CN101646669B - 嘌呤基衍生物及其作为钾通道调节剂的用途 - Google Patents
嘌呤基衍生物及其作为钾通道调节剂的用途 Download PDFInfo
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- CN101646669B CN101646669B CN2008800099645A CN200880009964A CN101646669B CN 101646669 B CN101646669 B CN 101646669B CN 2008800099645 A CN2008800099645 A CN 2008800099645A CN 200880009964 A CN200880009964 A CN 200880009964A CN 101646669 B CN101646669 B CN 101646669B
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- phenyl
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- pyrazol
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- 0 CC(C)(*)CC(C)(C)*c1nc(*)nc(nc2)c1[n]2I Chemical compound CC(C)(*)CC(C)(C)*c1nc(*)nc(nc2)c1[n]2I 0.000 description 1
- YEWYZXBTUJUIMT-UHFFFAOYSA-N C[n](cn1)c(c(NC2CCCCC2)n2)c1nc2Cl Chemical compound C[n](cn1)c(c(NC2CCCCC2)n2)c1nc2Cl YEWYZXBTUJUIMT-UHFFFAOYSA-N 0.000 description 1
- KLQQIOCMFLQRKU-UHFFFAOYSA-N C[n]1c2nc(Cl)nc(NCCc3ccccc3)c2nc1 Chemical compound C[n]1c2nc(Cl)nc(NCCc3ccccc3)c2nc1 KLQQIOCMFLQRKU-UHFFFAOYSA-N 0.000 description 1
- IVZJKPUNBLSGOH-UHFFFAOYSA-N Cc([n](-c1nc(Nc(cc2)ccc2Cl)c2nc[n](C)c2n1)nc1C)c1Cl Chemical compound Cc([n](-c1nc(Nc(cc2)ccc2Cl)c2nc[n](C)c2n1)nc1C)c1Cl IVZJKPUNBLSGOH-UHFFFAOYSA-N 0.000 description 1
- KFXJAONTTAGDMF-UHFFFAOYSA-N Cc(cc1CO)n[n]1-c1nc(Nc(cc2)ccc2Cl)c2nc[n](C)c2n1 Chemical compound Cc(cc1CO)n[n]1-c1nc(Nc(cc2)ccc2Cl)c2nc[n](C)c2n1 KFXJAONTTAGDMF-UHFFFAOYSA-N 0.000 description 1
- HKLGPONAUCIKNP-UHFFFAOYSA-N Cc1cc(-c2ccccc2)n[n]1-c1nc(Nc(cc2)ccc2Cl)c2nc[n](C)c2n1 Chemical compound Cc1cc(-c2ccccc2)n[n]1-c1nc(Nc(cc2)ccc2Cl)c2nc[n](C)c2n1 HKLGPONAUCIKNP-UHFFFAOYSA-N 0.000 description 1
- BQXNAWLDYCXWNU-UHFFFAOYSA-N Cc1cc(C(F)(F)F)n[n]1-c(nc1Nc(cc2)ccc2Cl)nc2c1nc[n]2C Chemical compound Cc1cc(C(F)(F)F)n[n]1-c(nc1Nc(cc2)ccc2Cl)nc2c1nc[n]2C BQXNAWLDYCXWNU-UHFFFAOYSA-N 0.000 description 1
- FCHDAFWIYTYUTH-UHFFFAOYSA-N Cc1cc(C)n[n]1-c1nc(Nc(cc2)ccc2F)c2nc[n](C)c2n1 Chemical compound Cc1cc(C)n[n]1-c1nc(Nc(cc2)ccc2F)c2nc[n](C)c2n1 FCHDAFWIYTYUTH-UHFFFAOYSA-N 0.000 description 1
- PBHFDUNUQBRNOP-UHFFFAOYSA-N Cc1cc(C)n[n]1-c1nc(Sc(cc2)ccc2Cl)c2nc[n](C)c2n1 Chemical compound Cc1cc(C)n[n]1-c1nc(Sc(cc2)ccc2Cl)c2nc[n](C)c2n1 PBHFDUNUQBRNOP-UHFFFAOYSA-N 0.000 description 1
- VBKNPSYHKKJAFB-UHFFFAOYSA-N O=CNc1ccc(C(F)(F)F)cc1 Chemical compound O=CNc1ccc(C(F)(F)F)cc1 VBKNPSYHKKJAFB-UHFFFAOYSA-N 0.000 description 1
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90850307P | 2007-03-28 | 2007-03-28 | |
| DKPA200700482 | 2007-03-28 | ||
| DKPA200700482 | 2007-03-28 | ||
| US60/908,503 | 2007-03-28 | ||
| PCT/EP2008/053648 WO2008116909A1 (en) | 2007-03-28 | 2008-03-27 | Purinyl derivatives and their use as potassium channel modulators |
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| JP2010522719A (ja) * | 2007-03-28 | 2010-07-08 | ノイロサーチ アクティーゼルスカブ | プリニル誘導体及びカリウムチャネルモジュレーターとしてのそれらの使用 |
| EP2132208A1 (en) * | 2007-03-28 | 2009-12-16 | NeuroSearch AS | Purinyl derivatives and their use as potassium channel modulators |
