CN101606905B - 一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法 - Google Patents
一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法 Download PDFInfo
- Publication number
- CN101606905B CN101606905B CN 200910016461 CN200910016461A CN101606905B CN 101606905 B CN101606905 B CN 101606905B CN 200910016461 CN200910016461 CN 200910016461 CN 200910016461 A CN200910016461 A CN 200910016461A CN 101606905 B CN101606905 B CN 101606905B
- Authority
- CN
- China
- Prior art keywords
- nitazoxanide
- percent
- suspension
- stabilizing agent
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- YQNQNVDNTFHQSW-UHFFFAOYSA-N acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 YQNQNVDNTFHQSW-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 229960002480 nitazoxanide Drugs 0.000 title claims abstract description 28
- 239000000725 suspension Substances 0.000 title claims abstract description 19
- 244000045947 parasite Species 0.000 title claims abstract description 12
- 244000144972 livestock Species 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title abstract description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000003381 stabilizer Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 11
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 10
- 229960001631 carbomer Drugs 0.000 claims abstract description 10
- 239000001509 sodium citrate Substances 0.000 claims abstract description 10
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims abstract description 10
- 229940038773 trisodium citrate Drugs 0.000 claims abstract description 10
- 239000000230 xanthan gum Substances 0.000 claims abstract description 10
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 10
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 10
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 10
- 239000003292 glue Substances 0.000 claims abstract description 6
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 2
- 239000000619 acesulfame-K Substances 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 241001494479 Pecora Species 0.000 abstract description 2
- 244000144992 flock Species 0.000 abstract description 2
- 238000010008 shearing Methods 0.000 abstract description 2
- 239000000796 flavoring agent Substances 0.000 abstract 2
- 235000013355 food flavoring agent Nutrition 0.000 abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 244000144980 herd Species 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 8
- 208000030852 Parasitic disease Diseases 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000000507 anthelmentic effect Effects 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 2
- 230000002141 anti-parasite Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 201000002045 Ancylostomiasis Diseases 0.000 description 1
- 208000033211 Ankylostomiasis Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000223935 Cryptosporidium Species 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 241000224466 Giardia Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020376 Hookworm infection Diseases 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 244000000054 animal parasite Species 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 244000079386 endoparasite Species 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 235000021471 food effect Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000004531 microgranule Substances 0.000 description 1
