CN101618077A - Wintergreen barberry root suppository and preparation method thereof - Google Patents
Wintergreen barberry root suppository and preparation method thereof Download PDFInfo
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- CN101618077A CN101618077A CN 200910114307 CN200910114307A CN101618077A CN 101618077 A CN101618077 A CN 101618077A CN 200910114307 CN200910114307 CN 200910114307 CN 200910114307 A CN200910114307 A CN 200910114307A CN 101618077 A CN101618077 A CN 101618077A
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- corydalis
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Abstract
The invention relates to a wintergreen barberry root suppository and a sustained and controlled release wintergreen barberry root suppository, belonging to the technical field of pharmaceuticals. The preparation is prepared by the following steps: using wintergreen barberry roots as raw materials and carrying out steps of pulverization, reflux extraction, decompression concentration, pH regulation, and the like to obtain a tan wintergreen barberry root extract; using the tan wintergreen barberry root extract as an active pharmaceutical ingredient and adding a fat-soluble suppository matrix or sustained and controlled release macromolecular materials to prepare the wintergreen barberry root suppository or the sustained and controlled release wintergreen barberry root suppository. The preparation has obvious anti-inflammatory effect and can be prepared into a rectal suppository used for treating internal hemorrhoids and rectal inflammations and a vaginal suppository used for treating vaginitis and acute vaginitis according to different application and administration routes.
Description
Technical field:
The invention belongs to technical field of pharmaceuticals, be specifically related to a kind of significant antiinflammation that has, the vaginal suppository that can be used for treating the rectal suppository of internal hemorrhoid and rectum inflammation and treat vaginitis, acute vaginitis.
Background technology:
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) (Corydalis saxicola Bunting) is Papaveraceae (Papaveraceae) Corydalis (Corydalis) plant, be Guangxi Zhuang Autonomous Region characteristic medical material, studies confirm that and separate to such an extent that leaf alkali, dextrorotation tetrahydropalmatine, berberine, dextrorotation 13-beta-hydroxy stylopine, left-handed scoulerine, corydalis, chelerythrine, protopine etc. are stitched in ten crystal chemistry composition: Ka Weiding, deydrokaividing (Corydalis Saxicolae), dextrorotation in vain in the Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).Medical material records in " Guangxi Chinese crude drug standard ", puts down in writing major function and has cured mainly: eliminating damp-heat, dissipating blood stasis for subsidence of swelling.Be used for the furuncle toxic swelling, hepatitis, liver cirrhosis, hepatocarcinoma.
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is made rectal suppository, can treat internal hemorrhoid and rectum inflammation; Make vaginal suppository and can be used for treating vaginitis, acute vaginitis, and be not the suppository of the above disease of Drug therapy also at present with the Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).
Summary of the invention:
The object of the present invention is to provide that a kind of Wintergreen barberry root suppository and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) are slow, the preparation method and its usage of controlled-release suppository.Said preparation is active constituents of medicine with the meadowrueleaf corydalis root extract, adds suitable fat-soluble suppository substrate or slow, controlled release high molecular material, prepares with modern preparation process technology.Purposes according to said preparation is different with route of administration, can be made into rectal suppository that is used for the treatment of internal hemorrhoid and rectum inflammation and the vaginal suppository for the treatment of vaginitis, acute vaginitis.
The present invention finishes by the following technical programs:
Wintergreen barberry root suppository of the present invention and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) are slow, controlled-release suppository, it is characterized in that said preparation contains the active constituents of medicine meadowrueleaf corydalis root extract, and adjuvant fat-soluble suppository substrate, as semi-synthetic fatty acid, cocoa butter etc., or slow, controlled release high molecular material, as ethyl cellulose, beta-schardinger dextrin-etc.The content of meadowrueleaf corydalis root extract is 10-200mg in every piece of preparation.Different with route of administration according to purposes, said preparation can be made into rectal suppository and vaginal suppository.
