CN101618109B

CN101618109B - Pharmaceutical composition for curing colpitis

Info

Publication number: CN101618109B
Application number: CN2009100658142A
Authority: CN
Inventors: 周大红
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-08-17
Filing date: 2009-08-17
Publication date: 2011-11-23
Anticipated expiration: 2029-08-17
Also published as: CN101618109A

Abstract

The invention relates to a pharmaceutical composition for curing colpitis, which belongs to the filed of traditional Chinese medicines, can be externally applied for curing the colpitis, in particular trichomonas vaginitis and colpitis mycotica. The invention adopts the technical scheme that the pharmaceutical composition for curing the colpitis is prepared by the following traditional Chinese medical materials in percentage by weight: 15-20 frutus cnidii, 15-20 broom cypress fruits, 6-15 prickly ash, 6-15 white vitriol, 6-15 rhizoma coptidis, 6-15 phellodendron, 6-15 sophora flavescens, 6-15 dittany peels and 10-30 dandelion. The traditional Chinese medicines in the prescription are used for decocting liquid which is applied for externally washing the vaginal twice every day for a week as a period of treatment. The pharmaceutical composition can achieve a curative ratio of 70.8 percent and a total effective rate of 91.0 percent for 89 patients with the colpitis in a period of treatment and can achieve a curative ratio of 85.2 percent for patients with the trichomonas vaginitis and the colpitis mycotica.

Description

Treat colpitic pharmaceutical composition

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of pharmaceutical composition for the treatment of the gynaecologic vaginal disease.

Background technology

Pathogen is invaded vagina, makes vaginal mucosa produce inflammation, is called vaginitis.Vaginitis belongs to the category of TCM Gynecology " leukorrheal diseases ", " pudendal pruritus ", four types of clinical common trichomonal vaginitis, colpitis mycotica, bacterial vaginosis and senile vaginitiss.Wherein trichomonal vaginitis is to be a kind of vagina that pathogen produces with the trichomonal vaginitis, and sickness rate is high and treat very obstinate.Except the pain of making us itching was felt bad, trichomonal vaginitis also can consume or engulf the glycogen in the vaginal epithelial cell, hindered lactic acid and generated, and not only destroyed the weak acid environment of vagina, also might cause vaginal cell abnormal development, brought out precancerous lesion.Infusorian not only parasitizes vagina, also often invades urethra or paraurethral gland, even bladder, renal pelvis, thereby causes urethritis, cystitis, pyelitis etc.

Colpitis mycotica be with candidiasis particularly Candida albicans be a kind of vagina of main pathogens, so claim monilial vaginitis again, its sickness rate has been higher than trichomonal vaginitis at present.Colpitis mycotica patient mainly shows as leucorrhoea grow in quantity, pudendum, pruritus of vagina, burning sensation, and painful urination, Chang Fahong, edema around the pudendum, epidermis changes varied; Very shallow vesicle pimple can take place; Also can form the erosion of eczema shape; Can cause small white pustule individually, ulcer takes place when serious.

Vaginitis has brought very big misery and inconvenient to the patient; Gynaecologic washing lotion directly acts on the focus quick result, and easy to use, is numerous vagina patients' first-selection.

Summary of the invention

The objective of the invention is for a kind of pharmaceutical composition is provided, external can be treated vaginitis, is particularly useful for trichomonal vaginitis and colpitis mycotica.

Based on above-mentioned purpose, the technical solution used in the present invention is: treat colpitic pharmaceutical composition, made by the Chinese crude drug of following weight parts: Fructus Cnidii 15-20 part, Fructus Kochiae 15-20 part, Pericarpium Zanthoxyli 6-15 part, Alumen 6-15 part, Rhizoma Coptidis 6-15 part, Cortex Phellodendri 6-15 part, Radix Sophorae Flavescentis 6-15 part, Cortex Dictamni 6-15 part, Herba Taraxaci 10-30.

