CN101647933B - Traditional Chinese medicine composition for treating infertility and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating infertility and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating infertility and a preparation method thereof. The composition comprises the components of dodders, barrenwort, medlar, c. deserticola, codonopsis pilosula, yam, tuckahoe, antlers, raspberries, rhizoma cyperi, radix bupleuri, radix paeoniae alba, angelica, cortex moutan radicis, prepared rehmannia root, and liquorice. The traditional Chinese medicine composition of the invention has reasonable proportion, and any one clinically oral agent or external-use agent can be prepared according to a conventional preparation method of traditional Chinese medicine. The composition, in particular matching with meridians buried line therapy, via multiple stimuli effect of acupuncture, medical gut can generate lasting benign stimulation to cutem in process of gradually liquidated absorption with the gut being buried to meridians as foreign proteins so that effect of cutem is more obvious and the composition has exact effect for treating infertility caused by man and woman endocrine disorder, yellow body dysfunction, anovulation, aspermia,atheno-spermia and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of endocrine regulation and the unsound infertility that causes of sexual function, the invention still further relates to the preparation method of this Chinese medicine composition, belong to the field of Chinese medicines.
Background technology
Cause the reason of infertility to have a lot, the women mainly contains vagina, cervix uteri, abnormal uterine, and ovary is unusual, sexually transmitted disease (STD), genital tuberculosis, multiple factors such as immunity reason or repeatability miscarriage; The male mainly contains factors such as seminal fluid cacospermia, sexual dysfunction, genitals are unusual, cryptorrhea.Wherein most of factor is owing to men and women's endocrine regulation and sexual function is unsound directly causes.Doctor trained in Western medicine mainly adopts methods such as operative treatment and artificial insemination; Existing be used for the treatment of infertility in, Western medicine has a variety ofly, wherein Chinese traditional treatment adopts the medicine activating blood circulation to dissipate blood stasis and dredge the collateral to take as the leading factor usually, is aided with the Therapeutic Method of heat-clearing and toxic substances removing.For example application number is 200510079322.0 Chinese patent employing Carapax et Plastrum Testudinis, Cornu Cervi tablet, and Hippocampus is a principal agent, with the Rhizoma Anemarrhenae, Radix Scutellariae, Herba Epimedii, Fructus Lycii, Fructus Corni, Hirudo, Radix Pseudostellariae, Radix Angelicae Sinensis, Radix Et Rhizoma Rhei and Caulis Spatholobi are that adjuvant is made the infertility due to diagnosis and treatment follicular dysplasia or the luteal insufficiency etc.; Application number is that 03112551.4 Chinese patent discloses a kind of Chinese medicine composition for the treatment of infertility, and this pharmaceutical composition comprises following bulk drugs material: Lignum Aquilariae Resinatum, Lignum Santali Albi, Rhizoma Arisaematis, the Rhizoma Pinelliae, Radix Aconiti, Herba Asari, Radix Et Rhizoma Rhei, long-pending real etc.; For example application number is that 02100870.1 the disclosed Chinese medicine of Chinese patent comprises Radix Ginseng, Cornu Cervi Pantotrichum, Colla Plastri Testudinis, Colla cornus cervi, Herba Epimedii, Radix Morindae Officinalis, Fructus Lycii, Radix Polygoni Multiflori, Air Bladder pseudosciaenae seu Acipenser, Cortex Phellodendri, Radix Rehmanniae Preparata, Semen Cuscutae, Rhizoma Curculiginis, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi etc. again, is prepared into various peroral dosage forms treatment infertilities.
The Chinese medicine preparation of present treatment infertility is reaching therapeutic effect in varying degrees, but still exist the materials complexity mostly, defective such as preparation is loaded down with trivial details, curative effect is remarkable inadequately, have much room for improvement.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of infertility and preparation method thereof, by rational compatibility, to men and women's endocrine regulation, luteal phase defect, do not ovulate, infertility that a variety of causes such as few essence, azoospermia cause reaches certain treatment and the obvious effect of improvement.
