CN101612202A - A kind of fat emulsion injection and preparation method thereof - Google Patents
A kind of fat emulsion injection and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of fat emulsion injection and preparation method thereof, research worker of the present invention is found through lot of experiments, contain the olive oil of effective dose and the fat emulsion injection of soybean oil and other proper auxiliary materials, has good stable, olive oil combines the preparation made from soybean oil, greatly reduce the untoward reaction that unsaturated fatty acid and satisfied fatty acid bring, research worker finds that the proportioning between olive oil and the soybean oil has material impact to the stability of fat emulsion injection of the present invention, and fat emulsion injection stability of the present invention is best when olive oil and soybean oil proportioning are 4: 1.
Description
Affiliated technical field
The invention belongs to medical technical field, be specifically related to a kind of fat emulsion injection and preparation method thereof.
Background technology
Fat milk is one of energy source of parenteral nutrition body, can energy is provided and can prevent the shortage of essential amino acids in the body for body as the fat milk of one of parenteral nutrition constituent, and this has become people's common recognition in clinical practice.Begin to use clinically the sixties in 20th century, over nearly 50 years, to nearest fish oil fat milk, fat milk generally is to use the long chain triglyceride and the egg yolk lecithin that extract from soybean oil to prepare to fat milk, has had polytype preparation to use at home from initial long chain fat emulsion.Add the lipomul that a certain amount of phosphatidylcholine (lecithin) emulsifying forms by Semen sojae atricolor, it is a kind of intravenous nutrition medicine, the clinical patient who is mainly used in tumor and other malignant diseases and can not absorbs nourishment through gastrointestinal tract for a certain reason must fatty acid to replenish suitable heat and human body.
Fat emulsion injection of the present invention is to be formed by soybean oil and mixed with olive oil, and olive oil is top quality fat, is the essential material of keeping health, is acknowledged as " pollution-free food " in the edible oil in the world, and in pharmacopeia is listed it already by states such as English, U.S..Be rich in a kind of antioxidant that is named as polyphenol in the olive oil, it can resist heart disease and cancer, and this material can slow down the growth of colon cancer, pulmonary carcinoma and skin cancer cell effectively.In addition olive oil also contains abundant vitamin such as vitamin e, and these materials combine and can effectively stop hyperlipidemia, reduces the danger that arteriosclerosis and some cancer take place.Soybean oil contains abundant linoleic acid, and significant reduction serum cholesterol content is arranged, and the effect of angiocardiopathy preventing also contains vitamin E, vitamin D and the abundant lecithin of volume in the Semen sojae atricolor, health all is highly profitable.Fat emulsion injection of the present invention can satisfy the fundamental need of human body to essential amino acids, greatly reduce the untoward reaction that unsaturated fatty acid and satisfied fatty acid bring simultaneously, can reduce lipid peroxidation to greatest extent, improve immunologic function, increase emulsion stability and accelerate the synthetic of long-chain fatty acid, compare with other fat milks simultaneously, fat emulsion injection of the present invention has therapeutic efficiency equally.
Summary of the invention
Research worker of the present invention is found through lot of experiments, contain the olive oil of effective dose and the fat emulsion injection of soybean oil and other proper auxiliary materials, has good stable, olive oil combines the preparation made from soybean oil, greatly reduce the untoward reaction that unsaturated fatty acid and satisfied fatty acid bring, research worker finds that the proportioning between olive oil and the soybean oil has material impact to the stability of fat emulsion injection of the present invention, and fat emulsion injection stability of the present invention is best when olive oil and soybean oil proportioning are 4: 1.
The object of the present invention is to provide a kind of fat emulsion injection.
The object of the present invention is to provide a kind of preparation method of fat emulsion injection.
The present invention is achieved by the following technical solutions:
Fat emulsion injection of the present invention contains:
Olive oil, soybean oil, glycerol, lecithin, enuatrol;
The weight ratio of olive oil and soybean oil is 4: 1 in the fat emulsion injection of the present invention.
Fat emulsion injection of the present invention makes that each components contents is in the 1000ml preparation: 160g olive oil, 40g soybean oil, 22.5g glycerol, 12.0g lecithin, 0.3g enuatrol.
