A CN101654407 A CN 101654407A CN 200810012866 A CN200810012866 A CN 200810012866A CN 200810012866 A CN200810012866 A CN 200810012866A CN 101654407 A CN101654407 A CN 101654407A
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- lithium
- reaction
- gluconate
- lithium gluconate
- acid solution
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a lithium-containing organic compound lithium gluconate suitable to be used as a pharmaceutical intermediate and a food additive, and a production method thereof. The lithiumgluconate is mainly invented to solve the problem that the present medicinal preparations are mainly lithium carbonate tablets and capsules, and the lithium carbonate is slightly dissolved in water, cannot be prepared into a liquid preparation and cannot be absorbed by a human body quickly. The lithium gluconate is prepared by the following steps: putting gluconic acid solution in a reaction kettle, and putting lithium carbonate into the reaction kettle for reaction when the temperature of the gluconic acid solution reaches 60 DEG C; after the material feeding, raising the temperature to 90 DEG C, and performing the reaction for 1 to 2 hours; and after the complete reaction, putting a reaction product into a crystallizer tank for cooling and crystallization, and then drying and grinding the reaction product. The lithium gluconate has the advantages that: the lithium gluconate is easily dissolved in the water, can be used as a preparation, is easily absorbed when used as the pharmaceutical intermediate and the food additive, can be prepared into the tablets, the capsules and the liquid preparation, and has simple and convenient production process.
Description
[technical field]
The present invention relates to a kind ofly be suitable for doing that medicine intermediate and foodstuff additive use contains lithium organic compound lithium gluconate and production method thereof.
[background technology]
Pharmacy at present and foodstuffs industry are badly in need of a kind of soluble in water, be convenient to absorption of human body be suitable for doing that medicine intermediate and foodstuff additive use contain the lithium organic compound, but medicinal preparations is mainly Lithotabs and capsule at present, the shortcoming of Quilonum Retard is to be slightly soluble in water, can not make liquid formulation, can not be absorbed rapidly by human body.
[summary of the invention]
Technical problem to be solved by this invention provides a kind of be suitable for doing medicine intermediate and foodstuff additive usefulness, lithium organic compound lithium gluconate and the production method thereof of containing soluble in water.
The object of the present invention is achieved like this, gluconic acid solution and Quilonum Retard put into reactor react, and is warmed up to 90 ℃ after having thrown material, reaction times 1.5-2 hour, after reacting completely resultant of reaction is put into the crystallizer tank crystallisation by cooling, oven dry, pulverizing gets final product.
Advantage of the present invention is that product is a white crystalline powder, it is little salty to distinguish the flavor of, soluble in water, can be used as preparation, be used for medicine intermediate and foodstuff additive absorb easily, lithium gluconate promptly can be made into tablet and capsule can be made into liquid formulation again, and production process is easy, thus be more satisfactory being suitable for do that medicine intermediate and foodstuff additive use contain the lithium organic compound.Be accompanied by the progress of science and technology, the production of lithium gluconate and application will be more and more widely.
[embodiment]
The first step adopts prior art to produce gluconic acid solution: calglucon is leached calcium sulfate precipitation after with sulfuric acid acidation, obtain gluconic acid solution.Concrete grammar is: Dilution of sulphuric acid liquid is put into reactor, slowly drop into calglucon again, reaction is 1.5 hours under 90 ℃ of temperature condition, leach calcium sulfate precipitation after reacting completely, the flow that cooling back is equivalent to the resin volume with per minute flows through the exchange column that the equivalent anion and cation exchange resin is housed and promptly obtains gluconic acid solution.Chemical equation is: (C
6H
11O
6O)
2CaH
2O+H
2SO
4→ (C
6H
12O
6O)
2+ CaSO
4↓+H
2O
Second step: at first the gluconic acid solution that makes is put into reactor, when the gluconic acid solution temperature reaches 60 ℃, Quilonum Retard (purity of Quilonum Retard should more than 99%) dropped in the reactor and react, be warmed up to 90 ℃ after having thrown material, reaction times 1.5-2 hour, after reacting completely resultant of reaction put into the crystallizer tank crystallisation by cooling, oven dry is pulverized.Chemical equation is: Li
2CO
3+ 2C
6H
12O
7→ 2C
6H
11LiO
7+ H
2O+CO
2
Claims (3)
1, lithium gluconate is characterized in that molecular formula is: C
6H
11LiO
7
2, the production method of lithium gluconate, it is characterized in that at first gluconic acid solution being put into reactor, then Quilonum Retard is dropped in the reactor and react, be warmed up to 90 ℃ after having thrown material, reaction times 1.5-2 hour, after reacting completely resultant of reaction is put into the crystallizer tank crystallisation by cooling, oven dry is pulverized; Chemical equation is: Li
2CO
3+ 2C
6H
12O
7→ 2C
6H
11LiO
7+ H
2O+CO
2
3,, when it is characterized in that gluconic acid solution temperature in reactor reaches 60 ℃ Quilonum Retard dropped in the reactor and react according to the production method of the described lithium gluconate of claim 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810012866A CN101654407A (en) | 2008-08-21 | 2008-08-21 | Lithium gluconate and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810012866A CN101654407A (en) | 2008-08-21 | 2008-08-21 | Lithium gluconate and production method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101654407A true CN101654407A (en) | 2010-02-24 |
Family
ID=41708894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810012866A Pending CN101654407A (en) | 2008-08-21 | 2008-08-21 | Lithium gluconate and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101654407A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105272847A (en) * | 2015-09-25 | 2016-01-27 | 栾广胜 | Lithium gluconate preparation method |
-
2008
- 2008-08-21 CN CN200810012866A patent/CN101654407A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105272847A (en) * | 2015-09-25 | 2016-01-27 | 栾广胜 | Lithium gluconate preparation method |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20100224 |