The top medicine decocts with water back gained medicinal liquid and can directly use as gynaecologic washing lotion, cleans pudendum or washing vagina for the patient; Also can add acceptable accessories makes the commodity washing liquid or makes exterior-applied formulations such as vagina spray, suppository, effervescent tablet.The preparation of commodity washing liquid can be carried out with reference to conventional method, and for example: medical material decocts with water twice, and each water yield there was not powder, collecting decoction; Filter the back and add proper amount of surfactant (as Tween 80, hibitane) and antiseptic (as sodium benzoate); Use Fructus Citri Limoniae acid for adjusting pH value to 3.5～5.5 after adding water move to full dose; Medicinal liquid gets product after leaving standstill, filtering.

Fructus Cnidii suffering, hardship among the present invention, temperature, slightly poisonous, have effects such as dampness, killing parasites for relieving itching, warming the kidney to invigorate YANG.Modern medicine study shows that Fructus cnidii extract has inhibitory action to drug resistance staphylococcus aureus, bacillus pyocyaneus and dermatophytosis, can kill trichomonas vaginitis, and contained xanthotoxol also has stronger antiinflammatory and analgesic activity.Fructus Kochiae suffering, hardship, cold, return kidney, urinary bladder channel, the energy clearing away heat-damp and promoting diuresis is to end the pudendal pruritus leukorrhagia.Pericarpium Zanthoxyli suffering, temperature are returned spleen, stomach, kidney channel, fry in shallow oil the soup washout, can control the eczema pruritus, and analgesic and anti-inflammatory effects is arranged.Alumen acid, puckery, cold, can dampness removing to stop itchin, but broad-spectrum antiseptic all has bacteriostasis in various degree to multiple gram-positive cocci and negative bacillus, some anaerobe, dermatophytosis, Candida albicans, external obvious anti-trichomonas vaginitis effect is arranged.Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Cortex Dictamni bitter in the mouth are cold in nature, all can heat clearing away, dampness, antipruritic.Herba Taraxaci hardship, sweet, cold, return liver, stomach warp, kind heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the available puckery pain of pyretic stranguria of controlling.But all medicines share heat clearing and damp drying, eliminating fire and detoxication, killing parasites for relieving itching, the hemostasis of dispeling the wind.

Clinical observation 89 routine vaginitis patients, trichomonal vaginitis 28 examples wherein, colpitis mycotica 33 examples, bacterial vaginosis and other vaginitiss be totally 28 examples.Medicine of the present invention is with it fried in shallow oil soup washout (every dose of medicine can be fried in shallow oil with twice), and twice, one week of every day is a course of treatment.Cure patient's 63 examples (wherein infusorian and colpitis mycotica 52 examples) in the course of treatment altogether, 18 examples that take a turn for the better, invalid 8 examples.That is to say that medicine of the present invention is 70.8% to colpitic cure rate, total effective rate can reach 91.0%, and can reach 85.2% to the cure rate of infusorian and colpitis mycotica.

The specific embodiment

Embodiment 1

Treat colpitic pharmaceutical composition, make: Fructus Cnidii 15g, Fructus Kochiae 15g, Pericarpium Zanthoxyli 9g, Alumen 6g, Rhizoma Coptidis 9g, Cortex Phellodendri 6g, Radix Sophorae Flavescentis 6g, Cortex Dictamni 9g, Herba Taraxaci 10g by the Chinese crude drug of following weight parts.

The top medicine adds the 800ml decocting and becomes the 300ml medicinal liquid, for patient's washout once; Medicinal residues add the 1000ml decocting and become the 300ml medicinal liquid, but reuse once.

Embodiment 2

Treat colpitic pharmaceutical composition, make: Fructus Cnidii 18g, Fructus Kochiae 18g, Pericarpium Zanthoxyli 6g, Alumen 8g, Rhizoma Coptidis 6g, Cortex Phellodendri 8g, Radix Sophorae Flavescentis 9g, Cortex Dictamni 6g, Herba Taraxaci 18g by the Chinese crude drug of following weight parts.