The preparation method of fat emulsion injection of the present invention:
(1) glycerol, the enuatrol that takes by weighing recipe quantity adds 50% water for injection, stirs and makes dissolving, is made into aqueous solution, regulates pH value to 9.5～10.5 as water with NaOH solution, and 75 ± 5 ℃ of insulations are standby;
(2) take by weighing the olive oil and the soybean oil of recipe quantity, stir, as oil phase, 75 ± 5 ℃ of insulations, standby;
(3) recipe quantity lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 25 ± 5min, make colostrum;
(4) regulate colostrum pH value to 8.5～9.5 with sodium hydroxide solution, be settled to full dose, be transferred in the high pressure homogenization machine with the water for injection dilution, under the 880bar condition, temperature is 45 ± 5 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Adopt 70 ℃～80 ℃ temperature in the fat emulsion injection preparation method of the present invention as the colostrum preparation.
The colostrum mixing time is defined as 20～30 minutes in the fat emulsion injection preparation method of the present invention.
PH with preparation in the fat emulsion injection preparation method of the present invention is decided to be 7.0～8.0.
Selecting homogenize pressure in the fat emulsion injection preparation method of the present invention is a step valve 800bar.
For obtaining the particle of uniform particle diameter, it is 5 times in the fat emulsion injection preparation method of the present invention with the even number of times of breast.
Select 121 ℃ in the fat emulsion injection preparation method of the present invention, the 15min rotary water bath is sterilized.
Olive oil is combined the back make fat emulsion injection with soybean oil with suitable adjuvant, greatly reduce the untoward reaction that unsaturated fatty acid and satisfied fatty acid bring, can reduce lipid peroxidation to greatest extent, improve immunologic function, increase emulsion stability and accelerate the synthetic of long-chain fatty acid, compare with other fat milks simultaneously, fat emulsion injection of the present invention has therapeutic efficiency equally.
Study on Preparation
According to the literature, the process conditions that influence the emulsion particles size mainly contain the pressure of the preparation temperature of colostrum, preparation time and high pressure homogenize and number of times etc., so mainly in technology investigation process investigate these several parameters.Because the particle diameter of colostrum part emulsion droplet had exceeded the measurement range of particle size analyzer when colostrum prepared, therefore do not use particle size analyzer to measure the particle diameter of colostrum, and with different preparation conditions down the centrifugal stability parameter of preparation colostrum and colostrum outward appearance as judging quota.
Visual examination: get fat emulsion injection 400ml of the present invention, slowly pour in the beaker of 500ml, cover beaker it was left standstill 1 hour, immediately 2 seconds of right-angle view outward appearance; Beaker is tilted 45 °, observed for 5 seconds.Repeat 3 times.The meansigma methods of 3 observed results should see Table 1 less than 5 grades.
1. the research of colostrum preparation temperature, time
According to the influence of temperature to oil water interfacial tension, select 60～90 ℃ of investigation scopes as the Emulsion preparation temperature, with the biphase temperature that is heated to required test respectively of profit, after the mixing, prepare Emulsion with tissue mashing machine, measurement result sees Table 2,3.
Table 2 colostrum preparation temperature is to the influence of centrifugal stability constant, outward appearance
Elevated temperature can reduce the viscosity of continuous phase, help the transmission of shearing force and the formation of Emulsion, but the elevated temperature interfacial film can expand, also increased simultaneously the kinetic energy of emulsion droplet, emulsion droplet is easily assembled merging, and temperature is too high, lecithin and oil for injection easily are hydrolyzed, and therefore select 80 ℃.Near the Emulsion that this temperature, prepares, the less and narrower particle size distribution of particle diameter, Emulsion is more stable, and this moment oil phase viscosity lower, therefore the merit that the shearing force that the outside applies is done is less, also is beneficial to emulsifying, adopts 70 ℃～80 ℃ temperature as the colostrum preparation.
Table 3 colostrum preparation time is to the influence of centrifugal stability constant, outward appearance
By above data as can be known, increase along with preparation time, the physical stability of colostrum strengthens, and performance to some extent in appearance, but after the time was increased to 30 minutes, its centrifugal stability constant and outward appearance did not see that significant change is arranged, and lecithin and oil for injection are present in the hot environment for a long time, easily be hydrolyzed, so the colostrum mixing time is defined as 20～30 minutes.
2.pH the investigation of value scope
PH value can influence the physical stability of Emulsion, according to prescription preparation liplid emulsions, sodium hydroxide solution with 0.1M is regulated pH, investigate the variation of preparation sterilization front and back pH and the variation of Emulsion outward appearance, the scoring of Emulsion outward appearance is with reference to the rank scores of existing national standard (JX20010352), and experimental result sees Table 4.
The investigation of table 4pH value scope
By The above results as can be known: pH value obviously reduces before and after the sterilization of this Emulsion, and after the sterilization, in the scope of pH value 7.0～8.0, preparation has better physical stability, considers the toleration of clinical application, and the pH of preparation is decided to be 7.0～8.0.
