CN103690478A - Olive oil containing long-chain triglyceride injection and preparation method thereof - Google Patents
Olive oil containing long-chain triglyceride injection and preparation method thereof Download PDFInfo
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- CN103690478A CN103690478A CN201310638974.8A CN201310638974A CN103690478A CN 103690478 A CN103690478 A CN 103690478A CN 201310638974 A CN201310638974 A CN 201310638974A CN 103690478 A CN103690478 A CN 103690478A
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Abstract
The invention discloses olive oil containing long-chain triglyceride injection. The injection comprises the following components: 140-170mg/ml of olive oil, 30-60mg/ml of soybean oil, 0.0002-0.0025mg/ml of oleic acid, 0.005-0.02mg/ml of purified lecithin and 20-28mg/ml of glycerinum, wherein the pH value of the injection is regulated to 7.0-9.5 by a pH regulating agent. The invention also discloses a method for preparing the olive oil containing long-chain triglyceride injection, which is simple in operation process, the product grains are uniform in side by controlling homogenizing pressure, time, temperature, nitrogenizing and other processes, the oxidation index, asepsis and other related indexes can reach standard, the product is good in stability, and the problems that oxidation index of grains easily exceeds the standard and the grains are easily aggregated when placed for a long time can be solved.
Description
Technical field
The present invention relates to pharmaceutical preparations technology field, be specifically related to a kind of olive oil long chain fat emulsion injection that contains, the invention still further relates to this containing the preparation method of olive oil long chain fat emulsion injection.
Background technology
The important component part that fat emulsion injection is supported as parenteral nutrition, is important energy source, and essential fatty acid and fatsoluble vitamin are also provided simultaneously, has important metabolic function.The maximum lipomul of clinical practice is long-chain fat Emulsion and the middle long-chain fat Emulsion based on soybean oil at present, in the fatty acid containing in soybean oil, approximately 62% is polyunsaturated fatty acid, a large amount of infusion polyunsaturated fatty acid can cause immune cell function to reduce, and increase patient's infection risk.In addition, the lipid overload that long period transportation parenteral nutrition brings, excessive glucose and bacterial multiplication etc. causes the risk that hepatic insufficiency occurs to increase, and the shortage (as EFA, VitE etc.) of some nutrient is also the reason that causes hepatic insufficiency simultaneously.
Contain the long chain fat emulsion injection of olive oil generally by its called after long chain fat emulsion injection (OO), long chain fat emulsion injection (OO) is the lipomul being mixed with the ratio of approximately 4: 1 by olive oil and soybean oil, and be applied to clinical (trade name ClinOleic, Clintec Baxter, Round Lake/Deerfield, IL, USA), the application of long chain fat emulsion injection (OO) has at present accounted for 20% of fat emulsion injection, in 2007 by the import of Belgian Bai Te company to China, commodity are called gram Ling Nuo, product base attribute is: essential fatty acid content 20%, glycerol content 22.0～24.0g/L, at present domestic there is no produced this quasi drugs.
The long chain fat emulsion injection of prior art (OO) formula is: every 100ml is containing olive oil and soybean oil 20.00g, be equivalent to essential fatty acid content 4.00g, containing lecithin 1.20g, glycerol 2.25g, enuatrol 0.03g, the easy layering of this long chain fat emulsion injection, anisidine value is too high, the against regulation requirement of lysophosphatide.In addition, the Chinese patent that the patent No. is 200810115380.8 discloses a kind of fat emulsion injection and preparation method thereof, and its preparation flow is: the preparation-colostrum-homogenizing of the preparation-oil phase of water five times.Yet the preparation temperature of this preparation method is high, and homogenization cycles is few, fail effectively to control oils oxidation, can not control to OK range being greater than 5 μ m breast grains, breast grain size is uneven, and easily layering, and indices is defective.Based on above background, aobvious particularly necessity of a set of fat emulsion injection preparation method containing olive oil that research is ripe.
Summary of the invention
The object of the invention is to propose a kind of olive oil long chain fat emulsion injection that contains, the good stability of this injection, evenly, the oxidation index that has solved newborn grain easily exceeds standard and places the problem of easily assembling for a long time breast grain.
In order to solve prior art problem, the present invention is achieved by the following technical solutions.
