CN101606992B - Compound traditional Chinese medicine perfusion liquor for preventing and treating endometritis of dairy cow and preparation method thereof - Google Patents
Compound traditional Chinese medicine perfusion liquor for preventing and treating endometritis of dairy cow and preparation method thereof Download PDFInfo
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Abstract
The invention discloses compound traditional Chinese medicine perfusion liquor for preventing and treating the endometritis of a dairy cow, which can be used for preventing and treating the diseases of the dairy cow, such as the endometritis and the like caused by bacteria, fungi and infusorium and belongs to the field of animal medicines. The invention also discloses a preparation method of the compound traditional Chinese medicine perfusion liquor, and the method has simple preparation process. The compound traditional Chinese medicine perfusion liquor comprises the following medicinal components of cnidium fruit, kuhseng, coptis root and licorice, and the compound traditional Chinese medicine perfusion liquor has obvious curative effect and fast effect taking in the diseases of the dairy cow, such as the endometritis and the like caused by the bacteria, the fungi and the infusorium and can effectively prevent and treat the uterine diseases of the dairy cow, such as postpartum infection and the like caused by the bacteria, the fungi and the infusorium. The compound traditional Chinese medicine perfusion liquor has stable quality, convenient use and low price, also has the advantages of no toxic or side effect, absence of antibiotics and the like and can effectively ensure the safety of a milk product.
Description
Technical field
The present invention relates to a kind of herbal mixture infusion liquid of preventing and treating cow endometritis and preparation method thereof, this medicine is used for the control of the diseases such as endometritis that milch cow causes because of antibacterial, fungus, infusorian, belongs to field of veterinary.
Background technology
Cow endometritis is a milch cow regular incidence in puerperal, is the one of the main reasons that causes barrenness of milk cow.This disease betides in the cow birth process or puerperal mostly, if can not get diagnosis and treatment timely and effectively, will secondary be metritis and pyometritis.This disease is to different and different with endometrium recovery time of degree of inflammation, damage and fallopian tube environment change etc. of the influence of cow reproduction.Investigation shows that in dairy, about 20% childbirth cow suffers from endometritis.Cow endometritis has very big influence to the reproductive performance of milch cow, as: the increase of artificial insemination number of times, puerperal, first service prolonged pregnancy rate reduction etc. with the blanking time of becoming pregnant for the first time at interval, cause the milch cow mortality to increase, cause enormous economic loss to dairy.
Cow endometritis can be caused that disease is also different by multiple pathogen.Usually according to the difference of classification foundation cow endometritis is divided into dissimilar, as: be divided into subclinical type endometritis and clinical type endometritis according to the endometritis clinical manifestation; Be divided into the most acute, acute, subacute and chronic endometritis according to course of disease length; Be divided into serosity, Catarrhal, fibrin, suppurative, hemorrhagic, gangrenosum acne and gangrenous endometritis according to inflammation character and the tolerant variation of intrauterine; Be divided into constitutional and Secondary cases endometritis according to the cause of disease; Can be divided into streptococcus endometritis, escherichia coli endometritis, mycotic endometritis etc. according to the cause of disease kind.
Both at home and abroad researcher and clinical staff have been done a large amount of work for research and the Therapeutic Method of exploring cow endometritis, have proposed many therapy measure, and the measure of taking has systemic treatment and at the local anti-infective therapy in uterus.Systemic treatment mainly contains for oral administration or intramuscular injection antibacterials, Chinese herbal medicine extract or hormone.But the partial medicine in uterus is difficult to reach or keep valid density during systemic administration, and uses antibiotic can cause that antibiotic residual quantity exceeds standard in blood and the dairy products in a large number.Topical therapeutic mainly is flushing uterus and to intrauterine perfusion antibacterials or bioactive substances such as Chinese herbal medicine extract or hormone, and what also have takes methods such as intrauterine sterilization, part massage, electrotherapy and rectal application.The intrauterine treatment is the method for generally using, and medicine directly contacts with focus, instant effect, and it is low that the relative whole body administration of drug level comes.
At present, in the intrauterine treatment of aspect the cow endometritis treatment, generally using, use maximum medicines still to be antibiotic and some disinfectant.But the application of these medicines can bring certain side effect, such as antibiotic remains in the milk product etc., has had a strong impact on the quality of milk product, comes certain risk for the food seat belt.
