CN101627027B - 氨基吡唑激酶抑制剂 - Google Patents

氨基吡唑激酶抑制剂 Download PDF

Info

Publication number
CN101627027B
CN101627027B CN2008800073289A CN200880007328A CN101627027B CN 101627027 B CN101627027 B CN 101627027B CN 2008800073289 A CN2008800073289 A CN 2008800073289A CN 200880007328 A CN200880007328 A CN 200880007328A CN 101627027 B CN101627027 B CN 101627027B
Authority
CN
China
Prior art keywords
alkyl
group
cancer
pyrrolo
ylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800073289A
Other languages
English (en)
Chinese (zh)
Other versions
CN101627027A (zh
Inventor
马科·多迪尔
克劳德·奎斯内尔
安妮·马里尼尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CN101627027A publication Critical patent/CN101627027A/zh
Application granted granted Critical
Publication of CN101627027B publication Critical patent/CN101627027B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008800073289A 2007-01-05 2008-01-04 氨基吡唑激酶抑制剂 Expired - Fee Related CN101627027B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88360107P 2007-01-05 2007-01-05
US60/883,601 2007-01-05
PCT/US2008/050157 WO2008086128A2 (en) 2007-01-05 2008-01-04 Aminopyrazole kinase inhibitors

Publications (2)

Publication Number Publication Date
CN101627027A CN101627027A (zh) 2010-01-13
CN101627027B true CN101627027B (zh) 2013-06-19

Family

ID=39493124

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800073289A Expired - Fee Related CN101627027B (zh) 2007-01-05 2008-01-04 氨基吡唑激酶抑制剂

Country Status (6)

Country Link
US (1) US7851500B2 (enExample)
EP (1) EP2111402B1 (enExample)
JP (1) JP5286281B2 (enExample)
CN (1) CN101627027B (enExample)
AT (1) ATE548364T1 (enExample)
WO (1) WO2008086128A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2559771A3 (en) 2007-05-17 2013-06-12 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
NZ701626A (en) * 2012-05-15 2016-02-26 Novartis Ag Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
CN105418616B (zh) * 2015-12-26 2018-01-12 山东大学 一种含有 4‑氨基吡唑结构的jak 激酶抑制剂及其制备方法和应用
WO2021072475A1 (en) * 2019-10-15 2021-04-22 Aucentra Therapeutics Pty Ltd Derivatives of 4-(imidazo[1,2-a]pyridin-3-yl)-n-(pyridin-3-yl) pyrimidin-2- amine for treating proliferative diseases and conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1351498A (zh) * 1999-05-21 2002-05-29 布里斯托尔-迈尔斯斯奎布公司 激酶的吡咯并三嗪抑制剂
CN1681508A (zh) * 2002-07-19 2005-10-12 布里斯托尔-迈尔斯斯奎布公司 新型激酶抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
DE60117605T2 (de) * 2000-12-21 2006-12-07 Bristol-Myers Squibb Co. Thiazolyl-inhibitoren von tyrosinkinasen der tec-familie
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1351498A (zh) * 1999-05-21 2002-05-29 布里斯托尔-迈尔斯斯奎布公司 激酶的吡咯并三嗪抑制剂
CN1681508A (zh) * 2002-07-19 2005-10-12 布里斯托尔-迈尔斯斯奎布公司 新型激酶抑制剂

Also Published As

Publication number Publication date
CN101627027A (zh) 2010-01-13
US20100022503A1 (en) 2010-01-28
EP2111402A2 (en) 2009-10-28
WO2008086128A3 (en) 2008-09-25
JP2010515688A (ja) 2010-05-13
ATE548364T1 (de) 2012-03-15
JP5286281B2 (ja) 2013-09-11
US7851500B2 (en) 2010-12-14
EP2111402B1 (en) 2012-03-07
WO2008086128A2 (en) 2008-07-17

Similar Documents

Publication Publication Date Title
JP5095626B2 (ja) ピロロトリアジンキナーゼ阻害剤
EP2051980B1 (en) Pyrrolotriazine kinase inhibitors
KR101443400B1 (ko) 피롤로트리아진 키나제 억제제
JP5180967B2 (ja) ピロロトリアジンキナーゼ阻害剤
EP2049542B1 (en) Pyrrolotriazine kinase inhibitors
CN101687874B (zh) 吡咯并三嗪激酶抑制剂
CN101679406B (zh) 用作激酶抑制剂的噻唑基化合物
CN106661056B (zh) 作为酪蛋白激酶1δ/ε抑制剂的咪唑并哒嗪衍生物
JP5225288B2 (ja) キナーゼ阻害剤として有用なチアゾリル化合物
CN101600714A (zh) 吡咯并吡啶激酶抑制剂
EP3141552A1 (en) Thienopyrimidine derivatives having inhibitory activity for protein kinase
CN104837844B (zh) 作为酪蛋白激酶1 d/e抑制剂的吡唑取代的咪唑并哌嗪
CN102015719A (zh) 吡咯并三嗪激酶抑制剂
CN101627027B (zh) 氨基吡唑激酶抑制剂

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130619

Termination date: 20150104

EXPY Termination of patent right or utility model