Containing an olive oil long chain fat emulsion injection, by olive oil, soybean oil, oleic acid, pH adjusting agent, purification lecithin, glycerol and injection water, formed, each component of this injection consists of:
Olive oil 140 ~ 170 mg/ml
Soybean oil 30 ~ 60mg/ml
Oleic acid 0.0002 ~ 0.0025mg/ml
Purification lecithin 0.005 ~ 0.02mg/ml
Glycerol 20 ~ 28mg/ml
It is 7.0 ~ 9.5 that pH adjusting agent adds to injection pH value.
Described pH adjusting agent is sodium hydroxide, sodium hydrogen phosphate, sodium citrate or enuatrol.
The present invention also provides a kind of preparation method containing olive oil long-chain fat emulsified injection, comprises the following steps:
1) olive oil and soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 30 ~ 60 ℃, adds purification lecithin, smashs to pieces to dissolving completely, then adds oleic acid, and 3 ~ 10min is stirred in continuation, obtains oil phase;
2) glycerol and injection water are added in preparing tank and stirred, filter, then add pH adjusting agent to regulate pH value to 7.0 ~ 9.5, obtain water;
3) oil phase is added in water, stir 10 ~ 40min, obtain colostric fluid;
4) adopt high pressure homogenizer more than 6 times, to obtain medicinal liquid to colostric fluid homogenizing, wherein, the temperature in homogenizing process is that 30 ~ 60 ℃, first class pressure are that 3000 ~ 8000psi, secondary pressure are 1000 ~ 2000psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 115 ~ 125 ℃, and sterilization time is 8 ~ 30min, obtains containing olive oil long chain fat emulsion injection.
Described oil phase preparation process is all carried out to canned step process in filling nitrogen environment.
Compared with prior art, beneficial effect of the present invention is as follows:
(1) the present invention is by product pH value, the pressure of homogenizing, isoparametric control of time, make product breast grain size evenly, outward appearance layering etc. solved, product adds Emulsion stabilizing agent oleic acid, can effectively guarantee the stability of product.
(2) by whole process, lead to nitrogen technique, the oxidation level of product is reduced greatly, anisidine value can be controlled.
(3) by controlling sterilizing F0 >=8, make, under prerequisite that product reduces greatly at microbiological hazards, to reduce the hydrolysis of adjuvant, lysophosphatide is controlled in scope.
(4) product of the present invention adopts purification lecithin, can, at lower pressure and temperature, form the product of the safety that particle diameter is even, stable, oxidation index is lower.
The specific embodiment
The present invention has disclosed a kind of olive oil long chain fat emulsion injection that contains, and olive oil, soybean oil, oleic acid, pH adjusting agent, purification lecithin, glycerol and injection water, consists of, and each component of this injection consists of:
Olive oil 140 ~ 170 mg/ml
Soybean oil 30 ~ 60mg/ml
Oleic acid 0.0002 ~ 0.0025mg/ml
Purification lecithin 0.005 ~ 0.02mg/ml
Glycerol 20 ~ 28mg/ml
It is 7.0 ~ 9.5 that pH adjusting agent adds to injection pH value.
The present invention is 40 mg/ml left and right containing the content of essential fatty acid in olive oil long chain fat emulsion injection, injection is difficult for layering, and breast grain size is even, all requirements up to specification of anisidine value, lysophosphatide in emulsion, place long-time and be difficult for assembling, product quality is good.
The present invention has also disclosed a kind of preparation method containing olive oil long chain fat emulsion injection, comprises the following steps:
1) olive oil and soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 30 ~ 60 ℃, adds purification lecithin, smashs to pieces to dissolving completely, then adds oleic acid, and 3 ~ 10min is stirred in continuation, obtains oil phase;
2) glycerol and injection water are added in preparing tank and stirred, filter, then add pH adjusting agent to regulate pH value to 7.0 ~ 9.5, obtain water;
3) oil phase is added in water, stir 10 ~ 40min, obtain colostric fluid;
4) adopt high pressure homogenizer more than 6 times, to obtain medicinal liquid to colostric fluid homogenizing, wherein, the temperature in homogenizing process is that 30 ~ 60 ℃, first class pressure are that 3000 ~ 8000psi, secondary pressure are 1000 ~ 2000psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 115 ~ 125 ℃, and sterilization time is 8 ~ 30min, obtains containing olive oil long chain fat emulsion injection.