Summary of the invention
The objective of the invention is to, a kind of herbal mixture infusion liquid of efficient, safe control cow endometritis is provided, can be effective to the control of diseases such as the inflammation of uterus that causes by antibacterial, fungus, infusorian etc. and puerperal infection.Ingredient among the present invention does not contain any antibiotic all from natural Chinese medicine, can not produce the antibiotic remains problem, simultaneously medicine of the present invention under Chinese veterinarian's theoretical direction, the science compatibility, drug effect is remarkable, effect is rapidly, and is with low cost.
Another object of the present invention is to provide the preparation method and its usage of this herbal mixture infusion liquid.
The objective of the invention is to be achieved through the following technical solutions:
The invention provides a kind of herbal mixture infusion liquid of preventing and treating cow endometritis, the ingredient of this infusion liquid is made up of Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis and 4 kinds of raw material of Chinese medicine of Radix Glycyrrhizae.
Wherein, the weight proportion of described raw material of Chinese medicine is as follows: Fructus Cnidii 1-60 part, Radix Sophorae Flavescentis 1-30 part, Rhizoma Coptidis 1-30 part, Radix Glycyrrhizae 1-20 part.
Further, the weight proportion of described raw material of Chinese medicine is: Fructus Cnidii 10-50 part, Radix Sophorae Flavescentis 5-25 part, Rhizoma Coptidis 5-25 part, Radix Glycyrrhizae 3-15 part.
Further, the weight proportion of described raw material of Chinese medicine is: Fructus Cnidii 20-45 part, Radix Sophorae Flavescentis 10-20 part, Rhizoma Coptidis 10-20 part, Radix Glycyrrhizae 5-15 part.
The present invention also provides the preparation method of the herbal mixture infusion liquid of this control cow endometritis, comprises the steps:
Take by weighing each raw material by weight ratio, pulverize, add 10 times of water gagings, soak 2h, decoct backflow 2h, filter; Filtering residue adds 10 times of water gagings again and decocts backflow 2h, filters, and 2 times filtrate merges, and adds 2 times of amount dehydrated alcohol and staticly settles 4h, and revaporization is concentrated in every mL extracting solution and contains primary crude drug 0.2g, adds 15% glycerol then, and mixing promptly.
Herbal mixture infusion liquid of the present invention, it can be used for preparing the medicine of preventing and treating cow endometritis.
Herbal mixture infusion liquid of the present invention, it also can be used for preparing the infertile and puerperal infection aspect medicine of breeding that the control milch cow is caused by chronic endometritis.
Herbal mixture infusion liquid of the present invention can be used separately, infertile and puerperal infection of the breeding that is used to prevent and treat cow endometritis or causes by chronic endometritis etc., also can with multiple medication combined uses such as betagen solution, part antibiotic to improve its prevention effect.
Each drug component in the herbal mixture infusion liquid of the present invention and consumption thereof be to control principle according to the dialectical opinion of Chinese veterinarian's prescription, gets by repeatedly practising in a large number, and advantage of the present invention and good effect are:
1) herbal mixture infusion liquid determined curative effect of the present invention, instant effect.Remarkable to the curative effect of disease such as cow endometritis that cause by antibacterial, fungus, trichomonas vaginitis etc.;
2) herbal mixture infusion liquid of the present invention directly acts on target organ by the uterus perfusion, has improved curative effect of medication;
3) herbal mixture infusion liquid of the present invention is a pure Chinese medicinal preparation, does not contain antibiotic, and is safe in utilization, have no side effect, and can not produce the milk milk product and pollute, and guarantee food safety; Can not produce harm humans health drug residue, be difficult for to produce drug resistance, free from environmental pollution, do not cause drug-induced disease;
4) herbal mixture infusion liquid of the present invention is that raw material processes by extraction with the Chinese herbal medicine, has improved effective ingredient content, has accelerated the stripping and the absorption of effective ingredient, improved the curative effect of medicine, compare with the common Chinese powder, drug use dosage reduces, and saves herb resource.
The specific embodiment
Embodiment 1
20 parts of Fructus Cnidiis, 10 parts of Radix Sophorae Flavescentiss, 1 part of Rhizoma Coptidis, 1 part in Radix Glycyrrhizae.
Take by weighing each raw material according to the above ratio, pulverize, add 10 times of water gagings, soak 2h, decoct backflow 2h; Filter, filtering residue adds 10 times of water gagings again and decocts backflow 2h, filters, and 2 times filtrate merges, and adds 2 times of amount dehydrated alcohol and staticly settles 4h, and revaporization is concentrated into every mL extracting solution and contains primary crude drug 0.2g, adds 15% glycerol then, and mixing promptly.
