CN101642533A - Traditional Chinese medicine preparation capable of enhancing SOD activity and lowering MDA content - Google Patents
Traditional Chinese medicine preparation capable of enhancing SOD activity and lowering MDA content Download PDFInfo
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- CN101642533A CN101642533A CN200910169013A CN200910169013A CN101642533A CN 101642533 A CN101642533 A CN 101642533A CN 200910169013 A CN200910169013 A CN 200910169013A CN 200910169013 A CN200910169013 A CN 200910169013A CN 101642533 A CN101642533 A CN 101642533A
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- caulis bambusae
- taenia
- fructus
- radix astragali
- chinese medicine
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Abstract
The invention belongs to the technical field of the processing of health-care foods, which relates to a traditional Chinese medicine preparation which is prepared by taking astragalus root, tangerinepeel, caulis bambusae in taenian, hawthorn, Chinese date and the like as raw materials and can enhance SOD activity and lower MDA content. 9g of astragalus root, 3g of tangerine peel, 5g of caulis bambusae in taenian, 3g of hawthorn, 5g of Chinese date and the like are washed and dried, and effective components are extracted after being pulverized, bottled and sealed for standby application. The product can be used for the rehabilitation of a patient with radioactive and chemical treatment after tumour prevention or tumour operation, and the invention is beneficial to industrialized production.
Description
Technical field
Health food processing technique field under the present invention, the present invention relates to the Radix Astragali, Pericarpium Citri tangerinae, Caulis Bambusae In Taenia, Fructus Crataegi, Fructus Jujubaes etc. are a kind of SOD (superoxide dismutase that can improve of feedstock production, Superoxide Dismutase) vigor, reduce MDA (malonaldehyde, Malondialdehyde) Chinese medicine preparation of content, with Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g etc. clean, dry, pulverize the back and extract active component, bottling, sealing back is standby, and product of the present invention can be used for chemicotherapy rehabilitation of patients behind prophylaxis of tumours or the tumor operation, and the present invention is beneficial to suitability for industrialized production.
Background technology
The generation development of oxygen-derived free radicals and lipid peroxidation and tumor has confidential relation.SOD (superoxide dismutase; Superoxide Dismutase) is one of the scavenger of oxygen-derived free radicals active oxygen in the body; can eliminate oxygen-derived free radicals by catalysis and play the obstruction oxygen production, suppress the generation of lipid peroxide, the normal function of protection cell.(malonaldehyde is the end product of the peroxide of lipid peroxidation generation Malondialdehyde) to MDA, and its content usually reflects the body cell level of lipid peroxidation, and also the indirect reaction cell is subjected to the order of severity that free radical is attacked.
The present invention relates to the Radix Astragali, Pericarpium Citri tangerinae, Caulis Bambusae In Taenia, Fructus Crataegi, Fructus Jujubae etc. is a kind of SOD vigor that can improve of feedstock production; reduce the Chinese medicine preparation of MDA content; suppress the generation of lipid peroxide; the normal function of protection cell; product of the present invention can be used for patient behind prophylaxis of tumours or the tumor operation; Pericarpium Citri tangerinae preventing or arresting vomiting warm in nature, Caulis Bambusae In Taenia preventing or arresting vomiting cold in nature in the side, hawthorn digesting, Fructus Jujubae spleen invigorating, chemicotherapy rehabilitation of patients behind the especially suitable tumor operation.
Summary of the invention
1. health food processing technique field under the present invention, the present invention relates to the Radix Astragali, Pericarpium Citri tangerinae, Caulis Bambusae In Taenia, Fructus Crataegi, Fructus Jujubae etc. is a kind of SOD vigor that can improve of feedstock production, reduce the Chinese medicine preparation of MDA content, with cleaning, drying such as Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g, pulverize the back and extract active component, bottling, sealing back is standby, and product of the present invention can be used for chemicotherapy rehabilitation of patients behind prophylaxis of tumours or the tumor operation, and the present invention is beneficial to suitability for industrialized production.
