CN101607025A - Medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof - Google Patents
Medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof Download PDFInfo
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- CN101607025A CN101607025A CNA2009101574892A CN200910157489A CN101607025A CN 101607025 A CN101607025 A CN 101607025A CN A2009101574892 A CNA2009101574892 A CN A2009101574892A CN 200910157489 A CN200910157489 A CN 200910157489A CN 101607025 A CN101607025 A CN 101607025A
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Abstract
The invention discloses medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof, is the medicine of being made by the raw material of following weight portion: Radix Rehmanniae Preparata 200-300, RHIIZOMA DIOSCOREAE frOm Henan of China 150-250, Rhizoma Dioscoreae 150-250, Radix Achyranthis Bidentatae 150-250, Cortex Eucommiae 150-250, Radix Morindae Officinalis 150-250, Radix Polygalae 150-250, Fructus Schisandrae Chinensis 150-250, Semen Cuscutae 150-250, Rhizoma Acori Graminei 100-200, Fructus Lycii 200-300, Poria 150-250, Herba Cistanches 150-250, reddish brown real 150-250, Cortex Magnoliae Officinalis 100-200, Pericarpium Citri Reticulatae 50-150, Fructus Aurantii 30-80, Fructus Foeniculi 30-80, Radix Glycyrrhizae 30-80, Radix Salviae Miltiorrhizae 50-150, Radix Angelicae Sinensis 30-80.Medicine of the present invention cures mainly cardiorenal failure, ill curing the disease, no treating diseases and making health-care, and life lengthening, also helpful to the fertility men and women.
Description
Technical field
The present invention relates to medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof, more particularly relating to a kind of is that medicine of cardiorenal failure and preparation method thereof is treated and prevented to raw material with Chinese medicine.
Background technology
Chronic renal failure (CRF) can cause each systemic-function disorder, and cardiovascular disease (CVD) is its main complication.Show according to foreign data, the incidence rate of CRF cardiovascular complication is 10-30 a times of general population, though the guarantee of replacement therapy is arranged, but still has 50% to die from CVD and the relevant complication of cardiovascular thereof approximately, apparently higher than the mortality rate (about 15%) that infects or septicemia causes.China shows have 86.0%CRF patient to have all kinds CVD complication (based on ischemic ST-T variation, heart rate depletion, arrhythmia etc.) to the geographic CRF patient's in Shanghai investigation; The associated death number accounts for the total death toll 44.2% of CRF.The scope of the concurrent cardiovascular disease of CRF is wider, comprise CRF the concurrent or coronary artery disease, cardiomyopathy, pericarditis and the hypertension that occur together, cardiac insufficiency etc., wherein based on the heart change cardiac damage.Initial myocardial damage, myocardial remodelling is the pathophysiological process of the continuous reconstruction of heart configuration then, because the result who reinvents is the most remarkable with the performance of ventricle, its meaning is also important, so adopt " ventricle is reinvented " (VR) speech summary at present more.Although the CRF heart reconstruction is the cardiac damage that multiple combined factors effect causes, its pathogeny also is not quite similar with hypertension or chronic heart failure, but there is the constantly pathophysiological process of reconstruction of myocardium configuration equally in it, also is that Myocardial Remodeling mainly is the generation of left ventricular remodeling.
Studies show that the cardiopathic morbidity of CRF is mainly that renal function goes down that the back toxic metabolite is piled up, the direct pathological effect of Water-Electrolyte disorder and acid base imbalance and hypertension, anemia factor etc. are to the long-term damage of heart.Therefore will improve CRF patient's cardiac function, modern medicine is at present mainly to correct or to eliminate reason and the already present pathological changes of treatment heart itself that causes heart change.As using controlling blood pressure such as ACEI, calcium ion antagonist, beta-blocker, EPO, chalybeate, folic acid etc. are corrected anemia, correct electrolyte and correct acidosis etc., give anti symptom treatment when arrhythmia, heart failure occurring.The end-stage renal failure patient then carries out replacement therapy.
There is inconsistent viewpoint in present research to above-mentioned pathogenesis, and current treatment measure also still can not significantly reduce mortality rate, therefore seeks the research focus that eutherapeutic medicine still is this area.
Summary of the invention:
The object of the present invention is to provide medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof.
This and other purpose of the present invention will further embody and set forth by following detailed description and explanation.