Described oil phase preparation process is all carried out to canned step process in filling nitrogen environment.
The inventive method is by adding Emulsion stabilizing agent, control pressure, time, temperature, the process of homogenizing and fill the parameters such as nitrogen, the breast grain size that makes product evenly, qualified, the outward appearance layering of indices etc. solved, the stability of injection in 2 years guaranteed, the oxidation index that has solved newborn grain easily exceeds standard and places the long-time easily problem of gathering.
In addition, high pressure homogenizer used in the present invention is prior art, adds water to the techniques such as full dose, canned, tamponade and Zha Gaifengkou and is prior art, therefore be not described in detail one by one.
For those skilled in the art's understanding, below in conjunction with specific embodiment, the present invention is done to further detailed description.
Embodiment 1
A preparation method containing olive oil long chain fat emulsion injection, comprises the following steps:
1) 330g olive oil and 70g soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 30 ℃, adds 40g purification lecithin, smashs to pieces to dissolving completely, then adds 0.5g oleic acid, and 6min is stirred in continuation, obtains oil phase;
2) 40g glycerol is added in preparing tank and stirred with appropriate injection water, filter, filling jetting is to 2L, then adds pH adjusting agent to regulate pH value to 9.5, obtains water;
3) oil phase is added in water, stir 25min, obtain colostric fluid;
4) adopt high pressure homogenizer to colostric fluid homogenizing 14 times, obtain medicinal liquid, wherein, the temperature in homogenizing process is that 30 ℃, first class pressure are that 3000psi, secondary pressure are 1000psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 115 ℃, and sterilization time is 30min, lamp inspection, and packing, obtains containing olive oil long chain fat emulsion injection.
Embodiment 2
A preparation method containing olive oil long chain fat emulsion injection, comprises the following steps:
1) 320g olive oil and 80g soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 40 ℃, adds 30g purification lecithin, smashs to pieces to dissolving completely, then adds 1.0g oleic acid, and 10min is stirred in continuation, obtains oil phase;
2) 45g glycerol is added in preparing tank and stirred with appropriate injection water, filter, filling jetting is to 2L, then adds pH adjusting agent to regulate pH value to 8.5, obtains water;
3) oil phase is added in water, stir 40min, obtain colostric fluid;
4) adopt high pressure homogenizer to colostric fluid homogenizing 10 times, obtain medicinal liquid, wherein, the temperature in homogenizing process is that 40 ℃, first class pressure are that 4000psi, secondary pressure are 1200psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 121 ℃, and sterilization time is 12min, lamp inspection, and packing, obtains containing olive oil long chain fat emulsion injection.
Embodiment 3
A preparation method containing olive oil long chain fat emulsion injection, comprises the following steps:
1) 300g olive oil and 100g soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 50 ℃, adds 20g purification lecithin, smashs to pieces to dissolving completely, then adds 2.0g oleic acid, and 3min is stirred in continuation, obtains oil phase;
2) 50g glycerol is added in preparing tank and stirred with appropriate injection water, filter, filling jetting is to 2L, then adds pH adjusting agent to regulate pH value to 8.0, obtains water;
3) oil phase is added in water, stir 10min, obtain colostric fluid;
4) adopt high pressure homogenizer to colostric fluid homogenizing 8 times, obtain medicinal liquid, wherein, the temperature in homogenizing process is that 50 ℃, first class pressure are that 6000psi, secondary pressure are 1500psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 115 ℃, and sterilization time is 30min, lamp inspection, and packing, obtains containing olive oil long chain fat emulsion injection.
Embodiment 4
A preparation method containing olive oil long chain fat emulsion injection, comprises the following steps:
1) 280g olive oil and 120g soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 60 ℃, adds 10g purification lecithin, smashs to pieces to dissolving completely, then adds 4.0g oleic acid, and 5min is stirred in continuation, obtains oil phase;
2) 50g glycerol is added in preparing tank and stirred with appropriate injection water, filter, filling jetting is to 2L, then adds pH adjusting agent to regulate pH value to 9.0, obtains water;
3) oil phase is added in water, stir 30min, obtain colostric fluid;
4) adopt high pressure homogenizer to colostric fluid homogenizing 6 times, obtain medicinal liquid, wherein, the temperature in homogenizing process is that 60 ℃, first class pressure are that 8000psi, secondary pressure are 2000psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 125 ℃, and sterilization time is 8min, lamp inspection, and packing, obtains containing olive oil long chain fat emulsion injection.