- 239000005645 nematicide Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种驱治牲畜体内寄生虫的硝唑尼特混悬液，其特征在于它的组分和质量百分数范围为硝唑尼特3-5％、黄原胶0.2％～0.5％、卡波姆0.2％～0.6％、柠檬酸0.3％～0.6％、柠檬酸三钠0.15～0.3％、稳定剂0.15～0.3％、矫味剂4％～9％，其余为水。制备时，将黄原胶及卡波姆加水制成胶液，置于乳化器中后加入柠檬酸、柠檬酸三钠、稳定剂、硝唑尼特、矫味剂，进行剪切。本发明生产工艺简单，产品质量稳定，可放置较长时间不变质，无需要现用现配，可大批量生产，能满足牧区牧民及养殖户对牛群、羊群进行寄生虫病防治用药的需要。
Description
技术领域
本发明涉及一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法。
背景技术
寄生虫病种类繁多、散布广泛，是牲畜极为常见、危害严重的疾病，它严重影响肉、乳、蛋的产量，影响皮毛质量和役畜的使役能力，某些人畜共患寄生虫病还直接危害人类的健康。因此，寄生虫病不仅妨碍畜牧业的发展，造成巨大的经济损失，而且也是最普遍、最严重的公共卫生问题。近10多年来，由于科技和资金的投入不足，适合于生产的新技术不多，寄生虫病防治技术基本没有较大突破和创新，化学防治仍是目前主导的防治手段。由于抗药性的日益严重和原有抗寄生虫药物本身的缺陷，新药的开发是寄生虫病化学防治中非常重要的问题，也是推动寄生虫化学防治的根本。抗寄生虫药物的发展趋势是：抗虫谱越来越广，抗虫活性越来越强，毒副作用越来越小。
近年来，硝唑尼特作为一种高效、广谱抗动物与人体寄生虫感染的药物被广泛关注，它是美国药品和食品监督管理局(FDA)批准的第一个和唯一的用于治疗隐孢子虫属的药物，也是40多年来批准用于治疗贾第虫属的第一种新药。大量临床试验研究表明，硝唑尼特可用于治疗多种寄生虫感染，如绦虫、线虫、钩虫感染等。但尚未见牲畜用硝唑尼特混悬液的报道及销售。
发明内容
本发明的目的在于提供一种制作工艺简单、投服方便、驱虫效果好的驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法，它能为临床提供一种新的解决办法。
一种驱治牲畜体内寄生虫的硝唑尼特混悬液，其特征在于它的组分和质量百分数范围为硝唑尼特3-5％、黄原胶0.2％～0.5％、卡波姆0.2％～0.6％、柠檬酸0.3％～0.6％、柠檬酸三钠0.15～0.3％、稳定剂0.15～0.3％、矫味剂4％～9％，其余为水。
上述混悬液的制备方法，其特征在于将黄原胶及卡波姆加水制成胶液，置于乳化器中后加入柠檬酸、柠檬酸三钠、稳定剂、硝唑尼特、矫味剂，进行剪切。
本发明生产工艺简单，产品质量稳定，可放置较长时间不变质，无需要现用现配，可大批量生产，能满足牧区牧民及养殖户对牛群、羊群进行寄生虫病防治用药的需要。
具体实施方式
本发明驱治牲畜体内寄生虫的硝唑尼特混悬液，其特征在于它的组分和质量百分数范围为硝唑尼特3-5％、黄原胶0.2％～0.5％、卡波姆0.2％～0.6％、柠檬酸0.3％～0.6％、柠檬酸三钠0.15～0.3％、稳定剂0.15～0.3％、矫味剂4％～9％，其余为水。制备时，将黄原胶及卡波姆加水制成胶液，置于乳化器中后加入柠檬酸、柠檬酸三钠、稳定剂、硝唑尼特、矫味剂，进行剪切。
将硝唑尼特制备成混悬液，主要考虑到如下几个方面：首先，硝唑尼特是疏水性药物，不适合制成水溶性制剂；其次，结合硝唑尼特药代动力学特性，即体内代谢极快，其活性代谢产物的消除半衰期也不长(1.03～1.6h)，制成混悬液既有给药方便、起效快等优点，也提高了该药物的生物利用度；制备成混悬液使得药物颗粒分布均匀，很少受到食物影响，因而不会对达峰时间、表观半衰期、药时曲线下面积等一系列参数造成很大影响，使用安全性能得到保障，也减轻了胃肠道刺激性。基于以上几点考虑，将硝唑尼特制成混悬型制剂是比较理想的。
本混悬液向硝唑尼特加适量助悬剂、絮凝剂、稳定剂经剪切制成。实际生产时，可取主药硝唑尼特粉5kg，黄原胶0.5kg、卡波姆0.5kg、柠檬酸0.4kg、柠檬酸三钠0.3kg、水85kg、稳定剂0.3kg、矫味剂8kg。制备时先将黄原胶及卡波姆加水制成胶液，置于乳化器后加入柠檬酸、柠檬酸三钠、稳定剂、硝唑尼特、矫味剂进行剪切制成。制备前各原辅料需粉碎过60～100目筛，制备过程中由于剪切作用，原辅料均制成了极细小的微粒，均匀地分散在悬浮液中。
本发明所述稳定剂为苯甲酸钠、苯甲酸或山梨酸。所述矫味剂为蔗糖、山梨醇或安塞蜜。
本发明比现有的牲畜体内寄生虫驱虫剂疗效更加确切，副作用更小，采用定量投药器投药，投服操作简单，刺激性小，尤其适用于大面积开展家畜寄生虫病的防治，可大大减轻工作人员的劳动强度。本发明驱虫效果显著，分散度大，易于吸水，通过定量投药器直接投入家畜的胃中后，能均匀地较大面积地附着于动物的胃中，增加原药与胃肠的接触时间，从而提高其药效。
Claims (3)
1.一种驱治牲畜体内寄生虫的硝唑尼特混悬液，其特征在于它的组分和质量百分数范围为硝唑尼特3-5%、黄原胶0.2%～0.5%、卡波姆0.2%～0.6%、柠檬酸0.3%～0.6%、柠檬酸三钠0.15～0.3%、稳定剂0.15～0.3%、矫味剂4%～9%，其余为水；所述混悬液的制备方法是将黄原胶及卡波姆加水制成胶液，置于乳化器中后加入柠檬酸、柠檬酸三钠、稳定剂、硝唑尼特、矫味剂和水，进行剪切。
2.如权利要求1所述的驱治牲畜体内寄生虫的硝唑尼特混悬液，其特征在于所述的稳定剂为苯甲酸钠、苯甲酸或山梨酸。
3.如权利要求1所述的驱治牲畜体内寄生虫的硝唑尼特混悬液，其特征在于所述的矫味剂为蔗糖、山梨醇或安塞蜜。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910016461 CN101606905B (zh) | 2009-06-30 | 2009-06-30 | 一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910016461 CN101606905B (zh) | 2009-06-30 | 2009-06-30 | 一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101606905A CN101606905A (zh) | 2009-12-23 |
| CN101606905B true CN101606905B (zh) | 2012-06-13 |
Family
ID=41480921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910016461 Expired - Fee Related CN101606905B (zh) | 2009-06-30 | 2009-06-30 | 一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101606905B (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012788B (zh) * | 2019-12-12 | 2021-01-15 | 武汉职业技术学院 | 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用 |