1, the preparation method of active constituents of medicine meadowrueleaf corydalis root extract
Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) cleaned dry, be ground into coarse powder, take by weighing the Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) coarse powder, with 5 times of amount 90% ethanol, flooded 24 hours, reflux, extract, 4 times, each 1 hour, merge extractive liquid,, decompression recycling ethanol also is concentrated into the clear paste that relative density is 0.92～1.02 (60 ℃), put coldly, filter, filtrate is concentrated into the thick paste that relative density is 1.16～1.20 (60 ℃).In thick paste, add an amount of distilled water, use 10% hydrochloric acid solution, regulate pH value 2～3, stir fully, filter, wash 4～5 times, merge acid liquid, regulate pH value 9～10, separate out brown precipitation, filter, be drying to obtain with sodium carbonate with 10% hydrochloric acid solution.
2, the preparation method of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) rectal suppository and vaginal suppository
Meadowrueleaf corydalis root extract is pulverized, crossed 200 mesh sieves, make powder.Preparation is during rectal suppository, is 1 part of meadowrueleaf corydalis root extract by the weight proportion of active constituents of medicine meadowrueleaf corydalis root extract and fat-soluble suppository substrate, the ratio of fat-soluble suppository substrate 1-200 part; During the preparation vaginal suppository, press 1 part of meadowrueleaf corydalis root extract, the ratio of fat-soluble suppository substrate 1-500 part, after heat fused such as fat-soluble suppository substrate such as semi-synthetic fatty acid, cocoa butter, add the meadowrueleaf corydalis root extract powder, mix homogeneously, pour the suppository mould into, take out promptly the cooling back.
3, the preparation method of slow, controlled release rectal suppository of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) and vaginal suppository
Meadowrueleaf corydalis root extract is pulverized, crossed 200 mesh sieves, make powder.Preparation is during rectal suppository, is 1 part of meadowrueleaf corydalis root extract by the weight proportion of active constituents of medicine meadowrueleaf corydalis root extract and fat-soluble suppository substrate, the ratio of fat-soluble suppository substrate 1-200 part; During the preparation vaginal suppository, press 1 part of meadowrueleaf corydalis root extract, the ratio of fat-soluble suppository substrate 1-500 part, after heat fused such as fat-soluble suppository substrate such as semi-synthetic fatty acid, cocoa butter, add the meadowrueleaf corydalis root extract powder behind slow, controlled release high molecular material such as the parcels such as ethyl cellulose, beta-schardinger dextrin-, mix homogeneously is poured the suppository mould into, and take out promptly the cooling back.
4, the purposes of slow, the controlled-release suppository of Wintergreen barberry root suppository and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae)
Different with route of administration according to purposes, Wintergreen barberry root suppository and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) are slow, controlled-release suppository can be made rectal suppository and vaginal suppository respectively.Rectal suppository is mainly used in treatment internal hemorrhoid and rectum inflammation; Vaginal suppository is mainly used in treatment vaginitis and acute vaginitis.
The invention has the advantages that, at present, be not the suppository of the above disease of Drug therapy with the Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) also on the market, the invention provides that a kind of Wintergreen barberry root suppository and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) are slow, controlled-release suppository, is used for above-mentioned treatment of diseases, filled up the technological gap and the market vacancy.In addition, the said preparation raw material sources are in Guangxi characteristic herb resource---Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae).Wintergreen barberry root suppository and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) are slow, the appearance of controlled-release suppository, can enrich the Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) medical product, and be significant to the development of the comprehensive utilization of Guangxi Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) resource and medicinal industry.
The specific embodiment:
Be embodiments of the invention below, the invention will be further described, but content of the present invention not only is confined to cited example.
Embodiment one
Take by weighing meadowrueleaf corydalis root extract 270g, meadowrueleaf corydalis root extract is pulverized, cross 200 mesh sieves, make powder 250g.After semi-synthetic fatty acid ester 500g heat fused, add the meadowrueleaf corydalis root extract powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of supp anals.