Comparative example
The patent No. is the preparation method that 200810115380.8 Chinese patent discloses a kind of middle fat emulsion injection, implements according to the following steps:
(1) take 50g glycerol, 0.8g enuatrol adds 50% water for injection, is stirred to dissolve, and is made into aqueous solution, with NaOH, regulates pH value to 10.5 as water, 80 ℃ of insulations are standby;
(2) take 320g olive oil and 80g soybean oil, stir, as oil phase, 80 ℃ of insulations are standby;
(3) 24.0g lecithin is added to oil phase, be stirred to dissolving, under the mixing speed of rotating speed 3000r/min, oil phase is slowly added in water, until add complete; Continue to stir 30min, make colostrum;
(4) with sodium hydroxide solution, regulate colostrum pH value to 9.5, with injection dilute with water, be settled to 2L, be transferred in high pressure homogenizer, under 880bar condition, temperature is 50 ℃, and cycle of higher pressure obtains Emulsion 5 times, omnidistance logical nitrogen protection in preparation process; The Emulsion making is crossed 3 μ m membrane filtrations, inflated with nitrogen, and embedding, 121 ℃ of rotary water bath sterilizing 15min, obtain fat emulsion injection.
Embodiment 1 ~ 4 is tested with the indices containing olive oil long chain fat emulsion injection of comparative example gained, and test result is as shown in table 2:
| Inspection item | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Comparative example |
| Outward appearance | The even emulsion of milky | The even emulsion liquid of milky | The even emulsion liquid of milky | The even emulsion liquid of milky | The even emulsion liquid of milky |
| pH | 8.1 | 8.1 | 7.9 | 7.2 | 8.6 |
| Free fatty (mmol/L) | 1.7 | 1.8 | 1.8 | 1.9 | 2.7 |
| Anisidine value | 1.3 | 1.5 | 1.4 | 1.3 | 3.5 |
| Lysophosphatide (mg/ml) | 0.4 | 0.5 | 0.48 | 0.45 | 0.7 |
| Particle diameter (μ m) | 0.28 | 0.29 | 0.28 | 0.30 | 0.33 |
| Whether be greater than 5 μ m granules | Nothing | Nothing | Nothing | Nothing | Have |
| Containing bacterium situation | Up to specification | Up to specification | Up to specification | Up to specification | Up to specification |
| Essential fatty acid content % | 20.4 | 20.2 | 19.9 | 19.6 | 20.2 |
Table 2: containing olive oil long chain fat emulsion injection indices test result.
The olive oil long chain fat emulsion injection that contains to embodiment 1 gained carries out following experiment work.
1) hemolytic test
The preparation of red blood cell suspension: get 1 of rabbit, from heart extracting blood 10ml, be placed in the triangular flask that bead is housed, with bamboo let, stir and remove Fibrinogen, then blood is moved in graduated centrifuge tube, add normal saline 10ml, mix rear centrifugal 5min rotating speed for (2500rpm), the supernatant that inclines, till repeatedly washing and not taking on a red color to supernatant for 4 times.Measure blood cell, by its volume, with normal saline, be made into red cell suspension.
Method of testing: get 7 of clean tube numbering, 1 ~ 5 pipe adds respectively the drug liquid tube of different amounts, the 6th pipe negative control tube (NS), the 7th pipe positive control tube (distilled water).Add successively red blood cell suspension, normal saline or distilled water, after mixing, in 37 ℃ of calorstats, place 30min, then add respectively not commensurability medicinal liquid, wherein, manage not dosing 6, No. 7, after shaking up, be placed in 37 ℃ of calorstats.Beginning is observed once every 30min, after 1h, every 1 hour, observes once, observes 3h, as solution is transparent redness, represents haemolysis.As having brownish red or rufous flocculent deposit in solution, indicate erythroagglutination, whether very now available vibration or slide drip normal saline method inspection cohesion.When negative control pipe occurs without haemolysis and cohesion, when positive control pipe has haemolysis to occur, if haemolysis and cohesion do not occur the solution in tested property management in 3h, tested material can be injected use; If haemolysis and (or) cohesion occur the solution in tested property management in 3h, tested material should not be injected use.