In order to achieve the above object, the present invention adopts following technical scheme:
The invention provides a kind of Chinese medicine composition for the treatment of sterility and infertility, comprise following crude drug: Semen Cuscutae, Herba Epimedii, Fructus Lycii, Herba Cistanches, Radix Codonopsis, Rhizoma Dioscoreae, Poria, Cornu Cervi tablet, Fructus Rubi, Rhizoma Cyperi, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Moutan, Radix Rehmanniae Preparata, Radix Glycyrrhizae.
The weight portion of each crude drug is: Semen Cuscutae 10-30 part, Herba Epimedii 10-30 part, Fructus Lycii 10-30 part, Herba Cistanches 10-30 part, Radix Codonopsis 7-17 part, Rhizoma Dioscoreae 5-15 part, Poria 7-17 part, Cornu Cervi tablet 3-11 part, Fructus Rubi 7-17 part, Rhizoma Cyperi 7-17 part, Radix Bupleuri 3-11 part, Radix Paeoniae Alba 7-17 part, Radix Angelicae Sinensis 5-15 part, Cortex Moutan 3-11 part, Radix Rehmanniae Preparata 3-11 part, Radix Glycyrrhizae 3-11 part.
Preferably, the weight portion of each crude drug is: Semen Cuscutae 15-25 part, Herba Epimedii 15-25 part, Fructus Lycii 15-25 part, Herba Cistanches 15-25 part, Radix Codonopsis 10-14 part, Rhizoma Dioscoreae 8-12 part, Poria 10-14 part, Cornu Cervi tablet 6-10 part, Fructus Rubi 10-14 part, Rhizoma Cyperi 10-14 part, Radix Bupleuri 6-10 part, Radix Paeoniae Alba 10-14 part, Radix Angelicae Sinensis 8-12 part, Cortex Moutan 6-10 part, Radix Rehmanniae Preparata 6-10 part, Radix Glycyrrhizae 6-10 part.
Preferred, the weight portion of each crude drug is: 20 parts of Semen Cuscutae, 20 parts of Herba Epimedii, 20 parts of Fructus Lycii, 20 parts of Herba Cistanches, 12 parts of Radix Codonopsis, 10 parts of Rhizoma Dioscoreaes, 12 parts in Poria, 8 parts of Cornu Cervi tablets, 12 parts of Fructus Rubies, 12 parts of Rhizoma Cyperis, 8 parts of Radix Bupleuri, 12 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 8 parts of Cortex Moutans, 8 parts of Radix Rehmanniae Preparata, 8 parts in Radix Glycyrrhizae.
Chinese medicine composition compatibility of the present invention is reasonable, with Semen Cuscutae, Herba Cistanches, Herba Epimedii, Cornu Cervi tablet, kidney invigorating and YANG supporting, promotes genitals's growth in the prescription, the secretion of nursing one's health various endocrine hormones is normal, with Fructus Lycii, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, nourishing kidney yin, tonifying both YIN and YANG is with Radix Codonopsis, Rhizoma Dioscoreae, Poria invigorating the spleen and benefiting QI, the spleen of mending the day after tomorrow is with hemopoietic, the essence and blood common source, the blood of refining, blood essence, therefore spleen reinforcing is the source of benefiting essence-blood, can play and mend the day after tomorrow to give birth to inborn effect.With Radix Bupleuri, Rhizoma Cyperi, Radix Paeoniae Alba depressed liver-energy dispersing and QI regulating, along its soothing the liver, because of infertility is all easy in asking son anxious generally, unsuccessful, the diseases such as puzzled or unhappy restless with anxiety of being worried of feelings will appear.Enrich blood with Radix Angelicae Sinensis, the Radix Paeoniae Alba and to invigorate blood circulation, make tonify without causing stagnation.In addition simply, can go into bloodization and stagnate, can divide the volt fire by saturating clearly the moon again, and the product of anti-temperature compensation help fire too far, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription with Cortex Moutan.
