CN101617678B - Pesticide composition - Google Patents
Pesticide composition Download PDFInfo
- Publication number
- CN101617678B CN101617678B CN200910109055.5A CN200910109055A CN101617678B CN 101617678 B CN101617678 B CN 101617678B CN 200910109055 A CN200910109055 A CN 200910109055A CN 101617678 B CN101617678 B CN 101617678B
- Authority
- CN
- China
- Prior art keywords
- dimethomorph
- fluazinam
- composition pesticide
- water
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 239000000575 pesticide Substances 0.000 title claims abstract description 30
- QNBTYORWCCMPQP-JXAWBTAJSA-N (Z)-dimethomorph Chemical compound C1=C(OC)C(OC)=CC=C1C(\C=1C=CC(Cl)=CC=1)=C/C(=O)N1CCOCC1 QNBTYORWCCMPQP-JXAWBTAJSA-N 0.000 claims abstract description 73
- 239000005780 Fluazinam Substances 0.000 claims abstract description 72
- UZCGKGPEKUCDTF-UHFFFAOYSA-N fluazinam Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=C(Cl)C([N+]([O-])=O)=C1NC1=NC=C(C(F)(F)F)C=C1Cl UZCGKGPEKUCDTF-UHFFFAOYSA-N 0.000 claims abstract description 72
- 239000005761 Dimethomorph Substances 0.000 claims abstract description 71
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- 238000011160 research Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a pesticide composition which contains effective quantities of fluazinam and dimethomorph. The pesticide composition has the following advantages: 1. the blending has remarkable synergic function, and the control efficiency is improved; 2. the composition has two effective ingredients with different functional mechanisms and is convenient to overcome and delay the occurrence of drug resistance among germs; and 3. the dosage is reduced due to drug blending, thereby the cost is reduced and the environment pollution is lightened.
Description
Technical field
The invention belongs to technical field of pesticide, relate in particular to a kind of composition pesticide, this composition pesticide, for various crop disease control, is particularly suitable for preventing and treating downy mildew of cucurbits and downy mildew of garpe.
Background technology
Downy mildew is the very strong important disease of a kind of popularity melon, that grape is produced, especially occurs general and is injured heavier with cucumber, sponge gourd, balsam pear, muskmelon.Generally occur in spring and autumn, Chun Mo and autumn to occur the most general.Germ is caused harm and survives the winter at seed or autumn and winter with mycelia on dish, also can on invalid body, survive the winter by egg spore, mainly by air-flow, water, farming and insect relay disease, easily morbidity under the conditions such as particularly water after, field planting overstocked in plantation too early, excessive, soil moisture large, impeded drainage.The gently underproduction 30～40% when disease is popular, serious reaches more than 70～80%, so that ruins kind.The downy mildew blade of mainly causing harm, is developed to upper leaf by base portion.Their early stage forms light yellow subcircular to polygonal scab on blade face, when there was dampness in the air, blade back produces the mould layer of white shape, sometimes can spread to blade face.Later stage scab is in flakes withered, is yellowish-brown, the withered and yellow death of whole siphonal lobes when serious.The common medicament of preventing and treating downy mildew uses separately control efficiency poor as metalaxyl, tpn, white urea cyanogen, thiophanate-methyl, and is very easy to accelerate the generation of disease to medicament resistance.
The chloro-N-of fluazinam: 3-(the chloro-5-trifluoromethyl-2-of 3-pyridine radicals)-α, α, α-tri-fluoro-2, 6-dinitro-p-toluidine, belong to 2, 6-dinitroanilines, broad spectrum protection bactericide, to interlink spore genus, Botrytis, Phytophthora, Plasmopara, Sclerotinia and black to cultivate Pseudomonas bacterium very effective, concrete disease is as gray mold of cucumber, rot, downy mildew, anthracnose, powdery mildew, stem's pestilence of rotting, tomato late blight, apple scab, leaf spot, Pear black spot, rust, paddy rice slightly pain is sick, banded sclerotial blight, oat hat lures disease, grape grey mould, downy mildew, citrus scab, gray mold, potato late blight, lawn spot disease.Botrytis cinerea to anti-benzimidazole type and dicarboximide class biocide agent also has good result, resistance of rainwater washing against, and the lasting period is long, has the effect of planting property of good control food mite class concurrently, and concrete mite class is engraved mite, kamisawa tetranychus etc. as citrus red mite, China pink.Crucifer club root and the microbial paddy rice damping off of head mold are also had to remarkable preventive effect.