Embodiment two
Take by weighing meadowrueleaf corydalis root extract 100g, meadowrueleaf corydalis root extract is pulverized, cross 200 mesh sieves, make powder 80g.After semi-synthetic fatty acid ester 370g heat fused, add the meadowrueleaf corydalis root extract powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of supp anals.
Embodiment three
Take by weighing meadowrueleaf corydalis root extract 370g, meadowrueleaf corydalis root extract is pulverized, cross 200 mesh sieves, make powder 350g.After semi-synthetic fatty acid ester 500g heat fused, add the meadowrueleaf corydalis root extract powder behind the ethyl cellulose parcel, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of supp anals.
Embodiment four
Take by weighing meadowrueleaf corydalis root extract 240g, meadowrueleaf corydalis root extract is pulverized, cross 200 mesh sieves, make powder 220g.After semi-synthetic fatty acid ester 930g heat fused, add the meadowrueleaf corydalis root extract powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of vaginal suppositories.
Embodiment five
Take by weighing meadowrueleaf corydalis root extract 430g, meadowrueleaf corydalis root extract is pulverized, cross 200 mesh sieves, make powder 400g.After semi-synthetic fatty acid ester 1550g heat fused, add the meadowrueleaf corydalis root extract powder, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of vaginal suppositories.
Embodiment six
Take by weighing meadowrueleaf corydalis root extract 580g, meadowrueleaf corydalis root extract is pulverized, cross 200 mesh sieves, make powder 550g.After semi-synthetic fatty acid ester 800g heat fused, add the meadowrueleaf corydalis root extract powder behind the parcel such as beta-schardinger dextrin-, stir and make its mix homogeneously, pour in the bolt mould after cold slightly, take out promptly the cooling back.Products obtained therefrom is 500 pieces of vaginal suppositories.
Claims (8)
1, a kind of Wintergreen barberry root suppository is characterized in that this suppository contains the active constituents of medicine meadowrueleaf corydalis root extract, and adjuvant fat-soluble suppository substrate, and the content of meadowrueleaf corydalis root extract is 10-200mg in every piece of suppository.
2, Wintergreen barberry root suppository as claimed in claim 1, the weight ratio that it is characterized in that active constituents of medicine meadowrueleaf corydalis root extract and fat-soluble suppository substrate are 1 part of meadowrueleaf corydalis root extracts, fat-soluble suppository substrate 1-500 part.
3, the preparation method of Wintergreen barberry root suppository as claimed in claim 1 is characterized in that meadowrueleaf corydalis root extract is pulverized, and crosses 200 mesh sieves, makes powder.After fat-soluble suppository substrate heat fused, add the meadowrueleaf corydalis root extract powder, mix homogeneously is poured the suppository mould into, and take out promptly the cooling back.
4,, it is characterized in that it can be made into slow, controlled-release suppository according to the described Wintergreen barberry root suppository of claim 1.
5, the preparation method of slow, the controlled-release suppository of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) as claimed in claim 4 is characterized in that meadowrueleaf corydalis root extract is pulverized, and crosses 200 mesh sieves, makes powder.After fat-soluble suppository substrate heat fused, add the Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) powder behind slow, the controlled release high molecular material parcel, mix homogeneously is poured the suppository mould into, and take out promptly the cooling back.
6, the preparation method of slow, the controlled-release suppository of Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) as claimed in claim 5 is characterized in that wherein slow, controlled release high molecular material are selected from ethyl cellulose and beta-schardinger dextrin-.