The top medicine adds the 900ml decocting and becomes the 400ml medicinal liquid, and medicinal residues add the 1000ml decocting again and become the 500ml medicinal liquid, collecting decoction, filter washing liquid.Washing liquid can be divided into two parts of uses when the patient uses, each is cleaned once sooner or later.

Embodiment 3

Treat colpitic pharmaceutical composition, make: Fructus Cnidii 20g, Fructus Kochiae 20g, Pericarpium Zanthoxyli 13g, Alumen 10g, Rhizoma Coptidis 12g, Cortex Phellodendri 10g, Radix Sophorae Flavescentis 12g, Cortex Dictamni 12g, Herba Taraxaci 25g by the Chinese crude drug of following weight parts.

The top medicine adds the 1000ml decocting and becomes the 750ml medicinal liquid, filter the back medicinal residues and add the 1000ml decocting again and become the 500ml medicinal liquid, collecting decoction, filter washing liquid.Washing liquid can be divided into two parts of uses when the patient uses, each is cleaned once sooner or later.

Embodiment 4

Treat colpitic pharmaceutical composition, make: Fructus Cnidii 20kg, Fructus Kochiae 20kg, Pericarpium Zanthoxyli 15kg, Alumen 15kg, Rhizoma Coptidis 15kg, Cortex Phellodendri 15kg, Radix Sophorae Flavescentis 15kg, Cortex Dictamni 15kg, Herba Taraxaci 30kg by the Chinese crude drug of following weight parts.The side's of getting Chinese crude drug is put into 1000L water, decocts into the 400L medicinal liquid behind the immersion 30min, and medicinal residues add the 1000L decocting once more and become the 400L medicinal liquid, and collecting decoction filters; Add 10L tween 80,2kg sodium benzoate, the back that stirs adds distilled water and transfers to 1000L, is 4.5 with the Fructus Citri Limoniae acid for adjusting pH value, leaves standstill, filters the back packing, is the colpitic washing liquid finished product of treatment.

Below in conjunction with concrete case drug effect of the present invention is described further.

Case 1

Lee, the woman, 33 years old, 08 year summer conscious pruritus vulvae, the woman examines and finds vaginal wall hyperemia, the surface is covered with white films sample thing, vaginal secretions is heavy-gravity yellow-white, is diagnosed as colpitis mycotica.The prescription of embodiment 1 with it, dose is fried in shallow oil soup washout twice every day, and then potion is itched gently, itches for two doses and ends three doses of healings.

Case 2

Zhang, the woman, 25 years old, conscious pudendum was very itched when examining, and was attended by diseases such as frequent micturition, urgent micturition.The woman examines and finds vaginal mucosa hyperemia, and vaginal secretions is the bean curd scoriform, is diagnosed as colpitis mycotica.Fry in shallow oil the soup washout, twice of every day with the prescription of embodiment 2 and with reference to correlation method; Take a turn for the better behind the medication potion, itch gently for two doses, itch for three doses and end; After with five doses, fully recover.

Case 3

Zhao, the woman, 28 years old, summer and autumn conscious pudendum, vagina formicant itching, be difficult to stand.The woman examines visible vagina the petechia, many places, and vaginal secretions is the foam sample, is diagnosed as trichomonal vaginitis.Prescription with embodiment 3 is fried in shallow oil the soup washout with reference to correlation method, twice of every day; Take a turn for the better behind the medication potion, itch gently for two doses, itch for three doses and end; Continue with seven doses recovery from illness.

Claims

1. treat colpitic pharmaceutical composition, make: Fructus Cnidii 15-20 part, Fructus Kochiae 15-20 part, Pericarpium Zanthoxyli 6-15 part, Alumen 6-15 part, Rhizoma Coptidis 6-15 part, Cortex Phellodendri 6-15 part, Radix Sophorae Flavescentis 6-15 part, Cortex Dictamni 6-15 part, Herba Taraxaci 10-30 by the Chinese crude drug of following weight parts.