CN105272847A - Lithium gluconate preparation method - Google Patents
Lithium gluconate preparation method Download PDFInfo
- Publication number
- CN105272847A CN105272847A CN201510615404.6A CN201510615404A CN105272847A CN 105272847 A CN105272847 A CN 105272847A CN 201510615404 A CN201510615404 A CN 201510615404A CN 105272847 A CN105272847 A CN 105272847A
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- CN
- China
- Prior art keywords
- lithium
- gluconate
- preparation
- lithium gluconate
- gluconic acid
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a lithium gluconate preparation method. The method is characterized in that lithium gluconate is obtained through the following steps: reacting gluconic acid used as a raw material with a lithium-containing compound, concentrating the obtained reaction solution, and purifying. Lithium gluconate can be widely used in fields of food additives and medicine intermediates as a novel lithium-containing compound. The method fills the gap in the lithium gluconate market, and overcomes the general shortcomings of poor water solubility, poor absorption and low safety of lithium-containing inorganic substances.
Description
Technical field
The present invention relates to a kind of preparation method of lithium gluconate, a kind ofly specifically prepare the new processing method of lithium gluconate.
Background technology
Lithium, as trace element a kind of in human body, was more and more subject to the attention of scientific circles in recent years to the value of HUMAN HEALTH.Research shows that lithium has raising body immunity, improves hemopoietic function, regulates the functions such as neural activity, prevention and cure of cardiovascular disease, Cell protection membrane stability.In human body lithium shortage can cause immunity degradation, the disease such as the life-span reduces, the bad and dystropy of psychological development.Therefore, from promote health, exploitation good water solubility, the organo lithium products that security is high, bioavailability is high are the effective ways realizing daily benefit lithium.Gluconic acid is that a kind of good water solubility, security are high, and a kind of organic acid good with human-body biological consistency, combining with most metals and show its exclusive effect, is the first-selected organic acid be combined with lithium.
At present, lithium gluconate is commercially still blank.Along with following China food function, the arrival in personalized epoch, lithium gluconate because of its specific absorption high, the advantage market outlook desirable that security is good.About the preparation method of lithium gluconate, one section of patent CN200810012866.9 is only had to be the patent that contriver applies for for 2008, disclose the lithium gluconate method with Quilonum Retard and gluconic acid reaction preparation in patent, but cost is higher, technique is more complicated also.Therefore, this patent discloses a kind of novel process of producing lithium gluconate, replace Quilonum Retard with Lithium Oxide 98min or lithium hydroxide, reaction process, without gaseous emission, no coupling product and be swift in response, easily operate, is applicable to large-scale production.
Summary of the invention
The present invention is a kind of preparation method of lithium gluconate.Its synthetic route is as follows:
1, a preparation method for lithium gluconate, is characterized in that: be that raw material and lithium-containing compound react with gluconic acid, and reaction solution obtains lithium gluconate after concentrated, purifying etc. processes.
2, the preparation method of a kind of lithium gluconate according to claim 1, is characterized in that: mol ratio=1 of gluconic acid and elemental lithium: 1 ~ 2: 1.
3, the preparation method of a kind of lithium gluconate according to claim 1, is characterized in that: the described lithium material that contains comprises titanium dioxide lithium, lithium hydroxide.
4, the preparation method of a kind of lithium gluconate according to claim 1, is characterized in that: described reaction conditions is solvent is water, heated for controlling temperature 40-80 DEG C, and the reaction times is 0.5-2 hour, and pH value is between 3-7.
Embodiment
The specific embodiment below enumerated is further detailed the present invention, does not represent protection scope of the present invention.If it is emphasized that according to prompting of the present invention make non-intrinsically safe change still belong to the scope of protection of the invention.
Embodiment
Under ice-water bath condition, by the solution that titanium dioxide lithium 5.0g and water are made into, be slowly added drop-wise in the solution that 33g glucose and 20g water is made into, be heated to 60 DEG C, and temperature control 1 hour.Reacting liquid filtering, concentrated, cooling, crystallization obtain white solid, after ethyl alcohol recrystallization white crystal lithium gluconate 51g.