3. the investigation of high pressure homogenization pressures
The colostrum of prescription preparation in the past is equipped with final Emulsion with high pressure homogenization mechanism, and a step valve and secondary valve to the different pressures of regulating the high pressure dispersing emulsification machine prepare Emulsion, and wherein the pressure of secondary valve is 1/10th of a step valve pressure.Regulate pressure, preparation Emulsion.Measure the particle diameter of homogenize gained Emulsion under the different pressures, the results are shown in Table 5.
The size of Emulsion particle diameter and distribution during table 5 different pressures
As seen from the above table, the particle diameter of Emulsion reduces with the increase of homogenization pressures, and particle size distribution tends to concentrated with the increase of pressure.And after increasing to 800bar with pressure, change of size trend reduces.Particle diameter of this test and Selection and distribution thereof all meet existing request of national standard, consider the energy consumption factor, and selecting homogenize pressure is a step valve 800bar, secondary valve 80bar.
4. the investigation of the even number of times of high pressure breast
By aforementioned prescription and prepared colostrum, be equipped with final Emulsion with high pressure homogenization mechanism, the pressure of regulating the secondary valve of high pressure homogenization machine respectively is 80bar, the pressure of a step valve is 800bar, and colostrum is carried out homogenize, the number of times that homogenize is different.Measure particle diameter after the homogenize, the results are shown in Table 6.
The size of the different homogenize number of times of table 6 Emulsion particle diameter and distribution
By above data as can be known: when breast was spared number of times less than 5 times, along with the increase of the even number of times of breast, particle diameter reduced, and the distribution of particles trend evenly; When breast was spared number of times greater than 5 times, it is big that particle size distribution begins to become, and may be because prepare Emulsion under above-mentioned pressure, the particle diameter of Emulsion has been tending towards stably dispersing, increases the homogenize number of times again, can increase the collision opportunity of particle, increase the possibility that small-particle merges, therefore should avoid the homogenize number of times too much.For obtaining the particle of uniform particle diameter, it is 5 times with the even number of times of breast.
5. the investigation of sterilization method
With reference to pertinent regulations under the moist heat sterilization item in Chinese Pharmacopoeia version appendix in 2005 the X VII sterilization sterilization, investigate 121 ℃, the variation of the particle diameter of Emulsion system and outward appearance under the 15min sterilising conditions, result of the test is as shown in table 7:
Table 7 sterilising conditions is to the influence of preparation stability
The result shows 121 ℃ of uses, and when 15min sterilized to fat emulsion injection of the present invention, Emulsion outward appearance, character, sterility test, bacterial endotoxin, particulate matter, free fatty and peroxide value were all up to specification.Mean diameter has increase slightly, considers practical condition, selects 121 ℃, and the 15min rotary water bath is sterilized to fat emulsion injection of the present invention, so that the homogeneity that fat emulsion injection of the present invention is heated when sterilization.Simultaneously, during sterilization, preferably reduce the time of being heated, Fast Heating, fast cooling.
The specific embodiment
Embodiment 1
(1) take by weighing 22.5g glycerol, the 0.3g enuatrol adds 50% water for injection, stirs to make dissolving, is made into aqueous solution, regulates pH value to 9.5 as water with NaOH solution, 75 ℃ of insulations are standby;
(2) take by weighing 160g olive oil and 40g soybean oil, stir, as oil phase, 75 ℃ of insulations, standby;
(3) 12.0g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 25min, make colostrum;
(4) regulate colostrum pH value to 8.5 with sodium hydroxide solution, be settled to full dose with the water for injection dilution, be transferred in the high pressure homogenization machine, under the 880bar condition, temperature is 45 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Embodiment 2
(1) 50g glycerol, the 0.8g enuatrol that takes by weighing recipe quantity adds 50% water for injection, stirs and makes dissolving, is made into aqueous solution, regulates pH value to 10.5 as water with NaOH solution, and 80 ℃ of insulations are standby;
(2) take by weighing 320g olive oil and 80g soybean oil, stir, as oil phase, 80 ℃ of insulations, standby;
(3) 24.0g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 30min, make colostrum;
(4) regulate colostrum pH value to 9.5 with sodium hydroxide solution, be settled to full dose with the water for injection dilution, be transferred in the high pressure homogenization machine, under the 880bar condition, temperature is 50 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Embodiment 3
(1) take by weighing 30g glycerol, the 0.5g enuatrol adds 50% water for injection, stirs to make dissolving, is made into aqueous solution, regulates pH value to 10 as water with NaOH solution, 70 ℃ of insulations are standby;
