CN102516441B - Method for synthesizing potassium polycarbophil - Google Patents
Method for synthesizing potassium polycarbophil Download PDFInfo
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- CN102516441B CN102516441B CN201110399171.2A CN201110399171A CN102516441B CN 102516441 B CN102516441 B CN 102516441B CN 201110399171 A CN201110399171 A CN 201110399171A CN 102516441 B CN102516441 B CN 102516441B
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Abstract
The invention relates to a method for preparing a medicine, in particular to a method for synthesizing potassium polycarbophil. The method for synthesizing the potassium polycarbophil comprises the following steps of: 1) fully dissolving magnesium sulfate and diethylene glycol in water, and raising temperature to 75 DEG C; 2) dripping a mixed solution of crylic acid and azodiisobutyronitrile, and preserving heat for 2 to 3 hours; 3) cleaning by using clear water at the temperature of 75 DEG C to obtain magnesium salt of polycarbophil; 4) fully stirring the magnesium salt of polycarbophil and a faintly acid salt aqueous solution of potassium, raising temperature to 95 to 100 DEG C and preserving heat for 4 to 6 hours; and 5) after reaction, placing, centrifuging, drying and crushing to obtain a finished product. The potassium polycarbophil can be synthesized by the method; and due to the reasonable reaction time and temperature control, the yield of the synthesized potassium polycarbophil product is very high.
Description
Technical field
The present invention relates to a kind of medicine preparation method, relate in particular to a kind of synthetic method of polycarbophil potassium.
Background technology
Polycarbophil potassium is as a kind of special polymer, the dual function with treatment constipation and diarrhoea the same as polycarbophil calcium.Polycarbophil calcium is as a kind of prodrug, and the activeconstituents that plays effect is polycarbophil, and under the effect of hydrochloric acid in gastric juice, the ion exchange reaction of polycarbophil calcium generation decalcification, generates by product calcium.When human body does not need calcium salt and when needing sylvite, can treat constipation and diarrhoea with polycarbophil potassio for polycarbophil calcium medication, can supplement human body sylvite again.
Therefore how synthesizing polycarbophil potassium becomes a technical barrier.
Summary of the invention
The invention provides a kind of synthetic method of polycarbophil potassium.In order to realize foregoing invention object, the present invention has adopted following technique means:
A synthetic method for polycarbophil potassium, comprises the following steps: 1. magnesium sulfate and DIETHYLENE GLYCOL are fully dissolved in water, are warmed up to 75 ℃; 2. drip the mixed solution of vinylformic acid and Diisopropyl azodicarboxylate, insulation reaction 2-3 hour; 3. with 75 ℃ of clear water, clean, obtain polycarbophil; 4. the aqueous solution of the slightly acidic salt of polycarbophil and potassium is fully stirred, be warming up to 95-100 ℃, insulation reaction 4-6 hour; 5. after having reacted, put down centrifugally, dry, pulverize, get product.
The step 4. slightly acidic salt of middle potassium adopts salt of wormwood.
Beneficial effect of the present invention is: utilize aforesaid method can synthesize polycarbophil potassium; Reasonably reaction times and temperature are controlled, and make the synthetic product yield of polycarbophil potassium very high.
Embodiment
Below in conjunction with accompanying drawing, the preferred implementation of the synthetic method of a kind of polycarbophil potassium of the present invention is made to detailed description:
embodiment mono-
A synthetic method for polycarbophil potassium, comprises the following steps:
1. first in having the reactor of stirring, magnesium sulfate and DIETHYLENE GLYCOL are fully dissolved in water, stir and be warmed up to 75 ℃ simultaneously, it is fully dissolved;
2. then drip the mixed solution of vinylformic acid and Diisopropyl azodicarboxylate, stir, insulation reaction 3 hours;
3. with 75 ℃ of clear water, clean, obtain polycarbophil;
4. the aqueous solution of polycarbophil and salt of wormwood is fully stirred in reactor, be warming up to 100 ℃ of reactions 6 hours simultaneously;
5. put down centrifuge dehydration, dry, pulverize, what be up to the standards can pack to obtain finished product.
Utilize the synthetic polycarbophil potassium of aforesaid method, the product yield of polycarbophil potassium reaches 93%.
embodiment bis-
A synthetic method for polycarbophil potassium, comprises the following steps:
1. first in having the reactor of stirring, magnesium sulfate and DIETHYLENE GLYCOL are fully dissolved in water, stir and be warmed up to 75 ℃ simultaneously, it is fully dissolved;
2. then drip the mixed solution of vinylformic acid and Diisopropyl azodicarboxylate, stir, insulation reaction 2 hours;
3. with 75 ℃ of clear water, clean, obtain polycarbophil;
4. the aqueous solution of polycarbophil and salt of wormwood is fully stirred in reactor, be warming up to 95 ℃ of reactions 4 hours simultaneously;
5. put down centrifuge dehydration, dry, pulverize, what be up to the standards can pack to obtain finished product.
Utilize the synthetic polycarbophil potassium of aforesaid method, the product yield of polycarbophil potassium reaches 85%.
embodiment tri-
A synthetic method for polycarbophil potassium, comprises the following steps:
1. first in having the reactor of stirring, magnesium sulfate and DIETHYLENE GLYCOL are fully dissolved in water, stir and be warmed up to 75 ℃ simultaneously, it is fully dissolved;
2. then drip the mixed solution of vinylformic acid and Diisopropyl azodicarboxylate, stir, insulation reaction 3 hours;
3. with 75 ℃ of clear water, clean, obtain polycarbophil;
4. the aqueous solution of polycarbophil and salt of wormwood is fully stirred in reactor, be warming up to 98 ℃ of reactions 5 hours simultaneously;
5. put down centrifuge dehydration, dry, pulverize, what be up to the standards can pack to obtain finished product.
Utilize the synthetic polycarbophil potassium of aforesaid method, the product yield of polycarbophil potassium reaches 98%.
Claims (2)
1. a synthetic method for polycarbophil potassium, is characterized in that, comprises the following steps: 1. magnesium sulfate and DIETHYLENE GLYCOL are fully dissolved in water, are warmed up to 75 ℃; 2. drip the mixed solution of vinylformic acid and Diisopropyl azodicarboxylate, insulation reaction 2-3 hour; 3. with 75 ℃ of clear water, clean, obtain polycarbophil; 4. the aqueous solution of the slightly acidic salt of polycarbophil and potassium is fully stirred, be warming up to 95-100 ℃, insulation reaction 4-6 hour; 5. after having reacted, put down centrifugally, dry, pulverize, get product.
2. the synthetic method of a kind of polycarbophil potassium according to claim 1, is characterized in that, the step 4. slightly acidic salt of middle potassium adopts salt of wormwood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110399171.2A CN102516441B (en) | 2011-12-06 | 2011-12-06 | Method for synthesizing potassium polycarbophil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110399171.2A CN102516441B (en) | 2011-12-06 | 2011-12-06 | Method for synthesizing potassium polycarbophil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102516441A CN102516441A (en) | 2012-06-27 |
| CN102516441B true CN102516441B (en) | 2014-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110399171.2A Active CN102516441B (en) | 2011-12-06 | 2011-12-06 | Method for synthesizing potassium polycarbophil |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401816A (en) * | 2008-11-11 | 2009-04-08 | 山东新华制药股份有限公司 | Method for preparing Calcium polycarbophil particle |
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2011
- 2011-12-06 CN CN201110399171.2A patent/CN102516441B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401816A (en) * | 2008-11-11 | 2009-04-08 | 山东新华制药股份有限公司 | Method for preparing Calcium polycarbophil particle |
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| CN102516441A (en) | 2012-06-27 |
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Inventor after: Xie Zaifa Inventor after: Yao Fengming Inventor before: Yao Fengming Inventor before: Xie Zaifa |
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