7, the preparation method of meadowrueleaf corydalis root extract in, the controlled-release suppository slow as claim 1 and 4 described Wintergreen barberry root suppositories and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae), it is characterized in that Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) cleaned and dry, be ground into coarse powder, take by weighing Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) coarse powder 10kg, with 5 times of amount 90% ethanol, flooded 24 hours, reflux, extract, 4 times, each 1 hour, merge extractive liquid,, decompression recycling ethanol also is concentrated into the clear paste that relative density is 0.92～1.02 (60 ℃), puts cold, filter, filtrate is concentrated into the thick paste that relative density is 1.16～1.20 (60 ℃).In thick paste, add an amount of distilled water, use 10% hydrochloric acid solution, regulate pH value 2～3, stir fully, filter, wash 4～5 times, merge acid liquid, regulate pH value 9～10, separate out brown precipitation, filter, be drying to obtain with sodium carbonate with 10% hydrochloric acid solution.
8,, controlled-release suppository slow as claim 1 and 4 described Wintergreen barberry root suppositories and Corydalis thalictrifolia Franch. (Radix Corydalis Thalictrifoliae) is characterized in that can be made into the vaginal suppository of the rectal suppository that is used for the treatment of internal hemorrhoid and rectum inflammation and treatment vaginitis, acute vaginitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910114307 CN101618077B (en) | 2009-08-13 | 2009-08-13 | Wintergreen barberry root suppository and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910114307 CN101618077B (en) | 2009-08-13 | 2009-08-13 | Wintergreen barberry root suppository and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101618077A true CN101618077A (en) | 2010-01-06 |
| CN101618077B CN101618077B (en) | 2013-02-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200910114307 Expired - Fee Related CN101618077B (en) | 2009-08-13 | 2009-08-13 | Wintergreen barberry root suppository and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102652777A (en) * | 2012-03-29 | 2012-09-05 | 武汉华大药业有限公司 | Kuh-seng and green tea suppository and preparation method thereof |
| CN104887793A (en) * | 2015-05-15 | 2015-09-09 | 宁玉梅 | Coptis chinensis total alkaloid vaginal suppository |
| CN113304193A (en) * | 2021-05-28 | 2021-08-27 | 肖萍 | Corydalis saxicola bunting for treating and/or preventing pelvic inflammation and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1185231C (en) * | 2003-05-19 | 2005-01-19 | 吴梅春 | Meadowrueleaf corydalis general alkaloid and its prepn and application |
| CN101028343B (en) * | 2006-03-03 | 2011-04-13 | 上海医药工业研究院 | Total alkaloid of meadowrue corydalis and its purification and medicinal composition |
| CN101172975B (en) * | 2006-11-03 | 2010-08-18 | 上海医药工业研究院 | Method of preparing five-alkaloid composition of corydalis saxicola bunting |
-
2009
- 2009-08-13 CN CN 200910114307 patent/CN101618077B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102652777A (en) * | 2012-03-29 | 2012-09-05 | 武汉华大药业有限公司 | Kuh-seng and green tea suppository and preparation method thereof |
| CN104887793A (en) * | 2015-05-15 | 2015-09-09 | 宁玉梅 | Coptis chinensis total alkaloid vaginal suppository |
| CN104887793B (en) * | 2015-05-15 | 2018-06-26 | 宁玉梅 | A kind of coptis chinensis total alkaloid vaginal plug |
| CN113304193A (en) * | 2021-05-28 | 2021-08-27 | 肖萍 | Corydalis saxicola bunting for treating and/or preventing pelvic inflammation and preparation method thereof |
| CN113304193B (en) * | 2021-05-28 | 2022-07-15 | 肖萍 | Corydalis saxicola bunting for treating and/or preventing pelvic inflammation and preparation method thereof |
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| CN101618077B (en) | 2013-02-27 |
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Application publication date: 20100106 Assignee: Guangxi Weimei Biotechnology Co., Ltd. Assignor: Jiang Weizhe Contract record no.: 2013450000070 Denomination of invention: Wintergreen barberry root suppository and preparation method thereof Granted publication date: 20130227 License type: Exclusive License Record date: 20130816 |
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Granted publication date: 20130227 Termination date: 20160813 |