Dimethomorph: containing morpholine ring in molecular structure, is the good bactericide of preventing and treating the Oomycete such as Peronospora, Phytophthora class disease after metalaxyl, the late blight that can effectively prevent and treat potato, tomato, the downy mildew of cucumber, cucurbit, grape etc.Absorption is strong in dimethomorph, root dispenser can be absorbed and transporting to each position of plant, foliage-spray can infiltrate blade interior.There is the activity of protection, treatment and anti-Sporulation.Bactericidal action mode uniqueness, is mainly the rearrangement that affects pathogen cell wall molecular structure, the polymeric assembling of interference cell wall, thus interference cell wall forms, and makes thalline death.Except zoospore form and spore swarm stage, all there is to effect in each stage of oomycetes history of life, especially the formation stages of sporangiophore and egg spore is more responsive, therefore, before sporulation, can suppress Sporulation.
The combination of active principles of different agricultural chemicals being carried out composite, obtain having the formula of synergistic function, can improve actual control efficiency, reduce the usage amount of agricultural chemicals, contribute to the generation of delaying drug resistance, is the important means of integrated control.Therefore, the combination of active principles of different agricultural chemicals being carried out composite is effectively and the efficiently mode of one that solves at present some problems in agricultural chemicals single dose application process.The agricultural chemicals of different cultivars shows three kinds of type of action after mixing conventionally, i.e. summation action, synergistic effect and antagonism, but be specially which kind of effect, and unpredictable, only have by lot of experiments and just can know.
At present, also do not occur the report of dimethomorph and the composite use of fluazinam.
summary of the invention
The object of the embodiment of the present invention is to provide a kind of composition pesticide, is intended to solve the weak effect of existing single dose pesticide control downy mildew, and easily accelerates the problem that disease produces medicament resistance.
The embodiment of the present invention is achieved in that a kind of composition pesticide, wherein, the fluazinam that contains effective dose and dimethomorph, described fluazinam and dimethomorph mass ratio are 1: 30 or 30: 1.
Compared with prior art, the composition pesticide tool of the embodiment of the present invention has the following advantages:
1, mixture has obvious synergistic function (referring to table 1 data in embodiment), has improved control efficiency;
2, composition is made up of two kinds of different active ingredients of mechanism of action, is conducive to overcome and delays the drug-fast generation of germ;
3, medicament mixture has reduced dosage, thereby has reduced cost and alleviated the pollution to environment.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Because the existing common medicament of preventing and treating downy mildew uses separately control efficiency poor as metalaxyl, tpn, white urea cyanogen, thiophanate-methyl, and the generation of very easy acceleration disease to medicament resistance, the embodiment of the present invention provides a kind of mixture to have obvious synergistic function, can overcome and delay the composition pesticide that germ pesticide resistance produces, particularly, the composition pesticide of the embodiment of the present invention, wherein, the fluazinam that contains effective dose and dimethomorph.
More specifically, above-mentioned composition pesticide, wherein, fluazinam and dimethomorph mass ratio be preferably 1: 30～and 30: 1, more preferably 1: 20～10: 1.
The composition pesticide of the embodiment of the present invention, can be by known method, add various this areas usual auxiliaries, be prepared into any one formulation that is applicable to agricultural use, for example, can be prepared into the wetting powder, missible oil, suspending agent, water dispersible granules, aqueous emulsion and the microemulsion that are applicable to agricultural use by known method.
Above-mentioned various formulation composition pesticide is except comprising active component fluazinam and dimethomorph, and suspending agent also comprises water, dispersant, thickener, antifreezing agent and wetting agent; Wetting powder also comprises wetting agent, dispersant and filler; Missible oil also comprises organic solvent, cosolvent and emulsifier; Aqueous emulsion also comprises organic solvent, dispersant, emulsifier and water; Microemulsion also comprises organic solvent, emulsifier and water; Water dispersible granules also comprises dispersant, disintegrant, filler and wetting agent.