| WO2009037247A1 (en) | 2007-09-17 | 2009-03-26 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| JP2011521968A (ja) * | 2008-05-30 | 2011-07-28 | ジェネンテック, インコーポレイテッド | プリンpi3k阻害剤化合物および使用方法 |
| CN102177154A (zh) * | 2008-09-02 | 2011-09-07 | 神经研究公司 | 吡唑基-嘧啶衍生物及其作为钾通道调节剂的应用 |
| EP2344501A1 (en) * | 2008-09-26 | 2011-07-20 | NeuroSearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| WO2010034707A1 (en) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| EP2414365B1 (en) | 2009-04-01 | 2013-12-25 | Aniona ApS | SUBSTITUTED [1,2,4¨TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS |
| EP2438069A1 (en) | 2009-04-01 | 2012-04-11 | NeuroSearch A/S | Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators |
| AR079814A1 (es) | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos |
| JP6121658B2 (ja) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | 治療用化合物、及び関連する使用の方法 |
| CA2876780A1 (en) | 2012-06-26 | 2014-01-03 | Saniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| HK1217695A1 (zh) * | 2013-03-05 | 2017-01-20 | F. Hoffmann-La Roche Ag | 布鲁顿氏酪氨酸激酶抑制剂 |
| CA2903925A1 (en) * | 2013-03-06 | 2014-09-12 | Bayer Pharma Aktiengesellschaft | Substituted thiazolopyrimidines |
| CN106458918B (zh) * | 2014-06-11 | 2019-07-09 | 拜耳作物科学股份公司 | 经由酮亚胺的酰化来制备3,5-双(卤代烷基)吡唑的方法 |
| AU2017275657B2 (en) | 2016-06-02 | 2021-08-19 | Novartis Ag | Potassium channel modulators |
| EP3528816A4 (en) * | 2016-10-21 | 2020-04-08 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| PL3571193T3 (pl) | 2017-01-23 | 2022-04-25 | Cadent Therapeutics, Inc. | Modulatory kanału potasowego |
| FR3066761B1 (fr) | 2017-05-23 | 2020-10-30 | Centre Nat Rech Scient | Nouveaux composes inhibiteurs des canaux ioniques |
| CN107698500A (zh) * | 2017-10-17 | 2018-02-16 | 扬子江药业集团四川海蓉药业有限公司 | 一种奈妥匹坦的制备方法 |
| EP3870291A1 (en) | 2018-10-22 | 2021-09-01 | Cadent Therapeutics, Inc. | Crystalline forms of potassium channel modulators |
| CN116178374B (zh) * | 2023-01-13 | 2024-10-08 | 河北医科大学 | 小电导钙激活钾离子通道激动剂及其合成和应用 |
| CN119684293A (zh) * | 2024-11-25 | 2025-03-25 | 山东第一医科大学(山东省医学科学院) | 嘌呤类化合物及其在制备防治脑衰老药物中的应用 |
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Also Published As
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| RU2468026C2 (ru) | 2012-11-27 |
| EP2402341A2 (en) | 2012-01-04 |
| EP2402341A3 (en) | 2014-11-12 |
| BRPI0808746B8 (pt) | 2021-05-25 |
| BRPI0808746B1 (pt) | 2020-09-24 |
| US20100105705A1 (en) | 2010-04-29 |
| JP2010522719A (ja) | 2010-07-08 |
| EP2402341B1 (en) | 2017-10-25 |
| KR101564233B1 (ko) | 2015-10-29 |
| JP2010522721A (ja) | 2010-07-08 |
| JP2010522718A (ja) | 2010-07-08 |
| NZ579248A (en) | 2011-08-26 |
| ZA200905796B (en) | 2010-10-27 |
| UA98482C2 (ru) | 2012-05-25 |
| JP2010522722A (ja) | 2010-07-08 |
| KR20100014648A (ko) | 2010-02-10 |
| BRPI0808746A2 (pt) | 2014-08-19 |
| CN101646669A (zh) | 2010-02-10 |
| US20120004246A1 (en) | 2012-01-05 |
| JP2010522720A (ja) | 2010-07-08 |
| JP5703432B2 (ja) | 2015-04-22 |
| RU2009132881A (ru) | 2011-05-10 |
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