CN101590062A - 孕烷二酮或二醇作为神经镇痛剂的应用 - Google Patents

孕烷二酮或二醇作为神经镇痛剂的应用 Download PDF

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Publication number
CN101590062A
CN101590062A CNA2009101264152A CN200910126415A CN101590062A CN 101590062 A CN101590062 A CN 101590062A CN A2009101264152 A CNA2009101264152 A CN A2009101264152A CN 200910126415 A CN200910126415 A CN 200910126415A CN 101590062 A CN101590062 A CN 101590062A
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CN
China
Prior art keywords
alkyl
alkenyl
alkanoyl
methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2009101264152A
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English (en)
Chinese (zh)
Inventor
C·S·古德恰尔德
R·内德森
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Monash University
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Monash University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monash University filed Critical Monash University
Publication of CN101590062A publication Critical patent/CN101590062A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2009101264152A 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用 Pending CN101590062A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR7319A AUPR731901A0 (en) 2001-08-28 2001-08-28 Method of treatment
AUPR7319 2001-08-28

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA02817027XA Division CN1549719A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用

Publications (1)

Publication Number Publication Date
CN101590062A true CN101590062A (zh) 2009-12-02

Family

ID=3831271

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2009101264152A Pending CN101590062A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用
CNA02817027XA Pending CN1549719A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA02817027XA Pending CN1549719A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用

Country Status (10)

Country Link
US (2) US20050009796A1 (https=)
EP (1) EP1450817A4 (https=)
JP (1) JP2005504776A (https=)
CN (2) CN101590062A (https=)
AU (2) AUPR731901A0 (https=)
BR (1) BR0212205A (https=)
CA (1) CA2468466A1 (https=)
MX (1) MXPA04001807A (https=)
RU (1) RU2346690C2 (https=)
WO (1) WO2003018027A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
GB0324423D0 (en) * 2003-10-18 2003-11-19 Vernalis Cambridge Ltd Analgesia method
WO2006010085A1 (en) * 2004-07-09 2006-01-26 Roxro Pharma, Inc. Use of neurosteroids to treat neuropathic pain
RU2302241C1 (ru) * 2005-12-28 2007-07-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и резвератрола при l-name-индуцированном дефиците оксида азота
RU2306929C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306930C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2296566C1 (ru) * 2005-12-28 2007-04-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией амлодипина и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306924C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и резвератрола при l-name-индуцированном дефиците оксида азота
WO2008120562A1 (ja) * 2007-04-02 2008-10-09 Toyo Boseki Kabushiki Kaisha 帯状疱疹後神経痛治療用錠剤および帯状疱疹後神経痛の治療方法
RU2364393C1 (ru) * 2008-03-19 2009-08-20 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции пикамилоном при l-name индуцированном дефиците оксида азота
WO2010025316A1 (en) * 2008-08-29 2010-03-04 Jeffrey Comanor Composition and methods for relief of neuropathological pain

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
GB1373913A (en) * 1970-12-17 1974-11-13 Glaxo Lab Ltd Pharmaceutical compositions
US5888996A (en) * 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
EP0840612A1 (en) * 1995-07-24 1998-05-13 Trustees Of Boston University Inhibition of nmda receptor activity by pregnenolone sulfate derivatives
AUPN498095A0 (en) * 1995-08-23 1995-09-14 Goodchild, Colin Stanley Compounds and compositions
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
US6787530B1 (en) * 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents
US6048848A (en) * 1996-08-23 2000-04-11 Monash University Use of pregnane-diones as analgesic agents
CA2383047A1 (en) * 1999-08-31 2001-03-08 Trustees Of Boston University Effect of steroids on nmda receptors depends on subunit composition
CA2446060A1 (en) * 2001-05-07 2002-11-14 Corium International Compositions and delivery systems for administration of a local anesthetic agent

Also Published As

Publication number Publication date
AUPR731901A0 (en) 2001-09-20
MXPA04001807A (es) 2005-03-07
CN1549719A (zh) 2004-11-24
BR0212205A (pt) 2004-09-21
US20050009796A1 (en) 2005-01-13
WO2003018027A1 (en) 2003-03-06
RU2004109517A (ru) 2005-06-27
EP1450817A1 (en) 2004-09-01
EP1450817A4 (en) 2009-02-25
CA2468466A1 (en) 2003-03-06
US20080227764A1 (en) 2008-09-18
JP2005504776A (ja) 2005-02-17
AU2008202729A1 (en) 2008-07-17
RU2346690C2 (ru) 2009-02-20

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Open date: 20091202