(2) take by weighing 240g olive oil and 60g soybean oil, stir, as oil phase, 70 ℃ of insulations, standby;
(3) 18.0g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 20min, make colostrum;
(4) regulate colostrum pH value to 9 with sodium hydroxide solution, be settled to full dose with the water for injection dilution, be transferred in the high pressure homogenization machine, under the 880bar condition, temperature is 40 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Embodiment 4
(1) take by weighing 50g glycerol, the 1g enuatrol adds 50% water for injection, stirs to make dissolving, is made into aqueous solution, regulates pH value to 9.8 as water with NaOH solution, 78 ℃ of insulations are standby;
(2) take by weighing 360g olive oil and 90g soybean oil, stir, as oil phase, 78 ℃ of insulations, standby;
(3) 30g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 28min, make colostrum;
(4) regulate colostrum pH value to 8.8 with sodium hydroxide solution, be settled to full dose with the water for injection dilution, be transferred in the high pressure homogenization machine, under the 880bar condition, temperature is 48 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Embodiment 5
(1) take by weighing 10g glycerol, the 0.15g enuatrol adds 50% water for injection, stirs to make dissolving, is made into aqueous solution, regulates pH value to 9 as water with NaOH solution, 75 ℃ of insulations are standby;
(2) take by weighing 60g olive oil and 15g soybean oil, stir, as oil phase, 80 ℃ of insulations, standby;
(3) 5g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 30min, make colostrum;
(4) regulate colostrum pH value to 9 with sodium hydroxide solution, be settled to full dose with the water for injection dilution, be transferred in the high pressure homogenization machine, under the 880bar condition, temperature is 50 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Embodiment 6
(1) take by weighing 25g glycerol, the 0.35g enuatrol adds 50% water for injection, stirs to make dissolving, is made into aqueous solution, regulates pH value to 10 as water with NaOH solution, 70 ℃ of insulations are standby;
(2) take by weighing 200g olive oil and 50g soybean oil, stir, as oil phase, 75 ℃ of insulations, standby;
(3) 15g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 25min, make colostrum;
(4) regulate colostrum pH value to 8.5 with sodium hydroxide solution, be settled to full dose with the water for injection dilution, be transferred in the high pressure homogenization machine, under the 880bar condition, temperature is 40 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
Stability experiment research
According to the regulation of relevant medicine stability test in " chemicals stability study technological guidance principle " and " new drug registration management way ", the stability of long chain fat emulsion injection is investigated, comprise accelerated test and long term test.According to drug standard, investigate the variation of character, outward appearance, pH value, breast grain, peroxide value, free fatty and fat, glycerol and content of phospholipid with the fat emulsion injection of preparation method development of the present invention.
1. accelerated test
Get fat emulsion injection of the present invention, press commercially available back (glass infusion bottle), put 30 ℃ ± 2 ℃, relative humidity and be in 65% ± 5% the calorstat, place, when 1,2,3,6 the end of month, take a sample, press the quality standard inspection, compare with 0 month result, the results are shown in Table 8,9,10.
Table 9 accelerated tests changes of contents
Aseptic and the bacterial endotoxin experiment of table 10 accelerated tests
Result of the test shows: fat emulsion injection of the present invention is under the condition of accelerated test, and the content of glycerol, phospholipid and fat remains unchanged substantially, and property of drug is stable.Peroxide value, free acid are all up to specification.Outward appearance rank and particle diameter slightly increase, and pH value has decline slightly, and be aseptic and bacterial endotoxin is all up to specification, this shows, under the accelerated test condition, fat emulsion injection of the present invention is stable.
2. long term test
Get fat emulsion injection of the present invention, press commercially available back (glass infusion bottle), put 25 ℃ ± 2 ℃, relative humidity and be in 60% ± 10% the calorstat, place, sampling in the time of 3,6,9,12,18 months is by the method inspection of stipulating in the quality standard, compare with 0 month result, the results are shown in Table 11,12,13.
Table 11 long-term experiment result
Table 12 long-term experiment changes of contents
Aseptic and the bacterial endotoxin of table 13 long-term experiment
Long-term test results shows: 18 months of long term test, and the content of glycerol, phospholipid and fat remains unchanged substantially, and property of drug is stable.Peroxide value, free acid are all up to specification.Outward appearance rank and particle diameter slightly increase, and pH value has decline slightly, and be aseptic and bacterial endotoxin is all up to specification, this shows, under the long term test condition, fat emulsion injection of the present invention is stable.
Claims (10)
1. a fat emulsion injection is characterized in that this fat emulsion injection contains olive oil and soybean oil.