The used crude drug of the present invention all can be bought from common Chinese material shop and obtain, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any oral formulations commonly used or external preparation, wherein, described oral formulations can be pill, capsule, tablet, powder, granule etc., is preferably pill; Described external preparation can be emplastrum, suppository, sunken cord etc.
The first method of preparation pharmaceutical composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion: Semen Cuscutae 10-30 part, Herba Epimedii 10-30 part, Fructus Lycii 10-30 part, Herba Cistanches 10-30 part, Radix Codonopsis 7-17 part, Rhizoma Dioscoreae 5-15 part, Poria 7-17 part, Cornu Cervi tablet 3-11 part, Fructus Rubi 7-17 part, Rhizoma Cyperi 7-17 part, Radix Bupleuri 3-11 part, Radix Paeoniae Alba 7-17 part, Radix Angelicae Sinensis 5-15 part, Cortex Moutan 3-11 part, Radix Rehmanniae Preparata 3-11 part, Radix Glycyrrhizae 3-11 part;
(2) said medicine is ground to form fine powder after, mix to be placed on and add water in the marmite and do not have powder, soak and use slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, decoct altogether three times, merge three decocting liquids and filter, behind adding preparation adjuvant commonly used or the carrier, preparations shaping obtains pill, capsule or tablet.
The second method of preparation pharmaceutical composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion: Semen Cuscutae 10-30 part, Herba Epimedii 10-30 part, Fructus Lycii 10-30 part, Herba Cistanches 10-30 part, Radix Codonopsis 7-17 part, Rhizoma Dioscoreae 5-15 part, Poria 7-17 part, Cornu Cervi tablet 3-11 part, Fructus Rubi 7-17 part, Rhizoma Cyperi 7-17 part, Radix Bupleuri 3-11 part, Radix Paeoniae Alba 7-17 part, Radix Angelicae Sinensis 5-15 part, Cortex Moutan 3-11 part, Radix Rehmanniae Preparata 3-11 part, Radix Glycyrrhizae 3-11 part;
(2) the above-mentioned raw materials medicine is put into adding Oleum Sesami immersion in the iron pan; Oleum Sesami is heated to 120 degrees centigrade with high heat, the heating of reuse slow fire is exploded to pitchy up to crude drug, and one pinches when being broken, and it is clean to pull crude drug out filter; Medicine oil is poured in the conventional plaster substrate, stirred, be cooled to 60 degrees centigrade, put into the cold water releasing fire-toxin, will spread out then on cotton, get emplastrum from fire.
The third method of preparation pharmaceutical composition of the present invention may further comprise the steps:
(1) takes by weighing each crude drug by described weight portion: Semen Cuscutae 10-30 part, Herba Epimedii 10-30 part, Fructus Lycii 10-30 part, Herba Cistanches 10-30 part, Radix Codonopsis 7-17 part, Rhizoma Dioscoreae 5-15 part, Poria 7-17 part, Cornu Cervi tablet 3-11 part, Fructus Rubi 7-17 part, Rhizoma Cyperi 7-17 part, Radix Bupleuri 3-11 part, Radix Paeoniae Alba 7-17 part, Radix Angelicae Sinensis 5-15 part, Cortex Moutan 3-11 part, Radix Rehmanniae Preparata 3-11 part, Radix Glycyrrhizae 3-11 part;
(2) said medicine is ground to form fine powder after, mix to be placed on and add water in the marmite and do not have powder, soak and use slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, decoct altogether three times, merge three decocting liquids and filter, high temperature sterilize then, be cut into No. 0 catgut three days of 1.5 ~ 2cm with the immersion of this filtrate, No. 0 catgut that will soak more at last was placed in 75% the alcoholic solution sterilization 30 minutes, promptly got described sunkening cord.