2. one kind can be improved the SOD vigor, reduces the Chinese medicine preparation of MDA content, it is characterized in that this technology comprises following process:
[prescription] Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g
(1) select high-quality Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g and clean, microwave drying, pulverizing is 20 orders, adds water boil and extracts 3 times, adds 8 times of water gagings first and soaks 4.0-6.0 hour, heated and boiled was extracted 2.0-3.0 hour; Add for the second time 6 times of water gaging heated and boiled and extracted 1.5-2.0 hour, add 4 times of water gaging heated and boiled for the third time and extracted 1.0-2.0 hour, merge extractive liquid, filters, and gets filtrate;
(2) concentrating filter liquor gets concentrated solution, and concentration is 0.25g/ml crude drug amount, bottling, sealing.
3. the described preparation of claim 1-2 is a kind of can improve the SOD vigor, the primary raw material that reduces the Chinese medicine preparation of MDA content is Radix Astragali Astragalus membranaceus (Fisch.) Bungede root,, Fructus Citri tangerinae Citrus reticulate Banco dry mature skin, Caulis Bambusae In Taenia be the intermediate layer of grass bambusa breviflora Munro Bambusa tuldoides Munro stem,, dry mature fruit and Fructus Jujubae Ziziphus jujuba Mill.var.inermis (Bunge) the Rehd. mature fruit of Fructus Crataegi Crataegus pinnatifida Bge..
According to the present invention, " % " among the present invention is percentage by weight.
The specific embodiment
The following examples can further specify the present invention, but do not limit the present invention in any way.
Embodiment 1:
[prescription] Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g
(1) select high-quality Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g and clean, microwave drying, pulverizing is 20 orders, adds water boil and extracts 3 times, adds 8 times of water gagings first and soaks 6.0 hours, heated and boiled was extracted 3.0 hours; Add for the second time 6 times of water gaging heated and boiled and extracted 2.0 hours, add 4 times of water gaging heated and boiled for the third time and extracted 2.0 hours, merge extractive liquid, filters, and gets filtrate;
(2) concentrating filter liquor gets concentrated solution, and concentration is 0.25g/ml crude drug amount, bottling, sealing.
Embodiment 2:
[prescription] Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g etc.
(1) select high-quality Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g and clean, microwave drying, pulverizing is 20 orders, adds water boil and extracts 3 times, adds 8 times of water gagings first and soaks 4.0 hours, heated and boiled was extracted 2.0 hours; Add for the second time 6 times of water gaging heated and boiled and extracted 1.5 hours, add 4 times of water gaging heated and boiled for the third time and extracted 1.0 hours, merge extractive liquid, filters, and gets filtrate;
(2) concentrating filter liquor gets concentrated solution, and concentration is 0.25g/ml crude drug amount, bottling, sealing.
Pharmacological testing
1 material and animal
1.1 laboratory animal and feedstuff: healthy cleaning level Kunming mouse, Shandong Luye Pharmaceutical Co., Ltd. provides, body weight 18-22g, male and female half and half (SCXK (Shandong) 20030008).Animal feed: the big feed corporation,Ltd of Jinan health (Shandong is raised to give birth to examine and stepped on word (2005) No. 0474).
1.2 be subjected to the reagent thing: Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g) fry in shallow oil into 100ml decocting liquid, concentration is 0.25g/ml crude drug amount.
SOD (superoxide dismutase) and MDA (malonaldehyde) test kit build up bio-engineering research by Nanjing and are produced, and lot number is 20090728.
1.3. experimental condition: ambient temperature: 22 ± 2 ℃, relative humidity 40-70%, animal is quarantined in feeding environment and adapts to 3d before the test.