2) local irritation test---vascular stimulation test
Select 6 of healthy earless disease rabbit, the slow this product of left auricular vein from sterilization pushes away rabbit, and 1 day 1 time, successive administration 3d.After right auricular vein sterilization, same method is injected and is given isopyknic normal saline, and 1 day 1 time, continuous 3d.In last, injected rear 48h, the blood vessel of first perusal injection site and the variation of surrounding tissue, then get 4 animals centered by injection site for every group, toward proximal part direction 2cm place, cut (containing blood vessel) 3 ~ 5 cm and in formalin, fix, carry out histopathologic examination.As obvious in irritative response, remain animal continuation observation and carried out again histopathological examination to the 14th day, to understand the degree of reversibility of irritative response.
3) Cavia porcellus systemic allergy test
Get 24 of healthy albino guinea-pigs, body weight 300 ~ 400g, male and female half and half, are divided into 4 groups at random, 6 every group, are respectively and are subject to reagent high dose group, low dose group, positive control 5% egg protein (normal saline dilution) group, negative control 0.9% sodium chloride injection group.Each organizes Cavia porcellus every other day intraperitoneal injection sensitization, and continuous 3 times, positive controls and negative control group Cavia porcellus are injected in the same way.Within 12nd ~ 14 days after the administration of last sensitizing injection, respectively organizing respectively row dorsalis pedis vein injection respectively organizes 2 times of concentration liquids and attacks, duration of test is observed animal state every day, first sensitization, last sensitization and excite and weighed every the weight of animals the same day, observe after administration Cavia porcellus in 30min and have or not the anaphylaxiss such as perpendicular hair, sneeze, retch, cough, dyspnea, rale, tic, collapse or death.
4) models of passive skin irritability of rats experiment (changing Cavia porcellus as rat is insensitive into)
Antiserum preparation: rat, 12, divide at random 4 groups, 3 every group, for antiserum, prepare.Be respectively: 5% egg protein (positive drug) group, is subject to reagent low dose group, high dose group and blank (NS) group.5% egg protein group, the next day every rat after leg muscle inject 5% egg protein 0.5ml/100g rat, lumbar injection pertussis vaccine 2 * 109ml/ only simultaneously, only, continuous 3 ~ 5 times, the next day that all the other respectively being organized, the corresponding medicinal liquid of lumbar injection is 3 ~ 5 times for volume injected 1ml/, in last administration in the time of the 14th day abdominal vein get blood, low-speed centrifugal, separation of serum, puts-20 ℃ of refrigerators standby.
Get 24 of rats of the same race, be divided at random 4 groups, 6 every group, be respectively: 5% egg protein (positive drug) group, be subject to low group of reagent, high dose group and blank (NS) group.Shave hair, in rat dorsal line both sides, apart from spinal column 1.5cm place's cropping, 3 points of every side, interval 2cm.Get respectively above-mentioned corresponding antiserum by dilution in 1: 2,1: 4,1: 8, get respectively successively the 0.1ml intradermal injection left and right sides, after 48h, press the intravenous injection of 1ml/100g rat body weight containing the tested medicinal liquid low (1ml/ only) of 0.5% azovan blue, containing the tested medicinal liquid of 0.5% azovan blue high (1ml/ only), 1% azovan blue+5% egg protein chloride injection liquor (positive controls, 1ml/ is only), 0.5% azovan blue sodium chloride injection (negative control group, 1ml/ only).Sacrificed by decapitation animal after 30min, upset skin of back, uses transparent adhesive tape chi, surveys respectively the blueness reaction spot diameter of the same corresponding point in the left and right sides, left and right sides tabulate statistics, the difference of comparative drug group and matched group.
| Pilot project | Result |
| Hemolytic | Do not cause rabbit erythrocyte hemolysis and agglutination phenomenon |
| Zest | To rabbit vein blood vessel without obvious irritation |
| Systemic anaphylaxis | Do not cause the anaphylaxis to Cavia porcellus |
Table 3: embodiment 1 experimental result.