Usage and consumption: the dosage of medicine of the present invention depends on concrete dosage form, and factor such as age of patient, body weight, health status.As guidance: (1) pill, each 6 grams, 3 times on the one.(2) emplastrum: every subsides 20 grams, be affixed on SHENYU acupoint, MINGMEN acupoint, Guanyuan acupoint, QIHAI acupoint, SANYINJIAO acupoint, Zhishi cave, the tsusanli acupoint, TAICHONG acupoint, select 2～3 in cave at every turn, paste in every cave one, changed once in three days, and 4 times is a course of treatment, 2 courses of treatment of concurrence, had a rest at interval per course of treatment 20 days.(3) sunken cord: SHENYU acupoint is selected at the acupuncture point, MINGMEN acupoint, Guanyuan acupoint, QIHAI acupoint, SANYINJIAO acupoint, the Zhishi cave, the tsusanli acupoint, TAICHONG acupoint, select 2 ~ 3 in cave with annotating collimation method at every turn, local anaesthesia behind the routine disinfection, penetrate 1.5 ~ 2 centimetres of No. 0 catguts after the herbal medicine immersion sterilization with No. 12 lumbar puncture needle cannula, the acupuncture point is thrust at the place fast on local anaesthesia skin mound, after bringing about the desired sensation, the hand-manipulating of needle imbeds catgut, push a moment with aseptic dry cotton ball, the external application adhesive bandage, during sunkening cord in 3 ~ 5 days the part can not get wet, in case infect, 2 weeks 1 time, 4 times is a course of treatment, 2 courses of treatment of concurrence, has a rest at interval per course of treatment 20 days.Illustrate: the selected acupuncture point of the present invention consists of shen shu, the gate of vitality, cv, Qihai, sp 6, Zhishi, tsu san li, Tai Chong.Wherein, dash very much and be the defeated cave of liver channel of foot-Jueyin, source points, the effect with depressed liver-energy dispersing and QI regulating, has reinforcing spleen and kidney, the effect of training unit benefit essence at shen shu, Zhishi, the gate of vitality, cv, Qihai.The meeting sp 6 of foot three the moon, traffic liver,spleen,kidney three dirty, the deficient of liver,spleen,kidney mended in uniting of benefit, nurse one's health the equilibrium between yin and yang of three warps, tsu san li is the strong cave of wanting of body, has benefiting QI and nourishing blood, spleen invigorating tonify deficiency, sets upright the merit of training unit, so all caves are harmonious, have the kidney invigorating unit, benefiting essence-blood, kidney-Yang invigorating, soothing the liver strongly fragrant, regulate yin-yang, qi and blood circulation promotion and all disease spontaneous recovery.Chinese medicine composition of the present invention cooperates acupoint thread-embedding therapy, multiple stimulation effect by acupuncture, medicinal catgut, and after catgut imbeds the acupuncture point as foreign protein, in it liquefies the process that absorbs gradually, can produce comparatively persistent optimal stimulation to acupuncture points on the human body, make the effect of acupuncture points on the human body, more outstanding.
It is raw material that Chinese medicine composition of the present invention is all selected natural Chinese medicine for use, utilize the comprehensive function of Chinese medicine and the meridians of catgut implantation at acupoint to stimulate, promote that genital orgnas,male's growth is perfect thereby play, adjust various endocrine hormones and make it secretion normally, improve blood circulation, improve women's hypothalamus--hypophysis---ovary and luteal function regulated menstrual cycle of female, promotes ovary to ovulate normally.Regulate the normal secretion of the sex hormone level of male's hypothalamus--hypophysis---testis axle system, promote the formation of male testical growth and sperm, to men and women's endocrine regulation, luteal phase defect, do not ovulate, sterility and infertility that a variety of causes such as few essence, azoospermia cause all has precise effects.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage of the present invention and characteristics will be more clear along with description.But these embodiment only are exemplary, scope of the present invention are not constituted any restriction.It will be understood by those skilled in the art that and down can make amendment or replace without departing from the spirit and scope of the present invention, but these modifications and replacing all fall within the scope of protection of the present invention the details of technical solution of the present invention and form.