The medicine of treatment of the present invention and prevention cardiorenal failure is the medicine of being made by the raw material of following weight portion:
Radix Rehmanniae Preparata 200-300 RHIIZOMA DIOSCOREAE frOm Henan of China 150-250 Rhizoma Dioscoreae 150-250
Radix Achyranthis Bidentatae 150-250 Cortex Eucommiae 150-250 halberd sky 150-250
Radix Polygalae 150-250 Fructus Schisandrae Chinensis 150-250 Semen Cuscutae 150-250
Rhizoma Acori Graminei 100-200 Fructus Lycii 200-300 Poria 150-250
The reddish brown real 150-250 Cortex Magnoliae Officinalis 100-200 of Herba Cistanches 150-250
Pericarpium Citri Reticulatae 50-150 Fructus Aurantii 30-80 Fructus Foeniculi 30-80
Radix Glycyrrhizae 30-80 Radix Salviae Miltiorrhizae 50-150 Radix Angelicae Sinensis 30-80.
Further, the medicine of treatment of the present invention and prevention cardiorenal failure is the medicine of being made by the raw material of following weight portion:
Radix Rehmanniae Preparata 220-270 RHIIZOMA DIOSCOREAE frOm Henan of China 170-220 Rhizoma Dioscoreae 170-220
Radix Achyranthis Bidentatae 170-220 Cortex Eucommiae 170-220 Radix Morindae Officinalis 170-220
Radix Polygalae 170-220 Fructus Schisandrae Chinensis 170-220 Semen Cuscutae 170-220
Rhizoma Acori Graminei 130-170 Fructus Lycii 220-270 Poria 170-220
The reddish brown real 170-220 Cortex Magnoliae Officinalis 130-170 of Herba Cistanches 170-220
Pericarpium Citri Reticulatae 70-120 Fructus Aurantii 40-60 Fructus Foeniculi 40-60
Radix Glycyrrhizae 40-60 Radix Salviae Miltiorrhizae 70-120 Radix Angelicae Sinensis 40-60.
Be preferably, the medicine of treatment of the present invention and prevention cardiorenal failure is the medicine of being made by the raw material of following weight portion:
Radix Rehmanniae Preparata 250 RHIIZOMA DIOSCOREAE frOm Henan of China 200 Rhizoma Dioscoreaes 200
Radix Achyranthis Bidentatae 200 Cortexs Eucommiae 200 Radix Morindae Officinaliss 200
Radix Polygalae 200 Fructus Schisandrae Chinensis 200 Semen Cuscutae 200
Rhizoma Acori Graminei 150 Fructus Lyciis 250 Poria 200
Herba Cistanches 200 reddish brown reality 200 Cortex Magnoliae Officinalis 150
Pericarpium Citri Reticulatae 100 Fructus Aurantiis 50 Fructus Foeniculi 50
Radix Glycyrrhizae 50 Radix Salviae Miltiorrhizaes 100 Radix Angelicae Sinensis 50.
The preparation method of the medicine of treatment of the present invention and prevention cardiorenal failure is fine powder is cleaned, worn into to said medicine mix.Or fine powder is cleaned, worn into to said medicine be mixed and made into honeyed pill.
Characteristics of the present invention are to control the medicine and the same usefulness of medicine of controlling the heart of kidney, and heart monarch is quiet, and kidney qi is from peace, and kidney qi is promptly pacified, and what is certainly in aroused in interest, and positive so-called heart kidney is interdependent.
Medicament composing prescription of the present invention can be worked hard in glove with heart kidney, makes kidney liter waterborne with the Ji painstaking effort, the system deficiency-heat, and heart-fire is descending to consolidate the source with kidney-replenishing, recovers and how dirty depletion such as antagonism heart kidney liver lung with adjustment human functional activity of vital energy elevating function, makes the coordination between the heart and kidney regulation between water and fire.
The present invention cures mainly: cardiorenal failure, ill curing the disease, and no treating diseases and making health-care, life lengthening, also helpful to the fertility men and women.
The present invention confirms to have following effect through zoopery:
(1), can reduce CRF rat serum creatinine (SCR) and blood urea nitrogen (BUN);
(2), can reduce CRF rat twenty-four-hour urine protein quantification;
(3), can reduce the anemia of CRF rat;
(4), can reduce the high density lipoprotein of CRF rat;
(5), can reduce the serum paraoxonase of CRF rat;
(6), can reduce the blood parathyroid hormone (PTH) of CRF rat;
(7), can reduce CRF rat plasma Angiotensin II and cardiac muscular tissue's Angiotensin II;
(8), can reduce the heavy exponential sum left ventricle of CRF rat heart relative indices;
(9), can reduce myocardial cell average area, average perimeter, maximum gauge and minimum diameter;
(10), can reduce CRF rat heart muscle transforming growth factor-beta (TGF-β 1) positive expression;
Compound preparation of the present invention can effectively prevent myocardial hypertrophy, stops the collagen hypertrophy, suppresses myocardial fibrosis, reverses left ventricular remodeling etc.Can be used for treating the patient of concurrent heart change of CRF such as the expansion of left chamber, angina pectoris, heart failure etc.