Embodiment 2
45 parts of Fructus Cnidiis, 25 parts of Radix Sophorae Flavescentiss, 30 parts of Rhizoma Coptidis, 20 parts in Radix Glycyrrhizae.
Take by weighing each raw material according to the above ratio, pulverize, add 10 times of water gagings, soak 2h, decoct backflow 2h; Filter, filtering residue adds 10 times of water gagings again and decocts backflow 2h, filters, and 2 times filtrate merges, and adds 2 times of amount dehydrated alcohol and staticly settles 4h, and revaporization is concentrated into every mL extracting solution and contains primary crude drug 0.2g, adds 15% glycerol then, and mixing promptly.
Embodiment 3
10 parts of Fructus Cnidiis, 30 parts of Radix Sophorae Flavescentiss, 10 parts of Rhizoma Coptidis, 5 parts in Radix Glycyrrhizae.
Take by weighing each raw material according to the above ratio, pulverize, add 10 times of water gagings, soak 2h, decoct backflow 2h; Filter, filtering residue adds 10 times of water gagings again and decocts backflow 2h, filters, and 2 times filtrate merges, and adds 2 times of amount dehydrated alcohol and staticly settles 4h, and revaporization is concentrated into every mL extracting solution and contains primary crude drug 0.2g, adds 15% glycerol then, and mixing promptly.
Embodiment 4
50 parts of Fructus Cnidiis, 10 parts of Radix Sophorae Flavescentiss, 20 parts of Rhizoma Coptidis, 10 parts in Radix Glycyrrhizae.
Take by weighing each raw material according to the above ratio, pulverize, add 10 times of water gagings, soak 2h, decoct backflow 2h; Filter, filtering residue adds 10 times of water gagings again and decocts backflow 2h, filters, and 2 times filtrate merges, and adds 2 times of amount dehydrated alcohol and staticly settles 4h, and revaporization is concentrated into every mL extracting solution and contains primary crude drug 0.2g, adds 15% glycerol then, and mixing promptly.
Embodiment 5
20 parts of Fructus Cnidiis, 30 parts of Radix Sophorae Flavescentiss, 1 part of Rhizoma Coptidis, 15 parts in Radix Glycyrrhizae.
Take by weighing each raw material according to the above ratio, pulverize, add 10 times of water gagings, soak 2h, decoct backflow 2h; Filter, filtering residue adds 10 times of water gagings again and decocts backflow 2h, filters, and 2 times filtrate merges, and adds 2 times of amount dehydrated alcohol and staticly settles 4h, and revaporization is concentrated into every mL extracting solution and contains primary crude drug 0.2g, adds 15% glycerol then, and mixing promptly.
Observe example 1
The herbal mixture infusion liquid of the embodiment of the invention 1 preparation is observed the therapeutic effect of milch cow postpartum subinvolution of uterus, inflammation of uterus
In April, 2009, Langfang canopy is given birth to section's hundred cattle farm cultured dairy generation diseases, and 8 miscarriages are wherein arranged, and recovers stage subinvolution of uterus, is inflamed, and has the yellowish-brown foreign body to discharge.Next day, with the oxytetracycline solution 50mL of 6g/L the morbidity milch cow is carried out uterus perfusion administration, medication detects antibiotic remains in milk after 2 days, this medicine of stopping using.Using the herbal mixture infusion liquid of the embodiment of the invention 1 preparation instead treats it.Concrete using method is as follows, and the herbal mixture infusion liquid that the sick cattle of every hair prepares with the 15mL embodiment of the invention 1 adds carries out the irrigation uterus after the 35mL normal saline mixes, and washes once continuous three times in per two days.The sick cattle disease reason of one week back 8 hairs symptom all disappears, and milch cow appetite is normal, gets well.Fall ill after testing and do not detect antibiotic remains, milk safety in the milch cow milk.
Observe example 2
The herbal mixture infusion liquid of the embodiment of the invention 2 preparations is observed the killing effect of cow endometritis pathogenic strain
Cow endometritis can cause by multiple pathogen, wherein based on the antibacterial of staphylococcus, streptococcus, enterobacteriaceae and bacillus pyocyaneus etc.Present case will be carried out drug sensitive test to isolating pathogen the milch cow that the cow endometritis disease takes place from the Beijing area, with the herbal mixture infusion liquid of the observing the embodiment of the invention 2 preparations killing effect to the main pathogenic bacterium of cow endometritis.The main pathogenic bacterium that present case is implemented have streptococcus pneumoniae, staphylococcus aureus, acinetobacter haemolyticus, Beta-hemolytic streptococcus and 5 kinds of pathogenic bacterium of bacillus pyocyaneus.