The preparation of embodiment 1 pill
(1) takes by weighing each crude drug by following weight: Semen Cuscutae 15g, Herba Epimedii 15g, Fructus Lycii 15g, Herba Cistanches 15g, Radix Codonopsis 7g, Rhizoma Dioscoreae 5g, Poria 7g, Cornu Cervi tablet 3g, Fructus Rubi 7g, Rhizoma Cyperi 7g, Radix Bupleuri 3g, Radix Paeoniae Alba 7g, Radix Angelicae Sinensis 5g, Cortex Moutan 3g, Radix Rehmanniae Preparata 3g, Radix Glycyrrhizae 3g;
(2) said medicine is mixed be placed on and adds water in the marmite and do not have powder, soak slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, merge three decocting liquids and filter, add preparation adjuvant commonly used or carrier after, preparations shaping obtains pill.
The preparation of embodiment 2 pills
(1) takes by weighing each crude drug by following weight: Semen Cuscutae 25g, Herba Epimedii 25g, Fructus Lycii 25g, Herba Cistanches 25g, Radix Codonopsis 17g, Rhizoma Dioscoreae 15g, Poria 17g, Cornu Cervi tablet 11g, Fructus Rubi 17g, Rhizoma Cyperi 17g, Radix Bupleuri 11g, Radix Paeoniae Alba 17g, Radix Angelicae Sinensis 15g, Cortex Moutan 11g, Radix Rehmanniae Preparata 11g, Radix Glycyrrhizae 11g;
(2) said medicine is mixed be placed on and adds water in the marmite and do not have powder, soak slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, merge three decocting liquids and filter, add preparation adjuvant commonly used or carrier after, preparations shaping obtains pill.
The preparation of embodiment 3 emplastrumes
(1) takes by weighing each crude drug by following weight: Semen Cuscutae 10g, Herba Epimedii 10g, Fructus Lycii 10g, Herba Cistanches 10g, Radix Codonopsis 10g, Rhizoma Dioscoreae 8g, Poria 10g, Cornu Cervi tablet 6g, Fructus Rubi 10g, Rhizoma Cyperi 10g, Radix Bupleuri 6g, Radix Paeoniae Alba 10g, Radix Angelicae Sinensis 8g, Cortex Moutan 6g, Radix Rehmanniae Preparata 6g, Radix Glycyrrhizae 6g;
(2) the above-mentioned raw materials medicine is put into adding Oleum Sesami immersion in the iron pan; Oleum Sesami is heated to 120 degrees centigrade with high heat, the heating of reuse slow fire is exploded to pitchy up to crude drug, and one pinches when being broken, and it is clean to pull crude drug out filter; Medicine oil is poured in the conventional plaster substrate, stirred, be cooled to 60 degrees centigrade, put into the cold water releasing fire-toxin, will spread out then on cotton, get emplastrum from fire.
The preparation that embodiment 4 sunkens cord
(1) takes by weighing each crude drug by following weight: Semen Cuscutae 20g, Herba Epimedii 20g, Fructus Lycii 20g, Herba Cistanches 20g, Radix Codonopsis 12g, Rhizoma Dioscoreae 10g, Poria 12g, Cornu Cervi tablet 8g, Fructus Rubi 12g, Rhizoma Cyperi 12g, Radix Bupleuri 8g, Radix Paeoniae Alba 12g, Radix Angelicae Sinensis 10g, Cortex Moutan 8g, Radix Rehmanniae Preparata 8g, Radix Glycyrrhizae 8g;
(2) said medicine is mixed be placed on and add water in the marmite and do not have powder, soak slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, merging three decocting liquids filters, high temperature sterilize then, be cut into 1.5 ~ 2 centimetres No. 0 catgut three days with the immersion of this filtrate, No. 0 catgut that will soak more at last was placed in 75% the alcoholic solution sterilization 30 minutes, promptly got described sunkening cord.