2. a kind of fat emulsion injection as claimed in claim 1 is characterized in that this fat emulsion injection also contains glycerol, lecithin, enuatrol.
3. a kind of fat emulsion injection as claimed in claim 2 is characterized in that the weight ratio of olive oil and soybean oil is 4: 1 in this fat emulsion injection.
4. a kind of fat emulsion injection as claimed in claim 2, its preparation method specifically comprises following step:
(1) glycerol, the enuatrol that takes by weighing recipe quantity adds 50% water for injection, stirs and makes dissolving, is made into aqueous solution, regulates pH value to 9.5～10.5 as water with NaOH solution, and 75 ± 5 ℃ of insulations are standby;
(2) take by weighing the olive oil and the soybean oil of recipe quantity, stir, as oil phase, 75 ± 5 ℃ of insulations, standby;
(3) recipe quantity lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase slowly is added to aqueous phase, finish until adding; Continue stir about 25 ± 5min, make colostrum;
(4) regulate colostrum pH value to 8.5～9.5 with sodium hydroxide solution, be settled to full dose, be transferred in the high pressure homogenization machine with the water for injection dilution, under the 880bar condition, temperature is 45 ± 5 ℃, and cycle of higher pressure gets Emulsion 5 times, omnidistance logical nitrogen protection in the Emulsion preparation process; The Emulsion that makes is crossed 3 μ m membrane filtrations, inflated with nitrogen, embedding, 121 ℃ of rotary water baths were sterilized 15 minutes, got fat emulsion injection.
5. the preparation method of a kind of fat emulsion injection as claimed in claim 4 is characterized in that adopting 70 ℃～80 ℃ temperature as the colostrum preparation.
6. the preparation method of a kind of fat emulsion injection as claimed in claim 4 is characterized in that the colostrum mixing time is defined as 20～30 minutes.
7. the preparation method of a kind of fat emulsion injection as claimed in claim 4 is characterized in that the pH of preparation is decided to be 7.0～8.0.
8. the preparation method of a kind of fat emulsion injection as claimed in claim 4, it is characterized in that selecting homogenize pressure is a step valve 800bar.
9. the preparation method of a kind of fat emulsion injection as claimed in claim 4 is characterized in that the even number of times of breast is 5 times.
10. the preparation method of a kind of fat emulsion injection as claimed in claim 4 is characterized in that selecting 121 ℃, and the 15min rotary water bath is sterilized.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103690478A (en) * | 2013-12-04 | 2014-04-02 | 广东嘉博制药有限公司 | Olive oil containing long-chain triglyceride injection and preparation method thereof |
| CN104288210A (en) * | 2014-09-22 | 2015-01-21 | 辽宁海思科制药有限公司 | Long chain fat emulsion medicine composition for injection and preparation method thereof |
| CN104411185A (en) * | 2012-07-03 | 2015-03-11 | 皇家飞利浦有限公司 | A method and apparatus for increasing the solubility of fat-soluble nutrient in water |
| CN104739764A (en) * | 2013-12-31 | 2015-07-01 | 四川科伦药业股份有限公司 | Fat emulsion injection and preparation method thereof |
| CN105456189A (en) * | 2014-09-12 | 2016-04-06 | 武汉大安制药有限公司 | Clevidipine butyrate emulsion injection and preparation method thereof |
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2008
- 2008-06-23 CN CN200810115380A patent/CN101612202A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104411185A (en) * | 2012-07-03 | 2015-03-11 | 皇家飞利浦有限公司 | A method and apparatus for increasing the solubility of fat-soluble nutrient in water |
| CN103690478A (en) * | 2013-12-04 | 2014-04-02 | 广东嘉博制药有限公司 | Olive oil containing long-chain triglyceride injection and preparation method thereof |
| CN103690478B (en) * | 2013-12-04 | 2016-08-17 | 广东嘉博制药有限公司 | A kind of containing olive oil long chain fat emulsion injection and preparation method thereof |
| CN104739764A (en) * | 2013-12-31 | 2015-07-01 | 四川科伦药业股份有限公司 | Fat emulsion injection and preparation method thereof |
| CN104739764B (en) * | 2013-12-31 | 2017-10-27 | 四川科伦药业股份有限公司 | A kind of fat emulsion injection and preparation method thereof |
| CN105456189A (en) * | 2014-09-12 | 2016-04-06 | 武汉大安制药有限公司 | Clevidipine butyrate emulsion injection and preparation method thereof |
| CN104288210A (en) * | 2014-09-22 | 2015-01-21 | 辽宁海思科制药有限公司 | Long chain fat emulsion medicine composition for injection and preparation method thereof |
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Open date: 20091230 |