Above-mentioned auxiliary agent is to be of value to active component fluazinam and dimethomorph stable known substance of bringing into play with drug effect in preparation, and be all various compositions conventional in pesticidal preparations or that permission is used, be not particularly limited, concrete composition and consumption require to determine by simple experiment according to formula.For example:
Organic solvent can be selected one or more in isopropyl alcohol, dimethylbenzene, DMF, ring ethyl ketone, toluene, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, trimethyl cyclic ethylene ketone, NOP, N-pyrrolidones, propyl alcohol, butanols, ethylene glycol, diethylene glycol, ethylene glycol monomethyl ether, butyl ether, ethyl acetate, vegetable oil.
Cosolvent can be selected one or more in 1-METHYLPYRROLIDONE, dimethyl formamide, ethanol, the third ethanol, acetone.
Dispersant can be selected sodium lignin sulfonate, wooden calcium sulfonate, pulls open powder, one or more in calcium dodecyl benzene sulfonate, polycarboxylate, alkyl benzene sulfonate calcium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Emulsifier can be selected agriculture breast 600
#(phenyl phenol polyoxy ethyl ether), agriculture breast 1601
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), agriculture breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (polyoxyethylene nonylphenol ether phosphate), 600
#phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene rice ammonium sulfate, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, agriculture breast 400
#(benzyl xylenol polyoxy ethyl ether), Nongru-700
#(alkyl phenolic resin polyoxy ethyl ether), peaceful breast 36
#(phenethyl fluosite polyoxy ethyl ether), agriculture breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (polyoxyethylene nonylphenol ether), agriculture breast 33
#(alkylaryl polyoxyethylene polyoxypropylene ether), agriculture breast 34
#one or more in (alkylaryl polyoxyethylene poly-oxygen propylene aether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), AEO series (fat alcohol alcohol APEO).
Antifreezing agent can be selected one or more in glycerine, urea, ethylene glycol, propane diols.
Wetting agent can select that methyl naphthalene sulfonate formaldehyde condensate, lauryl sodium sulfate, Negel, alkyl benzene calcium sulfonate, tea are withered, spaonin powder, silkworm excrement, soapberry powder, bay alcohol radical sodium sulphate, washing powder, pull open one or more in powder.
Disintegrant can be selected one or more in ammonium sulfate, urea, bentonite, aluminium chloride, citric acid, succinic acid, sodium bicarbonate.
Thickener can be selected in xanthans, CMC, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol one or more.
Filler can be selected one or more in White Carbon black, ridge soil, precipitated calcium carbonate, talcum, imvite or convex-concave rod stone, float stone, brickbat, sepiolite or bentonite and non-adsorptivity calcium soil or sand.
Product described in the invention can finished product preparation form provide, and in composition, each material mixes, and the composition of composition also can provide with single dose form, before use, directly in bucket or tank, directly mixes, and is then diluted to required concentration.
Bactericidal composition of the present invention can be used for preventing and treating cucumber, watermelon, pumpkin, muskmelon, strawberry, capsicum, Chinese cabbage, eggplant, potato, grape, etc. the multiple diseases on crop, control, because of fungus-caused plant diseases such as oomycetes, imperfect fungus, sac fungi, basidiomycetes, is particularly useful for preventing and treating cucumber downy mildew etc.Composition of the present invention can be used by common method, and as cast, injection, spraying, dusting, scatter or be fuming, its amount of application is with weather condition or crop state variation.
Embodiment 1
1% fluazinam dimethomorph suspending agent
Fluazinam 0.5%
Dimethomorph 0.5%
Methyl naphthalene sulfonate formaldehyde condensate (wetting agent) 10%
Xanthans (thickener) 2%
Methylcellulose (thickener) 1%
Agriculture breast 600# phosphate (emulsifier) 3%
Glycerine (antifreeze) 5%
Water complements to 100%
Each components such as active component, thickener, wetting agent and water are mixed in the ratio of formula, after grinding and/or high speed shear, obtain 1% fluazinam dimethomorph suspending agent.