The preparation that embodiment 5 sunkens cord
(1) takes by weighing each crude drug by following weight: Semen Cuscutae 30g, Herba Epimedii 30g, Fructus Lycii 30g, Herba Cistanches 30g, Radix Codonopsis 14g, Rhizoma Dioscoreae 12g, Poria 14g, Cornu Cervi tablet 10g, Fructus Rubi 14g, Rhizoma Cyperi 14g, Radix Bupleuri 10g, Radix Paeoniae Alba 14g, Radix Angelicae Sinensis 12g, Cortex Moutan 10g, Radix Rehmanniae Preparata 10g, Radix Glycyrrhizae 10g;
(2) said medicine is mixed be placed on and add water in the marmite and do not have powder, soak slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, merging three decocting liquids filters, high temperature sterilize then, be cut into 1.5 ~ 2 centimetres No. 0 catgut three days with the immersion of this filtrate, No. 0 catgut that will soak more at last was placed in 75% the alcoholic solution sterilization 30 minutes, promptly got described sunkening cord.
The clinical efficacy of the infertility that test example 1 medicine composite for curing endocrine regulation of the present invention and sexual inadequacy cause is summed up
Through 1999 to 2003 in the period of, age with medicine composite for curing sterility and infertility men and women of the present invention is not waited from 23 years old by 35 years old, it is multiple that it causes the reason of sterility and infertility to have, mainly comprise female menstrual disorder, endocrine regulation, ovarian dysfunction, cervical mucus is unusual, luteal function is unsound, habitual abortion; The locking that male's vas deferens, ejaculatory duct, epididymal duct cause because of deformity, inflammation or block, varicocele, reason such as sperm quantity is few, and motility of sperm is weak.
According to the difference of disease, adopt differentiation of tcm, the oral agents that can adopt pharmaceutical composition of the present invention for example pill is treated each 6 grams, 3 times on the one; Can also adopt the emplastrum of pharmaceutical composition of the present invention to treat, every subsides 20 grams, be affixed on shen shu, the gate of vitality, cv, Qihai, sp 6, Zhishi, tsu san li, Tai Chong, select 2～3 in cave at every turn, paste in every cave one, changed once in three days, and 4 times is a course of treatment, 2 courses of treatment of concurrence, had a rest at interval per course of treatment 20 days; The preferred acupuncture therapy of sunkening cord that adopts pharmaceutical composition of the present invention, the acupuncture point comprises: shen shu, the gate of vitality, cv, Qihai, sp 6, Zhishi, tsu san li, dash very much, select 2 ~ 3 in cave with annotating collimation method at every turn, local anaesthesia behind the routine disinfection, penetrate 1.5 ~ 2 centimetres of No. 0 catguts after the herbal medicine immersion sterilization with No. 12 lumbar puncture needle cannula, the acupuncture point is thrust at the place fast on local anaesthesia skin mound, imbed catgut after the hand-manipulating of needle is brought about the desired sensation, push a moment, external application adhesive bandage with aseptic dry cotton ball, during sunkening cord in 3 ~ 5 days the part can not get wet, in case infect, 2 weeks 1 time, 4 times is a course of treatment, 2 courses of treatment of concurrence, had a rest at interval per course of treatment 20 days.Also can adopt oral, external merging therapy.
Curative effect determinate standard: become pregnant and can keep 4 no spontaneous abortions for curing in the wife's side; Have only the ovulation reaction not have and become pregnant, or pregnant back spontaneous abortion is effective; The anovulation reaction is for invalid.Wherein treat male infertility patients with infertility 136 examples, cure 92 examples, effective 37 examples, invalid 7 examples, effective percentage is 94.8%; Treatment female acyesis and aphoria patient 32 examples are cured 21 examples, effective 8 examples, and invalid 3 examples, effective percentage is 90.17%.