1.4 experimental apparatus
SPN202F electronic balance (U.S. Ao Haosi), AR1140 electronic balance (U.S. Ao Haosi), 752 type ultraviolet-uisible spectrophotometers (Shanghai Spectrum Apparatus Co., Ltd.), SC-3610 low speed centrifuge (Keda Innovation Co., Ltd).
2 experimental techniques
SOD and MDA measure SOD and MDA measures according to the method for test kit.
3 experimental results
The results are shown in Table 1,2.
Table 1 male mice liver SOD, MDA value
Table 2 female mice liver SOD, MDA value
Be subjected to the reagent thing can obviously increase mouse liver SOD vigor, reduce MDA content, improve the activity of antioxidase, strengthen the ability of removing free radical, lipid peroxidation injury is reduced.
Claims (3)
1. health food processing technique field under the present invention, the present invention relates to the Radix Astragali, Pericarpium Citri tangerinae, Caulis Bambusae In Taenia, Fructus Crataegi, Fructus Jujubae etc. is a kind of SOD vigor that can improve of feedstock production, reduce the Chinese medicine preparation of MDA content, with cleaning, drying such as Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g, pulverize the back and extract active component, bottling, sealing back is standby, and product of the present invention can be used for chemicotherapy rehabilitation of patients behind prophylaxis of tumours or the tumor operation, and the present invention is beneficial to suitability for industrialized production.
2. one kind can be improved the SOD vigor, reduces the Chinese medicine preparation of MDA content, it is characterized in that this technology comprises following process:
[prescription] Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g
(1) select high-quality Radix Astragali 9g, Pericarpium Citri tangerinae 3g, Caulis Bambusae In Taenia 5g, Fructus Crataegi 3g, Fructus Jujubae 5g and clean, microwave drying, pulverizing is 20 orders, adds water boil and extracts 3 times, adds 8 times of water gagings first and soaks 4.0-6.0 hour, heated and boiled was extracted 2.0-3.0 hour; Add for the second time 6 times of water gaging heated and boiled and extracted 1.5-2.0 hour, add 4 times of water gaging heated and boiled for the third time and extracted 1.0-2.0 hour, merge extractive liquid, filters, and gets filtrate;
(2) concentrating filter liquor gets concentrated solution, bottling, sealing.
3. the described preparation of claim 1-2 is a kind of can improve the SOD vigor, the primary raw material that reduces the Chinese medicine preparation of MDA content is Radix Astragali Astragalus membranaceus (Fisch.) Bungede root, the dry mature skin of Fructus Citri tangerinae Citrus reticulate Banco, Caulis Bambusae In Taenia is the intermediate layer of grass bambusa breviflora Munro Bambusa tuldoides Munro stem, the dry mature fruit of Fructus Crataegi Crataegus pinnatifida Bge. and Fructus Jujubae Ziziphus jujuba Mill.var.inermis (Bunge) Rehd. mature fruit.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101690130A CN101642533B (en) | 2009-09-08 | 2009-09-08 | Traditional Chinese medicine preparation capable of enhancing SOD activity and lowering MDA content |
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| CN2009101690130A CN101642533B (en) | 2009-09-08 | 2009-09-08 | Traditional Chinese medicine preparation capable of enhancing SOD activity and lowering MDA content |
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| CN101642533A true CN101642533A (en) | 2010-02-10 |
| CN101642533B CN101642533B (en) | 2011-04-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000287A (en) * | 2010-11-24 | 2011-04-06 | 山东大学威海分校 | Preparation method and application of Chinese herbal medicine compound preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1268381C (en) * | 2003-11-27 | 2006-08-09 | 怀化正好制药有限公司 | Leukopenia treating Chinese traditional medicine |
| CN101167973B (en) * | 2007-10-26 | 2011-06-15 | 马万凯 | Traditional Chinese medicine for treating hyperlipemia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000287A (en) * | 2010-11-24 | 2011-04-06 | 山东大学威海分校 | Preparation method and application of Chinese herbal medicine compound preparation |
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