Grind to the powder altogether to add medicine to, early respectively obey 8-10 gram yellow wine decoction being taken warmly after ante cibum, the supper, the flat stomach in clothes back is had a rest, and rest 10-15 minute, do other thing again, but also making pellets by mixing medical powder with honey is made 300 balls, take medicine in per two weeks and stopped one day, be two months altogether, the medication phase is prohibited sexual life.
Medicine of the present invention is used for clinical, and treating how dirty depletion will be confirmed by clinical observation.I repeatedly make the patient pull through at the clinical treatment cardiorenal failure with this, and mostly am the heavy dead people that is critically ill.Zoology test shows that medicine of the present invention is to the how dirty determined curative effect that declines, be characterized in big reinforcing premodial qi, big taste is Kidney-Yin, makes ascending or descending movement of vital Qi, is usefulness to lead to, kidney liter waterborne, heart-fire descends, and coordination between the heart and kidney is coordinating water and fire, control psychological treatment in the side more than controlling the kidney medicine, the meaning cube medication of meaning " interior warp " cloud " master is bright then to be pacified down ".
Below further specify the present invention by specific embodiment, but embodiment only be used for the explanation, can not limit the scope of the invention.
In the present invention, if not refer in particular to, all parts, amount, percentage ratio are unit of weight, and all raw materials all can be buied from market.
The specific embodiment
Embodiment 1
Take by weighing raw material by following proportioning:
Radix Rehmanniae Preparata 250 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 200 grams, Rhizoma Dioscoreae 200 grams, Radix Achyranthis Bidentatae 200 grams, the Cortex Eucommiae 200 grams, Radix Morindae Officinalis 200 grams, Radix Polygalae 200 grams, Fructus Schisandrae Chinensis 200 grams, Semen Cuscutae 200 grams, Rhizoma Acori Graminei 150 grams, Fructus Lycii 250 grams, Poria 200 grams, Herba Cistanches 200 grams, reddish brown reality 200 grams, Cortex Magnoliae Officinalis 150 grams, Pericarpium Citri Reticulatae 100 grams, Fructus Aurantii 50 grams, Fructus Foeniculi 50 grams, Radix Glycyrrhizae 50 grams, Radix Salviae Miltiorrhizae 100 grams, Radix Angelicae Sinensis 50 grams.
Grind to the powder altogether to add medicine to, early respectively obey 8-10 gram yellow wine decoction being taken warmly after ante cibum, the supper, the flat stomach in clothes back is had a rest, and rest 10-15 minute, do other thing again, but also making pellets by mixing medical powder with honey is made 300 balls, take medicine in per two weeks and stopped one day, be two months medication phases to prohibit sexual life altogether.
Embodiment 2
Take by weighing raw material by following proportioning:
Radix Rehmanniae Preparata 200 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 150 grams, Rhizoma Dioscoreae 150 grams, Radix Achyranthis Bidentatae 150 grams, the Cortex Eucommiae 150 grams, Radix Morindae Officinalis 150 grams, Radix Polygalae 150 grams, Fructus Schisandrae Chinensis 150 grams, Semen Cuscutae 150 grams, Rhizoma Acori Graminei 100 grams, Fructus Lycii 200 grams, Poria 150 grams, Herba Cistanches 150 grams, reddish brown reality 150 grams, Cortex Magnoliae Officinalis 100 grams, Pericarpium Citri Reticulatae 50 grams, Fructus Aurantii 30 grams, Fructus Foeniculi 30 grams, Radix Glycyrrhizae 30 grams, Radix Salviae Miltiorrhizae 50 grams, Radix Angelicae Sinensis 30 grams.
Preparation, instructions of taking are with embodiment 1.