Clinical model case:
1, Lee, the woman, 24 years old, people from Kaifeng, Henan Province, married 5 years unpregnancies, the eumenorrhea, measure mediumly, through examination in hospital right side fallopian tube elongate curved, the left side obstruction of fallopian tube carries out all successes of hydrotubation for twice.Its lover's semen efamination is in normal range.Lee began to take medicine (during cooperate sunken cord acupuncture therapy) from April, 2002, confirm in July, 2002 pregnant, natural labor in May, 2,003 one girl baby.
2, Wang, man, 30 years old, the office worker of Hunan Province department store.Sterile for many years after marriage, suffer from low sperm activity, first checks that sperm concentration is normal, sperm motility is 15%, seriously condenses, and checks after the course of treatment of taking medicine to reach 45%, continues medication treatment, when carrying out semen efamination for the third time after two months, recovers normal fully.Inform its wife conceived 2 months after half a year.
3, bent certain, woman, 25 years old, Mt. Huang in Anhui people from city, twice pregnancy after marriage miscarried because of busy, wants to give birth to child after 2000, with many methods all do not have effect through how tame hospital therapy, adopt pill of the present invention to cooperate two courses of treatment of emplastrum, inferior annual output one girl.
4, Zhao, the woman, 30 years old, married 4 years unpregnancies, menstruation is undesired, through examination in hospital ooecium is arranged but does not have ovum.Bridegroom's or husband's side sperm survival rate 50% does not also belong to normal range, and both sides treat simultaneously, and the result is undesirable.From March two in 2000 people take this medicine simultaneously check (wife's side cooperate sunken cord acupuncture therapy) to January calendar year 2001 pregnant, natural labor one boy baby at the bottom of calendar year 2001.
5, model, man, 35 years old, the Anqing people suffers from sexual impotence, premature ejaculation, alopecia, cold perspiration, absentminded, limbs fatigue, can not cross normality life after marriage, adopt course of treatment of emplastrum, the state of an illness takes a favorable turn, continue to paste with a course of treatment, all symptom complete obiterations, energetic, from then on cross and go up happy life.
Clinical test results shows, pharmaceutical composition of the present invention is for endocrine regulation, luteal phase defect, do not ovulate, various sexual inadequacy diseases such as few essence, azoospermia all have precise effects, any toxicity is not seen in clinical observation, and medicine drug safety of the present invention is described.
Claims (9)
1. a Chinese medicine composition for the treatment of infertility is characterized in that each crude drug and parts by weight thereof are: Semen Cuscutae 10-30 part, Herba Epimedii 10-30 part, Fructus Lycii 10-30 part, Herba Cistanches 10-30 part, Radix Codonopsis 7-17 part, Rhizoma Dioscoreae 5-15 part, Poria 7-17 part, Cornu Cervi tablet 3-11 part, Fructus Rubi 7-17 part, Rhizoma Cyperi 7-17 part, Radix Bupleuri 3-11 part, Radix Paeoniae Alba 7-17 part, Radix Angelicae Sinensis 5-15 part, Cortex Moutan 3-11 part, Radix Rehmanniae Preparata 3-11 part, Radix Glycyrrhizae 3-11 part.
2. according to the Chinese medicine composition of the described treatment infertility of claim 1, it is characterized in that the weight portion of each crude drug is: Semen Cuscutae 15-25 part, Herba Epimedii 15-25 part, Fructus Lycii 15-25 part, Herba Cistanches 15-25 part, Radix Codonopsis 10-14 part, Rhizoma Dioscoreae 8-12 part, Poria 10-14 part, Cornu Cervi tablet 6-10 part, Fructus Rubi 10-14 part, Rhizoma Cyperi 10-14 part, Radix Bupleuri 6-10 part, Radix Paeoniae Alba 10-14 part, Radix Angelicae Sinensis 8-12 part, Cortex Moutan 6-10 part, Radix Rehmanniae Preparata 6-10 part, Radix Glycyrrhizae 6-10 part.