This embodiment is applied to and prevents and treats downy mildew of garpe.1% fluazinam dimethomorph suspending agent is by active ingredient 100g/ha dilution spraying, and after medicine, the control efficiency of 7 days and 14 days is 93.8% and 95.7%.30% fluazinam suspending agent is pressed active ingredient 120g/ha by active ingredient 200g/ha and 30% dimethomorph suspending agent, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 83.5%, 81.7% and 89.5%, 84.4%.The composite rear synergistic effect of fluazinam and dimethomorph is obvious, to the control efficiency of downy mildew of garpe significantly better than single dose; Because pharmacy effect improves, when the amount ratio of active ingredient uses separately in compound drug, obviously reduce, thereby also alleviated the pollution to environment.
Embodiment 2
11% fluazinam dimethomorph aqueous emulsion
Fluazinam 1%
Dimethomorph 10%
1-METHYLPYRROLIDONE (solvent) 10%
Calcium dodecyl benzene sulfonate (dispersant) 5%
Agriculture breast 600# (emulsifier) 5%
Water complements to 100%
Former medicine, solvent, emulsifier are added together, make to be dissolved into even oil phase; Water-soluble component and water mixing are made to water; Under high-speed stirred, oil phase is mixed with water, make 11% fluazinam dimethomorph aqueous emulsion.
This embodiment is applied to and prevents and treats downy mildew of garpe.11% fluazinam dimethomorph aqueous emulsion is by active ingredient 80g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 93.9% and 95.4%.40% fluazinam suspending agent is pressed active ingredient 90g/ha by active ingredient 250g/ha and 20% micellar emulsion of dimethomorph, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 76.8%, 84.6% and 83.5%, 87.4%.The composite rear synergistic effect of fluazinam and dimethomorph is obvious, and to the control efficiency of downy mildew of garpe, significantly better than single dose, and the consumption of active ingredient obviously reduces.
Embodiment 3
11% fluazinam dimethomorph aqueous emulsion
Fluazinam 10%
Dimethomorph 1%
1-METHYLPYRROLIDONE (solvent) 10%
Calcium dodecyl benzene sulfonate (dispersant) 5%
Agriculture breast 600# (emulsifier) 5%
Water complements to 100%
Former medicine, solvent, emulsifier are added together, make to be dissolved into even oil phase; Water-soluble component and water mixing are made to water; Under high-speed stirred, oil phase is mixed with water, make 11% fluazinam dimethomorph aqueous emulsion.
This embodiment is applied to and prevents and treats downy mildew of garpe.11% fluazinam dimethomorph aqueous emulsion is by active ingredient 150g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 91.9% and 95.4%.40% fluazinam suspending agent is pressed active ingredient 150g/ha by active ingredient 250g/ha and 20% micellar emulsion of dimethomorph, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 77.8%, 86.6% and 81.5%, 87.4%.The composite rear synergistic effect of fluazinam and dimethomorph is obvious, and to the control efficiency of downy mildew of garpe, significantly better than single dose, and the consumption of active ingredient obviously reduces.
Embodiment 4
21% fluazinam dimethomorph missible oil
Fluazinam 1%
Dimethomorph 20%
1-METHYLPYRROLIDONE (cosolvent) 10%
Agriculture breast 1601# (emulsifier) 5%
Agriculture breast 500# (emulsifier) 5%
Dimethylbenzene (solvent) complements to 100%
Active component, emulsifier and auxiliary agent are added in mixing kettle successively in the ratio of formula, stir, make 21% fluazinam dimethomorph missible oil.
This embodiment is applied to and prevents and treats downy mildew of garpe.21% fluazinam dimethomorph missible oil is by active ingredient 80g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 94.4% and 91.8%.40% fluazinam suspending agent is pressed active ingredient 100g/ha by active ingredient 300g/ha and 40% dimethomorph missible oil, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 74.5%, 86.4% and 87.5%, 80.7%.The composite rear synergistic effect of fluazinam and dimethomorph is obvious, to the control efficiency of downy mildew of garpe significantly better than single dose; Because pharmacy effect improves, when the amount ratio of active ingredient uses separately in compound drug, obviously reduce, thereby also alleviated the pollution to environment.