Test method adopts the test tube doubling dilution.Get 50 of 13mm * 100mm test tube, line up five rows, 10 of every rows.The herbal mixture infusion liquid that adopts doubling dilution with MH meat soup the embodiment of the invention 2 to be prepared is diluted to that concentration is respectively 256,128,64,32,16,8,4,2,1,0.5mg/L.(concentration is about 10 to draw the cultured bacterium liquid of difference 0.1ml with liquid-transfering gun
7CFU/mL) add successively in the good medicinal liquid of dilution by low concentration to high concentration, bacterium of every row adds above-mentioned streptococcus pneumoniae, staphylococcus aureus, acinetobacter haemolyticus, Beta-hemolytic streptococcus and 5 kinds of antibacterials of bacillus pyocyaneus successively.Mixing is observed after being placed on and cultivating 20h in 37 ℃ of constant incubators, naked eyes do not see that the lowest concentration of drug of growth is the minimal inhibitory concentration (MIC) of this medicine to above-mentioned antibacterial, continue to cultivate 48h, containing the concentration that minimum still is obviously haze-free test tube contained drug is minimal bactericidal concentration (MBC).
The herbal mixture infusion liquid of present embodiment 2 preparations sees Table 1 to MIC and the MBC of the main pathogenic bacterium of cow endometritis.
MIC of 2 pairs of main pathogenic bacterium of cow endometritis of table 1 embodiment of the invention and MBC mg/L
From the bacteriostasis and sterilization result of the test as can be seen, the herbal mixture infusion liquid of the embodiment of the invention 2 preparations is obvious to 5 kinds of common pathogen bacteriostasis and sterilization of cow endometritis effect.Wherein the most responsive to streptococcus pneumoniae, minimal inhibitory concentration is 1mg/L, and minimal bactericidal concentration is 2mg/L; To the sensitivity minimum of bacillus pyocyaneus, its minimal inhibitory concentration and minimal bactericidal concentration are 4mg/L.
Observe example 3
The herbal mixture infusion liquid of the embodiment of the invention 3 preparations is observed the therapeutic effect of cow endometritis
In October, 2008, certain cattle farm, sub-district is gone in in a big way in Beijing has 18 cattle to find the uterus acute inflammation, has dark green secretions to flow out, and is diagnosed as charrin's disease through technical staff's sample detecting and causes cow endometritis.On next day, 10% betagen solution (each 10ml+ normal saline 40ml) that adopts Henan factory to produce carries out uterus perfusion administration to the morbidity milch cow, and administration was 1 time in per two days, logotype 2 times, the commentaries on classics of not getting better.The 5th day, the herbal mixture infusion liquid of using the embodiment of the invention 3 preparation instead is carried out uterus perfusion administration in conjunction with 5% the betagen solution that the Beijing Dabei agricultural animal health science and technology limited liability company produces to the morbidity milch cow, once measure every cattle adds 10ml 5% with the herbal mixture infusion liquid of the 5ml embodiment of the invention 3 preparations betagen solution, be diluted to normal saline and carry out the uterus perfusion behind the 50ml, perfusion in per two days once, after the logotype 2 times, there is the sick milch cow inflammation of 15 hairs to disappear, after continuing to pour into 2 times, 18 are almost recovered.In the medication process, milch cow appetite is normal, and milk yield is progressively recovered normally, milk during the medication of morbidity milch cow is carried out the antibiotic detection find no antibiotic remains.
Observe example 4
The herbal mixture infusion liquid of the embodiment of the invention 4 preparation is observed the therapeutic effect of the cow endometritis that caused by infusorian
In March, 2009, the cattle farm, Fengning finds to have 8 cow head uterus to have canescence secretions to discharge, the milch cow inappetence, and milk yield descends.Be diagnosed as trichomonal cow endometritis through local technical staff.Adopt the herbal mixture infusion liquid of the embodiment of the invention 4 preparations that the morbidity milch cow is carried out uterus perfusion administration, once measure the herbal mixture infusion liquid of every cattle with 4 preparations of the 15ml embodiment of the invention, be diluted to normal saline and carry out the uterus perfusion behind the 50ml, poured into once in per two days, using 3 times continuously is a course of treatment.The sick milch cow inflammation of 8 hairs disappears after one course of treatment, appetite is recovered normally substantially, and milk yield is gone up, and continues to consolidate curative effect after the medication 2 times, the morbidity milk production of cow recovers normal level, milk during the medication of morbidity milch cow is carried out the antibiotic detection find no antibiotic remains.