3. according to the Chinese medicine composition of the described treatment infertility of claim 2, it is characterized in that the weight portion of each crude drug is: 20 parts of Semen Cuscutae, 20 parts of Herba Epimedii, 20 parts of Fructus Lycii, 20 parts of Herba Cistanches, 12 parts of Radix Codonopsis, 10 parts of Rhizoma Dioscoreaes, 12 parts in Poria, 8 parts of Cornu Cervi tablets, 12 parts of Fructus Rubies, 12 parts of Rhizoma Cyperis, 8 parts of Radix Bupleuri, 12 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 8 parts of Cortex Moutans, 8 parts of Radix Rehmanniae Preparata, 8 parts in Radix Glycyrrhizae.
4. each described Chinese medicine composition of claim 1-3 is characterized in that: be prepared into any suitable clinically preparation according to Chinese medicine conventional formulation method.
5. according to the described Chinese medicine composition of claim 4, it is characterized in that: described preparation is oral formulations or external preparation; Described oral formulations is pill, capsule, tablet, powder or granule; Described external preparation is emplastrum or sunkens cord.
6. method for preparing each described Chinese medicine composition of claim 1-3 comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) said medicine is ground to form fine powder after, mix to be placed on and add water in the marmite and do not have powder, soak and use slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, decoct altogether three times, merge three decocting liquids and filter, behind the adding preparation adjuvant commonly used, preparations shaping obtains pill, capsule or tablet.
7. method for preparing each described Chinese medicine composition of claim 1-3 comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) each crude drug is put into adding Oleum Sesami immersion in the iron pan; Oleum Sesami is heated to 120 degrees centigrade with high heat, the heating of reuse slow fire is exploded to pitchy up to crude drug, and one pinches when being broken, and it is clean to pull crude drug out filter; Medicine oil is poured in the conventional plaster substrate, stirred, be cooled to 60 degrees centigrade, put into the cold water releasing fire-toxin, spread out then on cotton, get emplastrum from fire.
8. method for preparing each described Chinese medicine composition of claim 1-3 comprises:
(1) takes by weighing each crude drug by described weight portion;
(2) said medicine is ground to form fine powder after, mix to be placed on and add water in the marmite and do not have powder, soak and use slow fire boiling after 20 ~ 40 minutes, renew after boiling and fry in shallow oil 30 minutes, decoct altogether three times, merge three decocting liquids and filter, high temperature sterilize then, be cut into No. 0 catgut three days of 1.5 ~ 2cm with the immersion of this filtrate, No. 0 catgut that will soak more at last was placed in 75% the alcoholic solution sterilization 30 minutes, promptly got and sunken cord.
9. the purposes of each described Chinese medicine composition of claim 1-3 in the medicine of infertility due to preparation treatment endocrine regulation, the sexual inadequacy.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102579751B (en) * | 2012-03-23 | 2013-08-28 | 曹思亮 | Plaster for treating female infertility |
| CN102908517A (en) * | 2012-10-11 | 2013-02-06 | 赵子山 | Chinese medicine composition for curing oligospermia and asthenozoospermia and preparation method of Chinese medicine composition |
| CN105232775A (en) * | 2015-11-05 | 2016-01-13 | 宋春生 | Medicine for treating varicocele |
| CN105833195A (en) * | 2016-05-20 | 2016-08-10 | 黄雨恢 | Traditional Chinese medicine composition for treating infertility due to luteal phase deficiency and preparation method |
| CN105999104A (en) * | 2016-07-11 | 2016-10-12 | 姚伊 | Pharmaceutical composition for improving infertility caused by endocrine disturbance |
| CN106692816A (en) * | 2017-01-03 | 2017-05-24 | 陈丽 | Traditional Chinese medicine preparation for treating male and female sterility |
| CN108434295A (en) * | 2018-05-10 | 2018-08-24 | 烟台金蕊女性用品有限公司 | A kind of Chinese medicine preparation and technique nourishing ovary |
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