Embodiment 5
30% fluazinam micellar emulsion of dimethomorph
Fluazinam 5%
Dimethomorph 25%
1-METHYLPYRROLIDONE (solvent) 10%
Isopropyl alcohol (solvent) 15%
Agriculture breast 600# (emulsifier) 5%
Agriculture breast 1601# (emulsifier) 5%
Lauryl sodium sulfate (emulsifier) 3%
Water complements to 100%
Former medicine, solvent, emulsifier are added together, make to be dissolved into even oil phase; Water-soluble component and water mixing are made to water; Under high-speed stirred, oil phase is mixed with water, make 30% fluazinam micellar emulsion of dimethomorph.
This embodiment is applied to and prevents and treats rice sheath blight disease.30% fluazinam micellar emulsion of dimethomorph is by active ingredient 80g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 93.8% and 94.8%.20% fluazinam suspending agent is pressed active ingredient 100g/ha by active ingredient 300g/ha and 40% dimethomorph wetting powder, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 76.6%, 87.8% and 89.5%, 80.8%.The composite rear synergistic effect of fluazinam dimethomorph is obvious, to the control efficiency of downy mildew of garpe significantly better than single dose; Because pharmacy effect improves, when the amount ratio of active ingredient uses separately in compound drug, obviously reduce, thereby also alleviated the pollution to environment.
Embodiment 6
31% fluazinam micellar emulsion of dimethomorph
Fluazinam 1%
Dimethomorph 30%
1-METHYLPYRROLIDONE (solvent) 10%
Isopropyl alcohol (solvent) 15%
Agriculture breast 600# (emulsifier) 5%
Agriculture breast 1601# (emulsifier) 5%
Lauryl sodium sulfate (emulsifier) 3%
Water complements to 100%
Former medicine, solvent, emulsifier are added together, make to be dissolved into even oil phase; Water-soluble component and water mixing are made to water; Under high-speed stirred, oil phase is mixed with water, make 31% fluazinam micellar emulsion of dimethomorph.
This embodiment is applied to and prevents and treats rice sheath blight disease.31% fluazinam micellar emulsion of dimethomorph is by active ingredient 80g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 95.8% and 91.8%.20% fluazinam suspending agent is pressed active ingredient 100g/ha by active ingredient 300g/ha and 40% dimethomorph wetting powder, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 74.6%, 87.8% and 86.5%, 73.8%.The composite rear synergistic effect of fluazinam dimethomorph is obvious, to the control efficiency of downy mildew of garpe significantly better than single dose; Because pharmacy effect improves, when the amount ratio of active ingredient uses separately in compound drug, obviously reduce, thereby also alleviated the pollution to environment.
Embodiment 7
30% fluazinam micellar emulsion of dimethomorph
Fluazinam 30%
Dimethomorph 1%
1-METHYLPYRROLIDONE (solvent) 10%
Isopropyl alcohol (solvent) 15%
Agriculture breast 600# (emulsifier) 5%
Agriculture breast 1601# (emulsifier) 5%
Lauryl sodium sulfate (emulsifier) 3%
Water complements to 100%
Former medicine, solvent, emulsifier are added together, make to be dissolved into even oil phase; Water-soluble component and water mixing are made to water; Under high-speed stirred, oil phase is mixed with water, make 31% fluazinam micellar emulsion of dimethomorph.
This embodiment is applied to and prevents and treats rice sheath blight disease.31% fluazinam micellar emulsion of dimethomorph is by active ingredient 80g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 95.2% and 90.8%.20% fluazinam suspending agent is pressed active ingredient 100g/ha by active ingredient 300g/ha and 40% dimethomorph wetting powder, thin up spraying, and after medicine, the control efficiency of 7 days, 14 days is respectively 74.4%, 82.8% and 84.5%, 76.8%.The composite rear synergistic effect of fluazinam dimethomorph is obvious, to the control efficiency of downy mildew of garpe significantly better than single dose; Because pharmacy effect improves, when the amount ratio of active ingredient uses separately in compound drug, obviously reduce, thereby also alleviated the pollution to environment.
Embodiment 8
60% fluazinam dimethomorph water dispersion granula
Fluazinam 50%
Dimethomorph 10%
Negel (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 7%
Lauryl sodium sulfate (dispersant) 2%
Ammonium sulfate (disintegrant) 5%
Precipitated calcium carbonate (filler) complements to 100%.
Active component, dispersant, wetting agent, disintegrant and filler are mixed in the ratio of formula, become wetting powder through air-flow crushing, add again a certain amount of water to mix extruding and make material, after drying screening, obtain 60% fluazinam dimethomorph water-dispersible granules.