-
2009
- 2009-06-30 CN CN 200910016461 patent/CN101606905B/zh not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| Jean-Francois.Nitrazoxanide in the treatment of amoebiasis.《transactions of the royal society of tropical medicine and hygiene》.2007,(第101期),1025-1031. * |
| 刘元元.硝唑尼特干混悬剂代谢物T及其结合物在狗体内的药代动力学初步研究.《西北药学杂志》.2009,第24卷(第1期),44. * |
| 崔福得.混悬剂的稳定剂.《药剂学》.2005,29-30. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101606905A (zh) | 2009-12-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2616058B1 (en) | Animal feed compositions of abscisic acid | |
| CN103283764A (zh) | 一种含有溴氰虫酰胺的杀虫组合物 | |
| CN101829211B (zh) | 一种鱼用复方中草药制剂及制备方法 | |
| CN102249799A (zh) | 一种利用申嗪霉素防治作物病害的方法及申嗪霉素制剂 | |
| CN101450068A (zh) | 一种用于防治家畜线虫病的预混剂 | |
| KR101358133B1 (ko) | 법제유황분말 제조방법 및 법제유황분말을 첨가제로 이용한 사료급이방법 | |
| CN101450055A (zh) | 一种用于治疗畜禽细菌感染及寄生虫病的可溶性粉 | |
| CN102643133A (zh) | 一种肥料与多种农药混合的配方及其制备方法 | |
| CN102084862B (zh) | 一种含有乙虫腈的杀虫组合物 | |
| CN101011408A (zh) | 一种治疗畜禽体内外寄生虫病的兽用复方制剂及其制备工艺 | |
| CN103283988A (zh) | 一种乳铁蛋白肽饲料添加剂 | |
| CN101606905B (zh) | 一种驱治牲畜体内寄生虫的硝唑尼特混悬液及其制备方法 | |
| CN108013230A (zh) | 饲料酸化剂及其制备方法 | |
| CN105028416A (zh) | 一种水产养殖专用杀螺分散片的制备方法 | |
| CN101300984B (zh) | 一种多靶位生物制剂及其应用 | |
| US20150351428A1 (en) | Methods and compositions for orally dosing postnatal swine | |
| CN108576481A (zh) | 一种蛋鸡饲料及其制备方法 | |
| CN107488077A (zh) | 茶麸有机肥制作方法 | |
| CN107157944A (zh) | 一种含诱食剂的兽用驱虫药片剂 | |
| CN101966197A (zh) | 用于治疗牛严重复合型寄生虫感染的组合物及制备方法 | |
| RU2440770C2 (ru) | Способ повышения продуктивности сельскохозяйственных животных | |
| CN105145642A (zh) | 一种含噻唑膦的杀线虫颗粒剂 | |
| CN104739857A (zh) | 一种防治仔兔皮肤真菌病的药物组合物 | |
| CN105309441B (zh) | 含有腈吡螨酯的农药组合物及其在防治害螨上的用途 | |
| CN103751199A (zh) | 一种复合杀虫剂及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: 266061 Shandong Province, Qingdao high tech park of Shandong Miao Road Building 6 floor, Room 606, high speed Applicant after: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Co-applicant after: Qingdao Agricultural University Co-applicant after: QINGDAO KDN BIOTECH Co.,Ltd. Address before: 266061 Shandong Province, Qingdao high tech park of Shandong Miao Road Building 6 floor, Room 606, high speed Applicant before: Qingdao Vland Biotech INC. Co-applicant before: Qingdao Agricultural University Co-applicant before: Qingdao Liuhe Pharmaceuticals Ltd. |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: QINGDAO CONTINENT BIOTECH CO., LTD. TO: QINGDAO KDN PHARMACEUTICAL CO., LTD. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: QINGDAO WEILAN BIOLOGY CO., LTD. Free format text: FORMER NAME: QINGDAO KDN PHARMACEUTICAL CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 266111 Shandong city of Qingdao province Chengyang Qingda Industrial Park, the first northbound dual Patentee after: QINGDAO VLAND BIOTECH Inc. Patentee after: Qingdao Agricultural University Patentee after: QINGDAO KDN BIOTECH Co.,Ltd. Address before: 266061 Shandong Province, Qingdao high tech park of Shandong Miao Road Building 6 floor, Room 606, high speed Patentee before: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Patentee before: Qingdao Agricultural University Patentee before: QINGDAO KDN BIOTECH Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120613 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |