CN103374044A - Method for preparing glucosamine sulfate - Google Patents
Method for preparing glucosamine sulfate Download PDFInfo
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- CN103374044A CN103374044A CN 201210110261 CN201210110261A CN103374044A CN 103374044 A CN103374044 A CN 103374044A CN 201210110261 CN201210110261 CN 201210110261 CN 201210110261 A CN201210110261 A CN 201210110261A CN 103374044 A CN103374044 A CN 103374044A
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- sulfuric acid
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- glucosamine
- glucosamine sulfate
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Abstract
The invention discloses a method for preparing glucosamine sulfate. The method is characterized by comprising the following steps of: acidizing chitin by utilizing sulfuric acid, and reacting for 3-5 hours by controlling the temperature at 90-100 DEG C; adding activated carbon to carry out decoloration, extracting a clear liquid by utilizing absolute ethyl alcohol, dissolving extracts by utilizing water, adding calcium hydroxide to remove the redundant sulfuric acid, and carrying out freeze drying on the solution, so as to obtain the glucosamine sulfate. Compared with the prior art, the method for preparing the glucosamine sulfate has the advantages that sulfate radicals are directly combined with glucosamine, so that a prepared product does not contain sodium metal, positive ions such as potassium and negative ions such as chloride ions, the influence on the utilization of the product can be eliminated, the product process is clean and sanitary and is little in three wastes; and the practicality is good, and good economic benefits and social effects can be generated.
Description
Technical field
The present invention relates to glucosamine sulphate, be specifically related to a kind of method for preparing glucosamine sulphate.
Background technology
Glucosamine sulphate is a kind of white crystalline powder, and odorlessness is slightly pleasantly sweet, soluble in water, is slightly soluble in methyl alcohol, is insoluble to the organic solvents such as ethanol.Can be as pharmaceutical raw material, rheumatic arthritis, heart trouble, pneumonia and fracture all there is auxiliary therapeutic action, in recent years find to have the physiological action that absorbs the multiple beneficial such as free radical, anti-ageing, fat-reducing, endocrine regulation, also has the joint motion of improvement, lenitive effect can be used for various osteoarthritis treatment.Existing preparation glucosamine sulphate method is a lot, but in the finished product more or less contain the negatively charged ion such as the positively charged ions such as sodium Metal 99.5, potassium and chlorion, the final utilization of product has been produced disadvantageous effect.
Summary of the invention
Goal of the invention: for the deficiencies in the prior art, the purpose of this invention is to provide a kind of method for preparing glucosamine sulphate, directly be combined with glucosamine by adopting sulfate radical, so that the product of the preparation negatively charged ion such as the positively charged ion such as containing metal sodium, potassium and chlorion not realizes having removed the impact of metal ion on product utilization.
Technical scheme: in order to realize the foregoing invention purpose, the technical solution used in the present invention is as follows:
A kind of method for preparing glucosamine sulphate: use the sulfuric acid acidation chitin, 90 ~ 100 ℃ of temperature controls, reaction 4 ~ 5h; Add activated carbon decolorizing, get extract with dehydrated alcohol extraction clear liquid, water dissolution extraction thing adds calcium hydroxide and removes unnecessary sulfuric acid, and solution is carried out lyophilize, obtains glucosamine sulphate.
Wherein, the mass ratio of chitin and sulfuric acid is 1:5 ~ 7.The g/g concentration of sulfuric acid is 70%.
Beneficial effect: compared with prior art, the method for preparing glucosamine sulphate of the present invention, adopt sulfate radical directly to be combined with glucosamine, so that the product of the preparation negatively charged ion such as the positively charged ion such as containing metal sodium, potassium and chlorion not, can remove metal ion to the impact of product utilization, the Product Process sanitation and hygiene, the three wastes are few, have good practicality, can produce good economic benefit and social effect.
Embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
Get the 50g chitin, the sulfuric acid 300g that adds concentration 70%g/g, the control temperature is at 90 ℃ of reaction 5h, acidolysis adds activated carbon decolorizing after finishing in acid hydrolysis solution, the dehydrated alcohol that clear liquid adds 10 times of volumes extracts, with extract again crystallization, remove unnecessary sulfuric acid with the calcium hydroxide precipitation, solution is carried out lyophilize, obtain glucosamine sulphate.After testing, product is metal ion and chlorion not, the Product Process sanitation and hygiene, and the three wastes are few.
Embodiment 2
Get the 50g chitin, the sulfuric acid 250g that adds concentration 70%g/g, the control temperature is at 100 ℃ of reaction 4h, acidolysis adds activated carbon decolorizing after finishing in acid hydrolysis solution, the dehydrated alcohol that clear liquid adds 9 times of volumes extracts, with extract again crystallization, remove unnecessary sulfuric acid with the calcium hydroxide precipitation, solution is carried out lyophilize, obtain glucosamine sulphate.After testing, product is metal ion and chlorion not, the Product Process sanitation and hygiene, and the three wastes are few.
Embodiment 3
Get the 50g chitin, the sulfuric acid 350g that adds concentration 70%g/g, the control temperature is at 950 ℃ of reaction 4.5h, acidolysis adds activated carbon decolorizing after finishing in acid hydrolysis solution, the dehydrated alcohol that clear liquid adds 11 times of volumes extracts, with extract again crystallization, remove unnecessary sulfuric acid with the calcium hydroxide precipitation, solution is carried out lyophilize, obtain glucosamine sulphate.After testing, product is metal ion and chlorion not, the Product Process sanitation and hygiene, and the three wastes are few.
Claims (3)
1. a method for preparing glucosamine sulphate is characterized in that: use the sulfuric acid acidation chitin, 90 ~ 100 ℃ of temperature controls, reaction 4 ~ 5h; Add activated carbon decolorizing, get extract with dehydrated alcohol extraction clear liquid, water dissolution extraction thing adds calcium hydroxide and removes unnecessary sulfuric acid, and solution is carried out lyophilize, obtains glucosamine sulphate.
2. the method for preparing glucosamine sulphate according to claim 1, it is characterized in that: the mass ratio of chitin and sulfuric acid is 1:5 ~ 7.
3. the method for preparing glucosamine sulphate according to claim 1, it is characterized in that: the g/g concentration of sulfuric acid is 70%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210110261 CN103374044A (en) | 2012-04-16 | 2012-04-16 | Method for preparing glucosamine sulfate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210110261 CN103374044A (en) | 2012-04-16 | 2012-04-16 | Method for preparing glucosamine sulfate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103374044A true CN103374044A (en) | 2013-10-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210110261 Pending CN103374044A (en) | 2012-04-16 | 2012-04-16 | Method for preparing glucosamine sulfate |
Country Status (1)
| Country | Link |
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| CN (1) | CN103374044A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104710483A (en) * | 2014-09-11 | 2015-06-17 | 迪沙药业集团有限公司 | Preparation method for glucosamine sulfate |
| CN110776538A (en) * | 2019-12-02 | 2020-02-11 | 山东润德生物科技有限公司 | Preparation method of low-potassium or low-sodium glucosamine sulfate |
| CN115340585A (en) * | 2021-05-13 | 2022-11-15 | 山东润德生物科技有限公司 | Extraction process of D-glucosamine sulfate |
-
2012
- 2012-04-16 CN CN 201210110261 patent/CN103374044A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104710483A (en) * | 2014-09-11 | 2015-06-17 | 迪沙药业集团有限公司 | Preparation method for glucosamine sulfate |
| CN110776538A (en) * | 2019-12-02 | 2020-02-11 | 山东润德生物科技有限公司 | Preparation method of low-potassium or low-sodium glucosamine sulfate |
| CN110776538B (en) * | 2019-12-02 | 2021-02-12 | 山东润德生物科技有限公司 | Preparation method of low-potassium or low-sodium glucosamine sulfate |
| CN115340585A (en) * | 2021-05-13 | 2022-11-15 | 山东润德生物科技有限公司 | Extraction process of D-glucosamine sulfate |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20131030 |