This embodiment is applied to and prevents and treats downy mildew of garpe.60% fluazinam dimethomorph water-dispersible granules is by active ingredient 160g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 93.7% and 95.3%.70% fluazinam water dispersible granules is pressed active ingredient 150g/ha by active ingredient 300g/ha and 80% dimethomorph water dispersion granula, thin up spraying, and after medicine, the control efficiency of 7 days is respectively 81.8%, 87.6% and 76.1%, 79.8%.The composite rear synergistic effect of fluazinam and dimethomorph is obvious, and to the control efficiency of downy mildew of garpe, significantly better than single dose, and the consumption of active ingredient obviously reduces.
Embodiment 9
80% fluazinam dimethomorph wetting powder
Fluazinam 30%
Dimethomorph 50%
Lauryl sodium sulfate (wetting agent) 2%
Sodium lignin sulfonate (dispersant) 5%
White Carbon black (filler) 8%
Kaolin (filler) complements to 100%
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of formula, after ultra-fine pulverizer disintegrating, obtain 80% fluazinam dimethomorph wetting powder.
This embodiment is applied to and prevents and treats downy mildew of garpe.80% fluazinam dimethomorph wetting powder is by active ingredient 100g/ha thin up spraying, and after medicine, the control efficiency of 7 days and 14 days is 93.4% and 92.8%.40% fluazinam suspending agent is pressed active ingredient 110g/ha by active ingredient 250g/ha and 40% dimethomorph suspending agent, thin up spraying, and the control efficiency after medicine after 7 days and 14 days is respectively 74.6%, 81.3% and 86.31%, 89.9%.It is obvious that fluazinam and dimethomorph are joined rear synergistic effect, and to the control efficiency of downy mildew of garpe, significantly better than single dose, and the consumption of active ingredient obviously reduces.
Biologicall test example
The present composition is taking fluazinam and dimethomorph as active ingredient, oomycetes has all been shown to very high activity, both sterilization mechanisms are not identical, between them, combination has obvious synergistic function to diseases such as cucumber downy mildews, and be not only the simple addition of two kinds of pharmacy effects, below biologicall test example be used for illustrating this point.
The resistance producing in downy mildew of garpe in order to delay fluazinam and dimethomorph, inventor is finding that fluazinam and dimethomorph composition have downy mildew of garpe on the basis of synergistic effect, has carried out mutual composite biologicall test synergy research.Test is taking downy mildew of garpe as tested object, and concrete grammar is:
Test material is Plasmopara viticola, and test medicine provides former medicine for producer.
Measure fluazinam, the fungistatic effect of dimethomorph complex preparation to downy mildew of garpe in indoor employing plate blade method.Test method: grape leave is put into culture dish and carry out moisturizing processing, and by design metering dispenser agent respectively, after 24 hours, inoculate Plasmopara viticola pathogen, after inoculation, in climatic cabinate, moisturizing is cultivated, after 6 days, carry out result investigation, process 10 repetitions at every turn.Morbidity is stable, by grape leave downy mildew grade scale investigation disease index, and makes evaluating drug effect with blank.
Statistical analysis technique
Severity Scaling standard
0 grade: blade is without scab;
1 grade: lesion area accounts for the area of whole blade below 5%;
3 grades: lesion area accounts for the 6-10% of the area of whole blade;
5 grades: lesion area accounts for the 11-25% of whole blade area;
7 grades: lesion area accounts for the 25-50% of whole blade area;
9 grades: lesion area accounts for the more than 50% of whole blade area.
Computational methods
Concentration EC in calculating virulence equation and suppress by method of least squares
50.
Actual measurement toxicity index (ATI)=standard medicament EC
50/ reagent agent EC
50× 100
The percentage composition of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
Co-toxicity coefficient (CTC)=[the theoretical toxicity index of mixture actual measurement toxicity index (ATI)/mixture (TTI)] × 100.
The method proposing according to Sun Pei cloud calculates the toxicity index of each medicament and the co-toxicity coefficient of mixture (CTC value), be that CTC≤80 are antagonism, 80 < CTC < 120 are summation action, and CTC >=120 are synergistic effect.
Test mixture result is as following table:
The formula the selection result of table 1 fluazinam dimethomorph to downy mildew of garpe
| Process | Mass ratio | EC50(mg/L) | ATI | TTI | Co-toxicity coefficient CTC |
| F (fluazinam) | - | 1.58 | 100.0 | - | - |
| X (dimethomorph) | - | 0.28 | 564.3 | - | - |
| F∶X | 30∶1 | 0.71 | 222.5 | 115.0 | 193.5 |
| F∶X | 20∶1 | 0.77 | 205.2 | 122.1 | 168.0 |
| F∶X | 10∶1 | 0.36 | 438.9 | 142.2 | 308.6 |
| F∶X | 5∶1 | 0.24 | 658.3 | 177.4 | 371.1 |
| F∶X | 1∶1 | 0.19 | 831.6 | 332.1 | 250.4 |
| F∶X | 1∶5 | 0.10 | 1580.0 | 486.9 | 324.5 |
| F∶X | 1∶10 | 0.09 | 1755.6 | 522.1 | 336.3 |
| F∶X | 1∶20 | 0.14 | 1128.6 | 542.2 | 208.2 |
| F∶X | 1∶30 | 0.21 | 752.4 | 549.3 | 137.0 |
The result of table 1 shows, the proportioning of fluazinam and dimethomorph is between 1: 30～30: 1 time, and co-toxicity coefficient is more than 130, downy mildew of garpe is had to obvious synergistic effect, especially when proportioning is between 1: 20～10: 1, synergy is more remarkable, and co-toxicity coefficient is more than 200.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. for preventing and treating a composition pesticide for rice sheath blight disease, the fluazinam that contains effective dose and dimethomorph, the mass ratio of described fluazinam and dimethomorph is 1:30 or 30:1.
2. composition pesticide as claimed in claim 1, is characterized in that, the formulation of described composition pesticide is suspending agent, and described suspending agent also comprises water, dispersant, thickener, antifreezing agent and wetting agent.
3. composition pesticide as claimed in claim 1, is characterized in that, the formulation of described composition pesticide is wetting powder, and described wetting powder also comprises wetting agent, dispersant and filler.
4. composition pesticide as claimed in claim 1, is characterized in that, the formulation of described composition pesticide is missible oil, and described missible oil also comprises solvent, cosolvent and emulsifier.
5. composition pesticide as claimed in claim 1, is characterized in that, the formulation of described composition pesticide is aqueous emulsion, and described aqueous emulsion also comprises organic solvent, dispersant, emulsifier and water.
6. composition pesticide as claimed in claim 1, is characterized in that, the formulation of described composition pesticide is microemulsion, and described microemulsion also comprises organic solvent, emulsifier and water.
7. composition pesticide as claimed in claim 1, is characterized in that, the formulation of described composition pesticide is water dispersible granules, and described water dispersible granules also comprises dispersant, disintegrant, filler and wetting agent.
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| CN200910109055.5A CN101617678B (en) | 2009-07-29 | 2009-07-29 | Pesticide composition |
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| CN200910109055.5A CN101617678B (en) | 2009-07-29 | 2009-07-29 | Pesticide composition |
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| CN101617678A CN101617678A (en) | 2010-01-06 |
| CN101617678B true CN101617678B (en) | 2014-07-02 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102696634B (en) * | 2012-05-09 | 2015-11-18 | 广东中迅农科股份有限公司 | A kind of composition pesticide containing dimethomorph and bromothalonil |
| CN104322521B (en) * | 2012-11-15 | 2016-03-16 | 江苏扬农化工股份有限公司 | A kind of combination sterilization composition containing fluazinam |
| WO2015068158A1 (en) * | 2013-11-07 | 2015-05-14 | Adama Makhteshim Ltd. | Synergistic fungicidal composition |
| CN104222121B (en) * | 2014-08-26 | 2016-08-24 | 中农立华生物科技股份有限公司 | A kind of bactericidal composition and preparation and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0956769A1 (en) * | 1998-05-13 | 1999-11-17 | American Cyanamid Company | Fungicidal mixtures |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0956769A1 (en) * | 1998-05-13 | 1999-11-17 | American Cyanamid Company | Fungicidal mixtures |
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| CN101617678A (en) | 2010-01-06 |
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