The content of mentioning in above-described embodiment is not limitation of the invention, is not departing under the prerequisite of inventive concept of the present invention, and any apparent replacement is all within protection scope of the present invention.
Claims (4)
1. containing an olive oil long chain fat emulsion injection, olive oil, soybean oil, oleic acid, pH adjusting agent, purification lecithin, glycerol and injection water, consist of, each component of this injection consists of:
Olive oil 140 ~ 170 mg/ml
Soybean oil 30 ~ 60mg/ml
Oleic acid 0.0002 ~ 0.0025mg/ml
Purification lecithin 0.005 ~ 0.02mg/ml
Glycerol 20 ~ 28mg/ml
It is 7.0 ~ 9.5 that pH adjusting agent adds to injection pH value.
2. according to claim 1 containing olive oil long chain fat emulsion injection, it is characterized in that: described pH adjusting agent is sodium hydroxide, sodium hydrogen phosphate, sodium citrate or enuatrol.
3. the preparation method containing olive oil long chain fat emulsion injection according to claim 1 and 2, comprises the following steps:
1) olive oil and soybean oil are filtered to rear input in preparing tank, open bruisher and stir, simultaneous temperature is controlled at 30 ~ 60 ℃, adds purification lecithin, smashs to pieces to dissolving completely, then adds oleic acid, and 3 ~ 10min is stirred in continuation, obtains oil phase;
2) glycerol and injection water are added in preparing tank and stirred, filter, then add pH adjusting agent to regulate pH value to 7.0 ~ 9.5, obtain water;
3) oil phase is added in water, stir 10 ~ 40min, obtain colostric fluid;
4) adopt high pressure homogenizer more than 6 times, to obtain medicinal liquid to colostric fluid homogenizing, wherein, the temperature in homogenizing process is that 30 ~ 60 ℃, first class pressure are that 3000 ~ 8000psi, secondary pressure are 1000 ~ 2000psi;
5) medicinal liquid is carried out to canned, tamponade, bundle lid sealing process, then adopt the sterilizing of rotation sterilization method, sterilising temp is 115 ~ 125 ℃, and sterilization time is 8 ~ 30min, obtains containing olive oil long chain fat emulsion injection.
4. the preparation method containing olive oil long chain fat emulsion injection according to claim 3, is characterized in that: described oil phase preparation process is all carried out to canned step process in filling nitrogen environment.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288210A (en) * | 2014-09-22 | 2015-01-21 | 辽宁海思科制药有限公司 | Long chain fat emulsion medicine composition for injection and preparation method thereof |
| CN105832667A (en) * | 2016-04-29 | 2016-08-10 | 济南康和医药科技有限公司 | Olive oil containing long-chain fat emulsion injection and preparation method thereof |
| CN115581665A (en) * | 2022-10-08 | 2023-01-10 | 广东大冢制药有限公司 | Sodium oleate-free medium/long-chain fat emulsion injection and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612202A (en) * | 2008-06-23 | 2009-12-30 | 佟兵 | A kind of fat emulsion injection and preparation method thereof |
| CN101797225A (en) * | 2009-02-10 | 2010-08-11 | 上海医药工业研究院 | High oxidation resistance long chain fat emulsion injection and preparation method thereof |
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2013
- 2013-12-04 CN CN201310638974.8A patent/CN103690478B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612202A (en) * | 2008-06-23 | 2009-12-30 | 佟兵 | A kind of fat emulsion injection and preparation method thereof |
| CN101797225A (en) * | 2009-02-10 | 2010-08-11 | 上海医药工业研究院 | High oxidation resistance long chain fat emulsion injection and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288210A (en) * | 2014-09-22 | 2015-01-21 | 辽宁海思科制药有限公司 | Long chain fat emulsion medicine composition for injection and preparation method thereof |
| CN105832667A (en) * | 2016-04-29 | 2016-08-10 | 济南康和医药科技有限公司 | Olive oil containing long-chain fat emulsion injection and preparation method thereof |
| CN105832667B (en) * | 2016-04-29 | 2018-11-30 | 济南康和医药科技有限公司 | A kind of long chain fat emulsion injection and preparation method thereof containing olive oil |
| CN115581665A (en) * | 2022-10-08 | 2023-01-10 | 广东大冢制药有限公司 | Sodium oleate-free medium/long-chain fat emulsion injection and preparation method thereof |
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