Claims (4)
1. a preparation method for lithium gluconate, is characterized in that: be that raw material and lithium-containing compound react with gluconic acid, and reaction solution obtains lithium gluconate after concentrated, purifying etc. processes.
2. the preparation method of a kind of lithium gluconate according to claim 1, is characterized in that: mol ratio=1 of gluconic acid and elemental lithium: 1 ~ 2: 1.
3. the preparation method of a kind of lithium gluconate according to claim 1, is characterized in that: the described lithium material that contains comprises titanium dioxide lithium, lithium hydroxide.
4. the preparation method of a kind of lithium gluconate according to claim 1, is characterized in that: described reaction conditions is solvent is water, heated for controlling temperature 40-80 DEG C, and the reaction times is 0.5-2 hour, and pH value is between 3-7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510615404.6A CN105272847A (en) | 2015-09-25 | 2015-09-25 | Lithium gluconate preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510615404.6A CN105272847A (en) | 2015-09-25 | 2015-09-25 | Lithium gluconate preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105272847A true CN105272847A (en) | 2016-01-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510615404.6A Pending CN105272847A (en) | 2015-09-25 | 2015-09-25 | Lithium gluconate preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN105272847A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2521989A1 (en) * | 1982-02-24 | 1983-08-26 | Labcatal | Prepn. of metal gluconate(s) - from metal hydroxide and gluconic acid |
| CN1162590A (en) * | 1997-03-27 | 1997-10-22 | 张世平 | Chromium gluconate and preparation thereof |
| CN101153005A (en) * | 2006-09-27 | 2008-04-02 | 栾广胜 | Gluconic acid strontium and method of preparing the same |
| CN101153006A (en) * | 2006-09-27 | 2008-04-02 | 栾广胜 | Gluconic acid cobalt and method of preparing the same |
| CN101153007A (en) * | 2006-09-27 | 2008-04-02 | 栾广胜 | Gluconic acid nickel and method of preparing the same |
| CN101654407A (en) * | 2008-08-21 | 2010-02-24 | 栾广胜 | Lithium gluconate and production method thereof |
| CN102190578A (en) * | 2011-03-09 | 2011-09-21 | 石允生 | Method for preparing hypophosphorous acid (salt) and gluconic acid (salt) from glucose phosphate serving as raw material |
| CN102992998A (en) * | 2012-12-21 | 2013-03-27 | 江西新赣江药业有限公司 | Preparation method of ferrous gluconate |
-
2015
- 2015-09-25 CN CN201510615404.6A patent/CN105272847A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2521989A1 (en) * | 1982-02-24 | 1983-08-26 | Labcatal | Prepn. of metal gluconate(s) - from metal hydroxide and gluconic acid |
| CN1162590A (en) * | 1997-03-27 | 1997-10-22 | 张世平 | Chromium gluconate and preparation thereof |
| CN101153005A (en) * | 2006-09-27 | 2008-04-02 | 栾广胜 | Gluconic acid strontium and method of preparing the same |
| CN101153006A (en) * | 2006-09-27 | 2008-04-02 | 栾广胜 | Gluconic acid cobalt and method of preparing the same |
| CN101153007A (en) * | 2006-09-27 | 2008-04-02 | 栾广胜 | Gluconic acid nickel and method of preparing the same |
| CN101654407A (en) * | 2008-08-21 | 2010-02-24 | 栾广胜 | Lithium gluconate and production method thereof |
| CN102190578A (en) * | 2011-03-09 | 2011-09-21 | 石允生 | Method for preparing hypophosphorous acid (salt) and gluconic acid (salt) from glucose phosphate serving as raw material |
| CN102992998A (en) * | 2012-12-21 | 2013-03-27 | 江西新赣江药业有限公司 | Preparation method of ferrous gluconate |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160127 |
|
| RJ01 | Rejection of invention patent application after publication |