CN101637611A - 眼的基因治疗 - Google Patents
眼的基因治疗 Download PDFInfo
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40647002P | 2002-08-28 | 2002-08-28 | |
| US60/406,470 | 2002-08-28 |
Related Parent Applications (1)
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| CNB038231344A Division CN100526332C (zh) | 2002-08-28 | 2003-08-27 | 内皮抑制素用于生产治疗视网膜疾病药物的用途 |
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| CN101637611A true CN101637611A (zh) | 2010-02-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200910150526A Pending CN101637611A (zh) | 2002-08-28 | 2003-08-27 | 眼的基因治疗 |
| CNB038231344A Expired - Fee Related CN100526332C (zh) | 2002-08-28 | 2003-08-27 | 内皮抑制素用于生产治疗视网膜疾病药物的用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| CNB038231344A Expired - Fee Related CN100526332C (zh) | 2002-08-28 | 2003-08-27 | 内皮抑制素用于生产治疗视网膜疾病药物的用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070104684A1 (enExample) |
| EP (1) | EP1534751B1 (enExample) |
| JP (1) | JP4612417B2 (enExample) |
| CN (2) | CN101637611A (enExample) |
| AT (1) | ATE464321T1 (enExample) |
| AU (1) | AU2003258675B2 (enExample) |
| CA (1) | CA2496820A1 (enExample) |
| DE (1) | DE60332122D1 (enExample) |
| IL (1) | IL166950A (enExample) |
| NZ (1) | NZ538958A (enExample) |
| WO (1) | WO2004020469A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100475270C (zh) * | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
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| US6174861B1 (en) | 1996-10-22 | 2001-01-16 | The Children's Medical Center Corporation | Methods of inhibiting angiogenesis via increasing in vivo concentrations of endostatin protein |
| JP2001517433A (ja) * | 1997-09-24 | 2001-10-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 非霊長類レンチウイルスベクターおよびパッケージングシステム |
| US6106826A (en) * | 1997-12-17 | 2000-08-22 | Wisconsin Alumni Research Foundation | Replication competent, avirulent Herpes simplex virus as a vector for neural and ocular gene therapy |
| US6670321B1 (en) * | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
| US6267954B1 (en) * | 1999-11-24 | 2001-07-31 | Universite De Paris V Rene-Descartes | Intraocular transplantation of encapsulated cells |
| EP1280929A2 (en) * | 2000-05-01 | 2003-02-05 | Novartis AG | Vectors for ocular transduction and use thereof for genetic therapy |
| WO2001093897A2 (en) * | 2000-06-02 | 2001-12-13 | Entremed, Inc. | Angiostatin and endostatin binding proteins and methods of use |
| AU2002224403A1 (en) * | 2000-10-13 | 2002-04-22 | Entremed, Inc | Endostatin and pitslre protein kinases as angiogenesis-inhibiting peptides and method of use |
| EP1401480B1 (en) * | 2001-02-22 | 2012-11-28 | Novartis AG | Viral vectors encoding endostatin in the treatment of ocular neovascularization |
| AU2003225544A1 (en) * | 2002-02-04 | 2003-09-02 | Novartis Ag | Recombinant bovine immunodeficiency virus based gene transfer system |
| CA2480809A1 (en) * | 2002-04-11 | 2003-10-23 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
| WO2004028635A1 (en) * | 2002-09-27 | 2004-04-08 | Novartis Ag | Ocular gene therapy |
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2003
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- 2003-08-27 JP JP2004532124A patent/JP4612417B2/ja not_active Expired - Fee Related
- 2003-08-27 US US10/526,127 patent/US20070104684A1/en not_active Abandoned
- 2003-08-27 AT AT03790928T patent/ATE464321T1/de not_active IP Right Cessation
- 2003-08-27 WO PCT/EP2003/009497 patent/WO2004020469A2/en not_active Ceased
- 2003-08-27 DE DE60332122T patent/DE60332122D1/de not_active Expired - Lifetime
- 2003-08-27 CN CNB038231344A patent/CN100526332C/zh not_active Expired - Fee Related
- 2003-08-27 CA CA002496820A patent/CA2496820A1/en not_active Abandoned
- 2003-08-27 EP EP03790928A patent/EP1534751B1/en not_active Expired - Lifetime
- 2003-08-27 NZ NZ538958A patent/NZ538958A/en not_active IP Right Cessation
- 2003-08-27 AU AU2003258675A patent/AU2003258675B2/en not_active Ceased
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2005
- 2005-02-17 IL IL166950A patent/IL166950A/en active IP Right Grant
Non-Patent Citations (1)
| Title |
|---|
| HENRIK S. RASMUSSEN等: "Looking into anti-angiogenic genetherapies for disorders of the eye", 《DRUG DISCOVERY TODAY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004020469A2 (en) | 2004-03-11 |
| JP2006516112A (ja) | 2006-06-22 |
| CN1708513A (zh) | 2005-12-14 |
| WO2004020469A3 (en) | 2004-04-29 |
| IL166950A (en) | 2011-04-28 |
| DE60332122D1 (de) | 2010-05-27 |
| EP1534751B1 (en) | 2010-04-14 |
| CA2496820A1 (en) | 2004-03-11 |
| AU2003258675B2 (en) | 2009-03-26 |
| AU2003258675A1 (en) | 2004-03-19 |
| HK1077306A1 (en) | 2006-02-10 |
| EP1534751A2 (en) | 2005-06-01 |
| NZ538958A (en) | 2006-09-29 |
| US20070104684A1 (en) | 2007-05-10 |
| ATE464321T1 (de) | 2010-04-15 |
| JP4612417B2 (ja) | 2011-01-12 |
| CN100526332C (zh) | 2009-08-12 |
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