Observe example 5
The herbal mixture infusion liquid of the embodiment of the invention 5 preparations is observed the therapeutic effect of milch cow chronic endometritis
In November, 2008, it is infertile that Red Star cattle farm, Weifang, Shandong has 10 cow heads repeatedly to breed, the technical staff checks when finding cow oestrus flows out the opaque mucus of volume from vagina, further inspection discovery milch cow cervix uteri is opened a little, sense of touch hysteranesis, cervix uteri thickens, and contractile response is faint, after the uterine irrigation thing leaves standstill precipitate is arranged.Local technical staff is diagnosed as recessive endometritis.The herbal mixture infusion liquid that adopts the embodiment of the invention 5 to prepare adds 5% betagen solution and carries out the uterus perfusion, simultaneously in conjunction with injection compound various vitamins injection.Once measure every cattle adds 10ml 5% with the herbal mixture infusion liquid of the 5ml embodiment of the invention 5 preparations betagen solution, be diluted to normal saline and carry out the uterus perfusion behind the 50ml, perfusion in per two days once, find behind the continuous use 5 times that morbidity milch cow inflammation disappears, continue to breed successfully once more after the medication 1 time.
Claims (4)
1. herbal mixture infusion liquid of preventing and treating cow endometritis, it is characterized in that its ingredient is made up of Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis and 4 kinds of raw material of Chinese medicine of Radix Glycyrrhizae, the weight proportion of above-mentioned raw material of Chinese medicine is: Fructus Cnidii 10-50 part, Radix Sophorae Flavescentis 5-25 part, Rhizoma Coptidis 5-25 part, Radix Glycyrrhizae 3-15 part.
2. the described herbal mixture infusion liquid of claim 1 is characterized in that the weight proportion of described raw material of Chinese medicine is: Fructus Cnidii 20-45 part, Radix Sophorae Flavescentis 10-20 part, Rhizoma Coptidis 10-20 part, Radix Glycyrrhizae 5-15 part.
3. each described herbal mixture infusion liquid of claim 1～2 is characterized in that it is in the application that is used to prepare aspect the control cow endometritis medicine.
4. each described herbal mixture infusion liquid of claim 1～2 is characterized in that it is in the application that is used to prepare aspect the infertile and puerperal infection medicine of breeding that the control milch cow causes by chronic endometritis.
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Families Citing this family (5)
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| CN105193934B (en) * | 2015-10-21 | 2020-12-22 | 中国农业科学院兰州畜牧与兽药研究所 | Compound essential oil for treating livestock endometritis and preparation method thereof |
| CN105853960A (en) * | 2016-04-12 | 2016-08-17 | 董雅娟 | Preparation for improving conception rate of cows, and method for improving conception rate of cows |
| CN105878987A (en) * | 2016-04-12 | 2016-08-24 | 董雅娟 | Earthworm extracting solution and preparation method thereof |
| CN105998220A (en) * | 2016-07-18 | 2016-10-12 | 成都乾坤动物药业股份有限公司 | Traditional Chinese veterinary material medicine for treating endometritis of cows as well as preparation method and use of traditional Chinese veterinary material medicine |
| CN106138369A (en) * | 2016-08-09 | 2016-11-23 | 成都乾坤动物药业股份有限公司 | A kind of pharmaceutical composition preventing and treating animal endometritis and preparation method thereof |
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Assignee: Shaoshan Dabeinong Animal Medicine Co.,Ltd. Assignor: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd.|Beijing Dabeinong Animal Health Care Technology Co.,Ltd.|Shaoshan Dabeinong Animal Medicine Co.,Ltd. Contract record no.: 2012430000081 Denomination of invention: Compound traditional Chinese medicine perfusion liquor for preventing and treating endometritis of dairy cow and preparation method thereof Granted publication date: 20111026 License type: Exclusive License Open date: 20091223 Record date: 20120511 |
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Application publication date: 20091223 Assignee: Shaoshan Dabeinong Animal Medicine Co.,Ltd. Assignor: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd.|Beijing Dabeinong Animal Health Care Technology Co.,Ltd.|Shaoshan Dabeinong Animal Medicine Co.,Ltd. Contract record no.: 2012430000081 Denomination of invention: Compound traditional Chinese medicine perfusion liquor for preventing and treating endometritis of dairy cow and preparation method thereof Granted publication date: 20111026 License type: Exclusive License Record date: 20120511 |
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Effective date of registration: 20220805 Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: Shaoshan Dabeinong Animal Medicine Co.,Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: Shaoshan Dabeinong Animal Medicine Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. |
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