Embodiment 3
Take by weighing raw material by following proportioning:
Radix Rehmanniae Preparata 300 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 250 grams, Rhizoma Dioscoreae 250 grams, Radix Achyranthis Bidentatae 250 grams, the Cortex Eucommiae 250 grams, Radix Morindae Officinalis 250 grams, Radix Polygalae 250 grams, Fructus Schisandrae Chinensis 250 grams, Semen Cuscutae 250 grams, Rhizoma Acori Graminei 200 grams, Fructus Lycii 300 grams, Poria 250 grams, Herba Cistanches 250 grams, reddish brown reality 250 grams, Cortex Magnoliae Officinalis 200 grams, Pericarpium Citri Reticulatae 150 grams, Fructus Aurantii 80 grams, Fructus Foeniculi 80 grams, Radix Glycyrrhizae 80 grams, Radix Salviae Miltiorrhizae 150 grams, Radix Angelicae Sinensis 80 grams.
Preparation, instructions of taking are with embodiment 1.
Embodiment 4: clinical
1, the U.S. fine jade woman of beam is 38 years old, lives Liaoning Province's Haicheng City, and six, go hospital's diagnosis that falls seven years old the time, cardiorenal failure is not clearly better in hospitalize half a year yet, listens the people to introduce and takes this medicine, three months all right, and heart and kidney are all got well as ordinary person now, and her mother says this very good.
2, Wang Li woman lived three trees, half room, Heilongjiang Province in 41 years old, set up a stall outside for many years, suffered from cardiorenal failure, and it is all right to take this medicine two months, and what taskwork now can both be done.
3, the Li Ying woman is 52 years old, lives Heilongjiang Province's Lanxi City and suffers from cardiorenal failure in 2002, has taken medicine half a year, and what disease has not all had, and the people who cures says than original youth has howed.
4, Sun Ya jasmine woman is 28 years old, and Qi Tamu town, Jiutai City, Jilin Province Ma Ta village one society married in 20 years old, 5 years after marriage atokes, removing hospital diagnosis is renal failure, takes this medicine half a year, sick all right, body was nourished pregnant present son and was all had April coming year, and health is very strong.
5, prosperous male 56 years old Yanji people of Jilin Province of Lee's generation goes in one's early years Korea S to do manual work, suffer from the sick people of listening of heart failure say take this medicine three months refreshing with regard to spiritual gas, heart disease and nephropathy have not all had now.
6, high extra large monarch man lived the lucky Shu Zhen in Shulan City, Jilin Province in 36 years old, because father and mother dead morning, from the little and social dubious woman renal failure of leading an aimless existence that, hear to have obeyed behind this medicine and just took a turn for the better in two months, but and woman's nephropathy of leading an aimless existence violated again, took medicine again five months, thoroughly cure nephropathy, present also spiritedness of people, also general on the face HONGGUANG.
7, few white flag people from town of Shulan City in prosperous male 60 years old Jilin of king's generation, through diagnosis heart and kidney for early stage depleted through friend introduce obeyed three months all right.
8, Li Chenggong man is 65 years old, few Er Dao people from village, Er Dao township of Shulan City in Jilin, diagnosis in 2000 be renal failure listen the people to say to take this medicine two months all right.
9,30 years old Yongji County cylinder kiln people from town of Jilin Province of Xu Meili woman to have taken two months medicines all right when Miss suffers from renal failure in bathing at an early age.
10, the Zhang Haiwen man grain depot worker of Shulan City of 48 years old Jilin Province is diagnosed as heart failure, take a favorable turn at Shulan county hospital two moonsets of being in hospital, after took this medicine two months, cardiac function is just normal.
11, the Li Yanli woman Er Dao of Shulan City township Bei Yao people from village of 45 years old Jilin Province suffers from renal failure during senior middle school, it is all right to have taken 2 months medicines.
12, Liu flows the man worker of 68 years old Jilin Province Shulan mineral bureau and was diagnosed as the senilism of heart kidney in 2005, and it is all right to take this medicine " heart renal aid " two months.
13, the bark pocket ditch people of Huadian City, 43 years old Jilin Province of Li beauty doctor in 2006 examines and is heart failure, obeys this " heart renal aid " and just recovers normal in three months.
14, the Lv Yan woman is 45 years old, and Jilin, Jilin Province Fengman District people doctor in 1998 examines and is renal failure, and listening the people to introduce this " heart renal aid " four months what disease of clothes has not all had.
15,48 years old Jilin Province's Baishan two road people from Baihe driver of Qiao Hong man is on the drink and suffers from renal failure to desire, obey this " heart renal aid " three months all right, strong just as individual big guy now.
16. Meng Xian and 70 years old Hunchun City people of Jilin Province of man, diagnosis in 2005 is heart failure and renal failure, and it is all right half a year that by the agency of is obeyed this " heart renal aid ", so big now age, and full of energy, body is hale and hearty.
Claims (5)
1, the medicine of a kind of treatment and prevention cardiorenal failure is characterized in that it is the medicine of being made by the raw material of following weight portion:
Radix Rehmanniae Preparata 200-300 RHIIZOMA DIOSCOREAE frOm Henan of China 150-250 Rhizoma Dioscoreae 150-250
Radix Achyranthis Bidentatae 150-250 Cortex Eucommiae 150-250 Radix Morindae Officinalis 150-250
Radix Polygalae 150-250 Fructus Schisandrae Chinensis 150-250 Semen Cuscutae 150-250
Rhizoma Acori Graminei 100-200 Fructus Lycii 200-300 Poria 150-250
The reddish brown real 150-250 Cortex Magnoliae Officinalis 100-200 of Herba Cistanches 150-250
Pericarpium Citri Reticulatae 50-150 Fructus Aurantii 30-80 Fructus Foeniculi 30-80
Radix Glycyrrhizae 30-80 Radix Salviae Miltiorrhizae 50-150 Radix Angelicae Sinensis 30-80.
2, the medicine of treatment according to claim 1 and prevention cardiorenal failure is characterized in that it is the medicine of being made by the raw material of following weight portion:
Radix Rehmanniae Preparata 220-270 RHIIZOMA DIOSCOREAE frOm Henan of China 170-220 Rhizoma Dioscoreae 170-220
Radix Achyranthis Bidentatae 170-220 Cortex Eucommiae 170-220 Radix Morindae Officinalis 170-220
Radix Polygalae 170-220 Fructus Schisandrae Chinensis 170-220 Semen Cuscutae 170-220
Rhizoma Acori Graminei 130-170 Fructus Lycii 220-270 Poria 170-220
The reddish brown real 170-220 Cortex Magnoliae Officinalis 130-170 of Herba Cistanches 170-220
Pericarpium Citri Reticulatae 70-120 Fructus Aurantii 40-60 Fructus Foeniculi 40-60
Radix Glycyrrhizae 40-60 Radix Salviae Miltiorrhizae 70-120 Radix Angelicae Sinensis 40-60.
3, the medicine of treatment according to claim 1 and prevention cardiorenal failure is characterized in that it is the medicine of being made by the raw material of following weight portion:
Radix Rehmanniae Preparata 250 RHIIZOMA DIOSCOREAE frOm Henan of China 200 Rhizoma Dioscoreaes 200
Radix Achyranthis Bidentatae 200 Cortexs Eucommiae 200 Radix Morindae Officinaliss 200
Radix Polygalae 200 Fructus Schisandrae Chinensis 200 Semen Cuscutae 200
Rhizoma Acori Graminei 150 Fructus Lyciis 250 Poria 200
Herba Cistanches 200 reddish brown reality 200 Cortex Magnoliae Officinalis 150
Pericarpium Citri Reticulatae 100 Fructus Aurantiis 50 Fructus Foeniculi 50
Radix Glycyrrhizae 50 Radix Salviae Miltiorrhizaes 100 Radix Angelicae Sinensis 50.
4,, it is characterized in that fine powder is cleaned, worn into to said medicine to be mixed according to the preparation method of medicine of described treatment of one of claim 1-3 and prevention cardiorenal failure.
5, according to the preparation method of medicine of described treatment of one of claim 1-3 and prevention cardiorenal failure, it is characterized in that fine powder is cleaned, worn into to said medicine is mixed and made into honeyed pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009101574892A CN101607025A (en) | 2009-07-31 | 2009-07-31 | Medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2009101574892A CN101607025A (en) | 2009-07-31 | 2009-07-31 | Medicine of a kind of treatment and prevention cardiorenal failure and preparation method thereof |
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| CN101607025A true CN101607025A (en) | 2009-12-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263624A (en) * | 2020-11-23 | 2021-01-26 | 宁夏大学 | Application of fructus Lycii extract and fructus Lycii polysaccharide in preparing medicine for preventing and treating cardiac fibrosis |
-
2009
- 2009-07-31 CN CNA2009101574892A patent/CN101607025A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263624A (en) * | 2020-11-23 | 2021-01-26 | 宁夏大学 | Application of fructus Lycii extract and fructus Lycii polysaccharide in preparing medicine for preventing and treating cardiac fibrosis |
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Application publication date: 20091223 |